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Results: 152
From sustainability commitment to performance
Organisations increasingly see sustainability as an important element of their business strategies, and the role of purchasing and supply functions is critical in translating sustainability commitment into performance. Yet, the...
Cryo-EM structure of metazoan TRAPPIII, the multi-subunit complex that activates the GTPase Rab1.
The TRAPP complexes are nucleotide exchange factors that play essential roles in membrane traffic and autophagy. TRAPPII activates Rab11, and TRAPPIII activates Rab1, with the two complexes sharing a core of small subunits that...
Modeling breast cancer progression to bone
Abstract: Background: Not all the mutations are equally important for the development of metastasis. What about their order? The survival of cancer cells from the primary tumour site to the secondary seeding sites depends on the...
Modeling breast cancer progression to bone
BACKGROUND: Not all the mutations are equally important for the development of metastasis. What about their order? The survival of cancer cells from the primary tumour site to the secondary seeding sites depends on the...
Modeling TGF-β in early stages of cancer tissue dynamics.
Recent works have highlighted a double role for the Transforming Growth Factor β (TGF-β): it inhibits cancer in healthy cells and potentiates tumor progression during late stage of tumorigenicity, respectively; therefore it has...
Lymphoscintigraphy defines new lymphatic pathways from cutaneous melanoma site
Sentinel lymph node biopsy is commonly applied as staging procedure of regional lymph nodes in patients with cutaneous melanoma. Dynamic lymphoscintigraphy defines the lymphatic pathways from a primary melanoma site and allows...
Lipopolysaccharide or Whole Bacteria Block the Conversion of Inflammatory Monocytes into Dendritic Cells In Vivo
Monocytes can develop into dendritic cells (DCs) that migrate to lymph nodes (LNs) and present antigens to T cells. However, we find that this differentiation is blocked when monocytes accumulate subcutaneously in response to...
Published by: Rockefeller University
Modelling circulating tumour cells for personalised survival prediction in metastatic breast cancer.
Ductal carcinoma is one of the most common cancers among women, and the main cause of death is the formation of metastases. The development of metastases is caused by cancer cells that migrate from the primary tumour site (the...
From sustainability commitment to performance
Organisations increasingly see sustainability as an important element of their business strategies, and the role of purchasing and supply functions is critical in translating sustainability commitment into performance. Yet, the...
Behind the developing brains and beating hearts of stem cell-derived embryo models.
Studies over the past decade have shown how stem cells representing embryonic and extra-embryonic tissues of the mouse can self-assemble in the culture dish to recapitulate an astonishing part of early embryonic development. A...
Haematopoiesis Stem Cells embryo models Brain Endoderm Animals Mice Cell Differentiation Embryonic Development Pregnancy Female Embryonic Stem Cells Embryo Mammalian
Published by: Open biology
Continuous Level Monte Carlo and Sample-Adaptive Model Hierarchies
In this paper, we present a generalization of the multilevel Monte Carlo (MLMC) method to a setting where the level parameter is a continuous variable. This continuous level Monte Carlo (CLMC) estimator provides a natural...
math.NA CLMC Adaptivity Complexity theorem Heterogeneous elliptic PDEs Unbiased estimator multilevel Monte Carlo /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics /dk/atira/pure/subjectarea/asjc/2600/2607 name=Discrete Mathematics and Combinatorics /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/1800/1804 name=Statistics, Probability and Uncertainty /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation
Facilitating the Adoption and Evolution of Digital Technologies Through Re-conceptualization.
Nicholas Pari Tekkis, Rebecca Richmond-Smith, Gianluca Pellino, Christos Kontovounisios
Apr 11, 2022
Background
The NHS has been making steps toward greater efficiency and cutting costs to maintain quality of care despite constraints, but without innovation the NHS will not be able to meet its increasing financial...
