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Accuracy of maturity prediction equations in individual elite football players
Background Equations predicting age at peak height velocity (APHV) are often used to assess somatic maturity and to adjust training load accordingly. However, information on the intra-individual accuracy of APHV in youth...
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Accuracy of maturity prediction equations in individual elite football players
Background Equations predicting age at peak height velocity (APHV) are often used to assess somatic maturity and to adjust training load accordingly. However, information on the intra-individual accuracy of APHV in youth...
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Ten false beliefs in neurocritical care.
In acute brain injury, the need for specific expertise on central nervous pathophysiology is evident. However, even when the primary reason for ICU admission is extracranial, the brain may be affected too, through inadequate...
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Methods for studying naturally occurring human pain and their analogues
Methods for investigating human pain have been developed over the last 100 years. Typically, researchers focus on people with clinical pain, or on healthy participants undergoing laboratory-controlled pain-induction techniques...
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The experience of cognitive intrusion of pain
Patients with chronic pain often report their cognition to be impaired by pain, and this observation has been supported by numerous studies measuring the effects of pain on cognitive task performance. Furthermore, cognitive...
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The experience of cognitive intrusion of pain
Patients with chronic pain often report their cognition to be impaired by pain, and this observation has been supported by numerous studies measuring the effects of pain on cognitive task performance. Furthermore, cognitive...
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Methods for studying naturally occurring human pain and their analogues
Methods for investigating human pain have been developed over the last 100 years. Typically, researchers focus on people with clinical pain, or on healthy participants undergoing laboratory-controlled pain-induction techniques...
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A deep learning approach to bilingual lexicon induction in the biomedical domain.
BACKGROUND: Bilingual lexicon induction (BLI) is an important task in the biomedical domain as translation resources are usually available for general language usage, but are often lacking in domain-specific settings. In this...
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Choosing Estimands in Clinical Trials

The National Research Council (NRC) Expert Panel Report on Prevention and Treatment of Missing Data in Clinical Trials highlighted the need for clearly defining objectives and estimands. That report sparked considerable...

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Ethylene Receptors, CTRs and EIN2 Target Protein Identification and Quantification Through Parallel Reaction Monitoring During Tomato Fruit Ripening.
Ethylene, the plant ripening hormone of climacteric fruit, is perceived by ethylene receptors which is the first step in the complex ethylene signal transduction pathway. Much progress has been made in elucidating the mechanism...
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Choosing Estimands in Clinical Trials

The National Research Council (NRC) Expert Panel Report on Prevention and Treatment of Missing Data in Clinical Trials highlighted the need for clearly defining objectives and estimands. That report sparked considerable...

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Continuously tuneable critical current in superconductor-ferromagnet multilayers
We demonstrate that the critical current of superconducting Nb/Ni multilayers can be continuously tuned by up to a factor of three during magnetization reversal of the Ni films under an applied in-plane magnetic field. Our...
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Continuously tuneable critical current in superconductor-ferromagnet multilayers
We demonstrate that the critical current of superconducting Nb/Ni multilayers can be continuously tuned by up to a factor of three during magnetization reversal of the Ni films under an applied in-plane magnetic field. Our...
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Tumors Widely Express Hundreds of Embryonic Germline Genes.
We have recently described a class of 756 genes that are widely expressed in cancers, but are normally restricted to adult germ cells, referred to as germ cell cancer genes (GC genes). We hypothesized that carcinogenesis...
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Transcriptome Sequence of the Bloodstream Form of Trypanoplasma borreli, a Hematozoic Parasite of Fish Transmitted by Leeches.
Here, we report a transcriptome sequence of Trypanoplasma borreli isolated from its natural host, the common carp, Cyprinus carpio The transcriptome allows an analysis of abundant cell surface proteins and acts as a comparator...
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Neurocomputational mechanisms underpinning aberrant social learning in young adults with low self-esteem.
Low self-esteem is a risk factor for a range of psychiatric disorders. From a cognitive perspective a negative self-image can be maintained through aberrant learning about self-worth derived from social feedback. We previously...
Published by: Translational psychiatry
Defining Efficacy Estimands in Clinical Trials

This paper provides examples of defining estimands in real-world scenarios following ICH E9(R1) guidelines. Detailed discussions on choosing the estimands and estimators can be found in our companion papers. Three scenarios...

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Defining Efficacy Estimands in Clinical Trials

This paper provides examples of defining estimands in real-world scenarios following ICH E9(R1) guidelines. Detailed discussions on choosing the estimands and estimators can be found in our companion papers. Three scenarios...

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