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Results: 136
From sustainability commitment to performance
Organisations increasingly see sustainability as an important element of their business strategies, and the role of purchasing and supply functions is critical in translating sustainability commitment into performance. Yet, the...
Modeling breast cancer progression to bone
Abstract: Background: Not all the mutations are equally important for the development of metastasis. What about their order? The survival of cancer cells from the primary tumour site to the secondary seeding sites depends on the...
Modeling breast cancer progression to bone
BACKGROUND: Not all the mutations are equally important for the development of metastasis. What about their order? The survival of cancer cells from the primary tumour site to the secondary seeding sites depends on the...
Modeling TGF-β in early stages of cancer tissue dynamics.
Recent works have highlighted a double role for the Transforming Growth Factor β (TGF-β): it inhibits cancer in healthy cells and potentiates tumor progression during late stage of tumorigenicity, respectively; therefore it has...
Lymphoscintigraphy defines new lymphatic pathways from cutaneous melanoma site
Sentinel lymph node biopsy is commonly applied as staging procedure of regional lymph nodes in patients with cutaneous melanoma. Dynamic lymphoscintigraphy defines the lymphatic pathways from a primary melanoma site and allows...
Lipopolysaccharide or Whole Bacteria Block the Conversion of Inflammatory Monocytes into Dendritic Cells In Vivo
Monocytes can develop into dendritic cells (DCs) that migrate to lymph nodes (LNs) and present antigens to T cells. However, we find that this differentiation is blocked when monocytes accumulate subcutaneously in response to...
Published by: Rockefeller University
From sustainability commitment to performance
Organisations increasingly see sustainability as an important element of their business strategies, and the role of purchasing and supply functions is critical in translating sustainability commitment into performance. Yet, the...
Behind the developing brains and beating hearts of stem cell-derived embryo models.
Studies over the past decade have shown how stem cells representing embryonic and extra-embryonic tissues of the mouse can self-assemble in the culture dish to recapitulate an astonishing part of early embryonic development. A...
Published by: Open biology
Continuous Level Monte Carlo and Sample-Adaptive Model Hierarchies

In this paper, we present a generalization of the multilevel Monte Carlo (MLMC) method to a setting where the level parameter is a continuous variable. This continuous level Monte Carlo (CLMC) estimator provides a natural...

Facilitating the Adoption and Evolution of Digital Technologies Through Re-conceptualization.

Background

The NHS has been making steps toward greater efficiency and cutting costs to maintain quality of care despite constraints, but without innovation the NHS will not be able to meet its increasing financial...
Published by: Frontiers in surgery
Continuous Level Monte Carlo and Sample-Adaptive Model Hierarchies

In this paper, we present a generalization of the multilevel Monte Carlo (MLMC) method to a setting where the level parameter is a continuous variable. This continuous level Monte Carlo (CLMC) estimator provides a natural...

Cost of Coexisting with a Relict Large Carnivore Population
Human-carnivore conflicts are a major conservation issue. As bears are expanding their range in Europe’s human-modified landscapes, it is increasingly important to understand, prevent, and address human-bear conflicts and...
Radiocarbon dating of lumps from aerial lime mortars and plasters
This paper deals with the potentialities and technical and methodological issues associated with the use of lumps of not completely melted lime as material suitable for the radiocarbon dating of aerial lime mortars and plasters....
Cost of Coexisting with a Relict Large Carnivore Population
Human-carnivore conflicts are a major conservation issue. As bears are expanding their range in Europe's human-modified landscapes, it is increasingly important to understand, prevent, and address human-bear conflicts and...
Radiocarbon dating of lumps from aerial lime mortars and plasters
This paper deals with the potentialities and technical and methodological issues associated with the use of lumps of not completely melted lime as material suitable for the radiocarbon dating of aerial lime mortars and plasters....

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