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Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas.
Nirmal Verma, Gopal Viswanathan Velmurugan, Edric Winford, Han Coburn, Deepak Kotiya, Noah Leibold, Laura Radulescu, Sanda Despa, Kuey C Chen, Linda J Van Eldik, Peter T Nelson, Donna M Wilcock, Gregory A Jicha, Ann M Stowe, Larry B Goldstein, David K Powel, Jeffrey H Walton, Manuel F Navedo, Matthew A Nystoriak, Andrew J Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Florin Despa
Jan 04, 2023
Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas.
Nirmal Verma, Gopal Viswanathan Velmurugan, Edric Winford, Han Coburn, Deepak Kotiya, Noah Leibold, Laura Radulescu, Sanda Despa, Kuey C Chen, Linda J Van Eldik, Peter T Nelson, Donna M Wilcock, Gregory A Jicha, Ann M Stowe, Larry B Goldstein, David K Powel, Jeffrey H Walton, Manuel F Navedo, Matthew A Nystoriak, Andrew J Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Florin Despa
Feb 09, 2023
Template-Based Question Answering System Over the Semantic Web
A question answering system is the most promising way of retrieving data from the available knowledge base to the end-users to get the appropriate result for their questions. Many question answering systems convert the questions...
Published by: IGI Global Scientific Publishing
Elongational stalling activates mitoribosome-associated quality control.
Nirupa Desai, Hanting Yang, Viswanathan Chandrasekaran, Razina Kazi, Michal Minczuk, V Ramakrishnan
Dec 01, 2020
The human mitochondrial ribosome (mitoribosome) and associated proteins regulate the synthesis of 13 essential subunits of the oxidative phosphorylation complexes. We report the discovery of a mitoribosome-associated quality...
Cryoelectron Microscopy Electron Transport Complex IV Escherichia coli Exoribonucleases HEK293 Cells Humans Mitochondrial Proteins Mitochondrial Ribosomes Nuclear Proteins Peptide Termination Factors Protein Domains RNA Transfer RNA-Binding Proteins Ribosomal Proteins Transcription Elongation Genetic Transcriptional Elongation Factors
Geospatial distributions reflect temperatures of linguistic features.
Quantifying the speed of linguistic change is challenging because the historical evolution of languages is sparsely documented. Consequently, traditional methods rely on phylogenetic reconstruction. Here, we propose a...
Performance of vertical drains in liquefaction mitigation under structures
Abstract: Several techniques have been developed in order to mitigate damage to buildings during and after liquefaction events. Benefits of using vertical drains have been verified by analysing their performance in the soil and...
Selection of Important Features for Optimizing Crop Yield Prediction
In agriculture, crop yield prediction is critical. Crop yield depends on various features including geographic, climate and biological. This research article discusses five Feature Selection (FS) algorithms namely Sequential...
Published by: IGI Global Scientific Publishing
Assessment of bridge natural frequency as an indicator of scour using centrifuge modelling
Kasun D. Kariyawasam, Campbell R. Middleton, Gopal Madabhushi, Stuart K. Haigh, James P. Talbot
Jul 28, 2021
Big Data Challenges and Opportunities in Agriculture
This article reviews various aspects of research concerning the background and state-of-the-art of big data in agriculture. This article focuses on data generation, storage, analysis and visualization in big data. In every...
Published by: IGI Global Scientific Publishing
Visualizing formation of the active site in the mitochondrial ribosome.
Viswanathan Chandrasekaran, Nirupa Desai, Nicholas O Burton, Hanting Yang, Jon Price, Eric A Miska, V Ramakrishnan
Nov 05, 2021
human Biochemistry C. elegans structural biology chemical biology cryo-EM RNA modifications peptidyl transferase center molecular biophysics mitochondrial ribosome
Published by: eLife
Visualizing formation of the active site in the mitochondrial ribosome
Viswanathan Chandrasekaran, Nirupa Desai, Nicholas O Burton, Hanting Yang, Jon Price, Eric A Miska, V Ramakrishnan
Oct 05, 2021
Assessment of bridge natural frequency as an indicator of scour using centrifuge modelling
Kasun D. Kariyawasam, Campbell R. Middleton, Gopal Madabhushi, Stuart K. Haigh, James P. Talbot
Sep 30, 2020
A Meta-Analysis of the Effect of Bacillus Calmette-Guérin Vaccination Against Bovine Tuberculosis
Sreenidhi Srinivasan, Andrew J. K. Conlan, Laurel A. Easterling, Christian Herrera, Premanshu Dandapat, Maroudam Veerasami, Gobena Ameni, Naresh Jindal, Gopal Dhinakar Raj, James Wood, Nick Juleff, Douwe Bakker, Martin Vordermeier, Vivek Kapur
Aug 12, 2021
More than 50 million cattle are likely exposed to bovine tuberculosis (bTB) worldwide, highlighting an urgent need for bTB control strategies in low- and middle-income countries (LMICs) and other regions where the disease...
Zinc-Embedded Polyamide Fabrics Inactivate SARS-CoV-2 and Influenza A Virus.
