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Computational analysis of GAL pathway pinpoints mechanisms underlying natural variation.
Quantitative traits are measurable phenotypes that show continuous variation over a wide phenotypic range. Enormous effort has recently been put into determining the genetic influences on a variety of quantitative traits with...
Computational Biology Computer Simulation Galactose Gene Expression Regulation Fungal genetic variation Metabolic Networks and Pathways Models Biological Monosaccharide Transport Proteins Mutation Phenotype Quantitative Trait Heritable Repressor Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Transcription Factors
Home-quarantine during the initial Covid-19 outbreak in Israel
Ayelet Arazi, Judah Koller, Ditza A Zachor, Ofer Golan, Yair Sadaka, Dganit Eytan, Orit Stolar, Naama Atzaba-Poria, Hava Golan, Idan Menashe, Gal Meiri, Lidia V Gabis, Ilan Dinstein
Jul 14, 2022
BACKGROUND: Studies have reported that Covid-19 home-quarantine periods have had mostly negative psychological impact on children with ASD and their families. Here we examined parent perceived impact of a 6-week quarantine...
Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis
Milica Grozdanovic, Christine Doyle, Li Lu, Brian Maybruck, Mark Kwatia, Nethaji Thiyagarajan, Ravi Acharya, Steven Ackerman
Aug 31, 2020
Background
The human eosinophil Charcot-Leyden Crystal (CLC) protein is a member of the Galectin superfamily and is also known as Galectin-10 (Gal-10). CLC/Gal-10 forms the distinctive hexagonal bipyramidal crystals...
The human eosinophil Charcot-Leyden Crystal (CLC) protein is a member of the Galectin superfamily and is also known as Galectin-10 (Gal-10). CLC/Gal-10 forms the distinctive hexagonal bipyramidal crystals...
Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity.
Estela González-Gualda, Marta Pàez-Ribes, Beatriz Lozano-Torres, David Macias, Joseph R Wilson, Cristina González-López, Hui-Ling Ou, Sofía Mirón-Barroso, Zhenguang Zhang, Araceli Lérida-Viso, Juan F Blandez, Andrea Bernardos, Félix Sancenón, Miguel Rovira, Ljiljana Fruk, Carla P Martins, Manuel Serrano, Gary J Doherty, Ramón Martínez-Máñez, Daniel Muñoz-Espín
Mar 24, 2020
Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse disease...
Navitoclax (ABT-263) Cellular Senescence chemotherapy-induced senescence Lung cancer prodrug senolytics Thrombocytopenia Aniline Compounds Animals Antineoplastic Agents Apoptosis Blood Platelets Cell Survival Cellular Senescence Drug Screening Assays Antitumor Female Galactose Humans Mice Mice Inbred C57BL Mice SCID Molecular Structure Neoplasms Experimental prodrugs Sulfonamides Tumor Cells Cultured
Two‐Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence
The tracking of cellular senescence usually depends on the detection of senescence‐associated β‐galactosidase (SA‐β‐gal). Previous probes for SA‐β‐gal with this purpose only cover a single dimension: the accumulation...
Yuan Guo, Ying Gao, Yulu Hu, Qimeng Liu, Xiaokang Li, Xinming Li, Chu-Young Kim, Tony D. James, Jian Li, Xi Chen
May 03, 2021
The tracking of cellular senescence usually depends on the detection of senescence‐associated β‐galactosidase (SA‐β‐gal). Previous probes for SA‐β‐gal with this purpose only cover a single dimension: the accumulation...
Real-time tracking and in vivo visualization of β-galactosidase activity in colorectal tumor with a ratiometric near-infrared fluorescent probe
Kaizhi Gu, Yisheng Xu, Hui Li, Zhiqian Guo, Shaojia Zhu, Shiqin Zhu, Ping Shi, Tony D. James, He Tian, Wei-Hong Zhu
Apr 27, 2016
Development of “smart” noninvasive bioimaging probes for trapping specific enzyme activities is highly desirable for cancer therapy in vivo. Given that β-galactosidase (β-gal) is an important biomarker for cell senescence and...
A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface.
Sarah E Stewart, Sam A Menzies, Stephanie J Popa, Natalia Savinykh, Anna Petrunkina Harrison, Paul J Lehner, Kevin Moreau
Dec 07, 2017
Galectins are a family of lectin binding proteins expressed both intracellularly and extracellularly. Galectin-3 (Gal-3, also known as LGALS3) is expressed at the cell surface; however, Gal-3 lacks a signal sequence, and the...
Real-time tracking and in vivo visualization of β-galactosidase activity in colorectal tumor with a ratiometric near-infrared fluorescent probe
Kaizhi Gu, Yisheng Xu, Hui Li, Zhiqian Guo, Shaojia Zhu, Shiqin Zhu, Ping Shi, Tony D. James, He Tian, Wei-Hong Zhu
Apr 27, 2016
Development of “smart” noninvasive bioimaging probes for trapping specific enzyme activities is highly desirable for cancer therapy in vivo. Given that β-galactosidase (β-gal) is an important biomarker for cell senescence and...
The Patterned Structure of Galactoglucomannan Suggests It May Bind to Cellulose in Seed Mucilage.
Li Yu, Jan J Lyczakowski, Caroline S Pereira, Toshihisa Kotake, Xiaolan Yu, An Li, Soren Mogelsvang, Munir S Skaf, Paul Dupree
Nov 13, 2018
The interaction between mannan polysaccharides and cellulose microfibrils contributes to cell wall properties in some vascular plants, but the molecular arrangement of mannan in the cell wall and the nature of the molecular...
A versatile drug delivery system targeting senescent cells.
