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Recent advances of HCI in decision-making tasks for optimized clinical workflows and precision medicine.
The ever-increasing amount of biomedical data is enabling new large-scale studies, even though ad hoc computational solutions are required. The most recent Machine Learning (ML) and Artificial Intelligence (AI) techniques have...
Running-coupling effects in the triple-differential charmless semileptonic decay width.
We compute the fully–differential ¯B → Xul¯ν decay width to all orders in
perturbation theory in the large–β0 limit. Each of the five structure functions that build
the hadronic tensor is expressed as a Borel integral, summing...
Efficacy and safety of the third-generation chloroethylnitrosourea fotemustine for the treatment of chemorefractory T-cell lymphomas.
Gaetano Corazzelli, Ferdinando Frigeri, Manuela Arcamone, Luigi Aloj, Gaetana Capobianco, Cristina Becchimanzi, Emanuela Morelli, Francesco Volzone, Gianpaolo Marcacci, Filippo Russo, Rosaria De Filippi, Secondo Lastoria, Antonio Pinto
Dec 21, 2018
Patients with recurring T-cell non-Hodgkin lymphoma (T-NHL) are incurable and candidate for investigational agents. Here, we report on five patients with T-NHL refractory to multiple chemotherapy lines, including in all cases...
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.
Chenjie Zeng, Xingyi Guo, Jirong Long, Karoline B Kuchenbaecker, Arnaud Droit, Kyriaki Michailidou, Maya Ghoussaini, Siddhartha Kar, Adam Freeman, John L Hopper, Roger L Milne, Manjeet K Bolla, Qin Wang, Joe Dennis, Simona Agata, Shahana Ahmed, Kristiina Aittomäki, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Adalgeir Arason, Volker Arndt, Banu K Arun, Brita Arver, Francois Bacot, Daniel Barrowdale, Caroline Baynes, Alicia Beeghly-Fadiel, Javier Benitez, Marina Bermisheva, Carl Blomqvist, William J Blot, Natalia V Bogdanova, Stig E Bojesen, Bernardo Bonanni, Anne-Lise Borresen-Dale, Judith S Brand, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Thomas Brüning, Barbara Burwinkel, Saundra S Buys, Qiuyin Cai, Trinidad Caldes, Ian Campbell, Jane Carpenter, Jenny Chang-Claude, Ji-Yeob Choi, Kathleen BM Claes, Christine Clarke, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Miguel de la Hoya, Kim De Leeneer, Peter Devilee, Orland Diez, Susan M Domchek, Michele Doody, Cecilia M Dorfling, Thilo Dörk, Isabel dos-Santos-Silva, Martine Dumont, Miriam Dwek, Bernd Dworniczak, Kathleen Egan, Ursula Eilber, Zakaria Einbeigi, Bent Ejlertsen, Steve Ellis, Debra Frost, Fiona Lalloo, EMBRACE, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Michael Friedlander, Eitan Friedman, Gaetana Gambino, Yu-Tang Gao, Judy Garber, Montserrat García-Closas, Andrea Gehrig, Francesca Damiola, Fabienne Lesueur, Sylvie Mazoyer, Dominique Stoppa-Lyonnet, behalf of GEMO Study Collaborators, Graham G Giles, Andrew K Godwin, David E Goldgar, Anna González-Neira, Mark H Greene, Pascal Guénel, Lothar Haeberle, Christopher A Haiman, Emily