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The vertical excursion of the body visceral mass during vertical jumps is affected by specific respiratory maneuver
Most of the inverse modelling of body dynamics in sports assumes that every segment is ‘rigid’ and moves ‘as a whole’, although we know that uncontrolled wobbling masses exist and in specific condition their motion should be...
The vertical excursion of the body visceral mass during vertical jumps is affected by specific respiratory maneuver
Most of the inverse modelling of body dynamics in sports assumes that every segment is ‘rigid’ and moves ‘as a whole’, although we know that uncontrolled wobbling masses exist and in specific condition their motion should be...
Hadroquarkonium from lattice QCD
he hadroquarkonium picture [S. Dubynskiy and M. B. Voloshin, Phys. Lett. B 666, 344 (2008)] provides one possible interpretation for the pentaquark candidates with hidden charm, recently reported by the LHCb Collaboration, as...
In vivo methods for the assessment of topical drug bioavailability
This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability...
In vivo methods for the assessment of topical drug bioavailability
This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability...
Adaptable P body physical states differentially regulate bicoid mRNA storage during early Drosophila development.
M Sankaranarayanan, Ryan J Emenecker, Elise L Wilby, Marcus Jahnel, Irmela REA Trussina, Matthew Wayland, Simon Alberti, Alex S Holehouse, Timothy Weil
Nov 22, 2021
Ribonucleoprotein condensates can exhibit diverse physical states in vitro and in vivo. Despite considerable progress, the relevance of condensate physical states for in vivo biological function remains limited. Here, we...
Global urban signatures of phenotypic change in animal and plant populations.
Marina Alberti, Cristian Correa, John M Marzluff, Andrew P Hendry, Eric P Palkovacs, Kiyoko M Gotanda, Victoria M Hunt, Travis M Apgar, Yuyu Zhou
Jan 30, 2017
Shared and Disorder-Specific Neurocomputational Mechanisms of Decision-Making in Autism Spectrum Disorder and Obsessive-Compulsive Disorder.
Christina O Carlisi, Luke Norman, Clodagh M Murphy, Anastasia Christakou, Kaylita Chantiluke, Vincent Giampietro, Andrew Simmons, Michael Brammer, Declan G Murphy, David Mataix-Cols, Katya Rubia, MRC AIMS Consortium
May 14, 2019
Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) often share phenotypes of repetitive behaviors, possibly underpinned by abnormal decision-making. To compare neural correlates underlying decision-making...
Autism spectrum disorder computational modeling decision-making fMRI Obsessive-Compulsive Disorder Adolescent Autism spectrum disorder Brain Brain Mapping Child Computer Simulation Decision Making Feedback Psychological Formative Feedback Gambling Humans Magnetic Resonance Imaging Male Models Neurological Neural Pathways Neuropsychological Tests Obsessive-Compulsive Disorder Reinforcement psychology
Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions.
Mrityunjoy Kar, Furqan Dar, Timothy J Welsh, Laura T Vogel, Ralf Kühnemuth, Anupa Majumdar, Georg Krainer, Titus M Franzmann, Simon Alberti, Claus AM Seidel, Tuomas PJ Knowles, Anthony A Hyman, Rohit V Pappu
Aug 05, 2022
Macromolecular phase separation is thought to be one of the processes that drives the formation of membraneless biomolecular condensates in cells. The dynamics of phase separation are thought to follow the tenets of classical...
Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition.
Yi Shen, Francesco Simone Ruggeri, Daniele Vigolo, Ayaka Kamada, Seema Qamar, Aviad Levin, Christiane Iserman, Simon Alberti, Peter St George-Hyslop, Tuomas PJ Knowles
Feb 24, 2021
Membrane-less organelles resulting from liquid-liquid phase separation of biopolymers into intracellular condensates control essential biological functions, including messenger RNA processing, cell signalling and...
Biomolecular condensate phase diagrams with a combinatorial microdroplet platform.
William E Arter, Runzhang Qi, Nadia A Erkamp, Georg Krainer, Kieran Didi, Timothy J Welsh, Julia Acker, Jonathan Nixon-Abell, Seema Qamar, Jordina Guillén-Boixet, Titus M Franzmann, David Kuster, Anthony A Hyman, Alexander Borodavka, Peter St George-Hyslop, Simon Alberti, Tuomas PJ Knowles
Dec 21, 2022
Methodology to Support the Triage of Suspected COVID-19 Patients in Resource-Limited Circumstances
Alexandre Alberti, Eduarda Frej, Lucia Roselli, Murilo Britto, Evônio Campelo, Adiel Teixeira de Almeida, Rodrigo Ferreira
Jan 01, 2022
COVID-19 pandemic has put health systems worldwide under pressure. Thus, establish a triage protocol to support the allocation of resources is important to deal with this public health crisis. In this paper, a structured...
Published by: IGI Global Scientific Publishing
Biomolecular condensate phase diagrams with a combinatorial microdroplet platform.
William E Arter, Runzhang Qi, Nadia A Erkamp, Georg Krainer, Kieran Didi, Timothy J Welsh, Julia Acker, Jonathan Nixon-Abell, Seema Qamar, Jordina Guillén-Boixet, Titus M Franzmann, David Kuster, Anthony A Hyman, Alexander Borodavka, Peter St George-Hyslop, Simon Alberti, Tuomas PJ Knowles
Jan 22, 2023
The assembly of biomolecules into condensates is a fundamental process underlying the organisation of the intracellular space and the regulation of many cellular functions. Mapping and characterising phase behaviour of...
Direct digital sensing of protein biomarkers in solution.
