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Results: 14
Induced Arp2/3 Complex Depletion Increases FMNL2/3 Formin Expression and Filopodia Formation.
Vanessa Dimchev, Ines Lahmann, Stefan A Koestler, Frieda Kage, Georgi Dimchev, Anika Steffen, Theresia EB Stradal, Franz Vauti, Hans-Henning Arnold, Klemens Rottner
Mar 18, 2021
The Arp2/3 complex generates branched actin filament networks operating in cell edge protrusion and vesicle trafficking. Here we employ a conditional knockout mouse model permitting tissue- or cell-type specific deletion of the...
Family Planning and Development
Abstract
What is the role of family planning interventions on fertility, savings, human capital investment and development? To examine this, endogenous unwanted fertility is...
Composition of Transcription Machinery and Its Crosstalk with Nucleoid-Associated Proteins and Global Transcription Factors.
The coordination of bacterial genomic transcription involves an intricate network of interdependent genes encoding nucleoid-associated proteins (NAPs), DNA topoisomerases, RNA polymerase subunits and modulators of transcription...
Enantioselective remote C-H activation directed by a chiral cation
Chiral cations have been used extensively as organocatalysts but their application to rendering transition metal catalyzed processes enantioselective remains rare. This is despite the success of the analogous charge-inverted...
Rise and fall of total mesorectal excision with lateral pelvic lymphadenectomy for rectal cancer
Gabriele Anania, Richard Justin Davies, Alberto Arezzo, Francesco Bagolini, Vito D'Andrea, Luigina Graziosi, Salomone Di Saverio, Georgi Popivanov, Isaac Cheruiyot, Roberto Cirocchi, Annibale Donini
Oct 11, 2021
Multiple Deeply Divergent Denisovan Ancestries in Papuans
Guy S Jacobs, Georgi Hudjashov, Lauri Saag, Pradiptajati Kusuma, Chelzie C Darusallam, Daniel J Lawson, Mayukh Mondal, Luca Pagani, François-Xavier Ricaut, Mark Stoneking, Mait Metspalu, Herawati Sudoyo, J Stephen Lansing, Murray P Cox
Feb 17, 2020
Genome sequences are known for two archaic
hominins—Neanderthals and Denisovans—which
interbred with anatomically modern humans as
they dispersed out of Africa. We identified high-confidence
archaic haplotypes in 161 new...
Genome-wide DNA methylation and gene expression patterns reflect genetic ancestry and environmental differences across the Indonesian archipelago.
Heini M Natri, Katalina S Bobowik, Pradiptajati Kusuma, Chelzie Crenna Darusallam, Guy S Jacobs, Georgi Hudjashov, J Stephen Lansing, Herawati Sudoyo, Nicholas E Banovich, Murray P Cox, Irene Gallego Romero
Jul 03, 2020
Indonesia is the world's fourth most populous country, host to striking levels of human diversity, regional patterns of admixture, and varying degrees of introgression from both Neanderthals and Denisovans. However, it has been...
The light skin allele of SLC24A5 in South Asians and Europeans shares identity by descent.
Chandana Basu Mallick, Florin Mircea Iliescu, Märt Möls, Sarah Hill, Rakesh Tamang, Gyaneshwer Chaubey, Rie Goto, Simon YW Ho, Irene Gallego Romero, Federica Crivellaro, Georgi Hudjashov, Niraj Rai, Mait Metspalu, CG Nicholas Mascie-Taylor, Ramasamy Pitchappan, Lalji Singh, Marta Mirazon-Lahr, Kumarasamy Thangaraj, Richard Villems, Toomas Kivisild
Sep 08, 2018
Skin pigmentation is one of the most variable phenotypic traits in humans. A non-synonymous substitution (rs1426654) in the third exon of SLC24A5 accounts for lighter skin in Europeans but not in East Asians. A previous...
Widespread Denisovan ancestry in Island Southeast Asia but no evidence of substantial super-archaic hominin admixture.
João C Teixeira, Guy S Jacobs, Chris Stringer, Jonathan Tuke, Georgi Hudjashov, Gludhug A Purnomo, Herawati Sudoyo, Murray P Cox, Raymond Tobler, Chris SM Turney, Alan Cooper, Kristofer M Helgen
Apr 20, 2021
The hominin fossil record of Island Southeast Asia (ISEA) indicates that at least two endemic 'super-archaic' species-Homo luzonensis and H. floresiensis-were present around the time anatomically modern humans arrived in the...
Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations.
Christina A Eichstaedt, Luca Pagani, Tiago Antao, Charlotte E Inchley, Alexia Cardona, Alexander Mörseburg, Florian J Clemente, Timothy J Sluckin, Ene Metspalu, Mario Mitt, Reedik Mägi, Georgi Hudjashov, Mait Metspalu, Maru Mormina, Guy S Jacobs, Toomas Kivisild
Mar 21, 2018
The aim of this study is to identify genetic variants that harbour signatures of recent positive selection and may facilitate physiological adaptations to hypobaric hypoxia. To achieve this, we conducted whole genome sequencing...
Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer.
Timothy J Humpton, Brinda Alagesan, Gina M DeNicola, Dan Lu, Georgi N Yordanov, Carl S Leonhardt, Melissa A Yao, Priya Alagesan, Maya N Zaatari, Youngkyu Park, Jeremy N Skepper, Kay F Macleod, Pedro A Perez-Mancera, Michael P Murphy, Gerard I Evan, Karen H Vousden, David A Tuveson
Oct 29, 2019
Animals Carcinoma Pancreatic Ductal Cell Line Tumor Gene Expression Regulation Neoplastic Glycolysis Humans Membrane Proteins Mice Mitochondria mitophagy Mutation NADP Neoplasm Transplantation Oxidation-Reduction Pancreatic Neoplasms Proto-Oncogene Proteins Proto-Oncogene Proteins p21(ras) Tumor Suppressor Proteins
Genomic analyses inform on migration events during the peopling of Eurasia.
Luca Pagani, Daniel John Lawson, Evelyn Jagoda, Alexander Mörseburg, Anders Eriksson, Mario Mitt, Florian Clemente, Georgi Hudjashov, Michael DeGiorgio, Lauri Saag, Jeffrey D Wall, Alexia Cardona, Reedik Mägi, Melissa A Wilson Sayres, Sarah Kaewert, Charlotte Inchley, Christiana L Scheib, Mari Järve, Monika Karmin, Guy S Jacobs, Tiago Antao, Florin Mircea Iliescu, Alena Kushniarevich, Qasim Ayub, Chris Tyler-Smith, Yali Xue, Bayazit Yunusbayev, Kristiina Tambets, Chandana Basu Mallick, Lehti Saag, Elvira Pocheshkhova, George Andriadze, Craig Muller, Michael C Westaway, David M Lambert, Grigor Zoraqi, Shahlo Turdikulova, Dilbar Dalimova, Zhaxylyk Sabitov, Gazi Nurun Nahar Sultana, Joseph Lachance, Sarah Tishkoff, Kuvat Momynaliev, Jainagul Isakova, Larisa D Damba, Marina Gubina, Pagbajabyn Nymadawa, Irina Evseeva, Lubov Atramentova, Olga Utevska, François-Xavier Ricaut, Nicolas Brucato, Herawati Sudoyo, Thierry Letellier, Murray P Cox, Nikolay A Barashkov, Vedrana Skaro, Lejla Mulahasanovic, Dragan Primorac, Hovhannes Sahakyan, Maru Mormina, Christina A Eichstaedt, Daria V Lichman, Syafiq Abdullah, Gyaneshwer Chaubey, Joseph TS Wee, Evelin Mihailov, Alexandra Karunas, Sergei Litvinov, Rita Khusainova, Natalya Ekomasova, Vita Akhmetova, Irina Khidiyatova, Damir Marjanović, Levon Yepiskoposyan, Doron M Behar, Elena Balanovska, Andres Metspalu, Miroslava Derenko, Boris Malyarchuk, Mikhail Voevoda, Sardana A Fedorova, Ludmila P Osipova, Marta Mirazón Lahr, Pascale Gerbault, Matthew Leavesley, Andrea Bamberg Migliano, Michael Petraglia, Oleg Balanovsky, Elza K Khusnutdinova, Ene Metspalu, Mark G Thomas, Andrea Manica, Rasmus Nielsen, Richard Villems, Eske Willerslev, Toomas Kivisild, Mait Metspalu
