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High order splitting methods for SDEs satisfying a commutativity condition
In this paper, we introduce a new simple approach to developing and establishing the convergence of splitting methods for a large class of stochastic differential equations (SDEs), including additive, diagonal, and scalar...
High order splitting methods for SDEs satisfying a commutativity condition
In this paper, we introduce a new simple approach to developing and establishing the convergence of splitting methods for a large class of stochastic differential equations (SDEs), including additive, diagonal, and scalar...
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Sarah L Kidd, Elaine Fowler, Till Reinhardt, Thomas Compton, Natalia Mateu, Hector Newman, Dom Bellini, Romain Talon, Joseph McLoughlin, Tobias Krojer, Anthony Aimon, Anthony Bradley, Michael Fairhead, Paul Brear, Laura Díaz-Sáez, Katherine McAuley, Hannah F Sore, Andrew Madin, Daniel H O'Donovan, Kilian VM Huber, Marko Hyvönen, Frank von Delft, Christopher G Dowson, David R Spring
May 26, 2020
Organic synthesis underpins the evolution of weak fragment hits into potent lead compounds. Deficiencies within current screening collections often result in the requirement of significant synthetic investment to enable...
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Sarah L Kidd, Elaine Fowler, Till Reinhardt, Thomas Compton, Natalia Mateu, Hector Newman, Dom Bellini, Romain Talon, Joseph McLoughlin, Tobias Krojer, Anthony Aimon, Anthony Bradley, Michael Fairhead, Paul Brear, Laura Díaz-Sáez, Katherine McAuley, Hannah F Sore, Andrew Madin, Daniel H O'Donovan, Kilian V M Huber, Marko Hyvönen, Frank von Delft, Christopher G Dowson, David R Spring
Jul 28, 2021
Organic synthesis underpins the evolution of weak fragment hits into potent lead compounds. Deficiencies within current screening collections often result in the requirement of significant synthetic investment to enable...
Published by: Chemical science
Direitos Sociais na Constituição Uma Análise da Constitucionalização dos Direitos Sociais em Portugal, 1975-76
Embora todas as constituições incluam direitos, e muitas delas incluam direitos sociais, a verdade é que algumas são mais generosas do que outras a este respeito. Mas nenhuma se aproxima da Constituição da República Portuguesa...
Grammatical Relations, Transitivity and Ergativity
Cheng Luo
Sep 05, 2013
Keenan and Comrie's Accessibility Hierarchy (AH) applied to clefting predicts greater c1eftability of subject (s U) than direct object (DO). However, in some Eastern Austronesian languages, particularly Tongan, some transitive...
Published by: Atlantic Provinces Linguistic Association
Grammatical Relations, Transitivity and Ergativity
Cheng Luo
Sep 05, 2013
Keenan and Comrie's Accessibility Hierarchy (AH) applied to clefting predicts greater c1eftability of subject (s U) than direct object (DO). However, in some Eastern Austronesian languages, particularly Tongan, some transitive...
Published by: Atlantic Provinces Linguistic Association
Multi-Pattern GPU Accelerated Collision-Less Rabin-Karp for NIDS
In the domain of network communication, network intrusion detection systems (NIDS) play a crucial role in maintaining security by identifying potential threats. NIDS relies on packet inspection, often using rule-based databases...
Published by: IGI Global Scientific Publishing
Machine learning for target discovery in drug development.
Chemical probes Chemical proteomics Drug Discovery Machine Learning target identification Antineoplastic Agents Computer Simulation Drug Evaluation Preclinical Humans lipoxygenase Machine Learning Molecular Targeted Therapy Naphthoquinones Pentacyclic Triterpenes Proteomics Receptors Cannabinoid Sesquiterpenes Sesquiterpenes Guaiane Transient Receptor Potential Channels
Atomic theory of viscoelastic response and memory effects in metallic glasses
An atomic-scale theory of the viscoelastic response of metallic glasses is derived from first principles, using a
Zwanzig-Caldeira-Leggett system-bath Hamiltonian as a starting point within the framework of nonaffine...