Hallberg, Ute Hamann, Thomas vO Hansen, Steven Hart, Jaana M Hartikainen, Mikael Hartman, Norhashimah Hassan, Sue Healey, Frans BL Hogervorst, Senno Verhoef, HEBON, Carolyn B Hendricks, Peter Hillemanns, Antoinette Hollestelle, Peter J Hulick, David J Hunter, Evgeny N Imyanitov, Claudine Isaacs, Hidemi Ito, Anna Jakubowska, Ramunas Janavicius, Katarzyna Jaworska-Bieniek, Uffe Birk Jensen, Esther M John, Charles Joly Beauparlant, Michael Jones, Maria Kabisch, Daehee Kang, Beth Y Karlan, Saila Kauppila, Michael J Kerin, Sofia Khan, Elza Khusnutdinova, Julia A Knight, Irene Konstantopoulou, Peter Kraft, Ava Kwong, Yael Laitman, Diether Lambrechts, Conxi Lazaro, Loic Le Marchand, Chuen Neng Lee, Min Hyuk Lee, Jenny Lester, Jingmei Li, Annelie Liljegren, Annika Lindblom, Artitaya Lophatananon, Jan Lubinski, Phuong L Mai, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, Frederik Marme, Keitaro Matsuo, Lesley McGuffog, Alfons Meindl, Florence Menegaux, Marco Montagna, Kenneth Muir, Anna Marie Mulligan, Katherine L Nathanson, Susan L Neuhausen, Heli Nevanlinna, Polly A Newcomb, Silje Nord, Robert L Nussbaum, Kenneth Offit, Edith Olah, Olufunmilayo I Olopade, Curtis Olswold, Ana Osorio, Laura Papi, Tjoung-Won Park-Simon, Ylva Paulsson-Karlsson, Stephanie Peeters, Bernard Peissel, Paolo Peterlongo, Julian Peto, Georg Pfeiler, Catherine M Phelan, Nadege Presneau, Paolo Radice, Nazneen Rahman, Susan J Ramus, Muhammad Usman Rashid, Gad Rennert, Kerstin Rhiem, Anja Rudolph, Ritu Salani, Suleeporn Sangrajrang, Elinor J Sawyer, Marjanka K Schmidt, Rita K Schmutzler, Minouk J Schoemaker, Peter Schürmann, Caroline Seynaeve, Chen-Yang Shen, Martha J Shrubsole, Xiao-Ou Shu, Alice Sigurdson, Christian F Singer, Susan Slager, Penny Soucy, Melissa Southey, Doris Steinemann, Anthony Swerdlow, Csilla I Szabo, Sandrine Tchatchou, Manuel R Teixeira, Soo H Teo, Mary Beth Terry, Daniel C Tessier, Alex Teulé, Mads Thomassen, Laima Tihomirova, Marc Tischkowitz, Amanda E Toland, Nadine Tung, Clare Turnbull, Ans Mw van den Ouweland, Elizabeth J van Rensburg, David Ven den Berg, Joseph Vijai, Shan Wang-Gohrke, Jeffrey N Weitzel, Alice S Whittemore, Robert Winqvist, Tien Y Wong, Anna H Wu, Drakoulis Yannoukakos, Jyh-Cherng Yu, Paul DP Pharoah, Per Hall, Georgia Chenevix-Trench, kConFab, AOCS Investigators, Alison M Dunning, Jacques Simard, Fergus J Couch, Antonis C Antoniou, Douglas F Easton, Wei Zheng
Oct 21, 2016
BRAC1 mutation carriers Breast Cancer CCDC91 Fine-scale mapping Genetic risk factor PTHLH Alleles BRCA1 Protein Breast Neoplasms Case-Control Studies Chromosome Mapping Chromosomes Human Pair 12 Computational Biology Databases Genetic Enhancer Elements Genetic Epigenesis Genetic Female Genetic Predisposition to Disease Genome-Wide Association Study Genotype Haplotypes Heterozygote Humans Mutation Odds Ratio Polymorphism Single Nucleotide Population Surveillance Promoter Regions Genetic Quantitative Trait Loci risk White People
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.
Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R Barnes, Jamie Allen, Siddhartha Kar, Karen A Pooley, Joe Dennis, Kyriaki Michailidou, Constance Turman, Penny Soucy, Audrey Lemaçon, Michael Lush, Jonathan P Tyrer, Maya Ghoussaini, Mahdi Moradi Marjaneh, Xia Jiang, Simona Agata, Kristiina Aittomäki, M Rosario Alonso, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Adalgeir Arason, Volker Arndt, Kristan J Aronson, Banu K Arun, Bernd Auber, Paul L Auer, Jacopo Azzollini, Judith Balmaña, Rosa B Barkardottir, Daniel Barrowdale, Alicia Beeghly-Fadiel, Javier Benitez, Marina Bermisheva, Katarzyna Białkowska, Amie M Blanco, Carl Blomqvist, William Blot, Natalia V Bogdanova, Stig E Bojesen, Manjeet K Bolla, Bernardo Bonanni, Ake Borg, Kristin Bosse, Hiltrud Brauch, Hermann Brenner, Ignacio Briceno, Ian W Brock, Angela Brooks-Wilson, Thomas Brüning, Barbara Burwinkel, Saundra S Buys, Qiuyin Cai, Trinidad Caldés, Maria A Caligo, Nicola J Camp, Ian Campbell, Federico Canzian, Jason S Carroll, Brian D Carter, Jose E Castelao, Jocelyne Chiquette, Hans Christiansen, Wendy K Chung, Kathleen BM Claes, Christine L Clarke, GEMO Study Collaborators, EMBRACE Collaborators, J Margriet Collée, Sten Cornelissen, Fergus J Couch, Angela Cox, Simon S Cross, Cezary Cybulski, Kamila Czene, Mary B Daly, Miguel de la Hoya, Peter Devilee, Orland Diez, Yuan Chun Ding, Gillian S Dite, Susan M Domchek, Thilo Dörk, Isabel dos-Santos-Silva, Arnaud Droit, Stéphane Dubois, Martine Dumont, Mercedes Duran, Lorraine Durcan, Miriam Dwek, Diana M Eccles, Christoph Engel, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Olivia Fletcher, Giuseppe Floris, Henrik Flyger, Lenka Foretova, William D Foulkes, Eitan Friedman, Lin Fritschi, Debra Frost, Marike Gabrielson, Manuela Gago-Dominguez, Gaetana Gambino, Patricia A Ganz, Susan M Gapstur, Judy Garber, José A García-Sáenz, Mia M Gaudet, Vassilios Georgoulias, Graham G Giles, Gord Glendon, Andrew K Godwin, Mark S Goldberg, David E Goldgar, Anna González-Neira, Maria Grazia Tibiletti, Mark H Greene, Mervi Grip, Jacek Gronwald, Anne Grundy, Pascal Guénel, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Patricia A Harrington, Jaana M Hartikainen, Mikael Hartman, Wei He, Catherine S Healey, Bernadette AM Heemskerk-Gerritsen, Jane Heyworth, Peter Hillemanns, Frans BL Hogervorst, Antoinette Hollestelle, Maartje J Hooning, John L Hopper, Anthony Howell, Guanmengqian Huang, Peter J Hulick, Evgeny N Imyanitov, kConFab Investigators, HEBON Investigators, ABCTB Investigators, Claudine Isaacs, Motoki Iwasaki, Agnes Jager, Milena Jakimovska, Anna Jakubowska, Paul A James, Ramunas Janavicius, Rachel C Jankowitz, Esther M John, Nichola Johnson, Michael E Jones, Arja Jukkola-Vuorinen, Audrey Jung, Rudolf Kaaks, Daehee Kang, Pooja Middha Kapoor, Beth Y Karlan, Renske Keeman, Michael J Kerin, Elza Khusnutdinova, Johanna I Kiiski, Judy Kirk, Cari M Kitahara, Yon-Dschun Ko, Irene Konstantopoulou, Veli-Matti