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Punnett squares and hybrid crosses
AbstractThe rapid reception of Gregor Mendel's paper ‘Experiments on plant hybrids’ (1866) in the early decades of the twentieth century remains poorly understood. We will suggest that this...
Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells
Abstract: The poly (ADP-ribose) polymerase (PARP) inhibitor olaparib is FDA approved for the treatment of BRCA-mutated breast, ovarian and pancreatic cancers. Olaparib inhibits PARP1/2 enzymatic activity and traps PARP1 on DNA...