Daniel Muñoz-Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano-Torres, Marta Paez-Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz-Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez-Máñez, Manuel Serrano
Sep 20, 2018
Senescent cells accumulate in multiple aging-associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β-galactosidase activity of...
Chemotherapy Fibrosis nanomedicine palbociclib Senescence Animals Cell Survival Cellular Senescence Cytotoxins Disease Models Animal Drug Compounding Drug Delivery Systems Fluorescent Dyes Galactose Heterografts Lysosomes Mice Neoplasm Transplantation Neoplasms Oligosaccharides Piperazines Pyridines Staining and Labeling beta-Galactosidase
Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis
Milica Grozdanovic, Christine Doyle, Li Lu, Brian Maybruck, Mark Kwatia, Nethaji Thiyagarajan, Ravi Acharya, Steven Ackerman
Aug 31, 2020
Background
The human eosinophil Charcot-Leyden Crystal (CLC) protein is a member of the Galectin superfamily and is also known as Galectin-10 (Gal-10). CLC/Gal-10 forms the distinctive hexagonal bipyramidal crystals...
The human eosinophil Charcot-Leyden Crystal (CLC) protein is a member of the Galectin superfamily and is also known as Galectin-10 (Gal-10). CLC/Gal-10 forms the distinctive hexagonal bipyramidal crystals...
Effective cylindrical cell decompositions for restricted sub-Pfaffian sets
The o-minimal structure generated by the restricted Pfaffian functions, known as restricted sub-Pfaffian sets, admits a natural measure of complexity in terms of a format F, recording information like the number of variables...
Two‐Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence
The tracking of cellular senescence usually depends on the detection of senescence‐associated β‐galactosidase (SA‐β‐gal). Previous probes for SA‐β‐gal with this purpose only cover a single dimension: the accumulation...
Yuan Guo, Ying Gao, Yulu Hu, Qimeng Liu, Xiaokang Li, Xinming Li, Chu-Young Kim, Tony D. James, Jian Li, Xi Chen
May 03, 2021
The tracking of cellular senescence usually depends on the detection of senescence‐associated β‐galactosidase (SA‐β‐gal). Previous probes for SA‐β‐gal with this purpose only cover a single dimension: the accumulation...
Effective cylindrical cell decompositions for restricted sub-Pfaffian sets
The o-minimal structure generated by the restricted Pfaffian functions, known as restricted sub-Pfaffian sets, admits a natural measure of complexity in terms of a format F, recording information like the number of variables...
Unlimited Sampling of Bandpass Signals
Bandpass signals are an important sub-class of bandlimited signals that naturally arise in a number of application areas but their high-frequency content poses an acquisition challenge. Consequently, “Bandpass Sampling Theory”...
Cross-presentation of glycolipid from tumor cells loaded with ?-galactosylceramide leads to potent and long-lived T cell-mediated immunity via dendritic cells
We report a mechanism to induce combined and long-lived CD4+ and CD8+ T cell immunity to several mouse tumors. Surprisingly, the initial source of antigen is a single low dose of tumor cells loaded with ?-galactosylceramide...
Published by: Rockefeller University
Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers
Xianzhi Chai, Hai Hao Han, Adam C. Sedgwick, Na Li, Yi Zang, Tony D. James, Junji Zhang, Xi Le Hu, Yang Yu, Yao Li, Yan Wang, Jia Li, Xiao Peng He, He Tian
Oct 21, 2020
Here, we report a β-galactosidase (β-Gal)-responsive photochromic fluorescent probe, NpG, that was designed to prebind to human serum albumin (HSA) to form the probe/protein hybrid, NpG@HSA. The formation of NpG@HSA led to an...
/dk/atira/pure/subjectarea/asjc/1500/1503 name=Catalysis /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1500/1505 name=Colloid and Surface Chemistry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers
Xianzhi Chai, Hai Hao Han, Adam C. Sedgwick, Na Li, Yi Zang, Tony D. James, Junji Zhang, Xi Le Hu, Yang Yu, Yao Li, Yan Wang, Jia Li, Xiao Peng He, He Tian
Oct 21, 2020
Here, we report a β-galactosidase (β-Gal)-responsive photochromic fluorescent probe, NpG, that was designed to prebind to human serum albumin (HSA) to form the probe/protein hybrid, NpG@HSA. The formation of NpG@HSA led to an...
/dk/atira/pure/subjectarea/asjc/1500/1503 name=Catalysis /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1500/1505 name=Colloid and Surface Chemistry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Unlimited Sampling of Bandpass Signals
Bandpass signals are an important sub-class of bandlimited signals that naturally arise in a number of application areas but their high-frequency content poses an acquisition challenge. Consequently, “Bandpass Sampling Theory”...
Photoactivatable senolysis with single-cell resolution delays aging
Donglei Shi, Wenwen Liu, Ying Gao, Xinming Li, Yunyuan Huang, Xiaokang Li, Tony James, Yuan Guo, Jian Li
Mar 31, 2023
Strategies that can selectively eliminate senescent cells (SnCs), namely senolytics, have been shown to promote healthy lifespan. However, it is challenging to achieve precise, broad-spectrum and tractable senolysis. Here, we...
A Self-Determination Theory Approach to Work Motivation of Autistic Adults
The study explores work motivation of autistic adults through the lens of Self-Determination Theory (SDT). Twelve autistic employees (ages 28-47; 3 females) participated in semi-structured qualitative interviews about their work...
Turán‐type problems for long cycles in random and pseudo‐random graphs
We study the Turán number of long cycles in random and pseudo‐random graphs. Denote by ex ( G ( n , p ) , H ) $\operatorname{ex}(G(n,p),H)$ the random variable counting the number of edges in a largest subgraph of G ( n , p )...
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