Georg Krainer, Kadi L Saar, William E Arter, Timothy J Welsh, Magdalena A Czekalska, Raphaël P B Jacquat, Quentin Peter, Walther C Traberg, Arvind Pujari, Akhila K Jayaram, Pavankumar Challa, Christopher G Taylor, Lize-Mari van der Linden, Titus Franzmann, Roisin M Owens, Simon Alberti, David Klenerman, Tuomas P J Knowles
Mar 09, 2023
Published by: Nature Communications
Experience of point-of-care HbA1c testing in the English National Health Service Diabetes Prevention Programme
Emma Barron, Shivani Misra, Emma English, W Garry John, Michael Sampson, Max O Bachmann, Julian Barth, Nick Oliver, KGMM Alberti, Chirag Bakhai, Simon O'Neill, Bob Young, Nicholas J Wareham, Kamlesh Khunti, Susan Jebb, Jenifer Smith, Jonathan Valabhji
Oct 15, 2020
Experience of point-of-care HbA1c testing in the English National Health Service Diabetes Prevention Programme
Emma Barron, Shivani Misra, Emma English, W Garry John, Michael Sampson, Max O Bachmann, Julian Barth, Nick Oliver, K G M M Alberti, Chirag Bakhai, Simon O'Neill, Bob Young, Nicholas J Wareham, Kamlesh Khunti, Susan Jebb, Jenifer Smith, Jonathan Valabhji
Dec 22, 2020
Introduction: To report the observations of point-of-care (POC) glycated hemoglobin (HbA1c) testing in people with non-diabetic hyperglycemia (NDH; HbA1c 42–47 mmol/mol (6.0%–6.4%)), applied in community settings, within the...
Direct digital sensing of protein biomarkers in solution.
Georg Krainer, Kadi L Saar, William E Arter, Timothy J Welsh, Magdalena A Czekalska, Raphaël PB Jacquat, Quentin Peter, Walther C Traberg, Arvind Pujari, Akhila K Jayaram, Pavankumar Challa, Christopher G Taylor, Lize-Mari van der Linden, Titus Franzmann, Roisin M Owens, Simon Alberti, David Klenerman, Tuomas PJ Knowles
Feb 09, 2023
Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor
Tatiana Tiago, Barbara Hummel, Federica F. Morelli, Valentina Basile, Jonathan Vinet, Veronica Galli, Laura Mediani, Francesco Antoniani, Silvia Pomella, Matteo Cassandri, Maria Giovanna Garone, Beatrice Silvestri, Marco Cimino, Giovanna Cenacchi, Roberta Costa, Vincent Mouly, Ina Poser, Esti Yeger-Lotem, Alessandro Rosa, Simon Alberti, Rossella Rota, Anat Ben-Zvi, Ritwick Sawarkar, Serena Carra
May 06, 2021
Abstract: One of the critical events that regulates muscle cell differentiation is the replacement of the lamin B receptor (LBR)-tether with the lamin A/C (LMNA)-tether to remodel transcription and induce...
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
Georg Krainer, Timothy J. Welsh, Jerelle A. Joseph, Jorge R. Espinosa, Sina Wittmann, Ella de Csilléry, Akshay Sridhar, Zenon Toprakcioglu, Giedre Gudiškytė, Magdalena A. Czekalska, William E. Arter, Jordina Guillén-Boixet, Titus M. Franzmann, Seema Qamar, Peter St George-Hyslop, Anthony A. Hyman, Rosana Collepardo-Guevara, Simon Alberti, Tuomas P. J. Knowles
Feb 17, 2021
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.
Georg Krainer, Timothy J Welsh, Jerelle A Joseph, Jorge R Espinosa, Sina Wittmann, Ella de Csilléry, Akshay Sridhar, Zenon Toprakcioglu, Giedre Gudiškytė, Magdalena A Czekalska, William E Arter, Jordina Guillén-Boixet, Titus M Franzmann, Seema Qamar, Peter St George-Hyslop, Anthony A Hyman, Rosana Collepardo-Guevara, Simon Alberti, Tuomas PJ Knowles
Mar 24, 2021
Liquid-liquid phase separation of proteins underpins the formation of membraneless compartments in living cells. Elucidating the molecular driving forces underlying protein phase transitions is therefore a key objective for...
Challenging the "old boys club" in academia
Sara Dada, Kim Robin van Daalen, Alanna Barrios-Ruiz, Kai-Ti Wu, Aidan Desjardins, Mayte Bryce-Alberti, Alejandra Castro-Varela, Parnian Khorsand, Ander Santamarta Zamorano, Laura Jung, Grace Malolos, Jiaqi Li, Dominique Vervoort, Nikita Charles Hamilton, Poorvaprabha Patil, Omnia El Omrani, Marie-Claire Wangari, Telma Sibanda, Conor Buggy, Ebele R I Mogo
Apr 17, 2023
In light of global environmental crises and the need for sustainable development, the fields of public health and environmental sciences have become increasingly interrelated. Both fields require interdisciplinary thinking and...
Published by: PLOS global public health
Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor.
Tatiana Tiago, Barbara Hummel, Federica F Morelli, Valentina Basile, Jonathan Vinet, Veronica Galli, Laura Mediani, Francesco Antoniani, Silvia Pomella, Matteo Cassandri, Maria Giovanna Garone, Beatrice Silvestri, Marco Cimino, Giovanna Cenacchi, Roberta Costa, Vincent Mouly, Ina Poser, Esti Yeger-Lotem, Alessandro Rosa, Simon Alberti, Rossella Rota, Anat Ben-Zvi, Ritwick Sawarkar, Serena Carra
Jun 07, 2021
One of the critical events that regulates muscle cell differentiation is the replacement of the lamin B receptor (LBR)-tether with the lamin A/C (LMNA)-tether to remodel transcription and induce differentiation-specific genes....
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