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The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions.
Predrag Kukic, Giuseppe Mattia Lo Piccolo, Marcela O Nogueira, Dmitri I Svergun, Michele Vendruscolo, Isabella C Felli, Roberta Pierattelli
Mar 29, 2019
Parton distributions for LO generators
We present a study of the results obtained combining LO partonic matrix
elements with either LO or NLO partons distributions. These are compared to the
best prediction using NLO for both matrix elements and parton...
The evolving view of the hematopoietic stem cell niche.
Hematopoietic stem cells (HSCs) reside in specialized microenvironments known as niches. The niche is essential to support HSC function and to maintain a correct balance between self-renewal and differentiation. Recent advances...
Multicentric breast cancer with heterogeneous histopathology
Giovanni Corso, Francesca Magnoni, Elena Provenzano, Antonia Girardi, Monica Iorfida, Alessandra Margherita De Scalzi, Alessandra Invento, Marco Colleoni, Enrico Cassano, Chiara Trentin, Roberto Lo Gullo, Gabriella Pravettoni, Laura Gilardi, Chiara Maria Grana, Mattia Intra, Viviana Galimberti, Paolo Veronesi, Francesca De Lorenzi, Maria Cristina Leonardi
Feb 06, 2020
Multiple synchronous (multifocal or multicentric) ipsilateral breast cancers with heterogeneous histopathology are a rare clinical occurrence, however, their incidence is increasing due to the use of MRI for breast cancer...
Metabolic control of DNA methylation in naive pluripotent cells.
Riccardo M Betto, Linda Diamante, Valentina Perrera, Matteo Audano, Stefania Rapelli, Andrea Lauria, Danny Incarnato, Mattia Arboit, Silvia Pedretti, Giovanni Rigoni, Vincent Guerineau, David Touboul, Giuliano Giuseppe Stirparo, Tim Lohoff, Thorsten Boroviak, Paolo Grumati, Maria E Soriano, Jennifer Nichols, Nico Mitro, Salvatore Oliviero, Graziano Martello
Feb 09, 2021
Naive epiblast and embryonic stem cells (ESCs) give rise to all cells of adults. Such developmental plasticity is associated with genome hypomethylation. Here, we show that LIF-Stat3 signaling induces genomic hypomethylation via...
Animals Blastocyst Cell Differentiation Cells Cultured DNA (Cytosine-5-)-Methyltransferases DNA Methylation DNA Methyltransferase 3A Embryonic Stem Cells Gene Expression Regulation Histones Ketoglutaric Acids Leukemia Inhibitory Factor Mice Knockout Nerve Tissue Proteins Otx Transcription Factors Pluripotent Stem Cells Promoter Regions Genetic STAT3 Transcription Factor
Isolated- and Beckwith-Wiedemann syndrome related- lateralised overgrowth (hemihypertrophy)
Jessica A Radley, Melissa Connolly, Ataf Sabir, Farah Kanani, Helena Carley, Rachel L Jones, Zerin Hyder, Lianne Gompertz, Willie Reardon, Ruth Richardson, Louise McClelland, Eamonn R Maher
Jul 28, 2021
The congenital imprinting disorder, Beckwith-Wiedemann syndrome (BWS) is associated with variable clinical features including hemihypertrophy/lateralised overgrowth (LO) and embryonal tumour predisposition. BWS-associated...
Beckwith-Wiedemann syndrome Wilms tumour hemihypertrophy lateralised overgrowth Score Adolescent Adult Beckwith-Wiedemann syndrome Child Child Preschool Cohort Studies Female Genetic Testing Humans hypertrophy Infant Infant Newborn Male Microsatellite Repeats Molecular Diagnostic Techniques Neoplasms Germ Cell and Embryonal Retrospective Studies Young Adult
The politics of international chemical weapon justice:
There has been near-universal condemnation of the use of chemical weapons in the Syrian conflict. The international community has nevertheless struggled to make progress on holding the perpetrators to account. This article...
civil war United Nations arms control and disarmament international regimes peacebuilding /dk/atira/pure/subjectarea/asjc/3300/3320 name=Political Science and International Relations /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions name=SDG 16 - Peace, Justice and Strong Institutions
An Interpretative View on Innovation Acceptance for Bitcoin and Blockchain Phenomena
The research, in its general lines, tends to open an interpretative perspective on the fact that the bitcoin and blockchain (BTC-BC) phenomenon could be defined primarily through the social learning lens, and in that case would...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
Fall 2009
Friends of Dacus Library
Jan 01, 0001
Inside this Issue:
Dean's WelcomeProgram highlights, reception, contTwitter!Online renewal optionBi-Lo BoostersBoard meetings, workNew library tools1,001 Books!About the Friends2011: Friends turn 15Message from Chair
Academic libraries--South Carolina--Rock Hill--Periodicals; Friends of Dacus Library--Periodicals; Ida Jane Dacus Library--Periodicals; Winthrop University--Libraries--Periodicals. Library and Information Science
Published by: Winthrop University
Wetting of nanotubes
Wettability studies of liquids inside nanometre scale channels commenced shortly after the discovery of carbon nanotubes in the early 1990s. Since then the field has progressively expanded to other kinds of nanotubes and...