Published by: Frontiers in surgery
Continuous Level Monte Carlo and Sample-Adaptive Model Hierarchies
In this paper, we present a generalization of the multilevel Monte Carlo (MLMC) method to a setting where the level parameter is a continuous variable. This continuous level Monte Carlo (CLMC) estimator provides a natural...
math.NA CLMC Adaptivity Complexity theorem Heterogeneous elliptic PDEs Unbiased estimator multilevel Monte Carlo /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics /dk/atira/pure/subjectarea/asjc/2600/2607 name=Discrete Mathematics and Combinatorics /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/1800/1804 name=Statistics, Probability and Uncertainty /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation
Cost of Coexisting with a Relict Large Carnivore Population
Andrea Galluzzi, Valerio Donfrancesco, Gianluca Mastrantonio, Cinzia Sulli, Paolo Ciucci
May 21, 2021
Human-carnivore conflicts are a major conservation issue. As bears are expanding their range in Europe’s human-modified landscapes, it is increasingly important to understand, prevent, and address human-bear conflicts and...
Radiocarbon dating of lumps from aerial lime mortars and plasters
Gianluca Pesce, G Quarta, L Calcagnile, M D'Elia, P Cavaciocchi, C Lastrico, R Guastella
Jan 01, 0001
This paper deals with the potentialities and technical and methodological issues associated with the use of lumps of not completely melted lime as material suitable for the radiocarbon dating of aerial lime mortars and plasters....
Getting to the Root of Selenium Hyperaccumulation—Localization and Speciation of Root Selenium and Its Effects on Nematodes
Christine N. Prins, Laura J. Hantzis, Jose R. Valdez Barillas, Jennifer J. Cappa, Sirine C. Fakra, Cecilia Milano de Tomasel, Diana H. Wall, Elizabeth A. H. Pilon-Smits
Jul 01, 2019
Elemental hyperaccumulation protects plants from many aboveground herbivores. Little is known about effects of hyperaccumulation on belowground herbivores or their ecological interactions. To examine effects of plant selenium...
Published by: Digital Commons @ Texas A&M University-San Antonio
Cost of Coexisting with a Relict Large Carnivore Population
Andrea Galluzzi, Valerio Donfrancesco, Gianluca Mastrantonio, Cinzia Sulli, Paolo Ciucci
Jul 07, 2021
Human-carnivore conflicts are a major conservation issue. As bears are expanding their range in Europe's human-modified landscapes, it is increasingly important to understand, prevent, and address human-bear conflicts and...
Radiocarbon dating of lumps from aerial lime mortars and plasters
Gianluca Pesce, G Quarta, L Calcagnile, M D'Elia, P Cavaciocchi, C Lastrico, R Guastella
Jan 01, 0001
This paper deals with the potentialities and technical and methodological issues associated with the use of lumps of not completely melted lime as material suitable for the radiocarbon dating of aerial lime mortars and plasters....
Getting to the Root of Selenium Hyperaccumulation—Localization and Speciation of Root Selenium and Its Effects on Nematodes
Christine N. Prins, Laura J. Hantzis, Jose R. Valdez Barillas, Jennifer J. Cappa, Sirine C. Fakra, Cecilia Milano de Tomasel, Diana H. Wall, Elizabeth A. H. Pilon-Smits
Jul 01, 2019
Elemental hyperaccumulation protects plants from many aboveground herbivores. Little is known about effects of hyperaccumulation on belowground herbivores or their ecological interactions. To examine effects of plant selenium...
Published by: Digital Commons @ Texas A&M University-San Antonio
Photodegradation and ecotoxicology of acyclovir in water under UV254 and UV 254/H2O2 processes
Danilo Russo, Antonietta Siciliano, Marco Guida, Emilia Galdiero, Angela Amoresano, Roberto Andreozzi, Nuno Reis, Gianluca Li Puma, Raffaele Marotta
Oct 01, 2017
The photochemical and ecotoxicological fate of acyclovir (ACY) through UV254 direct photolysis and in the presence of hydroxyl radicals (UV254/H2O2 process) were investigated in a microcapillary film (MCF) array photoreactor...
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