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Hypoxia-inducible factor in thyroid carcinoma.
Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote...
The Role of Georg Friedrich von Johnssen in the Emergence of the Unknown Superiors, 1763–64
Andrew McKenzie-McHarg
May 03, 2018
This article seeks to clarify the role played by the alchemist Georg
Friedrich Johnssen (c.1726-1775) in the emergence of the notion
that Freemasonry and other secret societies in the second half of
the eighteenth-century were...
Patients with mutations of the Thyroid hormone beta-receptor show an ADHD-like phenotype for performance monitoring
Jan Uter, Marcus Heldmann, Berenike Rogge, Martina Obst, Julia Steinhardt, Georg Brabant, Carla Moran, Krishna Chatterjee, Thomas F Münte
Apr 30, 2020
Resistance to thyroid hormone beta (RTHβ) is a syndrome of reduced responsiveness of peripheral tissue to thyroid hormone, caused by mutations in the thyroid hormone receptor beta (THRB). Its cognitive phenotype has been...
ADHD-like symptoms Action monitoring Event-related potentials Resistance to thyroid hormones TH beta receptor Thyroid hormones (TH) Adolescent Adult Aged Attention Deficit Disorder with Hyperactivity Electroencephalography Evoked Potentials Female Humans Male Middle Aged Mutation Phenotype Thyroid Hormone Receptors beta Thyroid Hormone Resistance Syndrome Young Adult
Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model.
Maik Pietzner, Beatrice Engelmann, Tim Kacprowski, Janine Golchert, Anna-Luise Dirk, Elke Hammer, K Alexander Iwen, Matthias Nauck, Henri Wallaschofski, Dagmar Führer, Thomas F Münte, Nele Friedrich, Uwe Völker, Georg Homuth, Georg Brabant
Nov 16, 2020
BACKGROUND: Determinations of thyrotropin (TSH) and free thyroxine (FT4) represent the gold standard in evaluation of thyroid function. To screen for novel peripheral biomarkers of thyroid function and to characterize...
A Thyroid Hormone-Independent Molecular Fingerprint of 3,5-Diiodothyronine Suggests a Strong Relationship with Coffee Metabolism in Humans.
Maik Pietzner, Josef Köhrle, Ina Lehmphul, Kathrin Budde, Gabi Kastenmüller, Georg Brabant, Henry Völzke, Anna Artati, Jerzy Adamski, Uwe Völker, Matthias Nauck, Nele Friedrich, Georg Homuth
Jan 10, 2020
Background: In numerous studies based predominantly on rodent models, administration of 3,5-diiodo-L-thyronine (3,5-T2), a metabolite of the thyroid hormones (TH) thyroxine (T4) and triiodo-L-thyronine (T3), was reported to...
3 5-diiodothyronine caffeine metabolism Metabolomics Thyroid thyrotoxicosis Adult caffeine Coffee DNA Fingerprinting Diiodothyronines Female Healthy Volunteers Humans Magnetic Resonance Spectroscopy Male Mass Spectrometry Metabolomics Middle Aged Reference Values Thyroid Function Tests Thyroid Hormones Thyrotoxicosis Thyrotropin Thyroxine
The Reality and Power of International Law
Carmen Chas Bartolome
Apr 06, 2024
Georg Schwarzenberger’s oeuvre has remained significantly underexplored in International Relations literature despite his status as one of the most important thinkers in International Relations and international law of the...
2018 European Thyroid Association (ETA) Guidelines on the Diagnosis and Management of Central Hypothyroidism.
Luca Persani, Georg Brabant, Mehul Dattani, Marco Bonomi, Ulla Feldt-Rasmussen, Eric Fliers, Annette Gruters, Dominique Maiter, Nadia Schoenmakers, AS Paul van Trotsenburg
Nov 30, 2018
The Reality and Power of International Law
Carmen Chas Bartolome
Apr 06, 2024
Georg Schwarzenberger’s oeuvre has remained significantly underexplored in International Relations literature despite his status as one of the most important thinkers in International Relations and international law of the...
Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas.
Natalie Burrows, Joseph Williams, Brian A Telfer, Julia Resch, Helen R Valentine, Richard J Fitzmaurice, Amanda Eustace, Joely Irlam, Emily J Rowling, Cuong Hoang-Vu, Catharine M West, Georg Brabant, Kaye J Williams
May 26, 2021
Anaplastic (ATC) and certain follicular thyroid-carcinomas (FTCs) are radioresistant. The Phosphatidylinositide 3-kinase (PI3K) pathway is commonly hyperactivated in thyroid-carcinomas. PI3K can modify the PI3K-related kinases...
ATM ATR DNA-PKcs PI3K radioresistance Animals Carcinoma Carcinoma Papillary Cell Cycle Cell Cycle Proteins Cell Line Tumor DNA Damage DNA-Binding Proteins Dose-Response Relationship Radiation Enzyme Activation Female Histones Humans Hypoxia Indazoles Mice Mice Nude Neoplasm Transplantation Oxygen Phosphatidylinositol 3-Kinases Radiation Tolerance Signal Transduction Sulfonamides Thyroid Cancer Papillary Thyroid Neoplasms
4D perfusion CT of prostate cancer for image-guided radiotherapy planning
Lucian Beer, Stephan H Polanec, Pascal AT Baltzer, Georg Schatzl, Dietmar Georg, Christian Schestak, Anja Dutschke, Harald Herrmann, Peter Mazal, Alexander K Brendel, Shahrokh F Shariat, Helmut Ringl, Thomas H Helbich, Paul Apfaltrer
Feb 03, 2020
PURPOSE: Advanced forms of prostate cancer (PCa) radiotherapy with either external beam therapy or brachytherapy delivery techniques aim for a focal boost and thus require accurate lesion localization and lesion segmentation for...
