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FRONTotemporal dementia Incidence European Research Study—FRONTIERS
Barbara Borroni, Caroline Graff, Orla Hardiman, Albert C. Ludolph, Fermin Moreno, Markus Otto, Marco Piccininni, Anne M Remes, James B Rowe, Harro Seelaar, Elka Stefanova, Latchezar Traykov, Giancarlo Logroscino, FRONTIERS
Aug 02, 2021
Abstract: Introduction: The incidence of Frontotemporal Lobar Degeneration (FTLD)–related disorders and their characteristics are not well known. The “FRONTotemporal dementia Incidence European Research Study” (FRONTIERS) is...
review article Review articles EPIDEMIOLOGY frontotemporal dementia Frontotemporal Lobar Degeneration Incidence Rare Diseases Registry
Published by: Alzheimer's & Dementia
FRONTotemporal dementia Incidence European Research Study-FRONTIERS
Barbara Borroni, Caroline Graff, Orla Hardiman, Albert C Ludolph, Fermin Moreno, Markus Otto, Marco Piccininni, Anne M Remes, James B Rowe, Harro Seelaar, Elka Stefanova, Latchezar Traykov, Giancarlo Logroscino, FRONTIERS
Sep 16, 2021
INTRODUCTION: The incidence of Frontotemporal Lobar Degeneration (FTLD)-related disorders and their characteristics are not well known. The "FRONTotemporal dementia Incidence European Research Study" (FRONTIERS) is designed to...
Unlocking the potential of supported liquid phase catalysts with supercritical fluids
Solution-phase catalysis using molecular transition metal complexes is an extremely powerful tool for chemical synthesis and a key technology for sustainable manufacturing. However, as the reaction complexity and thermal...
How to test for phasic modulation of neural and behavioural responses.
Research on whether perception or other processes depend on the phase of neural oscillations is rapidly gaining popularity. However, it is unknown which methods are optimally suited to evaluate the hypothesized phase effect....
Unlocking the potential of supported liquid phase catalysts with supercritical fluids
Solution-phase catalysis using molecular transition metal complexes is an extremely powerful tool for chemical synthesis and a key technology for sustainable manufacturing. However, as the reaction complexity and thermal...
Social distancing and supply disruptions in a pandemic.
We integrate an epidemiological model, augmented with contact and mobility analyses, with a two-sector macroeconomic model, to assess the economic costs of labor supply disruptions in a pandemic. The model is designed to capture...
The Temperature Role in the Manufacturing of an Electrode for Supercapacitors with Carbon Black and Graphene Oxide
Supercapacitors (SCs) are energy storage devices with a growing interest thanks to their high-power charge and discharge process and long-cycle life. Their main drawback, when compared to more common devices such as batteries...
The Temperature Role in the Manufacturing of an Electrode for Supercapacitors with Carbon Black and Graphene Oxide
Supercapacitors (SCs) are energy storage devices with a growing interest thanks to their high-power charge and discharge process and long-cycle life. Their main drawback, when compared to more common devices such as batteries...
Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs.
Active targeting by means of drug encapsulated nanoparticles decorated with targeting bioactive moieties represents the next frontier in drug delivery; it reduces drug side effects and increases the therapeutic index. Peptides...
Transgene codon usage drives viral fitness and therapeutic efficacy in oncolytic adenoviruses.
Estela Núñez-Manchón, Martí Farrera-Sal, Marc Otero-Mateo, Giancarlo Castellano, Rafael Moreno, David Medel, Ramon Alemany, Eneko Villanueva, Cristina Fillat
Aug 28, 2021
Arming oncolytic adenoviruses with therapeutic transgenes is a well-established strategy for multimodal tumour attack. However, this strategy sometimes leads to unexpected attenuated viral replication and a loss of oncolytic...
Leveraging Social Sustainability in the Amazonian Forest
Miriam Borchardt, Márcia Amado da Silva, Giancarlo Pereira, Annibal Scavarda, Edmond Filho
Jan 01, 2023
The social dimension of sustainability has not gained as much attention in bioeconomy (BE) literature as have the environmental and economic dimensions. Thus, this study's purpose is to analyze how social sustainability of the...