Vikram Gopal, Benjamin E Nilsson-Payant, Hollie French, Jurre Y Siegers, Wai-Shing Yung, Matthew Hardwick, Aartjan JW Te Velthuis
Jul 29, 2021
Influenza A viruses (IAV) and SARS-CoV-2 can spread via liquid droplets and aerosols. Face masks and other personal protective equipment (PPE) can act as barriers that prevent the spread of these viruses. However, IAV and...
Lifetime risk of diabetes in metropolitan cities in India.
Shammi Luhar, Dimple Kondal, Rebecca Jones, Ranjit M Anjana, Shivani A Patel, Sanjay Kinra, Lynda Clarke, Mohammed K Ali, Dorairaj Prabhakaran, M Masood Kadir, Nikhil Tandon, Viswanathan Mohan, KM Venkat Narayan
Feb 05, 2021
AIMS/HYPOTHESIS: We aimed to estimate the lifetime risk of diabetes and diabetes-free life expectancy in metropolitan cities in India among the population aged 20 years or more, and their variation by sex, age and BMI. METHODS...
Body Mass Index Diabetes Diabetes-free life expectancy india lifetime risk Metropolitan cities urban Adult Age Distribution Diabetes mellitus Disease-Free Survival Female Humans Incidence india Life Expectancy Male Markov Chains Middle Aged Models Theoretical obesity prevalence Risk Assessment Risk Factors Sex Distribution Time Factors Urban Health Young Adult
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes.
Taniya Bhardwaj, Kundlik Gadhave, Shivani K Kapuganti, Prateek Kumar, Zacharias Faidon Brotzakis, Kumar Udit Saumya, Namyashree Nayak, Ankur Kumar, Richa Joshi, Bodhidipra Mukherjee, Aparna Bhardwaj, Krishan Gopal Thakur, Neha Garg, Michele Vendruscolo, Rajanish Giri
Feb 20, 2023
Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy
Camilla Nehammer, Patrick Ejlerskov, Sandeep Gopal, Ava Handley, Leelee Ng, Pedro Moreira, Huikyong Lee, Shohreh Issazadeh-Navikas, David C Rubinsztein, Roger Pocock
Dec 17, 2019
Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. Defective autophagy results in accumulation of toxic protein aggregates that detrimentally affect cellular function and organismal survival....
Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects
Sergio Rodriguez‐Cuenca, Christopher J. Lelliot, Mark Campbell, Gopal Peddinti, Maite Martinez‐Uña, Camilla Ingvorsen, Ana Rita Dias, Joana Relat, Silvia Mora, Tuulia Hyötyläinen, Antonio Zorzano, Matej Orešič, Mikael Bjursell, Mohammad Bohlooly‐Y, Daniel Lindén, Antonio Vidal‐Puig
Aug 11, 2021
Abstract: Aging, obesity, and insulin resistance are associated with low levels of PGC1α and PGC1β coactivators and defective mitochondrial function. We studied mice deficient for PGC1α and PGC1β [double heterozygous (DH)] to...
RESEARCH ARTICLE RESEARCH ARTICLES Adipose Tissue hepatic lipidome lipotoxicity MITOCHONDRIAL DYSFUNCTION PGC‐1alpha
Published by: The FASEB Journal
A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells.
Gernot Walko, Samuel Woodhouse, Angela Oliveira Pisco, Emanuel Rognoni, Kifayathullah Liakath-Ali, Beate M Lichtenberger, Ajay Mishra, Stephanie B Telerman, Priyalakshmi Viswanathan, Meike Logtenberg, Lisa M Renz, Giacomo Donati, Sven R Quist, Fiona M Watt
Feb 07, 2019
Individual human epidermal cells differ in their self-renewal ability. To uncover the molecular basis for this heterogeneity, we performed genome-wide pooled RNA interference screens and identified genes conferring a clonal...
A Common Glaucoma-risk Variant of SIX6 Alters Retinal Nerve Fiber Layer and Optic Disc Measures in a European Population
Anthony P Khawaja, Michelle PY Chan, Jennifer LY Yip, David C Broadway, David F Garway-Heath, Ananth C Viswanathan, Robert Luben, Shabina Hayat, Michael A Hauser, Nicholas J Wareham, Kay-Tee Khaw, Brad Fortune, R Rand Allingham, Paul J Foster
Oct 03, 2018
A Meta-Analysis of the Effect of Bacillus Calmette-Guérin Vaccination Against Bovine Tuberculosis
Sreenidhi Srinivasan, Andrew JK Conlan, Laurel A Easterling, Christian Herrera, Premanshu Dandapat, Maroudam Veerasami, Gobena Ameni, Naresh Jindal, Gopal Dhinakar Raj, James Wood, Nick Juleff, Douwe Bakker, Martin Vordermeier, Vivek Kapur
May 24, 2021
More than 50 million cattle are likely exposed to bovine tuberculosis (bTB) worldwide, highlighting an urgent need for bTB control strategies in low- and middle-income countries (LMICs) and other regions where the disease...
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