Kosma, Stella Koutros, Katerina Kubelka-Sabit, Ava Kwong, Kyriacos Kyriacou, Yael Laitman, Diether Lambrechts, Eunjung Lee, Goska Leslie, Jenny Lester, Fabienne Lesueur, Annika Lindblom, Wing-Yee Lo, Jirong Long, Artitaya Lophatananon, Jennifer T Loud, Jan Lubiński, Robert J Macinnis, Tom Maishman, Enes Makalic, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Maria Elena Martinez, Keitaro Matsuo, Tabea Maurer, Dimitrios Mavroudis, Rebecca Mayes, Lesley McGuffog, Catriona Mclean, Noura Mebirouk, Alfons Meindl, Austin Miller, Nicola Miller, Marco Montagna, Fernando Moreno, Kenneth Muir, Anna Marie Mulligan, Victor M Muñoz-Garzon, Taru A Muranen, Steven A Narod, Rami Nassir, Katherine L Nathanson, Susan L Neuhausen, Heli Nevanlinna, Patrick Neven, Finn C Nielsen, Liene Nikitina-Zake, Aaron Norman, Kenneth Offit, Edith Olah, Olufunmilayo I Olopade, Håkan Olsson, Nick Orr, Ana Osorio, V Shane Pankratz, Janos Papp, Sue K Park, Tjoung-Won Park-Simon, Michael T Parsons, James Paul, Inge Sokilde Pedersen, Bernard Peissel, Beth Peshkin, Paolo Peterlongo, Julian Peto, Dijana Plaseska-Karanfilska, Karolina Prajzendanc, Ross Prentice, Nadege Presneau, Darya Prokofyeva, Miquel Angel Pujana, Katri Pylkäs, Paolo Radice, Susan J Ramus, Johanna Rantala, Rohini Rau-Murthy, Gad Rennert, Harvey A Risch, Mark Robson, Atocha Romero, Maria Rossing, Emmanouil Saloustros, Estela Sánchez-Herrero, Dale P Sandler, Marta Santamariña, Christobel Saunders, Elinor J Sawyer, Maren T Scheuner, Daniel F Schmidt, Rita K Schmutzler, Andreas Schneeweiss, Minouk J Schoemaker, Ben Schöttker, Peter Schürmann, Christopher Scott, Rodney J Scott, Leigha Senter, Caroline M Seynaeve, Mitul Shah, Priyanka Sharma, Chen-Yang Shen, Xiao-Ou Shu, Christian F Singer, Thomas P Slavin, Snezhana Smichkoska, Melissa C Southey, John J Spinelli, Amanda B Spurdle, Jennifer Stone, Dominique Stoppa-Lyonnet, Christian Sutter, Anthony J Swerdlow, Rulla M Tamimi, Yen Yen Tan, William J Tapper, Jack A Taylor, Manuel R Teixeira, Maria Tengström, Soo Hwang Teo, Mary Beth Terry, Alex Teulé, Mads Thomassen, Darcy L Thull, Marc Tischkowitz, Amanda E Toland, Rob AEM Tollenaar, Ian Tomlinson, Diana Torres, Gabriela Torres-Mejía, Melissa A Troester, Thérèse Truong, Nadine Tung, Maria Tzardi, Hans-Ulrich Ulmer, Celine M Vachon, Christi J van Asperen, Lizet E van der Kolk, Elizabeth J van Rensburg, Ana Vega, Alessandra Viel, Joseph Vijai, Maartje J Vogel, Qin Wang, Barbara Wappenschmidt, Clarice R Weinberg, Jeffrey N Weitzel, Camilla Wendt, Hans Wildiers, Robert Winqvist, Alicja Wolk, Anna H Wu, Drakoulis Yannoukakos, Yan Zhang, Wei Zheng, David Hunter, Paul DP Pharoah, Jenny Chang-Claude, Montserrat García-Closas, Marjanka K Schmidt, Roger L Milne, Vessela N Kristensen, Juliet D French, Stacey L Edwards, Antonis C Antoniou, Georgia Chenevix-Trench, Jacques Simard, Douglas F Easton, Peter Kraft, Alison M Dunning
Nov 05, 2019
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.
