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To Debt or Not to Debt
We empirically analyze the market risk profiles of Islamic banks with two sets of conventional banks taken from the same geographical locations as Islamic banks and from a random global sample respectively for the period...
Study on International Indices And Instructional Leadership Style of College Principals in The Rural Context of Sindh
Educational leadership is to run an educational institution with an intention to achieve better learning out comes. Principal, head teachers or masters lead schools. The way the leaders try to achieve those goals is known as a...
Published by: Department of History, University of Karachi
To Debt or Not to Debt
We empirically analyze the market risk profiles of Islamic banks with two sets of conventional banks taken from the same geographical locations as Islamic banks and from a random global sample respectively for the period...
Adjoint-based optimization of displacement ventilation flow
We demonstrate the use of the ‘Direct-Adjoint-Looping method’ for the identification of optimal buoyancy-driven ventilation flows governed by Boussinesq equations. We use the incompressible Reynolds-averaged Navier-Stokes (RANS)...
National implementation of multi-parametric magnetic resonance imaging for prostate cancer detection - recommendations from a UK consensus meeting.
Mrishta Brizmohun Appayya, Jim Adshead, Hashim U Ahmed, Clare Allen, Alan Bainbridge, Tristan Barrett, Francesco Giganti, John Graham, Phil Haslam, Edward W Johnston, Christof Kastner, Alexander PS Kirkham, Alexandra Lipton, Alan McNeill, Larissa Moniz, Caroline M Moore, Ghulam Nabi, Anwar R Padhani, Chris Parker, Amit Patel, Jacqueline Pursey, Jonathan Richenberg, John Staffurth, Jan van der Meulen, Darren Walls, Shonit Punwani
Sep 20, 2018
OBJECTIVES: To identify areas of agreement and disagreement in the implementation of multi-parametric magnetic resonance imaging (mpMRI) of the prostate in the diagnostic pathway. MATERIALS AND METHODS: Fifteen UK experts in...
consensus methods multi-parametric MRI prostate cancer Recommendations Biopsy Needle Contrast Media Early Detection of Cancer Education Medical Humans Magnetic Resonance Imaging Male Middle Aged Prostate Prostate-specific antigen Prostatic Neoplasms Quality of Health Care Radiologists Referral and Consultation Research Design Tumor Burden
Autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation
Meng Wang, Wenjia Wang, Ayesha Abeywardane, Malinthi Adikarama, Donal McLornan, Kavita Raj, Hugues de Lavallade, Stephen Devereux, Ghulam J Mufti, Antonio Pagliuca, Victoria T Potter, Aleksandar Mijovic
Apr 16, 2019
Autoimmune hemolytic anemia (AIHA) is a recognized complication of hematopoietic stem cell transplantation (HSCT); it is often refractory to treatment and carries a high mortality. To improve understanding of the incidence, risk...
Allogeneic hematopoietic stem cell transplantation Autoimmune hemolytic anemia Mortality Adult Anemia Hemolytic Autoimmune Female Hematologic Neoplasms Hematopoietic Stem Cell Transplantation Hospitals University Humans Male Middle Aged Risk Factors Siblings Survival Analysis Transplantation Homologous Treatment Outcome United Kingdom Unrelated Donors
Should Age-Dependent Absolute Risk Thresholds Be Used for Risk Stratification in Risk-Stratified Breast Cancer Screening?
Should Age-Dependent Absolute Risk Thresholds Be Used for Risk Stratification in Risk-Stratified Breast Cancer Screening?
Nora Pashayan, Antonis C Antoniou, Andrew Lee, Michael Wolfson, Jocelyne Chiquette, Laurence Eloy, Andrea Eisen, Tracy L Stockley, Hermann Nabi, Jennifer D Brooks, Michel Dorval, Douglas F Easton, Bartha Maria Knoppers, Anna M Chiarelli, Jacques Simard
Oct 29, 2021
In risk-stratified cancer screening, multiple risk factors are incorporated into the risk assessment. An individual's estimated absolute cancer risk is linked to risk categories with tailored screening recommendations for each...