Aged Biopsy Large-Core Needle Contrast Media Diffusion Magnetic Resonance Imaging Feasibility Studies Four-Dimensional Computed Tomography Humans Image-guided biopsy Male Middle Aged Neoplasm Grading Perfusion Imaging Proof of Concept Study Prospective Studies Prostate Prostatic Neoplasms Radiation Dosage Radiotherapy Planning Computer-Assisted Radiotherapy Image-Guided
Identité Voilée: Le Républicanisme et la Femme Franco-musulmane
Helen Brabant-Bleakley
Jan 01, 0001
Ce projet examine les angoisses culturelles vécues par la Musulmane voilée en France afin de tenter d'expliquer sa marginalisation et son oppression dans la société française contemporaine. Pour déterminer la racine du récit que...
France Muslim women veil Marianne French femininity Arts and Humanities French and Francophone Language and Literature Islamic Studies Social and Cultural Anthropology Sociology Women's Studies
Published by: Ursinus College
Veiled Identity: Republicanism and the Franco-Muslim Woman
Helen Brabant-Bleakley
Jan 01, 0001
This project examines the cultural anxieties experienced by the veiled Muslim woman in France in order to attempt to explain her marginalization and oppression in contemporary French society. In order to determine the root of...
France Muslim women veil Marianne French femininity Islamic Studies Social and Cultural Anthropology Sociology Women's Studies
Published by: Ursinus College
Ex epistulis Philippinensibus
S Kroupa
May 03, 2017
When sent as a pharmacist to the Philippines in 1688, the Bohemian Jesuit Georg Joseph Kamel turned to the local nature to identify resources, which he could use in his practice. Remarkably for a Jesuit of his low rank, Kamel...
Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption.
Kornelia Johann, Anna Lena Cremer, Alexander W Fischer, Markus Heine, Eva Rial Pensado, Julia Resch, Sebastian Nock, Samuel Virtue, Lisbeth Harder, Rebecca Oelkrug, Mariana Astiz, Georg Brabant, Amy Warner, Antonio Vidal-Puig, Henrik Oster, Anita Boelen, Miguel López, Joerg Heeren, Jeffrey W Dalley, Heiko Backes, Jens Mittag
Oct 09, 2020
Regulation of body temperature critically depends on thyroid hormone (TH). Recent studies revealed that TH induces browning of white adipose tissue, possibly contributing to the observed hyperthermia in hyperthyroid patients and...
beige adipose tissue beta3-adrenergic receptor Body Temperature brown adipose tissue glucose tolerance hyperthermia metabolism Norepinephrine pyrexia sympathetic nervous system thyroid hormone receptor Uncoupling Protein 1 Adipose Tissue Beige Adipose Tissue Brown Adipose Tissue White Animals Glucose Male Mice Mice Inbred C57BL Muscle Skeletal Receptors Adrenergic beta-3 Thermogenesis Thyroid Hormones Uncoupling Protein 1
Topology From Analysis
Nicholas A Scoville
Jan 01, 0001
Topology is often described as having no notion of distance, but a notion of nearness. How can such a thing be possible? Isn't this just a distinction without a difference? In this project, we will discover the notion of...
topology analysis derived set limit point Curriculum and Instruction Educational Methods Geometry and Topology Higher Education Science and Mathematics Education
Published by: Ursinus College
Dilthey, Gadamer, and Facebook
R Craig
Dec 01, 2016
This article offers a rereading of aspects of the twentieth-century German hermeneutic tradition, with a specific emphasis on Wilhelm Dilthey and Hans-Georg Gadamer. It aims to show how we could re-evaluate their work's...
Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas.
N Burrows, J Resch, RL Cowen, R von Wasielewski, C Hoang-Vu, CM West, KJ Williams, G Brabant
May 26, 2021
Hypoxia-inducible factor 1 alpha (HIF-1 alpha) is upregulated by hypoxia and oncogenic signalling in many solid tumours. Its regulation and function in thyroid carcinomas are unknown. We evaluated the regulation of HIF-1 alpha...
Adenocarcinoma Follicular Anaerobiosis Antigens Neoplasm Carbonic Anhydrase IX Carbonic Anhydrases Carcinoma Carcinoma Papillary Cell Hypoxia Cell Line Tumor Chromones cobalt Gene Expression Regulation Neoplastic Glucose Transporter Type 1 Humans Hypoxia-Inducible Factor 1 alpha Subunit Morpholines Neoplasm Proteins PTEN Phosphohydrolase Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Proto-Oncogene Proteins B-raf RNA Interference RNA Small Interfering Signal Transduction Thyroid Neoplasms
Automatic music composition using answer set programming
Music composition used to be a pen and paper activity. These days music is often composed with the aid of computer software, even to the point where the computer composes parts of the score autonomously. The composition of most...
The thy-1-bearing cell of murine epidermis: A distinctive leukocyte perhaps related to natural killer cells
[No abstract available]
Published by: Rockefeller University
Enrichment and Transcriptome Analysis of CD4+ T Cell Clones Harboring Intact HIV-1 Proviruses
Georg Hartmut Johannes Weymar
Jan 01, 0001
More than 40 years after its onset, the Human Immunodeficiency Virus Type 1 (HIV-1) epidemic remains a major global health burden. HIV-1 is a retrovirus that infects and destroys predominantly CD4+ T cells. Since CD4+ T cells...
Published by: Rockefeller University
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