K Lawrenson, S Kar, K McCue, K Kuchenbaeker, K Michailidou, J Tyrer, J Beesley, SJ Ramus, Q Li, MK Delgado, JM Lee, K Aittomäki, IL Andrulis, H Anton-Culver, V Arndt, BK Arun, B Arver, EV Bandera, M Barile, RB Barkardottir, D Barrowdale, MW Beckmann, J Benitez, A Berchuck, M Bisogna, L Bjorge, C Blomqvist, W Blot, N Bogdanova, A Bojesen, SE Bojesen, MK Bolla, B Bonanni, A-L Børresen-Dale, H Brauch, P Brennan, H Brenner, F Bruinsma, J Brunet, SA Buhari, B Burwinkel, R Butzow, SS Buys, Q Cai, T Caldes, I Campbell, R Canniotto, J Chang-Claude, J Chiquette, J-Y Choi, KBM Claes, GEMO Study Collaborators, LS Cook, A Cox, DW Cramer, SS Cross, C Cybulski, K Czene, MB Daly, F Damiola, A Dansonka-Mieszkowska, H Darabi, J Dennis, P Devilee, O Diez, JA Doherty, SM Domchek, CM Dorfling, T Dörk, M Dumont, H Ehrencrona, B Ejlertsen, S Ellis, EMBRACE, C Engel, E Lee, DG Evans, PA Fasching, L Feliubadalo, J Figueroa, D Flesch-Janys, O Fletcher, H Flyger, L Foretova, F Fostira, WD Foulkes, BL Fridley, E Friedman, D Frost, G Gambino, PA Ganz, J Garber, M García-Closas, A Gentry-Maharaj, M Ghoussaini, GG Giles, R Glasspool, AK Godwin, MS Goldberg, DE Goldgar, A González-Neira, EL Goode, MT Goodman, MH Greene, J Gronwald, P Guénel, CA Haiman, P Hall, E Hallberg, U Hamann, TVO Hansen, PA Harrington, M Hartman, N Hassan, S Healey, Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), F Heitz, J Herzog, E Høgdall, CK Høgdall, FBL Hogervorst, A Hollestelle, JL Hopper, PJ Hulick, T Huzarski, EN Imyanitov, kConFab Investigators, Australian Ovarian Cancer Study Group, C Isaacs, H Ito, A Jakubowska, R Janavicius, A Jensen, EM John, N Johnson, M Kabisch, D Kang, M Kapuscinski, BY Karlan, S Khan, LA Kiemeney, SK Kjaer, JA Knight, I Konstantopoulou, V-M Kosma, V Kristensen, J Kupryjanczyk, A Kwong, M de la Hoya, Y Laitman, D Lambrechts, N Le, K De Leeneer, J Lester, DA Levine, J Li, A Lindblom, J Long, A Lophatananon, JT Loud, K Lu, J Lubinski, A Mannermaa, S Manoukian, L Le Marchand, S Margolin, F Marme, LFAG Massuger, K Matsuo, S Mazoyer, L McGuffog, C McLean, I McNeish, A Meindl, U Menon, AR Mensenkamp, RL Milne, M Montagna, KB Moysich, K Muir, AM Mulligan, KL Nathanson, RB Ness, SL Neuhausen, H Nevanlinna, S Nord, RL Nussbaum, K Odunsi, K Offit, E Olah, OI Olopade, JE Olson, C Olswold, D O'Malley, I Orlow, N Orr, A Osorio, SK Park, CL Pearce, T Pejovic, P Peterlongo, G Pfeiler, CM Phelan, EM Poole, K Pylkäs, P Radice, J Rantala, MU Rashid, G Rennert, V Rhenius, K Rhiem, HA Risch, G Rodriguez, MA Rossing, A Rudolph, HB Salvesen, S Sangrajrang, EJ Sawyer, JM Schildkraut, MK Schmidt, RK Schmutzler, TA Sellers, C Seynaeve, M Shah, C-Y Shen, X-O Shu, W Sieh, CF Singer, OM Sinilnikova, S Slager, H Song, P Soucy, MC Southey, M Stenmark-Askmalm, D Stoppa-Lyonnet, C Sutter, A Swerdlow, S Tchatchou, MR Teixeira, SH Teo, KL Terry, MB Terry, M Thomassen, MG Tibiletti, L Tihomirova, S Tognazzo, AE Toland, I Tomlinson, D Torres, T Truong, C-C Tseng, N Tung, SS Tworoger, C Vachon, AMW van den Ouweland, HC van Doorn, EJ van Rensburg, LJ Van't Veer, A Vanderstichele, I Vergote, J Vijai, Q Wang, S Wang-Gohrke, JN Weitzel, N Wentzensen, AS Whittemore, H Wildiers, R Winqvist, AH Wu, D Yannoukakos, S-Y Yoon, J-C Yu, W Zheng, Y Zheng, KK Khanna, J Simard, AN Monteiro, JD French, FJ Couch, ML Freedman, DF Easton, AM Dunning, PD Pharoah, SL Edwards, G Chenevix-Trench, AC Antoniou, SA Gayther
Jun 07, 2016