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Results: 35
Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood.
Nicole Toepfner, Christoph Herold, Oliver Otto, Philipp Rosendahl, Angela Jacobi, Martin Kräter, Julia Stächele, Leonhard Menschner, Maik Herbig, Laura Ciuffreda, Lisa Ranford-Cartwright, Michal Grzybek, Ünal Coskun, Elisabeth Reithuber, Geneviève Garriss, Peter Mellroth, Birgitta Henriques-Normark, Nicola Tregay, Meinolf Suttorp, Martin Bornhäuser, Edwin R Chilvers, Reinhard Berner, Jochen Guck
Jun 12, 2018
Blood is arguably the most important bodily fluid and its analysis provides crucial health status information. A first routine measure to narrow down diagnosis in clinical practice is the differential blood count, determining...
Atomic permutationally invariant polynomials for fitting molecular force fields
Abstract: We introduce and explore an approach for constructing force fields for small molecules, which combines intuitive low body order empirical force field terms with the concepts of data driven statistical fits of recent...
Atomic permutationally invariant polynomials for fitting molecular force fields
Abstract: We introduce and explore an approach for constructing force fields for small molecules, which combines intuitive low body order empirical force field terms with the concepts of data driven statistical fits of recent...
Atomic permutationally invariant polynomials for fitting molecular force fields
Abstract: We introduce and explore an approach for constructing force fields for small molecules, which combines intuitive low body order empirical force field terms with the concepts of data driven statistical fits of recent...
Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology
Olivier Lurette, Hala Guedouari, Jordan L. Morris, Rebeca Martín-Jiménez, Julie-Pier Robichaud, Geneviève Hamel-Côté, Mehtab Khan, Nicholas Dauphinee, Nicolas Pichaud, Julien Prudent, Etienne Hebert-Chatelain
Jun 29, 2022
Abstract: The architecture of mitochondria adapts to physiological contexts: while mitochondrial fragmentation is usually associated to quality control and cell death, mitochondrial elongation often enhances cell survival during...
Proteomic analysis of the actin cortex in interphase and mitosis.
Neza Vadnjal, Sami Nourreddine, Geneviève Lavoie, Murielle Serres, Philippe P Roux, Ewa K Paluch
Sep 02, 2022
Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology.
Olivier Lurette, Hala Guedouari, Jordan L Morris, Rebeca Martín-Jiménez, Julie-Pier Robichaud, Geneviève Hamel-Côté, Mehtab Khan, Nicholas Dauphinee, Nicolas Pichaud, Julien Prudent, Etienne Hebert-Chatelain
Jul 01, 2022
The architecture of mitochondria adapts to physiological contexts: while mitochondrial fragmentation is usually associated to quality control and cell death, mitochondrial elongation often enhances cell survival during stress....
Role of the general practitioner in the care of BRCA1 and BRCA2 mutation carriers
Pierre Vande Perre, Daniel Toledano, Carole Corsini, Elsa Escriba, Marine Laporte, Helena Bertet, Kevin Yauy, Alain Toledano, Virginie Galibert, Karen Baudry, Lucie Clotet, Elodie Million, Marie-Christine Picot, David Geneviève, Pascal Pujol
Sep 26, 2019
BRCA1 BRCA2 general practitioners genetic screening Hereditary Breast and Ovarian Cancer Syndrome Adult Aged Aged 80 and over BRCA1 Protein BRCA2 Protein Breast Neoplasms Female general practitioners Genetic Carrier Screening Genetic Counseling Health Knowledge Attitudes practice Humans Middle Aged Referral and Consultation
F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis.
Murielle P Serres, Matthias Samwer, Binh An Truong Quang, Geneviève Lavoie, Upamali Perera, Dirk Görlich, Guillaume Charras, Mark Petronczki, Philippe P Roux, Ewa K Paluch
Jul 02, 2020
Most metazoan cells entering mitosis undergo characteristic rounding, which is important for accurate spindle positioning and chromosome separation. Rounding is driven by contractile tension generated by myosin motors in the...
