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The Journal of Cardiovascular Computed Tomography
Todd C Villines, Subhi J Al'Aref, Daniele Andreini, Marcus Y Chen, Andrew D Choi, Carlo N De Cecco, Damini Dey, James P Earls, Maros Ferencik, Heidi Gransar, Harvey Hecht, Jonathon A Leipsic, Michael T Lu, Mohamed Marwan, Pál Maurovich-Horvat, Edward Nicol, Gianluca Pontone, Jonathan Weir-McCall, Seamus P Whelton, Michelle C Williams, Armin Arbab-Zadeh, Gudrun M Feuchtner
Oct 11, 2021
The purpose of this review is to highlight the most impactful, educational, and frequently downloaded articles published in the Journal of Cardiovascular Computed Tomography (JCCT) for the year 2020. The JCCT reached new records...
covid-19 cardiac CT Cardiac computed tomography Coronary CT angiography coronary artery calcium Journal of cardiovascular computed tomography Structural heart disease Biomedical Research covid-19 Computed Tomography Angiography Coronary Angiography Coronary Artery Disease Heart Diseases Host-Pathogen Interactions Humans Periodicals as Topic Prognosis Risk Factors SARS-CoV-2
The 1919 eclipse results that verified general relativity and their later detractors
Einstein became world famous on 7 November 1919, following press publication of a meeting held in London on 6 November 1919 where the results were announced of two British expeditions led by Eddington, Dyson and Davidson...
The Isolation and Characterization of Soluble Brain Proteins
Gudrun Staub Bennett
Jan 01, 0001
The experiments described in this thesis were undertaken in order to define and purify proteins that might have a specific function in nerve activity. The studies were limited to rat brain proteins soluble in dilute aqueous...
Published by: Rockefeller University
Publisher Correction
Astrid von Mentzer, Joshua Tobias, Gudrun Wiklund, Stefan Nordqvist, Martin Aslett, Gordon Dougan, Åsa Sjöling, Ann-Mari Svennerholm
Oct 03, 2018
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Myosin VI is required for sorting of AP-1B-dependent cargo to the basolateral domain in polarized MDCK cells.
In polarized epithelial cells, newly synthesized membrane proteins are delivered on specific pathways to either the apical or basolateral domains, depending on the sorting motifs present in these proteins. Because myosin VI has...
Adaptor Protein Complex 1 Amino Acid Motifs Animals Cell Cycle Proteins Cell Line Cell Polarity Dogs Endosomes Humans Membrane Glycoproteins Membrane Transport Proteins Mutagenesis Site-Directed Myosin Heavy Chains Protein Isoforms Protein Transport Transcription Factor TFIIIA Viral Envelope Proteins
The Journal of Cardiovascular Computed Tomography year in review - 2019.
Jeong W Choi, Alexander R van Rosendael, A Maxim Bax, Inge J van den Hoogen, Umberto Gianni, Lohendran Baskaran, Daniele Andreini, Carlo N De Cecco, James Earls, Maros Ferencik, Harvey Hecht, Jonathon A Leipsic, Pál Maurovich-Horvat, Edward Nicol, Gianluca Pontone, Subha Raman, Paul Schoenhagen, Armin Arbab-Zadeh, Andrew D Choi, Gudrun Feuchtner, Jonathan Weir-McCall, Kavitha Chinnaiyan, Seamus Whelton, James K Min, Todd C Villines, Subhi J Al'Aref
Sep 28, 2020
The purpose of this review is to summarize the work published by the Journal of Cardiovascular Computed Tomography (JCCT) for the year 2019, highlighting original research and new guidelines.
Identification and characterization of the novel colonization factor CS30 based on whole genome sequencing in enterotoxigenic Escherichia coli (ETEC).
Astrid von Mentzer, Joshua Tobias, Gudrun Wiklund, Stefan Nordqvist, Martin Aslett, Gordon Dougan, Åsa Sjöling, Ann-Mari Svennerholm
Jun 25, 2018
The ability to colonize the small intestine is essential for enterotoxigenic Escherichia coli (ETEC) to cause diarrhea. Although 22 antigenically different colonization factors (CFs) have been identified and characterized in...
