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Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker.
Georgina E T Blake, Xiaohui Zhao, Hong Wa Yung, Graham J Burton, Anne C Ferguson-Smith, Russell S Hamilton, Erica D Watson
Jul 28, 2021
The mechanism behind transgenerational epigenetic inheritance is unclear, particularly through the maternal grandparental line. We previously showed that disruption of folate metabolism in mice by the Mtrr hypomorphic mutation...
Liver Germ Cells Spermatozoa Trophoblasts Animals Mice Inbred C57BL Mice Folic Acid Ferredoxin-NADP Reductase Cell Cycle Proteins Transcription Factors Pedigree DNA Methylation Epigenesis Genetic Heredity Inheritance Patterns Phenotype Polymorphism Single Nucleotide Female Male Embryo Mammalian Histone Chaperones Epigenomics Biomarkers Maternal Inheritance whole genome sequencing
Published by: Nature Communications
Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker.
Georgina Et Blake, Xiaohui Zhao, Hong Wa Yung, Graham J Burton, Anne C Ferguson-Smith, Russell S Hamilton, Erica D Watson
Jun 02, 2021
Animals Biomarkers Cell Cycle Proteins DNA Methylation Embryo Mammalian Epigenesis Genetic Epigenomics Female Ferredoxin-NADP Reductase Folic Acid Germ Cells Heredity Histone Chaperones Inheritance Patterns Liver Male Maternal Inheritance Mice Mice Inbred C57BL Pedigree Phenotype Polymorphism Single Nucleotide Spermatozoa Transcription Factors Trophoblasts whole genome sequencing
Blastocyst transfer in mice alters the placental transcriptome and growth.
Katerina Menelaou, Malwina Prater, Simon J Tunster, Georgina Et Blake, Colleen Geary Joo, James C Cross, Russell S Hamilton, Erica D Watson
Nov 29, 2019
Abnormal folate metabolism causes age-, sex- and parent-of-origin-specific haematological defects in mice.
Nisha Padmanabhan, Katerina Menelaou, Jiali Gao, Alexander Anderson, Georgina Et Blake, Tanya Li, B Nuala Daw, Erica D Watson
Sep 05, 2018
Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker
Georgina E. T. Blake, Xiaohui Zhao, Hong Wa Yung, Graham J. Burton, Anne C. Ferguson-Smith, Russell S. Hamilton, Erica D. Watson
Jun 17, 2021
Epigenetics and Language
Chomsky claims that linguistics should be thought of as a branch of biology. Lorenzo and Longa claim that the Minimalist Program is better than previous approaches at connecting language to biology because it relies on...
Published by: Atlantic Provinces Linguistic Association
Coleridge
Blake Allen
Oct 11, 2019
This article argues that the sublime, as formulated by Samuel Taylor Coleridge, has been systematically misunderstood. It demonstrates that texts principally concerned with the beautiful have been interpreted as if they were...
President's Award Recipients Honored at Commencement
Winthrop University
Jan 01, 0001
HIGHLIGHTS The five students given the President's Award are: Sarah Ondrish, Cooper Aiken, Terrell Stauffer, Blake Wallert and Casson Helms. Each has plans to attend graduate school or has a professional job lined up.
Published by: Winthrop University
Merleau-Ponty
Blake Allen
Apr 13, 2021
In a landmark text, ‘The Theological Turn of French Phenomenology’, Dominique Janicaud posits a boundary that sharply divides the legitimate phenomenological tradition from a problematic variant seen to be fundamentally...
Published by: SAGE Publications
Epigenetics and Language
Chomsky claims that linguistics should be thought of as a branch of biology. Lorenzo and Longa claim that the Minimalist Program is better than previous approaches at connecting language to biology because it relies on...
Published by: Atlantic Provinces Linguistic Association
Structure and stability of symptoms in first episode psychosis
Decoupling the Roles of Cell Shape and Mechanical Stress in Orienting and Cueing Epithelial Mitosis.
Alexander Nestor-Bergmann, Georgina A Stooke-Vaughan, Georgina K Goddard, Tobias Starborg, Oliver E Jensen, Sarah Woolner
May 01, 2019
Distinct mechanisms involving cell shape and mechanical force are known to influence the rate and orientation of division in cultured cells. However, uncoupling the impact of shape and force in tissues remains challenging....
A novel product representation to highlight cross-assembly dependencies and product robustness
Manufacturing industry has traditionally used Bill of Materials (BOMs) and Product Lifecycle Management (PLM) tools to track components and sub-assemblies within a product. These apply a hierarchical structure to product...
Negative and positive emotional complexity in the autobiographical representations of sexual trauma survivors.
This study examined the diversity of experienced positive and negative emotions - emodiversity - within two existing datasets involving female survivors of sexual abuse and assault, who all met criteria for chronic Posttraumatic...
Structure and stability of symptoms in first episode psychosis
Siân Lowri Griffiths, Samuel P Leighton, Pavan Kumar Mallikarjun, Georgina Blake, Linda Everard, Peter B Jones, David Fowler, Joanne Hodgekins, Tim Amos, Nick Freemantle, Vimal Sharma, Max Marshall, Paul McCrone, Swaran P Singh, Max Birchwood, Rachel Upthegrove
Jan 07, 2022
Early psychosis is characterised by heterogeneity in illness trajectories, where outcomes remain poor for many. Understanding psychosis symptoms and their relation to illness outcomes, from a novel network perspective, may help...
Fractured Pasts
We examined the organization of past and future affective autobiographical knowledge in sexual-trauma survivors compared with control participants. Participants (N = 113) divided their past (and future) life into chapters (e.g....
Acute Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or paraquat on core temperature in C57BL/6J mice
MPTP and paraquat are two compounds that have been used to model Parkinson's disease in mice. Previous studies in two non-traditional strains of mice have shown that a single dose of MPTP can induce changes in body...
Clinical frailty and functional trajectories in hospitalized older adults
Peter Hartley, Jennifer Adamson, Carol Cunningham, Georgina Embleton, Roman Romero-Ortuno
Apr 27, 2016
Clinical Frailty Scale disability Frail Elderly functional trajectory hospital medicine Aged Aged 80 and over Cohort Studies England Female Frail Elderly frailty Geriatric Assessment Health Status Indicators Hospital Mortality Hospitalization Humans Length of Stay Male Predictive Value of Tests Prognosis Retrospective Studies Tertiary Care Centers
Framing aquatic life
Georgina Evans
Mar 09, 2020
This article considers the way aquatic life appears on screen, and the implications of the resemblance between the film frame and the other frames through which human spectators habitually encounter aquatic life: the aquarium...
A novel product representation to highlight cross-assembly dependencies and product robustness
Manufacturing industry has traditionally used Bill of Materials (BOMs) and Product Lifecycle Management (PLM) tools to track components and sub-assemblies within a product. These apply a hierarchical structure to product...
The transfer of social exclusion and inclusion functions through derived stimulus relations
Previous studies have found that social exclusion can cause distress to those excluded. One method used to study social exclusion is through a virtual ball-toss game known as Cyberball. In this game, participants may be excluded...
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