Autosomal recessive primary microcephaly due to ASPM mutations
Pascaline Létard, Séverine Drunat, Yoann Vial, Sarah Duerinckx, Anais Ernault, Daniel Amram, Stéphanie Arpin, Marta Bertoli, Tiffany Busa, Berten Ceulemans, Julie Desir, Martine Doco-Fenzy, Siham Chafai Elalaoui, Koenraad Devriendt, Laurence Faivre, Christine Francannet, David Geneviève, Marion Gérard, Cyril Gitiaux, Sophie Julia, Sébastien Lebon, Toni Lubala, Michèle Mathieu-Dramard, Hélène Maurey, Julia Metreau, Sanaa Nasserereddine, Mathilde Nizon, Geneviève Pierquin, Nathalie Pouvreau, Clothilde Rivier-Ringenbach, Massimiliano Rossi, Elise Schaefer, Abdelaziz Sefiani, Sabine Sigaudy, Yves Sznajer, Yusuf Tunca, Sophie Guilmin Crepon, Corinne Alberti, Monique Elmaleh-Bergès, Brigitte Benzacken, Bernd Wollnick, C Geoffrey Woods, Anita Rauch, Marc Abramowicz, Vincent El Ghouzzi, Pierre Gressens, Alain Verloes, Sandrine Passemard
Apr 24, 2019
Autosomal recessive microcephaly or microcephaly primary hereditary (MCPH) is a genetically heterogeneous neurodevelopmental disorder characterized by a reduction in brain volume, indirectly measured by an occipitofrontal...
Predicted antiviral activity of tenofovir versus abacavir in combination with a cytosine analogue and the integrase inhibitor dolutegravir in HIV-1-infected South African patients initiating or failing first-line ART.
Anne Derache, Collins C Iwuji, Siva Danaviah, Jennifer Giandhari, Anne-Geneviève Marcelin, Vincent Calvez, Tulio de Oliveira, François Dabis, Deenan Pillay, Ravindra K Gupta
Oct 22, 2019
OBJECTIVES: The WHO recently recommended the use of a new first-line ART containing dolutegravir. We investigated the efficacy of NRTI backbones (tenofovir or abacavir with a cytosine analogue) in low- and middle-income...
Adult Anti-HIV Agents Antiretroviral Therapy Highly Active Cytosine Dideoxynucleosides Drug Combinations Drug Resistance Viral Female HIV Infections HIV Integrase Inhibitors HIV-1 Heterocyclic Compounds 3-Ring Humans Male Middle Aged Mutation Oxazines Piperazines Pyridones South Africa Tenofovir Viral Load Young Adult
Decision Support Tool for the Agri-Food Sector Using Data Annotated by Ontology and Bayesian Network
Cédric Baudrit, Patrice Buche, Nadine Leconte, Christophe Fernandez, Maëllis Belna, Geneviève Gésan-Guiziou
Jan 01, 2022
The scientific literature is a valuable source of information for developing predictive models to design decision support systems. However, scientific data are heterogeneously structured expressed using different vocabularies....
Published by: IGI Global Scientific Publishing
Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology.
Olivier Lurette, Hala Guedouari, Jordan L Morris, Rebeca Martín-Jiménez, Julie-Pier Robichaud, Geneviève Hamel-Côté, Mehtab Khan, Nicholas Dauphinee, Nicolas Pichaud, Julien Prudent, Etienne Hebert-Chatelain
Jun 07, 2022
The architecture of mitochondria adapts to physiological contexts: while mitochondrial fragmentation is usually associated to quality control and cell death, mitochondrial elongation often enhances cell survival during stress....
SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization.
Luyan Cao, Amina Yonis, Malti Vaghela, Elias H Barriga, Priyamvada Chugh, Matthew B Smith, Julien Maufront, Geneviève Lavoie, Antoine Méant, Emma Ferber, Miia Bovellan, Art Alberts, Aurélie Bertin, Roberto Mayor, Ewa K Paluch, Philippe P Roux, Antoine Jégou, Guillaume Romet-Lemonne, Guillaume Charras
Oct 05, 2020
Cell shape is controlled by the submembranous cortex, an actomyosin network mainly generated by two actin nucleators: the Arp2/3 complex and the formin mDia1. Changes in relative nucleator activity may alter cortical...
The sympathomimetic agonist mirabegron did not lower JAK2-V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms
Beatrice Drexler, Jakob R Passweg, Alexandar Tzankov, Martin Bigler, Alexandre Pa Theocharides, Nathan Cantoni, Peter Keller, Georg Stussi, Axel Ruefer, Rudolf Benz, Geneviève Favre, Pontus Lundberg, Ronny Nienhold, Andrea Fuhrer, Christine Biaggi, Markus G Manz, Mario Bargetzi, Simon Mendez-Ferrer, Radek C Skoda, Swiss Group for Clinical Cancer Research (SAKK)
Dec 13, 2018
The β-3 sympathomimetic agonist BRL37344 restored nestin-positive cells within the stem cell niche, and thereby normalized blood counts and improved myelofibrosis in a mouse model of JAK2-V617F-positive myeloproliferative...
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.
Yibo Xue, Jordan L Morris, Kangning Yang, Zheng Fu, Xianbing Zhu, Fraser Johnson, Brian Meehan, Leora Witkowski, Amber Yasmeen, Tunde Golenar, Mackenzie Coatham, Geneviève Morin, Anie Monast, Virginie Pilon, Pierre Olivier Fiset, Sungmi Jung, Anne V Gonzalez, Sophie Camilleri-Broet, Lili Fu, Lynne-Marie Postovit, Jonathan Spicer, Walter H Gotlieb, Marie-Christine Guiot, Janusz Rak, Morag Park, William Lockwood, William D Foulkes, Julien Prudent, Sidong Huang
Jun 30, 2021
Inactivating mutations in SMARCA4 and concurrent epigenetic silencing of SMARCA2 characterize subsets of ovarian and lung cancers. Concomitant loss of these key subunits of SWI/SNF chromatin remodeling complexes in both cancers...
Animals Antineoplastic Agents Apoptosis Calcium Cell Line Tumor DNA Helicases Gene Expression Profiling Gene Expression Regulation Neoplastic HEK293 Cells Humans Inositol 1 4 5-Trisphosphate Receptors Ion Transport Male Mice Inbred NOD Mice Knockout Mice SCID Mitochondria Mutation Neoplasms Nuclear Proteins Transcription Factors Xenograft Model Antitumor Assays
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca<sup>2+</sup> flux to mitochondria.
Yibo Xue, Jordan L Morris, Kangning Yang, Zheng Fu, Xianbing Zhu, Fraser Johnson, Brian Meehan, Leora Witkowski, Amber Yasmeen, Tunde Golenar, Mackenzie Coatham, Geneviève Morin, Anie Monast, Virginie Pilon, Pierre Olivier Fiset, Sungmi Jung, Anne V Gonzalez, Sophie Camilleri-Broet, Lili Fu, Lynne-Marie Postovit, Jonathan Spicer, Walter H Gotlieb, Marie-Christine Guiot, Janusz Rak, Morag Park, William Lockwood, William D Foulkes, Julien Prudent, Sidong Huang
Oct 18, 2021
Inactivating mutations in SMARCA4 and concurrent epigenetic silencing of SMARCA2 characterize subsets of ovarian and lung cancers. Concomitant loss of these key subunits of SWI/SNF chromatin remodeling complexes in both cancers...
Published by: Nature Communications
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca 2+ flux to mitochondria
Yibo Xue, Jordan L. Morris, Kangning Yang, Zheng Fu, Xianbing Zhu, Fraser Johnson, Brian Meehan, Leora Witkowski, Amber Yasmeen, Tunde Golenar, Mackenzie Coatham, Geneviève Morin, Anie Monast, Virginie Pilon, Pierre Olivier Fiset, Sungmi Jung, Anne V. Gonzalez, Sophie Camilleri-Broet, Lili Fu, Lynne-Marie Postovit, Jonathan Spicer, Walter H. Gotlieb, Marie-Christine Guiot, Janusz Rak, Morag Park, William Lockwood, William D. Foulkes, Julien Prudent, Sidong Huang
Sep 13, 2021
Abstract: Inactivating mutations in SMARCA4 and concurrent epigenetic silencing of SMARCA2 characterize subsets of ovarian and lung cancers. Concomitant loss of these key subunits of SWI/SNF chromatin remodeling complexes in...
