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MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era.
Patrick Beckert, Elisabeth Sanchez-Padilla, Matthias Merker, Viola Dreyer, Thomas A Kohl, Christian Utpatel, Claudio U Köser, Ivan Barilar, Nazir Ismail, Shaheed Vally Omar, Marisa Klopper, Robin M Warren, Harald Hoffmann, Gugu Maphalala, Elisa Ardizzoni, Bouke C de Jong, Bernhard Kerschberger, Birgit Schramm, Sönke Andres, Katharina Kranzer, Florian P Maurer, Maryline Bonnet, Stefan Niemann
Nov 25, 2020
BACKGROUND: Multidrug-resistant (MDR) Mycobacterium tuberculosis complex strains not detected by commercial molecular drug susceptibility testing (mDST) assays due to the RpoB I491F resistance mutation are threatening the...
Diagnostice escape MDR outbreak strains multidrug resistance Resistance evolution Treatment escape Treatment Failure Tuberculosis Antitubercular Agents Bacterial Proteins Clone Cells Diarylquinolines Disease Outbreaks Eswatini Humans Microbial Sensitivity Tests Mutation Mycobacterium tuberculosis Tuberculosis Multidrug-Resistant