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Day-and-Night Closed-Loop Insulin Delivery in a Broad Population of Pregnant Women With Type 1 Diabetes
Zoe A Stewart, Malgorzata E Wilinska, Sara Hartnell, Leanne K O'Neil, Gerry Rayman, Eleanor M Scott, Katharine Barnard, Conor Farrington, Roman Hovorka, Helen R Murphy
Jul 18, 2018
OBJECTIVE: Despite advances in technology, optimal glucose control remains elusive and neonatal complications remain ubiquitous in type 1 diabetes (T1D) pregnancy. Our aim was to examine the safety, efficacy, and longer-term...
Adolescent Adult Blood Glucose Circadian Rhythm Cross-Over Studies delivery Obstetric Diabetes mellitus Type 1 Female Humans Hyperinsulinism Hypoglycemia Hypoglycemic Agents Insulin Insulin Infusion Systems Middle Aged Postpartum Period Pregnancy Pregnancy Outcome Pregnancy in Diabetics Time Factors Treatment Outcome Young Adult
Community-based pre-pregnancy care programme improves pregnancy preparation in women with pregestational diabetes.
Jennifer M Yamamoto, Deborah JF Hughes, Mark L Evans, Vithian Karunakaran, John DA Clark, Nicholas J Morrish, Gerry A Rayman, Peter H Winocour, Clare Hambling, Amanda W Harries, Michael J Sampson, Helen R Murphy
Sep 14, 2018
AIMS/HYPOTHESIS: Women with diabetes remain at increased risk of adverse pregnancy outcomes associated with poor pregnancy preparation. However, women with type 2 diabetes are less aware of and less likely to access...
Closed-Loop Insulin Delivery during Pregnancy in Women with Type 1 Diabetes.
Zoe A Stewart, Malgorzata E Wilinska, Sara Hartnell, Rosemary C Temple, Gerry Rayman, Katharine P Stanley, David Simmons, Graham R Law, Eleanor M Scott, Roman Hovorka, Helen R Murphy
May 13, 2019
BACKGROUND: In patients with type 1 diabetes who are not pregnant, closed-loop (automated) insulin delivery can provide better glycemic control than sensor-augmented pump therapy, but data are lacking on the efficacy, safety...
Flash glucose monitoring with the FreeStyle Libre 2 compared with self-monitoring of blood glucose in suboptimally controlled type 1 diabetes
Emma G Wilmot, Mark Evans, Katharine Barnard-Kelly, M Burns, Iain Cranston, Rachel Ann Elliott, G Gkountouras, N Kanumilli, A Krishan, C Kotonya, S Lumley, P Narendran, Sankalpa Neupane, Gerry Rayman, Christopher Sutton, VP Taxiarchi, H Thabit, L Leelarathna
Sep 24, 2021
Clinical Trials DIABETES & ENDOCRINOLOGY general diabetes health economics Adolescent Blood Glucose Blood Glucose Self-Monitoring covid-19 Diabetes mellitus Type 1 Humans Hypoglycemic Agents Multicenter Studies as Topic Pandemics Randomized Controlled Trials as Topic SARS-CoV-2 State Medicine United Kingdom
Flash glucose monitoring with the FreeStyle Libre 2 compared with self-monitoring of blood glucose in suboptimally controlled type 1 diabetes
Emma G Wilmot, Mark Evans, Katharine Barnard-Kelly, M Burns, Iain Cranston, Rachel Ann Elliott, G Gkountouras, N Kanumilli, A Krishan, C Kotonya, S Lumley, P Narendran, Sankalpa Neupane, Gerry Rayman, Christopher Sutton, V P Taxiarchi, H Thabit, L Leelarathna
Aug 15, 2021
Introduction
Optimising glycaemic control in type 1 diabetes (T1D) remains challenging. Flash glucose monitoring with FreeStyle Libre 2 (FSL2) is a novel alternative to the current standard of care self-monitoring of...
Clinical Trials health economics general diabetes DIABETES & ENDOCRINOLOGY Humans Diabetes mellitus Type 1 Blood Glucose Hypoglycemic Agents Blood Glucose Self-Monitoring Adolescent State Medicine Multicenter Studies as Topic Randomized Controlled Trials as Topic Pandemics United Kingdom covid-19 SARS-CoV-2
Published by: BMJ Open
Closed-loop insulin delivery during pregnancy complicated by type 1 diabetes.