Aug 15, 2017
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
Michael P. Menden, Dennis Wang, Mike J. Mason, Bence Szalai, Krishna C. Bulusu, Yuanfang Guan, Thomas Yu, Jaewoo Kang, Minji Jeon, Russ Wolfinger, Tin Nguyen, Mikhail Zaslavskiy, In Sock Jang, Zara Ghazoui, Mehmet Eren Ahsen, Robert Vogel, Elias Chaibub Neto, Thea Norman, Eric K. Y. Tang, Mathew J. Garnett, Giovanni Y. Di Veroli, Stephen Fawell, Gustavo Stolovitzky, Justin Guinney, Jonathan R. Dry, Julio Saez-Rodriguez, Jordi Abante, Barbara Schmitz Abecassis, Nanne Aben, Delasa Aghamirzaie, Tero Aittokallio, Farida S. Akhtari, Bissan Al-Lazikani, Tanvir Alam, Amin Allam, Chad Allen, Mariana Pelicano de Almeida, Doaa Altarawy, Vinicius Alves, Alicia Amadoz, Benedict Anchang, Albert A. Antolin, Jeremy R. Ash, Victoria Romeo Aznar, Wail Ba-alawi, Moeen Bagheri, Vladimir Bajic, Gordon Ball, Pedro J. Ballester, Delora Baptista, Christopher Bare, Mathilde Bateson, Andreas Bender, Denis Bertrand, Bhagya Wijayawardena, Keith A. Boroevich, Evert Bosdriesz, Salim Bougouffa, Gergana Bounova, Thomas Brouwer, Barbara Bryant, Manuel Calaza, Alberto Calderone, Stefano Calza, Stephen Capuzzi, Jose Carbonell-Caballero, Daniel Carlin, Hannah Carter, Luisa Castagnoli, Remzi Celebi, Gianni Cesareni, Hyeokyoon Chang, Guocai Chen, Haoran Chen, Huiyuan Chen, Lijun Cheng, Ariel Chernomoretz, Davide Chicco, Kwang-Hyun Cho, Sunghwan Cho, Daeseon Choi, Jaejoon Choi, Kwanghun Choi, Minsoo Choi, Martine De Cock, Elizabeth Coker, Isidro Cortes-Ciriano, Miklós Cserzö, Cankut Cubuk, Christina Curtis, Dries Van Daele, Cuong C. Dang, Tjeerd Dijkstra, Joaquin Dopazo, Sorin Draghici, Anastasios Drosou, Michel Dumontier, Friederike Ehrhart, Fatma-Elzahraa Eid, Mahmoud ElHefnawi, Haitham Elmarakeby, Bo van Engelen, Hatice Billur Engin, Iwan de Esch, Chris Evelo, Andre O. Falcao, Sherif Farag, Carlos Fernandez-Lozano, Kathleen Fisch, Asmund Flobak, Chiara Fornari, Amir B. K. Foroushani, Donatien Chedom Fotso, Denis Fourches, Stephen Friend, Arnoldo Frigessi, Feng Gao, Xiaoting Gao, Jeffrey M. Gerold, Pierre Gestraud, Samik Ghosh, Jussi Gillberg, Antonia Godoy-Lorite, Lizzy Godynyuk, Adam Godzik, Anna Goldenberg, David Gomez-Cabrero, Mehmet Gonen, Chris de Graaf, Harry Gray, Maxim Grechkin, Roger Guimera, Emre Guney, Benjamin Haibe-Kains, Younghyun Han, Takeshi Hase, Di He, Liye He, Lenwood S. Heath, Kristoffer H. Hellton, Manuela Helmer-Citterich, Marta R. Hidalgo, Daniel Hidru, Steven M. Hill, Sepp Hochreiter, Seungpyo Hong, Eivind Hovig, Ya-Chih Hsueh, Zhiyuan Hu, Justin K Huang, R. Stephanie Huang, László Hunyady, Jinseub Hwang, Tae Hyun Hwang, Woochang Hwang, Yongdeuk Hwang, Olexandr Isayev, Oliver Bear Don’t Walk, John Jack, Samad Jahandideh, Jiadong Ji, Yousang Jo, Piotr J. Kamola, Georgi K. Kanev, Loukia Karacosta, Mostafa Karimi, Samuel Kaski, Marat Kazanov, Abdullah M Khamis, Suleiman Ali Khan, Narsis