Published by: IGI Global Scientific Publishing
FiCoS
Andrea Tangherloni, Marco S. Nobile, Paolo Cazzaniga, Giulia Capitoli, Simone Spolaor, Leonardo Rundo, Giancarlo Mauri, Daniela Besozzi
Sep 27, 2021
Mathematical models of biochemical networks can largely facilitate the comprehension of the mechanisms at the basis of cellular processes, as well as the formulation of hypotheses that can be tested by means of targeted...
Prevalence and prognostic impact of retropharyngeal lymph nodes metastases in oropharyngeal squamous cell carcinoma
Giancarlo Tirelli, Nicoletta Gardenal, Enrico Zanelli, Daniele Borsetto, Veronica Phillips, Alberto Vito Marcuzzo, Jonathan Fussey, Jerry Polesel, Paolo Boscolo-Rizzo
Aug 01, 2022
BACKGROUND: This systematic review and meta-analysis aims to estimate the prevalence and prognostic impact of retropharyngeal lymph node metastases (RLNMs) in oropharyngeal squamous cell carcinoma (OPSCC). METHODS: This...
HPV human papillomavirus oropharyngeal cancer retropharyngeal lymph nodes retropharyngeal metastasis Carcinoma Squamous Cell Head and Neck Neoplasms Humans Lymph Nodes Lymphatic Metastasis Oropharyngeal Neoplasms Papillomavirus Infections prevalence Prognosis Retrospective Studies Squamous Cell Carcinoma of Head and Neck
FiCoS
Andrea Tangherloni, Marco S Nobile, Paolo Cazzaniga, Giulia Capitoli, Simone Spolaor, Leonardo Rundo, Giancarlo Mauri, Daniela Besozzi
Oct 10, 2021
Mathematical models of biochemical networks can largely facilitate the comprehension of the mechanisms at the basis of cellular processes, as well as the formulation of hypotheses that can be tested by means of targeted...
Published by: PLoS computational biology
The societal burden of chronic liver diseases
Luciana Scalone, Stefano Fagiuoli, Roberta Ciampichini, Ivan Gardini, Raffaele Bruno, Luisa Pasulo, Maria Grazia Lucà, Francesco Fusco, Laura Gaeta, Anna Del Prete, Giancarlo Cesana, Lorenzo Giovanni Mantovani
Jan 22, 2020
OBJECTIVE: Chronic liver diseases (CLDs) impose a significant socioeconomic burden on patients and the healthcare system, but to what extent remains underexplored. We estimated costs and health-related-quality-of-life (HRQoL)...
Predictive and prognostic significance of telomerase levels/telomere length in tissues and peripheral blood in head and neck squamous cell carcinoma.
Paolo Boscolo-Rizzo, Enrica Rampazzo, Jerry Polesel, Silvia Giunco, Anna Menegaldo, Monica Mantovani, Marco Stellin, Luigia Bandolin, Giacomo Spinato, Annarosa Del Mistro, Daniele Borsetto, Jonathan Fussey, Giancarlo Tirelli, Maria Cristina Da Mosto, Anita De Rossi
Nov 25, 2020
A growing body of evidence indicates that the expression of TERT, the catalytic subunit of telomerase, is a biological marker of progression in several cancers. We investigated the predictive and prognostic role of TERT levels...
Exciton-phonon coupling strength in single-layer MoSe2 at room temperature.
Donghai Li, Chiara Trovatello, Stefano Dal Conte, Matthias Nuß, Giancarlo Soavi, Gang Wang, Andrea C Ferrari, Giulio Cerullo, Tobias Brixner
Dec 22, 2020
Single-layer transition metal dichalcogenides are at the center of an ever increasing research effort both in terms of fundamental physics and applications. Exciton-phonon coupling plays a key role in determining the...
Pre-clinical evaluation of eight DOTA coupled gastrin-releasing peptide receptor (GRP-R) ligands for in vivo targeting of receptor-expressing tumors.