Published by: Journal of personalized medicine
GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain
Ghulam Hassan Dar, Cláudia C. Mendes, Wei-Li Kuan, Alfina A. Speciale, Mariana Conceição, André Görgens, Inna Uliyakina, Miguel J. Lobo, Wooi F. Lim, Samir El Andaloussi, Imre Mäger, Thomas C. Roberts, Roger A. Barker, Deborah C. I. Goberdhan, Clive Wilson, Matthew J. A. Wood
Jan 05, 2022
Abstract: Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular communication, and potential as drug delivery vehicles. Here we demonstrate a role for the glycolytic enzyme...
Diagnosis of bladder cancer by immunocytochemical detection of minichromosome maintenance protein-2 in cells retrieved from urine.
K Saeb-Parsy, A Wilson, C Scarpini, M Corcoran, S Chilcott, M McKean, B Thottakam, B Rai, G Nabi, D Rana, M Perera, K Stewart, RA Laskey, DE Neal, N Coleman
Aug 19, 2020
BACKGROUND: We tested the accuracy of immunocytochemistry (ICC) for minichromosome maintenance protein-2 (MCM-2) in diagnosing bladder cancer, using cells retrieved from urine. METHODS: Adequate samples were obtained from 497...
Should Age-Dependent Absolute Risk Thresholds Be Used for Risk Stratification in Risk-Stratified Breast Cancer Screening?
Nora Pashayan, Antonis C. Antoniou, Andrew Lee, Michael Wolfson, Jocelyne Chiquette, Laurence Eloy, Andrea Eisen, Tracy L. Stockley, Hermann Nabi, Jennifer D. Brooks, Michel Dorval, Douglas F. Easton, Bartha Maria Knoppers, Anna M. Chiarelli, Jacques Simard
Sep 17, 2021
In risk-stratified cancer screening, multiple risk factors are incorporated into the risk assessment. An individual’s estimated absolute cancer risk is linked to risk categories with tailored screening recommendations for each...
GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain
Ghulam Hassan Dar, Cláudia C. Mendes, Wei-Li Kuan, Alfina A. Speciale, Mariana Conceição, André Görgens, Inna Uliyakina, Miguel J. Lobo, Wooi F. Lim, Samir El Andaloussi, Imre Mäger, Thomas C. Roberts, Roger A. Barker, Deborah C. I. Goberdhan, Clive Wilson, Matthew J. A. Wood
Jan 05, 2022
Abstract: Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular communication, and potential as drug delivery vehicles. Here we demonstrate a role for the glycolytic enzyme...
Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index.
Allan Gurtan, John Dominy, Shareef Khalid, Linh Vong, Shari Caplan, Treeve Currie, Sean Richards, Lindsey Lamarche, Daniel Denning, Diana Shpektor, Anastasia Gurinovich, Asif Rasheed, Shahid Hameed, Subhan Saeed, Imran Saleem, Anjum Jalal, Shahid Abbas, Raffat Sultana, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Nabi Shah, Mohammad Ishaq, Amit V Khera, John Danesh, Philippe Frossard, Danish Saleheen
Apr 21, 2022
Novel drug targets for sustained reduction in body mass index (BMI) are needed to curb the epidemic of obesity, which affects 650 million individuals worldwide and is a causal driver of cardiovascular and metabolic disease and...
GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain.
Ghulam Hassan Dar, Cláudia C Mendes, Wei-Li Kuan, Alfina A Speciale, Mariana Conceição, André Görgens, Inna Uliyakina, Miguel J Lobo, Wooi F Lim, Samir El Andaloussi, Imre Mäger, Thomas C Roberts, Roger A Barker, Deborah CI Goberdhan, Clive Wilson, Matthew JA Wood
Jan 07, 2022
Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular communication, and potential as drug delivery vehicles. Here we demonstrate a role for the glycolytic enzyme...
Animals Brain Cell Line Tumor Disease Models Animal Drug Delivery Systems extracellular vesicles Glyceraldehyde-3-Phosphate Dehydrogenases HEK293 Cells HeLa Cells Humans Huntingtin Protein Huntington Disease Mesenchymal Stem Cells Mice Inbred C57BL Phosphatidylserines Protein Binding RNA Small Interfering
GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain.
Ghulam Hassan Dar, Cláudia C Mendes, Wei-Li Kuan, Alfina A Speciale, Mariana Conceição, André Görgens, Inna Uliyakina, Miguel J Lobo, Wooi F Lim, Samir El Andaloussi, Imre Mäger, Thomas C Roberts, Roger Barker, Deborah CI Goberdhan, Clive Wilson, Matthew JA Wood
Nov 22, 2021
Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular communication, and potential as drug delivery vehicles. Here we demonstrate a role for the glycolytic enzyme...
Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index.
Allan Gurtan, John Dominy, Shareef Khalid, Linh Vong, Shari Caplan, Treeve Currie, Sean Richards, Lindsey Lamarche, Daniel Denning, Diana Shpektor, Anastasia Gurinovich, Asif Rasheed, Shahid Hameed, Subhan Saeed, Imran Saleem, Anjum Jalal, Shahid Abbas, Raffat Sultana, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Nabi Shah, Mohammad Ishaq, Amit V Khera, John Danesh, Philippe Frossard, Danish Saleheen
May 09, 2022
Novel drug targets for sustained reduction in body mass index (BMI) are needed to curb the epidemic of obesity, which affects 650 million individuals worldwide and is a causal driver of cardiovascular and metabolic disease and...
Evaluating the effectiveness and reliability of the Vibrant Soundbridge and Bonebridge auditory implants in clinical practice
Deborah Vickers, Angela Canas, Aneeka Degun, John Briggs, Mina Bingham, Joseph Toner, Huw Cooper, Sarah Rogers, Stacey Cooper, Richard Irving, Patrick Spielman, Samantha Batty, Stephen Jones, Abi Asher, Mark Chung, Neil Donnelly, Anna Skibinska, Robert Gardner, Chris Raine, Rachel Andrew, Kevin Green, Hashmat Ghulam, Terry Nunn, Dan Jiang, Severin Fürhapter, Michael Urban, Kate Hanvey, Sarah Flynn, David Lovegrove, Shakeel Saeed
Jul 02, 2020
BACKGROUND: The Vibrant Soundbridge middle ear implant and the Bonebridge bone conducting hearing device are hearing implants that use radio frequency transmission to send information from the sound processor to the internal...
Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward)
Adrian Murray Brunt, Joanne S Haviland, Duncan A Wheatley, Mark A Sydenham, Abdulla Alhasso, David J Bloomfield, Charlie Chan, Mark Churn, Susan Cleator, Charlotte E Coles, Andrew Goodman, Adrian Harnett, Penelope Hopwood, Anna M Kirby, Cliona C Kirwan, Carolyn Morris, Zohal Nabi, Elinor Sawyer, Navita Somaiah, Liba Stones, Isabel Syndikus, Judith M Bliss, John R Yarnold, FAST-Forward Trial Management Group
May 26, 2020
BACKGROUND: We aimed to identify a five-fraction schedule of adjuvant radiotherapy (radiation therapy) delivered in 1 week that is non-inferior in terms of local cancer control and is as safe as an international standard...
Adult Aged Aged 80 and over Breast Neoplasms Female Follow-Up Studies Humans Kaplan-Meier Estimate Mastectomy Middle Aged Neoplasm Grading Neoplasm Metastasis Neoplasm Recurrence Local Neoplasm Staging Radiation Dose Hypofractionation Radiation Injuries Radiotherapy Adjuvant Risk Assessment Treatment Outcome United Kingdom
Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer
Jennifer D Brooks, Hermann H Nabi, Irene L Andrulis, Antonis C Antoniou, Jocelyne Chiquette, Philippe Després, Peter Devilee, Michel Dorval, Arnaud Droit, Douglas F Easton, Andrea Eisen, Laurence Eloy, Samantha Fienberg, David Goldgar, Eric Hahnen, Yann Joly, Bartha Maria Knoppers, Aisha Lofters, Jean-Yves Masson, Nicole Mittmann, Jean-Sébastien Paquette, Nora Pashayan, Rita Schmutzler, Tracy Stockley, Sean V Tavtigian, Meghan J Walker, Michael Wolfson, Anna Maria Chiarelli, Jacques Simard
Aug 02, 2021
Early detection of breast cancer through screening reduces breast cancer mortality. The benefits of screening must also be considered within the context of potential harms (e.g., false positives, overdiagnosis). Furthermore...
Published by: Journal of personalized medicine
An Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors.