Evaluation of allelic expression of imprinted genes in adult human blood
Jennifer M Frost, Dave Monk, Taita Stojilkovic-Mikic, Kathryn Woodfine, Lyn S Chitty, Adele Murrell, Philip Stanier, Gudrun E Moore
Jan 01, 0001
Imprinted genes are expressed from only one allele in a parent-of-origin dependent manner. Loss of imprinted (LOI) expression can result in a variety of human disorders and is frequently reported in cancer. Biallelic expression...
Evaluation of allelic expression of imprinted genes in adult human blood
Jennifer M Frost, Dave Monk, Taita Stojilkovic-Mikic, Kathryn Woodfine, Lyn S Chitty, Adele Murrell, Philip Stanier, Gudrun E Moore
Jan 01, 0001
Imprinted genes are expressed from only one allele in a parent-of-origin dependent manner. Loss of imprinted (LOI) expression can result in a variety of human disorders and is frequently reported in cancer. Biallelic expression...
Effect of high-flow nasal therapy on patient-centred outcomes in patients at high risk of postoperative pulmonary complications after cardiac surgery
Melissa Earwaker, Sofia Villar, Julia Fox-Rushby, Melissa Duckworth, Sarah Dawson, Jo Steele, Yi-da Chiu, Edward Litton, Gudrun Kunst, Gavin Murphy, Guillermo Martinez, Vasileios Zochios, Val Brown, Geoff Brown, Andrew Klein
Mar 31, 2022
BACKGROUND: High-flow nasal therapy is a non-invasive form of respiratory support that delivers low-level, flow dependent positive airway pressure. The device can be better tolerated by patients than alternatives such as...
Effect of high-flow nasal therapy on patient-centred outcomes in patients at high risk of postoperative pulmonary complications after cardiac surgery
Melissa Earwaker, Sofia Villar, Julia Fox-Rushby, Melissa Duckworth, Sarah Dawson, Jo Steele, Yi-da Chiu, Edward Litton, Gudrun Kunst, Gavin Murphy, Guillermo Martinez, Vasileios Zochios, Val Brown, Geoff Brown, Andrew Klein
Apr 29, 2022
BACKGROUND: High-flow nasal therapy is a non-invasive form of respiratory support that delivers low-level, flow dependent positive airway pressure. The device can be better tolerated by patients than alternatives such as...
EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity.
Johannes Lorenz Berg, Bianca Perfler, Stefan Hatzl, Barbara Uhl, Andreas Reinisch, Gudrun Pregartner, Andrea Berghold, Thomas Penz, Michael Schuster, Klaus Geissler, Andreas Prokesch, Carsten Müller-Tidow, Gerald Hoefler, Karl Kashofer, Albert Wölfler, Heinz Sill, Veronica Caraffini, Armin Zebisch
May 06, 2021
Increased respiratory morbidity associated with exposure to a mature volcanic plume from a large Icelandic fissure eruption.
Hanne Krage Carlsen, Evgenia Ilyinskaya, Peter J Baxter, Anja Schmidt, Throstur Thorsteinsson, Melissa Anne Pfeffer, Sara Barsotti, Francesca Dominici, Ragnhildur Gudrun Finnbjornsdottir, Thorsteinn Jóhannsson, Thor Aspelund, Thorarinn Gislason, Unnur Valdimarsdóttir, Haraldur Briem, Thorolfur Gudnason
May 28, 2021
The 2014-15 Holuhraun eruption in Iceland was the largest fissure eruption in over 200 years, emitting prodigious amounts of gas and particulate matter into the troposphere. Reykjavík, the capital area of Iceland (250 km from...
Adult Air Pollutants Air Pollution Asthma Delivery of Health Care Emergency Service hospital Environmental Exposure Humans Iceland Morbidity Physicians Primary Care Public Health Regression Analysis Respiratory Tract Diseases risk Self Report Sulfur Dioxide Surveys and Questionnaires Volcanic eruptions
SSBP1 mutations in dominant optic atrophy with variable retinal degeneration.