Didattica della sessualità e del genere tra Svizzera, Gran Bretagna e Italia [Teaching of sexuality and gender between Switzerland, Britain and Italy]
Per capire meglio sia gli sviluppi disciplinari che la didattica delle questioni della sessualità e del genere nelle università italiane e straniere, abbiamo chiesto ad alcune colleghe una riflessione sulle loro esperienze....
Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor.
Tiago Rodrigues, Markus Werner, Jakob Roth, Eduardo HG da Cruz, Marta C Marques, Padma Akkapeddi, Susana A Lobo, Andreas Koeberle, Francisco Corzana, Eufrânio N da Silva Júnior, Oliver Werz, Gonçalo JL Bernardes
Mar 04, 2019
Using machine learning, targets were identified for β-lapachone. Resorting to biochemical assays, β-lapachone was validated as a potent, ligand efficient, allosteric and reversible modulator of 5-lipoxygenase (5-LO). Moreover...
Dual role of splenic mononuclear and polymorphonuclear cells in the outcome of ciprofloxacin treatment of Salmonella enterica infections.
OBJECTIVES: To determine the immune cell populations associated with Salmonella enterica serovar Typhimurium before and after ciprofloxacin treatment using a murine model of systemic infection. The effect of depletion of immune...
Multicentric breast cancer with heterogeneous histopathology
Giovanni Corso, Francesca Magnoni, Elena Provenzano, Antonia Girardi, Monica Iorfida, Alessandra Margherita De Scalzi, Alessandra Invento, Marco Colleoni, Enrico Cassano, Chiara Trentin, Roberto Lo Gullo, Gabriella Pravettoni, Laura Gilardi, Chiara Maria Grana, Mattia Intra, Viviana Galimberti, Paolo Veronesi, Francesca De Lorenzi, Maria Cristina Leonardi
Feb 26, 2020
Multiple synchronous (multifocal or multicentric) ipsilateral breast cancers with heterogeneous histopathology are a rare clinical occurrence, however, their incidence is increasing due to the use of MRI for breast cancer...
Breast Cancer breast cancer histotypes Diagnosis lobular carcinoma multicentric cancer Multidisciplinary team multifocal cancer Prognosis surgical management Breast Neoplasms Combined Modality Therapy Disease Management Disease Susceptibility Female Genetic Predisposition to Disease Humans Lymphoscintigraphy Multimodal Imaging Neoplasm Grading Neoplasm Staging Prognosis Retreatment Sentinel Lymph Node Biopsy Treatment Outcome Tumor Burden
Environmental Policy Stringency, Technical Progress and Pollution Haven Hypothesis
The present inquiry provides a common ground for the analysis of two strands of literature, the environmental Kuznets curve (EKC) and the pollution haven hypothesis (PHH). To this end, the study sets out a simple...
When Kings Are Criminals
Mattia Cacciatori
Nov 30, 2018
The attempts by the International Criminal Court (ICC) to prosecute sitting heads of state have proven to be one of the thorniest issues for this new institution. These rest on the claim that there are crimes of such magnitude...
When Kings Are Criminals
Mattia Cacciatori
Nov 30, 2018
The attempts by the International Criminal Court (ICC) to prosecute sitting heads of state have proven to be one of the thorniest issues for this new institution. These rest on the claim that there are crimes of such magnitude...
Fish consumption and frying of fish in relation to type 2 diabetes incidence
Alice Wallin, Daniela Di Giuseppe, Nicola Orsini, Agneta Åkesson, Nita G Forouhi, Alicja Wolk
Jan 13, 2016
cohort study fish Fried foods Methyl mercury Polychlorinated biphenyls Type 2 diabetes Aged Animals Cohort Studies Cooking Diabetes mellitus Type 2 Diet Healthy Diet High-Fat Fishes Follow-Up Studies Food Contamination Humans Incidence Male Methylmercury Compounds Middle Aged Patient Compliance Polychlorinated Biphenyls Proportional Hazards Models Prospective Studies Registries seafood Shellfish Sweden Water Pollutants
Water flow enhancement in hydrophilic nanochannels
All published reports on fluid flow enhancement and water slippage are associated with hydrophobic surfaces, such as carbon nanotubes. Here, we investigate water flow in hydrophilic alumina nanochannels with diameters ranging...
Involving Faculty with Student Affairs: Some Personal Pointers
Frank Ardaiolo
Jan 01, 0001
Involving faculty with student affairs has become increasingly critical in recent years; this article presents personal pointers for tire student affairs practitioner to follow lo foster these relationships.
Education Educational Administration and Supervision Higher Education Higher Education Administration
Published by: Winthrop University
New models to study vascular mural cell embryonic origin
A key question in vascular biology is how the diversity of origin of vascular mural cells, namely smooth muscle cells (SMCs) and pericytes influences vessel properties, in particular the regional propensity to vascular diseases....
Non-coding genetic variation in regulatory elements determines thrombosis and hemostasis phenotypes.
Since the early inception of genome-wide association studies (GWAS), it became clear that, in all diseases or traits studied, most genetic variants are likely to exert their effect on gene expression mainly by altering the...
Interaction between the Cockayne syndrome B and p53 proteins
The CSB protein plays a role in the transcription coupled repair (TCR) branch of the nucleotide excision repair pathway. CSB is very often found mutated in Cockayne syndrome, a segmental progeroid genetic disease characterized...
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