Structural basis of synaptic vesicle assembly promoted by α-synuclein.
Giuliana Fusco,
Tillmann Pape,
Amberley D Stephens,
Pierre Mahou,
Ana Rita Costa,
Clemens F Kaminski,
Gabriele S Kaminski Schierle,
Michele Vendruscolo,
Gianluigi Veglia,
Christopher M Dobson,
Alfonso De Simone
Mar 04, 2020
α-synuclein (αS) is an intrinsically disordered protein whose fibrillar aggregates are the major constituents of Lewy bodies in Parkinson's disease. Although the specific function of αS is still unclear, a general consensus is...