Neringa Jurkute, Costin Leu, Hans-Martin Pogoda, Gavin Arno, Anthony G Robson, Gudrun Nürnberg, Janine Altmüller, Holger Thiele, Susanne Motameny, Mohammad Reza Toliat, Kate Powell, Wolfgang Höhne, Michel Michaelides, Andrew R Webster, Anthony T Moore, Matthias Hammerschmidt, Peter Nürnberg, Patrick Yu-Wai-Man, Marcela Votruba
Jul 26, 2019
OBJECTIVE: Autosomal dominant optic atrophy (ADOA) starts in early childhood with loss of visual acuity and color vision deficits. OPA1 mutations are responsible for the majority of cases, but in a portion of patients with a...
EMQN best practice guidelines for the molecular genetic testing and reporting of chromosome 11p15 imprinting disorders
Katja Eggermann, Jet Bliek, Frédéric Brioude, Elizabeth Algar, Karin Buiting, Silvia Russo, Zeynep Tümer, David Monk, Gudrun Moore, Thalia Antoniadi, Fiona MacDonald, Irène Netchine, Paolo Lombardi, Lukas Soellner, Matthias Begemann, Dirk Prawitt, Eamonn R Maher, Marcel Mannens, Andrea Riccio, Rosanna Weksberg, Pablo Lapunzina, Karen Grønskov, Deborah JG Mackay, Thomas Eggermann
Apr 13, 2016
Increased respiratory morbidity associated with exposure to a mature volcanic plume from a large Icelandic fissure eruption
Hanne Krage Carlsen, Evgenia Ilyinskaya, Peter J. Baxter, Anja Schmidt, Throstur Thorsteinsson, Melissa Anne Pfeffer, Sara Barsotti, Francesca Dominici, Ragnhildur Gudrun Finnbjornsdottir, Thorsteinn Jóhannsson, Thor Aspelund, Thorarinn Gislason, Unnur Valdimarsdóttir, Haraldur Briem, Thorolfur Gudnason
Apr 12, 2021
Abstract: The 2014–15 Holuhraun eruption in Iceland was the largest fissure eruption in over 200 years, emitting prodigious amounts of gas and particulate matter into the troposphere. Reykjavík, the capital area of Iceland (250...
Elongation rate and average length of amyloid fibrils in solution using isotope-labelled small-angle neutron scattering.
Ben J Eves, James J Doutch, Ann E Terry, Han Yin, Martine Moulin, Michael Haertlein, V Trevor Forsyth, Patrick Flagmeier, Tuomas PJ Knowles, David M Dias, Gudrun Lotze, Annela M Seddon, Adam M Squires
Oct 01, 2021
The Lantern Vol. 64, No. 2, Spring 1997
Jim Marinell, Oana Nechita, Kristen Sabol, Tim McCoy, Jim Maynard, Brian Hamrick, Michael Podgorski, Gudrun Ewertz, James Clarke Robinson, Jen Mintzer, Bonnie Lyons Price, Joe Catalfano, Lyndsay Petersen, Jaime DuBois, Lauren G. Newkirk, Jessica Demers, Jared Rakes, Jodi Levinthal, Gino Cerulli, Dennis Cormac McCarthy
Jan 01, 0001
Year's End, with Resolutions Addicted Muerte, Carlos Motions At the Wyeth Gallery Between Contexts I'm Allowed (and More Nonsense) Wall and Piece Timekeeper's Workspace The Process Second Sex: A Portrait of...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta.
Caroline Daelemans, Matthew E Ritchie, Guillaume Smits, Sayeda Abu-Amero, Ian M Sudbery, Matthew S Forrest, Susana Campino, Taane G Clark, Philip Stanier, Dominic Kwiatkowski, Panos Deloukas, Emmanouil T Dermitzakis, Simon Tavaré, Gudrun E Moore, Ian Dunham
Jun 14, 2011
Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body.