A. Kiani, Allen Kim, Jinhan Kim, Juntae Kim, Kiseong Kim, Kyung Kim, Sunkyu Kim, Yongsoo Kim, Yunseong Kim, Paul D. W. Kirk, Hiroaki Kitano, Gunter Klambauer, David Knowles, Melissa Ko, Alvaro Kohn-Luque, Albert J. Kooistra, Melaine A. Kuenemann, Martin Kuiper, Christoph Kurz, Mijin Kwon, Twan van Laarhoven, Astrid Laegreid, Simone Lederer, Heewon Lee, Jeon Lee, Yun Woo Lee, Eemeli Lepp_aho, Richard Lewis, Jing Li, Lang Li, James Liley, Weng Khong Lim, Chieh Lin, Yiyi Liu, Yosvany Lopez, Joshua Low, Artem Lysenko, Daniel Machado, Neel Madhukar, Dries De Maeyer, Ana Belen Malpartida, Hiroshi Mamitsuka, Francesco Marabita, Kathleen Marchal, Pekka Marttinen, Daniel Mason, Alireza Mazaheri, Arfa Mehmood, Ali Mehreen, Magali Michaut, Ryan A. Miller, Costas Mitsopoulos, Dezso Modos, Marijke Van Moerbeke, Keagan Moo, Alison Motsinger-Reif, Rajiv Movva, Sebastian Muraru, Eugene Muratov, Mushthofa Mushthofa, Niranjan Nagarajan, Sigve Nakken, Aritro Nath, Pierre Neuvial, Richard Newton, Zheng Ning, Carlos De Niz, Baldo Oliva, Catharina Olsen, Antonio Palmeri, Bhawan Panesar, Stavros Papadopoulos, Jaesub Park, Seonyeong Park, Sungjoon Park, Yudi Pawitan, Daniele Peluso, Sriram Pendyala, Jian Peng, Livia Perfetto, Stefano Pirro, Sylvia Plevritis, Regina Politi, Hoifung Poon, Eduard Porta, Isak Prellner, Kristina Preuer, Miguel Angel Pujana, Ricardo Ramnarine, John E. Reid, Fabien Reyal, Sylvia Richardson, Camir Ricketts, Linda Rieswijk, Miguel Rocha, Carmen Rodriguez-Gonzalvez, Kyle Roell, Daniel Rotroff, Julian R. de Ruiter, Ploy Rukawa, Benjamin Sadacca, Zhaleh Safikhani, Fita Safitri, Marta Sales-Pardo, Sebastian Sauer, Moritz Schlichting, Jose A. Seoane, Jordi Serra, Ming-Mei Shang, Alok Sharma, Hari Sharma, Yang Shen, Motoki Shiga, Moonshik Shin, Ziv Shkedy, Kevin Shopsowitz, Sam Sinai, Dylan Skola, Petr Smirnov, Izel Fourie Soerensen, Peter Soerensen, Je-Hoon Song, Sang Ok Song, Othman Soufan, Andreas Spitzmueller, Boris Steipe, Chayaporn Suphavilai, Sergio Pulido Tamayo, David Tamborero, Jing Tang, Zia-ur-Rehman Tanoli, Marc Tarres-Deulofeu, Jesper Tegner, Liv Thommesen, Seyed Ali Madani Tonekaboni, Hong Tran, Ewoud De Troyer, Amy Truong, Tatsuhiko Tsunoda, Gábor Turu, Guang-Yo Tzeng, Lieven Verbeke, Santiago Videla, Daniel Vis, Andrey Voronkov, Konstantinos Votis, Ashley Wang, Hong-Qiang Horace Wang, Po-Wei Wang, Sheng Wang, Wei Wang, Xiaochen Wang, Xin Wang, Krister Wennerberg, Lorenz Wernisch, Lodewyk Wessels, Gerard J. P. van Westen, Bart A. Westerman, Simon Richard White, Egon Willighagen, Tom Wurdinger, Lei Xie, Shuilian Xie, Hua Xu, Bhagwan Yadav, Christopher Yau, Huwate Yeerna, Jia Wei Yin, Michael Yu, MinHwan Yu, So Jeong Yun, Alexey Zakharov, Alexandros Zamichos, Massimiliano Zanin, Li Zeng, Hector Zenil, Frederick Zhang, Pengyue Zhang, Wei Zhang, Hongyu Zhao, Lan Zhao, Wenjin Zheng, AZEDINE Zoufir, Manuela Zucknick
Jun 16, 2020
Abstract: The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating...