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Results: 284
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Mary-Ellen Lynall, Blagoje Soskic, James Hayhurst, Jeremy Schwartzentruber, Daniel Levey, Gita Pathak, Renato Polimanti, Joel Gelernter, Murray Stein, Gosia Trynka, Menna Clatworthy, Ed Bullmore, Mary-Ellen Lynall
Nov 16, 2022
Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events.
Frank R Wendt, Varun Warrier, Gita A Pathak, Karestan C Koenen, Murray B Stein, John H Krystal, Robert H Pietrzak, Joel Gelernter, Elizabeth V Goldfarb, Simon Baron-Cohen, Renato Polimanti
Apr 03, 2022
BACKGROUND: Posttraumatic stress disorder (PTSD) is triggered by environmental stressors. Empathy may predispose an individual to respond to life events differently if high empathizers are emotionally more sensitive to trauma....
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Abstract Multiple psychiatric disorders have been associated with abnormalities in both the innate and adaptive immune systems. The role of these abnormalities in pathogenesis, and whether they...
Mary-Ellen Lynall, Blagoje Soskic, James Hayhurst, Jeremy Schwartzentruber, Daniel F Levey, Gita A Pathak, Renato Polimanti, Joel Gelernter, Murray B Stein, Gosia Trynka, Menna R Clatworthy, Ed Bullmore
Oct 15, 2022
Molecular analysis of accessory gene regulator functionality and virulence genes in Staphylococcus aureus derived from pediatric wound infections
Donya Taghizadeh Maleki, Zohreh Ghalavand, Maisem Laabei, Bahram Nikmanesh, Hamidreza Houri, Mansoor Kodori, Ali Hashemi, Hiva Kadkhoda, Gita Eslami
Sep 30, 2019
Staphylococcus aureus is a major human pathogen causing infections with high morbidity and mortality in both healthcare and community settings. The accessory gene regulator (Agr)is a key genetic element controlling the...
Agr functionality Pediatrics Staphylococcus aureus Wound infections /dk/atira/pure/subjectarea/asjc/2400/2404 name=Microbiology /dk/atira/pure/subjectarea/asjc/1100/1105 name=Ecology, Evolution, Behavior and Systematics /dk/atira/pure/subjectarea/asjc/1300/1312 name=Molecular Biology /dk/atira/pure/subjectarea/asjc/1300/1311 name=Genetics /dk/atira/pure/subjectarea/asjc/2700/2726 name=Microbiology (medical) /dk/atira/pure/subjectarea/asjc/2700/2725 name=Infectious Diseases /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Molecular analysis of accessory gene regulator functionality and virulence genes in Staphylococcus aureus derived from pediatric wound infections
Donya Taghizadeh Maleki, Zohreh Ghalavand, Maisem Laabei, Bahram Nikmanesh, Hamidreza Houri, Mansoor Kodori, Ali Hashemi, Hiva Kadkhoda, Gita Eslami
Sep 30, 2019
Staphylococcus aureus is a major human pathogen causing infections with high morbidity and mortality in both healthcare and community settings. The accessory gene regulator (Agr)is a key genetic element controlling the...
Agr functionality Pediatrics Staphylococcus aureus Wound infections /dk/atira/pure/subjectarea/asjc/2400/2404 name=Microbiology /dk/atira/pure/subjectarea/asjc/1100/1105 name=Ecology, Evolution, Behavior and Systematics /dk/atira/pure/subjectarea/asjc/1300/1312 name=Molecular Biology /dk/atira/pure/subjectarea/asjc/1300/1311 name=Genetics /dk/atira/pure/subjectarea/asjc/2700/2726 name=Microbiology (medical) /dk/atira/pure/subjectarea/asjc/2700/2725 name=Infectious Diseases /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
How do the prevalence and relative risk of non-suicidal self-injury and suicidal thoughts vary across the population distribution of common mental distress (the p factor)? Observational analyses replicated in two independent UK cohorts of young people.
Ela Polek, Sharon AS Neufeld, Paul Wilkinson, Ian Goodyer, Michelle St Clair, Gita Prabhu, Ray Dolan, Edward T Bullmore, Peter Fonagy, Jan Stochl, Peter B Jones
Apr 03, 2020
child & adolescent psychiatry EPIDEMIOLOGY Public Health suicide & self-harm Adolescent Cohort Studies Female Health Surveys Humans Logistic Models Male Patient Dropouts prevalence psychological distress Reproducibility of Results risk Self-Injurious Behavior Suicidal Ideation United Kingdom Young Adult Suicide Prevention
Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data
Lina Keutzer, Huifang You, Ali Farnoud, Joakim Nyberg, Sebastian G Wicha, Gareth Maher-Edwards, Georgios Vlasakakis, Gita Khalili Moghaddam, Elin M Svensson, Michael P Menden, Ulrika SH Simonsson, On Behalf Of The Unite Tb Consortium
Jul 23, 2022
Pharmacometrics (PM) and machine learning (ML) are both valuable for drug development to characterize pharmacokinetics (PK) and pharmacodynamics (PD). Pharmacokinetic/pharmacodynamic (PKPD) analysis using PM provides mechanistic...
Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data
Lina Keutzer, Huifang You, Ali Farnoud, Joakim Nyberg, Sebastian G Wicha, Gareth Maher-Edwards, Georgios Vlasakakis, Gita Khalili Moghaddam, Elin M Svensson, Michael P Menden, Ulrika SH Simonsson, On Behalf Of The Unite Tb Consortium
Sep 02, 2022
Pharmacometrics (PM) and machine learning (ML) are both valuable for drug development to characterize pharmacokinetics (PK) and pharmacodynamics (PD). Pharmacokinetic/pharmacodynamic (PKPD) analysis using PM provides mechanistic...
Developing Personal Traits by using Divine Tool – Bhagwad Gita
Every day from morning to evening we all are in the battlefield. We are facing number of problems and challenges in day to day life. In this research paper, some important teachings of Bhagwad-Geeta are highlighted. Such as;...
Published by: Singh Publication
Developing Personal Traits by using Divine Tool – Bhagwad Gita
Every day from morning to evening we all are in the battlefield. We are facing number of problems and challenges in day to day life. In this research paper, some important teachings of Bhagwad-Geeta are highlighted. Such as;...
Published by: Singh Publication
How do the prevalence and relative risk of non-suicidal self-injury and suicidal thoughts vary across the population distribution of common mental distress (the p factor)? Observational analyses replicated in two independent UK cohorts of young people
Ela Polek, Sharon A S Neufeld, Paul Wilkinson, Ian Goodyer, Michelle St Clair, Gita Prabhu, Ray Dolan, Edward T Bullmore, Peter Fonagy, Jan Stochl, Peter B Jones
May 15, 2020
Intelligent Framework With Controlled Behavior for Gene Regulatory Network Reconstruction
Gene Regulatory Networks (GRNs) are the pioneering methodology for finding new gene interactions getting insights of the biological processes using time series gene expression data. It remains a challenge to study the temporal...
Published by: IGI Global Scientific Publishing
Priorities for research on equity and health
Piroska Östlin, Ted Schrecker, Ritu Sadana, Josiane Bonnefoy, Lucy Gilson, Clyde Hertzman, Michael P Kelly, Tord Kjellstrom, Ronald Labonté, Olle Lundberg, Carles Muntaner, Jennie Popay, Gita Sen, Ziba Vaghri
Mar 04, 2021
Piroska Östlin and colleagues argue that a paradigm shift is needed to keep the focus on health equity within the social determinants of health research agenda.
CD32-Expressing CD4 T Cells Are Phenotypically Diverse and Can Contain Proviral HIV DNA.
Genevieve E Martin, Matthew Pace, John P Thornhill, Chansavath Phetsouphanh, Jodi Meyerowitz, Morgane Gossez, Helen Brown, Natalia Olejniczak, Julianne Lwanga, Gita Ramjee, Pontiano Kaleebu, Kholoud Porter, Christian B Willberg, Paul Klenerman, Nneka Nwokolo, Julie Fox, Sarah Fidler, John Frater
Nov 26, 2019
Efforts to both characterize and eradicate the HIV reservoir have been limited by the rarity of latently infected cells and the absence of a specific denoting biomarker. CD32a (FcγRIIa) has been proposed to be a marker for an...
CD32 HIV HIV DNA primary HIV infection Reservoir Adult Biomarkers CD4 Lymphocyte Count CD4-Positive T-Lymphocytes DNA Viral Female Gene Expression HIV Infections HIV-1 Humans Immunologic Memory Immunophenotyping Male Phenotype Proviruses RNA Viral Receptors HIV Receptors IgG T-Lymphocyte Subsets Young Adult
G-protein α-subunit (GPA1) regulates stress, nitrate and phosphate response, flavonoid biosynthesis, fruit/seed development and substantially shares GCR1 regulation in A. <i>thaliana</i>
Navjyoti Chakraborty, Priyanka Sharma, Kostya Kanyuka, Ravi Ramesh Pathak, Devapriya Choudhury, Richard Hooley, Nandula Raghuram
Dec 01, 2015
Heterotrimeric G-proteins are implicated in several plant processes, but the mechanisms of signal-response coupling and the roles of G-protein coupled receptors in general and GCR1 in particular, remain poorly understood. We...