Michael-John Dolan, Shahar Frechter, Alexander Shakeel Bates, Chuntao Dan, Paavo Huoviala, Ruairí JV Roberts, Philipp Schlegel, Serene Dhawan, Remy Tabano, Heather Dionne, Christina Christoforou, Kari Close, Ben Sutcliffe, Bianca Giuliani, Feng Li, Marta Costa, Gudrun Ihrke, Geoffrey Wilson Meissner, Davi D Bock, Yoshinori Aso, Gerald M Rubin, Gregory SXE Jefferis
May 24, 2019
Animals exhibit innate behaviours to a variety of sensory stimuli including olfactory cues. In Drosophila, one higher olfactory centre, the lateral horn (LH), is implicated in innate behaviour. However, our structural and...
Thomas Eggermann, Frédéric Brioude, Silvia Russo, Maria P Lombardi, Jet Bliek, Eamonn R Maher, Lidia Larizza, Dirk Prawitt, Irène Netchine, Marie Gonzales, Karen Grønskov, Zeynep Tümer, David Monk, Marcel Mannens, Krystyna Chrzanowska, Malgorzata K Walasek, Matthias Begemann, Lukas Soellner, Katja Eggermann, Jair Tenorio, Julián Nevado, Gudrun E Moore, Deborah JG Mackay, Karen Temple, Gabriele Gillessen-Kaesbach, Tsutomu Ogata, Rosanna Weksberg, Elizabeth Algar, Pablo Lapunzina
Oct 15, 2015
Accelerating drug development for neuroblastoma
Lucas Moreno, Giuseppe Barone, Steven G DuBois, Jan Molenaar, Matthias Fischer, Johannes Schulte, Angelika Eggert, Gudrun Schleiermacher, Frank Speleman, Louis Chesler, Birgit Geoerger, Michael D Hogarty, Meredith S Irwin, Nick Bird, Guy B Blanchard, Sean Buckland, Hubert Caron, Susan Davis, Bram De Wilde, Hedwig E Deubzer, Emmy Dolman, Martin Eilers, Rani E George, Sally George, Štěrba Jaroslav, John M Maris, Lynley Marshall, Melinda Merchant, Peter Mortimer, Cormac Owens, Anna Philpott, Evon Poon, Jerry W Shay, Roberto Tonelli, Dominique Valteau-Couanet, Gilles Vassal, Julie R Park, Andrew DJ Pearson
Jul 29, 2020
Only one class of targeted agents (anti-GD2 antibodies) has been incorporated into front-line therapy for neuroblastoma since the 1980s. The Neuroblastoma New Drug Development Strategy (NDDS) initiative commenced in 2012 to...
Clinical Trials Drug development epigenetics MYCN Neuroblastoma phase I Preclinical testing Antineoplastic Agents Brain Neoplasms Child Congresses as Topic Drug development Drug Discovery Europe Humans Medical Oncology Molecular Targeted Therapy Neuroblastoma Pediatrics Protein Kinase Inhibitors therapies Investigational
IL10RA modulates crizotinib sensitivity in NPM1-ALK+ anaplastic large cell lymphoma.
Nina Prokoph, Nicola A Probst, Liam C Lee, Jack M Monahan, Jamie D Matthews, Huan-Chang Liang, Klaas Bahnsen, Ivonne A Montes-Mojarro, Elif Karaca-Atabay, Geeta G Sharma, Vikas Malik, Hugo Larose, Sorcha D Forde, Stephen P Ducray, Cosimo Lobello, Qi Wang, Shi-Lu Luan, Šárka Pospíšilová, Carlo Gambacorti-Passerini, GA Amos Burke, Shahid Pervez, Andishe Attarbaschi, Andrea Janíková, Hélène Pacquement, Judith Landman-Parker, Anne Lambilliotte, Gudrun Schleiermacher, Wolfram Klapper, Ralf Jauch, Wilhelm Woessmann, Gilles Vassal, Lukas Kenner, Olaf Merkel, Luca Mologni, Roberto Chiarle, Laurence Brugières, Birgit Geoerger, Isaia Barbieri, Suzanne D Turner
May 26, 2020
Anaplastic large cell lymphoma (ALCL) is a T-cell malignancy predominantly driven by a hyperactive anaplastic lymphoma kinase (ALK) fusion protein. ALK inhibitors, such as crizotinib, provide alternatives to standard...
