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Personalized and graph genomes reveal missing signal in epigenomic data.
BACKGROUND: Epigenomic studies that use next generation sequencing experiments typically rely on the alignment of reads to a reference sequence. However, because of genetic diversity and the diploid nature of the human genome...
Personalized and graph genomes reveal missing signal in epigenomic data
Abstract: Background: Epigenomic studies that use next generation sequencing experiments typically rely on the alignment of reads to a reference sequence. However, because of genetic diversity and the diploid nature of the human...
Ten things you should know about transposable elements.
Guillaume Bourque, Kathleen H Burns, Mary Gehring, Vera Gorbunova, Andrei Seluanov, Molly Hammell, Michaël Imbeault, Zsuzsanna Izsvák, Henry L Levin, Todd S Macfarlan, Dixie L Mager, Cédric Feschotte
Dec 18, 2018
Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and...
Paired rRNA-depleted and polyA-selected RNA sequencing data and supporting multi-omics data from human T cells.
Li Chen, Ruirui Yang, Tony Kwan, Chao Tang, Stephen Watt, Yiming Zhang, Guillaume Bourque, Bing Ge, Kate Downes, Mattia Frontini, Willem H Ouwehand, Jing-Wen Lin, Nicole Soranzo, Tomi Pastinen, Lu Chen
Nov 09, 2020
Phosphate Deprivation Can Impair Mechano-Stimulated Cytosolic Free Calcium Elevation in Arabidopsis Roots.
Elsa Matthus, Nicholas H Doddrell, Gaëtan Guillaume, Amirah B Mohammad-Sidik, Katie A Wilkins, Stéphanie M Swarbreck, Julia M Davies
Dec 04, 2020
The root tip responds to mechanical stimulation with a transient increase in cytosolic free calcium as a possible second messenger. Although the root tip will grow through a heterogeneous soil nutrient supply, little is known of...
From behavioural simulation to computer models
Simulation is a technique that evokes or replicates substantial aspects of the real world, in order to experiment with a simplified imitation of an operations system, for the purpose of better understanding and/or improving that...
Who’s afraid of the big, bad wolf? How corporations maintain hegemony by using counterinsurgency tactics to undermine activism
This article contributes to critical theory building in relation to political corporate social responsibility (PCSR) by conceptualizing the underlying processes and practices through which corporations seek to counter threats...
Gramsci activism counterinsurgency genealogy political corporate social responsibility power /dk/atira/pure/subjectarea/asjc/1400/1405 name=Management of Technology and Innovation /dk/atira/pure/subjectarea/asjc/1400/1407 name=Organizational Behavior and Human Resource Management /dk/atira/pure/subjectarea/asjc/1400/1408 name=Strategy and Management /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
Chemical Reporters for Investigating Lipidated Proteins at the Host-Pathogen Interface
Guillaume Charron
Jan 01, 0001
Lipidation of proteins regulates many cellular processes such as signaling transduction and membrane sorting by modulating protein localization and proteinprotein interactions. As such, defects in protein lipidation can render...
Published by: Rockefeller University
Robust modulation of integrate-and-fire models
By controlling the state of neuronal populations, neuromodulators ultimately affect behaviour. A key neuromodulation mechanism is the alteration of neu- ronal excitability via the modulation of ion channel expression. This type...
Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitors.
Drosophila Gene regulation Myogenesis Notch Reck Talin Trio Animals Drosophila Drosophila Proteins Guanine Nucleotide Exchange Factors In Situ Hybridization Muscle Development Muscles Phosphoproteins Protein Serine-Threonine Kinases Receptors Notch Reverse Transcriptase Polymerase Chain Reaction Stem Cells Talin
Challenges in making standardisation work in healthcare
OBJECTIVE:To identify and learn from efforts to design and implement a standardised policy for labelling of invasive tubing and lines across a regional health system. DESIGN:Single case study involving qualitative interviews and...
Neuroscience out of control
A major challenge in systems neuroscience is to understand how the dynamics of neural circuits give rise to behaviour. Analysis of complex dynamical systems is also at the heart of control engineering, where it is central to the...
The dynamic mechanical properties of cellularised aggregates.
Nargess Khalilgharibi, Jonathan Fouchard, Pierre Recho, Guillaume Charras, Alexandre Kabla
Nov 23, 2018
Cellularised materials are composed of cells interfaced through specialised intercellular junctions that link the cytoskeleton of one cell to that of its neighbours allowing for transmission of forces. Cellularised materials are...
Flt3 signaling-dependent dendritic cells protect against atherosclerosis
Early events in atherosclerosis occur in the aortic intima and involve monocytes that become macrophages. We looked for these cells in the steady state adult mouse aorta, and surprisingly, we found a dominance of dendritic cells...
Published by: Rockefeller University
Optimal anticipatory control as a theory of motor preparation
Across a range of motor and cognitive tasks, cortical activity can be accurately described by low-dimensional dynamics unfolding from specific initial conditions on every trial. These "preparatory states" largely determine the...
Cellular switches orchestrate rhythmic circuits.
Small inhibitory neuronal circuits have long been identified as key neuronal motifs to generate and modulate the coexisting rhythms of various motor functions. Our paper highlights the role of a cellular switching mechanism to...
DNA polymerase stalling at structured DNA constrains the expansion of short tandem repeats.
BACKGROUND: Short tandem repeats (STRs) contribute significantly to de novo mutagenesis, driving phenotypic diversity and genetic disease. Although highly diverse, their repetitive sequences induce DNA polymerase slippage and...
Using clinical simulation to study how to improve quality and safety in healthcare.
Simulation can offer researchers access to events that can otherwise not be directly observed, and in a safe and controlled environment. How to use simulation for the study of how to improve the quality and safety of healthcare...
Published by: BMJ simulation & technology enhanced learning
Guillaumean Linguistics
R.M. Jones
Sep 05, 2013
It has long been suspected that Guillaumean linguistics provided suggestions for literary critics or theorists. Gabriel Guillaume (1962, 1967, 1968) was a pioneer. The most useful summary is Wilmet (1980). But what was lacking...
Published by: Atlantic Provinces Linguistic Association
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