G-protein α-subunit (GPA1) regulates stress, nitrate and phosphate response, flavonoid biosynthesis, fruit/seed development and substantially shares GCR1 regulation in A. <i>thaliana</i>
Navjyoti Chakraborty, Priyanka Sharma, Kostya Kanyuka, Ravi Ramesh Pathak, Devapriya Choudhury, Richard Hooley, Nandula Raghuram
Dec 01, 2015
Heterotrimeric G-proteins are implicated in several plant processes, but the mechanisms of signal-response coupling and the roles of G-protein coupled receptors in general and GCR1 in particular, remain poorly understood. We...
Metacognitive impairments extend perceptual decision making weaknesses in compulsivity
Tobias U. Hauser, Micah Allen, Geraint Rees, Raymond J. Dolan, Edward T. Bullmore, Ian Goodyer, Peter Fonagy, Peter Jones, Pasco Fearon, Gita Prabhu, Michael Moutoussis, Michelle St Clair, Kalia Cleridou, Hina Dadabhoy, Sian Granville, Elizabeth Harding, Alexandra Hopkins, Daniel Isaacs, Janchai King, Danae Kokorikou, Harriet Mills, Sara Pantaleone
Jul 26, 2017
Awareness of one's own abilities is of paramount importance in adaptive decision making. Psychotherapeutic theories assume such metacognitive insight is impaired in compulsivity, though this is supported by scant empirical...
Co-trimoxazole versus azithromycin for the treatment of undifferentiated febrile illness in Nepal
Sunil Pokharel, Buddha Basnyat, Amit Arjyal, Saruna Pathak Mahat, Raj Kumar Kc, Abhusani Bhuju, Buddhi Poudyal, Evelyne Kestelyn, Ritu Shrestha, Dung Nguyen Thi Phuong, Rajkumar Thapa, Manan Karki, Sabina Dongol, Abhilasha Karkey, Marcel Wolbers, Stephen Baker, Guy Thwaites
Apr 10, 2019
BACKGROUND: Undifferentiated febrile illness (UFI) includes typhoid and typhus fevers and generally designates fever without any localizing signs. UFI is a great therapeutic challenge in countries like Nepal because of the lack...
Azithromycin Co-trimoxazole enteric fever Fever clearance time Undifferentiated febrile illness Administration Oral Adolescent Adult Aged Anti-Bacterial Agents Azithromycin Child Child Preschool Clinical Protocols Double-Blind Method Drug Resistance Bacterial Female Fever Humans Male Middle Aged Nepal Research Design Time Factors Treatment Outcome Trimethoprim Sulfamethoxazole Drug Combination Typhoid Fever Typhus Epidemic Louse-Borne Young Adult
Multiple Holdouts With Stability
Agoston Mihalik, Fabio S Ferreira, Michael Moutoussis, Gabriel Ziegler, Rick A Adams, Maria J Rosa, Gita Prabhu, Leticia de Oliveira, Mirtes Pereira, Edward T Bullmore, Peter Fonagy, Ian M Goodyer, Peter B Jones, John Shawe-Taylor, Raymond Dolan, Janaina Mourão-Miranda
Mar 12, 2020
BACKGROUND:In 2009, the National Institute of Mental Health launched the Research Domain Criteria, an attempt to move beyond diagnostic categories and ground psychiatry within neurobiological constructs that combine different...
Published by: Biological psychiatry
The need for widely available genomic testing in rare eye diseases
Graeme C Black, Panagiotis Sergouniotis, Andrea Sodi, Bart P Leroy, Caroline Van Cauwenbergh, Petra Liskova, Karen Grønskov, Artur Klett, Susanne Kohl, Gita Taurina, Marius Sukys, Lonneke Haer-Wigman, Katarzyna Nowomiejska, João Pedro Marques, Dorothée Leroux, Frans PM Cremers, Elfride De Baere, Hélène Dollfus, ERN-EYE study group
May 17, 2021
BACKGROUND: Rare Eye Diseases (RED) are the leading cause of visual impairment and blindness for children and young adults in Europe. This heterogeneous group of conditions includes over 900 disorders ranging from relatively...
Multiple Holdouts With Stability
Agoston Mihalik, Fabio S Ferreira, Michael Moutoussis, Gabriel Ziegler, Rick A Adams, Maria J Rosa, Gita Prabhu, Leticia de Oliveira, Mirtes Pereira, Edward T Bullmore, Peter Fonagy, Ian M Goodyer, Peter B Jones, NeuroScience in Psychiatry Network (NSPN) Consortium, John Shawe-Taylor, Raymond Dolan, Janaina Mourão-Miranda
Mar 02, 2020
BACKGROUND: In 2009, the National Institute of Mental Health launched the Research Domain Criteria, an attempt to move beyond diagnostic categories and ground psychiatry within neurobiological constructs that combine different...
An Innovative Approach to Solve Healthcare Issues Using Big Data Image Analytics
The increasing adoption of transmission of medical images through internet in healthcare has led to several security threats to patient medical information. Permitting quiet data to be in peril may prompt hopeless harm...
Published by: IGI Global Scientific Publishing
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