Helen R Murphy, Daniela Elleri, Janet M Allen, Julie Harris, David Simmons, Gerry Rayman, Rosemary Temple, David B Dunger, Ahmad Haidar, Marianna Nodale, Malgorzata E Wilinska, Roman Hovorka
Feb 24, 2020
Exceptional longevity and potential determinants of successful ageing in a cohort of 39 Labrador retrievers
Vicki Jean Adams, Penny Watson, Stuart Carmichael, Stephen Gerry, Johanna Penell, David Mark Morgan
May 16, 2016
Exploiting tumour addiction with a serine and glycine-free diet.
Understanding cancer metabolism is key to unveil the Achilles’ heel of cancer cells and provide novel therapeutic interventions for patients. While the rerouting of metabolic pathways during development1 or cancer transformation...
ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma.
Marco Pieraccioli, Sara Nicolai, Consuelo Pitolli, Massimiliano Agostini, Alexey Antonov, Michal Malewicz, Richard A Knight, Giuseppe Raschellà, Gerry Melino
Oct 15, 2020
Derangement of cellular differentiation because of mutation or inappropriate expression of specific genes is a common feature in tumors. Here, we show that the expression of ZNF281, a zinc finger factor involved in several...
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Dissecting the regulatory microenvironment of a large animal model of non-Hodgkin lymphoma
Dammy Pinheiro, Yu-Mei Chang, Hannah Bryant, Balazs Szladovits, Tim Dalessandri, Lucy J Davison, Elizabeth Yallop, Emily Mills, Chiara Leo, Ana Lara, Anneliese Stell, Gerry Polton, Oliver A Garden
Aug 15, 2014
Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia.
Julian M Rozenberg, Olga S Rogovaya, Gerry Melino, Nickolai A Barlev, Alexander Kagansky
Dec 26, 2020
Epithelial organs are the first barrier against microorganisms and genotoxic stress, in which the p53 family members p63 and p73 have both overlapping and distinct functions. Intriguingly, p73 displays a very specific...
Context is everything
Abstract: The TP53 genomic locus is a target of mutational events in at least half of cancers. Despite several decades of study, a full consensus on the relevance of the acquisition of p53 gain-of-function missense mutants has...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Context is everything
Abstract: The TP53 genomic locus is a target of mutational events in at least half of cancers. Despite several decades of study, a full consensus on the relevance of the acquisition of p53 gain-of-function missense mutants has...
Faculty Members Showcase Their New Works at Winthrop Galleries
Winthrop University
Jan 01, 0001
As part of the "New Works" exhibition, fine arts faculty members Paul Martyka and Marge Loudon Moody will exhibit new pieces in the Rutledge Gallery. Phil Moody of fine arts has collaborated with design faculty Gerry Derksen...
Published by: Winthrop University
Context is everything
The TP53 genomic locus is a target of mutational events in at least half of cancers. Despite several decades of study, a full consensus on the relevance of the acquisition of p53 gain-of-function missense mutants has not been...
Fast hierarchical Bayesian analysis of population structure.
We present fastbaps, a fast solution to the genetic clustering problem. Fastbaps rapidly identifies an approximate fit to a Dirichlet process mixture model (DPM) for clustering multilocus genotype data. Our efficient model-based...
RhierBAPS
Identifying structure in collections of sequence data sets remains a common problem in genomics. hierBAPS, a popular algorithm for identifying population structure in haploid genomes, has previously only been available as a...
A randomised controlled trial of three or one breathing technique training sessions for breathlessness in people with malignant lung disease.
Miriam J Johnson, Mona Kanaan, Gerry Richardson, Samantha Nabb, David Torgerson, Anne English, Rachael Barton, Sara Booth
Sep 29, 2016
BACKGROUND: About 90 % of patients with intra-thoracic malignancy experience breathlessness. Breathing training is helpful, but it is unknown whether repeated sessions are needed. The present study aims to test whether three...
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Ocular adverse events associated with immune checkpoint inhibitors
Orthi Shahzad, Nicola Thompson, Gerry Clare, Sarah Welsh, Erika Damato, Philippa Corrie
Feb 13, 2021
Ocular immune-related adverse events (IrAEs) associated with use of checkpoint inhibitors (CPIs) in cancer therapeutics are relatively rare, occurring in approximately 1% of treated patients. Recognition and early intervention...
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