Antineoplastic Agents CRISPR-Cas Systems Cell Line Crizotinib Dose-Response Relationship Drug Drug Resistance Neoplasm Gene Editing Gene Expression Humans Immunohistochemistry Interleukin-10 Receptor alpha Subunit Lymphoma Large-Cell Anaplastic Models Biological Nucleophosmin Protein Kinase Inhibitors Protein-Tyrosine Kinases STAT3 Transcription Factor Signal Transduction
Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.
Stephen Newhouse, Martin Farrall, Chris Wallace, Mimoza Hoti, Beverley Burke, Philip Howard, Abiodun Onipinla, Kate Lee, Sue Shaw-Hawkins, Richard Dobson, Morris Brown, Nilesh J Samani, Anna F Dominiczak, John M Connell, G Mark Lathrop, Jaspal Kooner, John Chambers, Paul Elliott, Robert Clarke, Rory Collins, Maris Laan, Elin Org, Peeter Juhanson, Gudrun Veldre, Margus Viigimaa, Susana Eyheramendy, Francesco P Cappuccio, Chen Ji, Roberto Iacone, Pasquale Strazzullo, Meena Kumari, Michael Marmot, Eric Brunner, Mark Caulfield, Patricia B Munroe
Nov 16, 2017
WNK1--a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control--is an excellent candidate gene for essential hypertension (EH). We and others have previously reported association between WNK1...
Spectrum and prevalence of genetic predisposition in medulloblastoma
Sebastian M Waszak, Paul A Northcott, Ivo Buchhalter, Giles W Robinson, Christian Sutter, Susanne Groebner, Kerstin B Grund, Laurence Brugières, David TW Jones, Kristian W Pajtler, A Sorana Morrissy, Marcel Kool, Dominik Sturm, Lukas Chavez, Aurelie Ernst, Sebastian Brabetz, Michael Hain, Thomas Zichner, Maia Segura-Wang, Joachim Weischenfeldt, Tobias Rausch, Balca R Mardin, Xin Zhou, Cristina Baciu, Christian Lawerenz, Jennifer A Chan, Pascale Varlet, Lea Guerrini-Rousseau, Daniel W Fults, Wiesława Grajkowska, Peter Hauser, Nada Jabado, Young-Shin Ra, Karel Zitterbart, Suyash S Shringarpure, Francisco M De La Vega, Carlos D Bustamante, Ho-Keung Ng, Arie Perry, Tobey J MacDonald, Pablo Hernáiz Driever, Anne E Bendel, Daniel C Bowers, Geoffrey McCowage, Murali M Chintagumpala, Richard Cohn, Timothy Hassall, Gudrun Fleischhack, Tone Eggen, Finn Wesenberg, Maria Feychting, Birgitta Lannering, Joachim Schüz, Christoffer Johansen, Tina V Andersen, Martin Röösli, Claudia E Kuehni, Michael Grotzer, Kristina Kjaerheim, Camelia M Monoranu, Tenley C Archer, Elizabeth Duke, Scott L Pomeroy, Redmond Shelagh, Stephan Frank, David Sumerauer, Wolfram Scheurlen, Marina V Ryzhova, Till Milde, Christian P Kratz, David Samuel, Jinghui Zhang, David A Solomon, Marco Marra, Roland Eils, Claus R Bartram, Katja von Hoff, Stefan Rutkowski, Vijay Ramaswamy, Richard J Gilbertson, Andrey Korshunov, Michael D Taylor, Peter Lichter, David Malkin, Amar Gajjar, Jan O Korbel, Stefan M Pfister
Sep 11, 2018
BACKGROUND: Medulloblastoma is associated with rare hereditary cancer predisposition syndromes; however, consensus medulloblastoma predisposition genes have not been defined and screening guidelines for genetic counselling and...
Adolescent Adult Biomarkers Tumor Cerebellar Neoplasms Child Child Preschool DNA Methylation DNA Mutational Analysis Female Gene Expression Profiling Genetic Predisposition to Disease Genetic Testing Germ-Line Mutation Heredity Humans Infant Male Medulloblastoma Models Genetic Pedigree Phenotype Predictive Value of Tests Progression-Free Survival Prospective Studies Reproducibility of Results Retrospective Studies Risk Factors Transcriptome Exome Sequencing Young Adult
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