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PhenomeNET
Phenotypes are investigated in model organisms to understand and reveal the molecular mechanisms underlying disease. Phenotype ontologies were developed to capture and compare phenotypes within the context of a single species....
Linking common human diseases to their phenotypes; development of a resource for human phenomics.
Background
In recent years a large volume of clinical genomics data has become available due to rapid advances in sequencing technologies. Efficient exploitation of this genomics data requires linkage to patient...
Published by: Journal of biomedical semantics
Linking common human diseases to their phenotypes; development of a resource for human phenomics
Şenay Kafkas, Sara Althubaiti, Georgios V. Gkoutos, Robert Hoehndorf, Paul N. Schofield
Aug 26, 2021
Abstract: Background: In recent years a large volume of clinical genomics data has become available due to rapid advances in sequencing technologies. Efficient exploitation of this genomics data requires linkage to patient...
Integrating phenotype ontologies with PhenomeNET.
BACKGROUND: Integration and analysis of phenotype data from humans and model organisms is a key challenge in building our understanding of normal biology and pathophysiology. However, the range of phenotypes and anatomical...
DeepPVP
Imane Boudellioua, Maxat Kulmanov, Paul N Schofield, Georgios V Gkoutos, Robert Hoehndorf
Feb 15, 2019
BACKGROUND: Prioritization of variants in personal genomic data is a major challenge. Recently, computational methods that rely on comparing phenotype similarity have shown to be useful to identify causative variants. In these...
Interoperability between biomedical ontologies through relation expansion, upper-level ontologies and automatic reasoning.
Robert Hoehndorf, Michel Dumontier, Anika Oellrich, Dietrich Rebholz-Schuhmann, Paul N Schofield, Georgios V Gkoutos
Aug 08, 2017
Researchers design ontologies as a means to accurately annotate and integrate experimental data across heterogeneous and disparate data- and knowledge bases. Formal ontologies make the semantics of terms and relations explicit...
The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers.
Leila Jahangiri, Perla Pucci, Tala Ishola, Ricky M Trigg, John A Williams, Joao Pereira, Megan L Cavanagh, Suzanne D Turner, Georgios V Gkoutos, Loukia Tsaprouni
Aug 06, 2021
MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this...
The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers
Leila Jahangiri, Perla Pucci, Tala Ishola, Ricky M. Trigg, John A. Williams, Joao Pereira, Megan L. Cavanagh, Suzanne D. Turner, Georgios V. Gkoutos, Loukia Tsaprouni
Aug 11, 2021
MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this...
A Review of Current Standards and the Evolution of Histopathology Nomenclature for Laboratory Animals.
Susan A Elmore, Robert Cardiff, Mark F Cesta, Georgios V Gkoutos, Robert Hoehndorf, Charlotte M Keenan, Colin McKerlie, Paul N Schofield, John P Sundberg, Jerrold M Ward
Dec 21, 2018
The need for international collaboration in rodent pathology has evolved since the 1970s and was initially driven by the new field of toxicologic pathology. First initiated by the World Health Organization's International Agency...
International Agency for Research on Cancer International Harmonization of Nomenclature and Diagnostic Criteria International Mouse Phenotyping Consortium National Cancer Institute Mouse Models of Human Cancer Consortium National Toxicology Program Nonneoplastic Lesion Atlas mouse pathology ontology Nomenclature standard for exchange of nonclinical data Animals Animals Laboratory Biomedical Research Dogs Guinea Pigs Humans Mice Rabbits Rats Terminology as Topic
Ontology-based prediction of cancer driver genes
Sara Althubaiti, Andreas Karwath, Ashraf Dallol, Adeeb Noor, Shadi Salem Alkhayyat, Rolina Alwassia, Katsuhiko Mineta, Takashi Gojobori, Andrew D. Beggs, Paul N. Schofield, Georgios V. Gkoutos, Robert Hoehndorf
Nov 21, 2020
Abstract: Identifying and distinguishing cancer driver genes among thousands of candidate mutations remains a major challenge. Accurate identification of driver genes and driver mutations is critical for advancing cancer...
Ontology-based prediction of cancer driver genes.
Sara Althubaiti, Andreas Karwath, Ashraf Dallol, Adeeb Noor, Shadi Salem Alkhayyat, Rolina Alwassia, Katsuhiko Mineta, Takashi Gojobori, Andrew D Beggs, Paul N Schofield, Georgios V Gkoutos, Robert Hoehndorf
Jan 03, 2020
Identifying and distinguishing cancer driver genes among thousands of candidate mutations remains a major challenge. Accurate identification of driver genes and driver mutations is critical for advancing cancer research and...
The Role of Autophagy and lncRNAs in the Maintenance of Cancer Stem Cells
Leila Jahangiri, Tala Ishola, Perla Pucci, Ricky M. Trigg, Joao Pereira, John A. Williams, Megan L. Cavanagh, Georgios V. Gkoutos, Loukia Tsaprouni, Suzanne D. Turner
Mar 12, 2021
Cancer stem cells (CSCs) possess properties such as self-renewal, resistance to apoptotic cues, quiescence, and DNA-damage repair capacity. Moreover, CSCs strongly influence the tumour microenvironment (TME) and may account for...
Ontology-based prediction of cancer driver genes.
Sara Althubaiti, Andreas Karwath, Ashraf Dallol, Adeeb Noor, Shadi Salem Alkhayyat, Rolina Alwassia, Katsuhiko Mineta, Takashi Gojobori, Andrew D Beggs, Paul N Schofield, Georgios V Gkoutos, Robert Hoehndorf
Nov 27, 2019
Identifying and distinguishing cancer driver genes among thousands of candidate mutations remains a major challenge. Accurate identification of driver genes and driver mutations is critical for advancing cancer research and...
A Role for RAS in V-CRK Transformation
Heidi Greulich
Jan 01, 0001
The v-Crk oncogene product, while possessing no intrinsic tyrosine kinase activity, causes an elevation in levels of cellular phosphotyrosine as it transforms chicken embryo fibroblasts (CEF). Because of this similarity to v-Src...
Published by: Rockefeller University
LITTLE v IN INUKTITUT
Bettina Spreng
Jul 30, 2013
This paper provides an in-depth examination of the distribution of the Antipassive morpheme -si- in Mittimatalik, a dialect of !nuktitut spoken in North Baffin. It is demonstrated that the occurrence of the overt Antipassive...
Published by: Atlantic Provinces Linguistic Association
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