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca 2+ flux to mitochondria
Yibo Xue, Jordan L. Morris, Kangning Yang, Zheng Fu, Xianbing Zhu, Fraser Johnson, Brian Meehan, Leora Witkowski, Amber Yasmeen, Tunde Golenar, Mackenzie Coatham, Geneviève Morin, Anie Monast, Virginie Pilon, Pierre Olivier Fiset, Sungmi Jung, Anne V. Gonzalez, Sophie Camilleri-Broet, Lili Fu, Lynne-Marie Postovit, Jonathan Spicer, Walter H. Gotlieb, Marie-Christine Guiot, Janusz Rak, Morag Park, William Lockwood, William D. Foulkes, Julien Prudent, Sidong Huang
Mar 21, 2023
article /631/67/68/2486 /631/67/1059/2326 /631/67/1244 /631/80/82/23 /13/106 /13/89 /13/95 /13/44 /13/51 /13/31 /13/2 /14/19 /38/15 /38/39 /49/47 /82/80 article
Published by: Nature Publishing Group UK
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca 2+ flux to mitochondria
Yibo Xue, Jordan L. Morris, Kangning Yang, Zheng Fu, Xianbing Zhu, Fraser Johnson, Brian Meehan, Leora Witkowski, Amber Yasmeen, Tunde Golenar, Mackenzie Coatham, Geneviève Morin, Anie Monast, Virginie Pilon, Pierre Olivier Fiset, Sungmi Jung, Anne V. Gonzalez, Sophie Camilleri-Broet, Lili Fu, Lynne-Marie Postovit, Jonathan Spicer, Walter H. Gotlieb, Marie-Christine Guiot, Janusz Rak, Morag Park, William Lockwood, William D. Foulkes, Julien Prudent, Sidong Huang
Mar 22, 2023
article /631/67/68/2486 /631/67/1059/2326 /631/67/1244 /631/80/82/23 /13/106 /13/89 /13/95 /13/44 /13/51 /13/31 /13/2 /14/19 /38/15 /38/39 /49/47 /82/80 article
Published by: Nature Publishing Group UK
Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity.
Pauline Morigny, Marianne Houssier, Aline Mairal, Claire Ghilain, Etienne Mouisel, Fadila Benhamed, Bernard Masri, Emeline Recazens, Pierre-Damien Denechaud, Geneviève Tavernier, Sylvie Caspar-Bauguil, Sam Virtue, Veronika Sramkova, Laurent Monbrun, Anne Mazars, Madjid Zanoun, Sandra Guilmeau, Valentin Barquissau, Diane Beuzelin, Sophie Bonnel, Marie Marques, Boris Monge-Roffarello, Corinne Lefort, Barbara Fielding, Thierry Sulpice, Arne Astrup, Bernard Payrastre, Justine Bertrand-Michel, Emmanuelle Meugnier, Laetitia Ligat, Frédéric Lopez, Hervé Guillou, Charlotte Ling, Cecilia Holm, Remi Rabasa-Lhoret, Wim HM Saris, Vladimir Stich, Peter Arner, Mikael Rydén, Cedric Moro, Nathalie Viguerie, Matthew Harms, Stefan Hallén, Antonio Vidal-Puig, Hubert Vidal, Catherine Postic, Dominique Langin
Nov 16, 2020
Impaired adipose tissue insulin signalling is a critical feature of insulin resistance. Here we identify a pathway linking the lipolytic enzyme hormone-sensitive lipase (HSL) to insulin action via the glucose-responsive...
ChREBP ELOVL Fatty Acid Elongase 6 ELOVL6 Expression Hormone-sensitive Lipase Insulin Signaling Adipocytes Adipose Tissue Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Biomarkers Fatty Acid Elongases Gene Expression Glucose Insulin Insulin Resistance Membrane Fluidity Mice Mice Transgenic Protein Interaction Mapping Protein Interaction Maps Signal Transduction Sterol Esterase
Coffee and Tea Consumption and the Contribution of Their Added Ingredients to Total Energy and Nutrient Intakes in 10 European Countries
Edwige Landais, Aurélie Moskal, Amy Mullee, Geneviève Nicolas, Marc J Gunter, Inge Huybrechts, Kim Overvad, Nina Roswall, Aurélie Affret, Guy Fagherazzi, Yahya Mahamat-Saleh, Verena Katzke, Tilman Kühn, Carlo La Vecchia, Antonia Trichopoulou, Elissavet Valanou, Calogero Saieva, Maria Santucci de Magistris, Sabina Sieri, Tonje Braaten, Guri Skeie, Elisabete Weiderpass, Eva Ardanaz, Maria-Dolores Chirlaque, Jose Ramon Garcia, Paula Jakszyn, Miguel Rodríguez-Barranco, Louise Brunkwall, Ena Huseinovic, Lena Nilsson, Peter Wallström, Bas Bueno-de-Mesquita, Petra H Peeters, Dagfinn Aune, Tim Key, Marleen Lentjes, Elio Riboli, Nadia Slimani, Heinz Freisling
Sep 08, 2018
BACKGROUND: Coffee and tea are among the most commonly consumed nonalcoholic beverages worldwide, but methodological differences in assessing intake often hamper comparisons across populations. We aimed to (i) describe coffee...
24-h dietary recall European Prospective Investigation into Cancer and Nutrition Coffee Tea Adult Aged Benchmarking Coffee Energy Intake Europe Feeding Behavior Female Humans Life Style Male Middle Aged Nutrition Surveys Nutritional Status Nutritive Value Prospective Studies Recommended Dietary Allowances Smoking Socioeconomic Factors Tea Time Factors
Characterization of the degree of food processing in the European Prospective Investigation into Cancer and Nutrition
Inge Huybrechts, Fernanda Rauber, Geneviève Nicolas, Corinne Casagrande, Nathalie Kliemann, Roland Wedekind, Carine Biessy, Augustin Scalbert, Mathilde Touvier, Krasimira Aleksandrova, Paula Jakszyn, Guri Skeie, Rashmita Bajracharya, Jolanda MA Boer, Yan Borné, Veronique Chajes, Christina C Dahm, Lucia Dansero, Marcela Guevara, Alicia K Heath, Daniel B Ibsen, Keren Papier, Verena Katzke, Cecilie Kyrø, Giovanna Masala, Esther Molina-Montes, Oliver JK Robinson, Carmen Santiuste de Pablos, Matthias B Schulze, Vittorio Simeon, Emily Sonestedt, Anne Tjønneland, Rosario Tumino, Yvonne T van der Schouw, WM Monique Verschuren, Beatrice Vozar, Anna Winkvist, Marc J Gunter, Carlos A Monteiro, Christopher Millett, Renata Bertazzi Levy
Jan 04, 2023
Clinical spectrum of MTOR-related hypomelanosis of Ito with neurodevelopmental abnormalities.
Virginie Carmignac, Cyril Mignot, Emmanuelle Blanchard, Paul Kuentz, Marie-Hélène Aubriot-Lorton, Victoria ER Parker, Arthur Sorlin, Sylvie Fraitag, Jean-Benoît Courcet, Yannis Duffourd, Diana Rodriguez, Rachel G Knox, Satyamaanasa Polubothu, Anne Boland, Robert Olaso, Marc Delepine, Véronique Darmency, Melissa Riachi, Chloé Quelin, Paul Rollier, Louise Goujon, Sarah Grotto, Yline Capri, Marie-Line Jacquemont, Sylvie Odent, Daniel Amram, Martin Chevarin, Catherine Vincent-Delorme, Benoît Catteau, Laurent Guibaud, Alexis Arzimanoglou, Malika Keddar, Catherine Sarret, Patrick Callier, Didier Bessis, David Geneviève, Jean-François Deleuze, Christel Thauvin, Robert K Semple, Christophe Philippe, Jean-Baptiste Rivière, Veronica A Kinsler, Laurence Faivre, Pierre Vabres
Aug 11, 2021
PURPOSE: Hypomelanosis of Ito (HI) is a skin marker of somatic mosaicism. Mosaic MTOR pathogenic variants have been reported in HI with brain overgrowth. We sought to delineate further the pigmentary skin phenotype and clinical...
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