Eric L Harshfield, Albert Koulman, Daniel Ziemek, Luke Marney, Eric B Fauman, Dirk S Paul, David Stacey, Asif Rasheed, Jung-Jin Lee, Nabi Shah, Sehrish Jabeen, Atif Imran, Shahid Abbas, Zoubia Hina, Nadeem Qamar, Nadeem Hayyat Mallick, Zia Yaqoob, Tahir Saghir, Syed Nadeem Hasan Rizvi, Anis Memon, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Irshad Hussain Qureshi, Muhammad Ishaq, Philippe Frossard, John Danesh, Danish Saleheen, Adam S Butterworth, Angela M Wood, Julian L Griffin
Mar 28, 2019
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid...
An open dataset of <i>Plasmodium vivax</i> genome variation in 1,895 worldwide samples.
Ishag Adam, Mohammad Shafiul Alam, Sisay Alemu, Chanaki Amaratunga, Roberto Amato, Voahangy Andrianaranjaka, Nicholas M Anstey, Abraham Aseffa, Elizabeth Ashley, Ashenafi Assefa, Sarah Auburn, Bridget E Barber, Alyssa Barry, Dhelio Batista Pereira, Jun Cao, Nguyen Hoang Chau, Kesinee Chotivanich, Cindy Chu, Arjen M Dondorp, Eleanor Drury, Diego F Echeverry, Berhanu Erko, Fe Espino, Rick Fairhurst, Abdul Faiz, María Fernanda Villegas, Qi Gao, Lemu Golassa, Sonia Goncalves, Matthew J Grigg, Yaghoob Hamedi, Tran Tinh Hien, Ye Htut, Kimberly J Johnson, Nadira Karunaweera, Wasif Khan, Srivicha Krudsood, Dominic P Kwiatkowski, Marcus Lacerda, Benedikt Ley, Pharath Lim, Yaobao Liu, Alejandro Llanos-Cuentas, Chanthap Lon, Tatiana Lopera-Mesa, Jutta Marfurt, Pascal Michon, Olivo Miotto, Rezika Mohammed, Ivo Mueller, Chayadol Namaik-Larp, Paul N Newton, Thuy-Nhien Nguyen, Francois Nosten, Rintis Noviyanti, Zuleima Pava, Richard D Pearson, Beyene Petros, Aung P Phyo, Ric N Price, Sasithon Pukrittayakamee, Awab Ghulam Rahim, Milijaona Randrianarivelojosia, Julian C Rayner, Angela Rumaseb, Sasha V Siegel, Victoria J Simpson, Kamala Thriemer, Alberto Tobon-Castano, Hidayat Trimarsanto, Marcelo Urbano Ferreira, Ivan D Vélez, Sonam Wangchuk, Thomas E Wellems, Nicholas J White, Timothy William, Maria F Yasnot, Daniel Yilma
Jul 02, 2022
This report describes the MalariaGEN Pv4 dataset, a new release of curated genome variation data on 1,895 samples of Plasmodium vivax collected at 88 worldwide locations between 2001 and 2017. It includes 1,370 new...
Published by: Wellcome open research
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
Ayush Giri, Jacklyn N Hellwege, Jacob M Keaton, Jihwan Park, Chengxiang Qiu, Helen R Warren, Eric S Torstenson, Csaba P Kovesdy, Yan V Sun, Otis D Wilson, Cassianne Robinson-Cohen, Christianne L Roumie, Cecilia P Chung, Kelly A Birdwell, Scott M Damrauer, Scott L DuVall, Derek Klarin, Kelly Cho, Yu Wang, Evangelos Evangelou, Claudia P Cabrera, Louise V Wain, Rojesh Shrestha, Brian S Mautz, Elvis A Akwo, Muralidharan Sargurupremraj, Stéphanie Debette, Michael Boehnke, Laura J Scott, Jian'an Luan, Jing-Hua Zhao, Sara M Willems, Sébastien Thériault, Nabi Shah, Christopher Oldmeadow, Peter Almgren, Ruifang Li-Gao, Niek Verweij, Thibaud S Boutin, Massimo Mangino, Ioanna Ntalla, Elena Feofanova, Praveen Surendran, James P Cook, Savita Karthikeyan, Najim Lahrouchi, Chunyu Liu, Nuno Sepúlveda, Tom G Richardson, Aldi Kraja, Philippe Amouyel, Martin Farrall, Neil R Poulter, Understanding Society Scientific Group, International Consortium for Blood Pressure, Blood Pressure-International Consortium of Exome Chip Studies, Markku Laakso, Eleftheria Zeggini, Peter Sever, Robert A Scott, Claudia Langenberg, Nicholas J Wareham, David Conen, Colin Neil Alexander Palmer, John Attia, Daniel I Chasman, Paul M Ridker, Olle Melander, Dennis Owen Mook-Kanamori, Pim van der Harst, Francesco Cucca, David Schlessinger, Caroline Hayward, Tim D Spector, Marjo-Riitta Jarvelin, Branwen J Hennig, Nicholas J Timpson, Wei-Qi Wei, Joshua C Smith, Yaomin Xu, Michael E Matheny, Edward E Siew, Cecilia Lindgren, Karl-Heinz Herzig, George Dedoussis, Joshua C Denny, Bruce M Psaty, Joanna MM Howson, Patricia B Munroe, Christopher Newton-Cheh, Mark J Caulfield, Paul Elliott, J Michael Gaziano, John Concato, Peter WF Wilson, Philip S Tsao, Digna R Velez Edwards, Katalin Susztak, Million Veteran Program, Christopher J O'Donnell, Adriana M Hung, Todd L Edwards
Feb 01, 2019
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood...