Antonella Accardo, Filippo Galli, Rosalba Mansi, Luigi Del Pozzo, Michela Aurilio, Anna Morisco, Paola Ringhieri, Alberto Signore, Giancarlo Morelli, Luigi Aloj
Dec 18, 2018
BACKGROUND: Overexpression of the gastrin-releasing peptide receptor (GRP-R) has been documented in several human neoplasms such as breast, prostate, and ovarian cancer. There is growing interest in developing radiolabeled...
FiCoS
Andrea Tangherloni, Marco S Nobile, Paolo Cazzaniga, Giulia Capitoli, Simone Spolaor, Leonardo Rundo, Giancarlo Mauri, Daniela Besozzi
Nov 22, 2021
Mathematical models of biochemical networks can largely facilitate the comprehension of the mechanisms at the basis of cellular processes, as well as the formulation of hypotheses that can be tested by means of targeted...
Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells
Antonella Accardo, Giuseppina Salsano, Anna Morisco, Michela Aurilio, Antonio Parisi, Francesco Maione, Carla Cicala, Diego Tesauro, Luigi Aloj, Giuseppe De Rosa, Giancarlo Morelli
Dec 21, 2018
OBJECTIVES: Drug delivery systems consisting of liposomes displaying a cell surface receptor-targeting peptide are being developed to specifically deliver chemotherapeutic drugs to tumors overexpressing a target receptor. This...
PC-3 Cells bombesin peptide doxorubicin delivery gastrin-releasing peptide receptors theranostic applications Animals Antineoplastic Agents Bombesin Cell Line Tumor Doxorubicin Drug Carriers Drug Delivery Systems Female Humans Liposomes Male Mice Mice Inbred BALB C Mice Nude nanomedicine Pentetic Acid Peptide Fragments Phosphatidylcholines Prostatic Neoplasms Receptors Bombesin Surface-Active Agents Xenograft Model Antitumor Assays
Coronavirus disease 2019 (COVID-19)-related smell and taste impairment with widespread diffusion of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) Omicron variant.
Paolo Boscolo-Rizzo, Giancarlo Tirelli, Pierluigi Meloni, Claire Hopkins, Giordano Madeddu, Andrea De Vito, Nicoletta Gardenal, Romina Valentinotti, Margherita Tofanelli, Daniele Borsetto, Jerome R Lechien, Jerry Polesel, Giacomo De Riu, Luigi Angelo Vaira
Mar 31, 2022
BACKGROUND: The aim of this study was to estimate the prevalence of self-reported chemosensory dysfunction in a study cohort of subjects who developed a mild-to-moderate coronavirus disease 2019 (COVID-19) in the period from...
Electrostatic Tuning of the Ligand Binding Mechanism by Glu27 in Nitrophorin 7.
Stefania Abbruzzetti, Alessandro Allegri, Axel Bidon-Chanal, Hideaki Ogata, Giancarlo Soavi, Giulio Cerullo, Stefano Bruno, Chiara Montali, F Javier Luque, Cristiano Viappiani
Nov 21, 2018
Nitrophorins (NP) 1-7 are NO-carrying heme proteins found in the saliva of the blood-sucking insect Rhodnius prolixus. The isoform NP7 displays peculiar properties, such as an abnormally high isoelectric point, the ability to...
A Low-Dose CT-Based Radiomic Model to Improve Characterization and Screening Recall Intervals of Indeterminate Prevalent Pulmonary Nodules.
Leonardo Rundo, Roberta Eufrasia Ledda, Christian di Noia, Evis Sala, Giancarlo Mauri, Gianluca Milanese, Nicola Sverzellati, Giovanni Apolone, Maria Carla Gilardi, Maria Cristina Messa, Isabella Castiglioni, Ugo Pastorino
Oct 29, 2021
Lung cancer (LC) is currently one of the main causes of cancer-related deaths worldwide. Low-dose computed tomography (LDCT) of the chest has been proven effective in secondary prevention (i.e., early detection) of LC by several...
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