Fine-scale computations for adaptive processing in the human brain
Elisa Zamboni, Valentin G Kemper, Nuno Reis Goncalves, Ke Jia, Vasilis M Karlaftis, Samuel J Bell, Joseph Giorgio, Reuben Rideaux, Rainer Goebel, Zoe Kourtzi
Nov 26, 2020
Adapting to the environment statistics by reducing brain responses to repetitive sensory information is key for efficient information processing. Yet, the fine-scale computations that support this adaptive processing in the...
The Grizzly, October 4, 2012
Jessica Orbon, Sara Sherr, Larissa Coyne, Rosemary Clark, Alexa LaMontagne, Chris Rountree, Courtney Scott, Christine Dobisch, Jillian Goldstein, Amanda Frekot, Austin Fox, Jordan Demcher, Allen Weaver
Jan 01, 0001
Campus Crime Rates Banners Call for Student Power UC Prepares to Vote Professors up for Tenure Resumania Offers Resume Aid Phoenixville To-Dos Marisa Roman Joins Ursinus Faculty Grad School Guru Returns to Offer Tips and...
Ursinus College Collegeville Pennsylvania newspaper campus safety voter ID law career services Phoenixville Marisa Roman Don Asher Campus Activities Board Rugby Football Volleyball Soccer field hockey Joe Groff cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Antikörpergerichtete Therapien
In its various forms, cancer remains a leading cause of mortality and morbidity worldwide. Thus, it is widely accepted that finding innovative, life-changing drugs and therapeutic regimens is key for successful future cancer...
Strategies for the Diversity-Oriented Synthesis of Macrocycles.
Macrocycles have long been recognized as useful chemical entities for medicine, with naturally occurring and synthetic macrocycles clinically approved for use as prescription drugs. Despite this promise, the synthesis of...
Protein-Protein Conjugates
The residues cysteine and lysine are the undisputed champions of bioconjugation chemistry. Targeting other amino acids has been touted as a potential way to improve the synthesis of protein–peptide and protein–protein conjugates...
A protocol for ultra-high field laminar fMRI in the human brain.
Ke Jia, Elisa Zamboni, Catarina Rua, Nuno Reis Goncalves, Valentin Kemper, Adrian Ka Tsun Ng, Christopher T Rodgers, Guy Williams, Rainer Goebel, Zoe Kourtzi
Feb 26, 2021
Interleukin-8-251T > A, Interleukin-1α-889C > T and Apolipoprotein E polymorphisms in Alzheimer's disease.
Alex Augusto Vendramini, Roger Willian de Lábio, Lucas Trevizani Rasmussen, Nathali Mattiuzo Dos Reis, Thais Minett, Paulo Henrique Ferreira Bertolucci, Marcela Augusta de Souza Pinhel, Dorotéia Rossi Silva Souza, Diego Robles Mazzotti, Marília de Arruda Cardoso Smith, Spencer Luiz Marques Payão
Aug 09, 2018
An inflammatory process has been involved in numerous neurodegenerative disorders such as Parkinson's disease, stroke and Alzheimer's disease (AD). In AD, the inflammatory response is mainly located in the vicinity of amyloid...
The Impact of Activity-Based Protein Profiling in Malaria Drug Discovery.
Activity-based protein profiling (ABPP) is an approach used at the interface of chemical biology and proteomics that uses small molecular probes to provide dynamic fingerprints of enzymatic activity in complex proteomes. Malaria...
Bioorthogonal Decaging Reactions for Targeted Drug Activation.
Bioorthogonal decaging reactions are highly selective transformations which involve the cleavage of a protecting group from a molecule of interest. Decaging reactions can be classified into subgroups depending on the nature of...
Immunocapture of <i>Escherichia coli</i> in a fluoropolymer microcapillary array
This study presents novel experimental insights into the direct quantitation and immunocapture of bacteria cells in a fluoropolymer microcapillary array, using Escherichia coli as work model, a pathogen responsible for around...
Development of Antibody-Directed Therapies
Less is more: The efficacy of antibody-drug conjugates (ADCs) for cancer therapy is traditionally associated with cleavable linkers for payload release. Evidence now suggests that simpler constructs without cleavable moieties...
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