Genetic determinants of risk in pulmonary arterial hypertension
Christopher J Rhodes, Ken Batai, Marta Bleda, Matthias Haimel, Laura Southgate, Marine Germain, Michael W Pauciulo, Charaka Hadinnapola, Jurjan Aman, Barbara Girerd, Amit Arora, Jo Knight, Ken B Hanscombe, Jason H Karnes, Marika Kaakinen, Henning Gall, Anna Ulrich, Lars Harbaum, Inês Cebola, Jorge Ferrer, Katie Lutz, Emilia M Swietlik, Ferhaan Ahmad, Philippe Amouyel, Stephen L Archer, Rahul Argula, Eric D Austin, David Badesch, Sahil Bakshi, Christopher Barnett, Raymond Benza, Nitin Bhatt, Harm J Bogaard, Charles D Burger, Murali Chakinala, Colin Church, John G Coghlan, Robin Condliffe, Paul A Corris, Cesare Danesino, Stéphanie Debette, C Gregory Elliott, Jean Elwing, Melanie Eyries, Terry Fortin, Andre Franke, Robert P Frantz, Adaani Frost, Joe GN Garcia, Stefano Ghio, Hossein-Ardeschir Ghofrani, J Simon R Gibbs, John Harley, Hua He, Nicholas S Hill, Russel Hirsch, Arjan C Houweling, Luke S Howard, Dunbar Ivy, David G Kiely, James Klinger, Gabor Kovacs, Tim Lahm, Matthias Laudes, Rajiv D Machado, Robert V MacKenzie Ross, Keith Marsolo, Lisa J Martin, Shahin Moledina, David Montani, Steven D Nathan, Michael Newnham, Andrea Olschewski, Horst Olschewski, Ronald J Oudiz, Willem H Ouwehand, Andrew J Peacock, Joanna Pepke-Zaba, Zia Rehman, Ivan Robbins, Dan M Roden, Erika B Rosenzweig, Ghulam Saydain, Laura Scelsi, Robert Schilz, Werner Seeger, Christian M Shaffer, Robert W Simms, Marc Simon, Olivier Sitbon, Jay Suntharalingam, Haiyang Tang, Alexander Y Tchourbanov, Thenappan Thenappan, Fernando Torres, Mark R Toshner, Carmen M Treacy, Anton Vonk Noordegraaf, Quinten Waisfisz, Anna K Walsworth, Robert E Walter, John Wharton, R James White, Jeffrey Wilt, Stephen J Wort, Delphine Yung, Allan Lawrie, Marc Humbert, Florent Soubrier, David-Alexandre Trégouët, Inga Prokopenko, Richard Kittles, Stefan Gräf, William C Nichols, Richard C Trembath, Ankit A Desai, Nicholas W Morrell, Martin R Wilkins, UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium
Jan 08, 2019
BACKGROUND: Rare genetic variants cause pulmonary arterial hypertension, but the contribution of common genetic variation to disease risk and natural history is poorly characterised. We tested for genome-wide association for...
Female Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Genotyping Techniques HLA-DP alpha-Chains HLA-DP beta-Chains Humans Male Middle Aged Polymorphism Single Nucleotide pulmonary arterial hypertension Risk Assessment SOXF Transcription Factors Signal Transduction Survival Analysis
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