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Amino acid dependent formaldehyde metabolism in mammals
Matthias Pietzke, Guillermo Burgos-Barragan, Niek Wit, Jacqueline Tait-Mulder, David Sumpton, Gillian M. Mackay, Ketan J. Patel, Alexei Vazquez
Feb 18, 2021
Abstract: Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways...
Amino acid dependent formaldehyde metabolism in mammals
Matthias Pietzke, Guillermo Burgos-Barragan, Niek Wit, Jacqueline Tait-Mulder, David Sumpton, Gillian M. Mackay, Ketan J. Patel, Alexei Vazquez
Jun 16, 2020
Abstract: Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways...
Amino acid dependent formaldehyde metabolism in mammals.
Matthias Pietzke, Guillermo Burgos-Barragan, Niek Wit, Jacqueline Tait-Mulder, David Sumpton, Gillian M Mackay, Ketan J Patel, Alexei Vazquez
Jun 17, 2021
Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways starting...
Modernity, gender and the spectre of coloniality in the "Moroccan Texts" of Carmen de Burgos and Aurora Bertrana
B Epps
Jan 10, 2017
This article examines two works by Carmen de Burgos and Aurora Bertrana situated in Morocco—En la guerra, from 1909, and El Marroc sensual i fanatic from 1936—in the light of three interrelated questions: gender, nationality and...
Monogenic Diabetes Modeling
The occurrence of diabetes mellitus is characterized by pancreatic β cell loss and chronic hyperglycemia. While Type 1 and Type 2 diabetes are the most common types, rarer forms involve mutations affecting a single gene. This...
Monogenic Diabetes Modeling
The occurrence of diabetes mellitus is characterized by pancreatic β cell loss and chronic hyperglycemia. While Type 1 and Type 2 diabetes are the most common types, rarer forms involve mutations affecting a single gene. This...
Expansion of Intrinsically Disordered Proteins Increases the Range of Stability of Liquid–Liquid Phase Separation
Proteins containing intrinsically disordered regions (IDRs) are ubiquitous within biomolecular condensates, which are liquid-like compartments within cells formed through liquid−liquid phase separation (LLPS). The sequence of...
Valency and Binding Affinity Variations Can Regulate the Multilayered Organization of Protein Condensates with Many Components.
Expansion of Intrinsically Disordered Proteins Increases the Range of Stability of Liquid-Liquid Phase Separation.
Proteins containing intrinsically disordered regions (IDRs) are ubiquitous within biomolecular condensates, which are liquid-like compartments within cells formed through liquid-liquid phase separation (LLPS). The sequence of...
Valency and Binding Affinity Variations Can Regulate the Multilayered Organization of Protein Condensates with Many Components
Ignacio Sanchez-Burgos, Jorge R. Espinosa, Jerelle A. Joseph, Rosana Collepardo-Guevara
Feb 15, 2021
Biomolecular condensates, which assemble via the process of liquid–liquid phase separation (LLPS), are multicomponent compartments found ubiquitously inside cells. Experiments and simulations have shown that biomolecular...
RápidoPGS
MOTIVATION: Polygenic scores (PGS) aim to genetically predict complex traits at an individual level. PGS are typically trained on genome-wide association summary statistics and require an independent test dataset to tune...
Structural and Functional Brain Abnormalities in Mouse Models of Lafora Disease.
Daniel F Burgos, Lorena Cussó, Gentzane Sánchez-Elexpuru, Daniel Calle, Max Bautista Perpinyà, Manuel Desco, José M Serratosa, Marina P Sánchez
Oct 21, 2020
Mutations in the EPM2A and EPM2B genes, encoding laforin and malin proteins respectively, are responsible for Lafora disease, a fatal form of progressive myoclonus epilepsy with autosomal recessive inheritance. Neuroimaging...
1H-HRMAS MRS FDG PET Lafora disease MRI brain metabolites Mouse models Volumetry Animals Atrophy basal ganglia Brain Brain Diseases cerebellum Cerebral Cortex Disease Models Animal Glucose Hippocampus Humans Lafora Disease Magnetic Resonance Imaging Mice Knockout Mutation Positron-Emission Tomography Protein Tyrosine Phosphatases Non-Receptor Ubiquitin-Protein Ligases
Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it.
Measuring Green Practices in Sport
Environmental sustainability has often been associated with increased organizational profitability, efficiency, and competitiveness. A related example is green practices which have become a central component of many...
Green Practices Scale development Sports sustainability /dk/atira/pure/subjectarea/asjc/1700/1701 name=Computer Science (miscellaneous) /dk/atira/pure/subjectarea/asjc/3300/3305 name=Geography, Planning and Development /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2300/2301 name=Environmental Science (miscellaneous) /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/subjectarea/asjc/1700/1708 name=Hardware and Architecture /dk/atira/pure/subjectarea/asjc/1700/1705 name=Computer Networks and Communications /dk/atira/pure/subjectarea/asjc/2300/2308 name=Management, Monitoring, Policy and Law /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it.
A Brain for Language and the Language of the Brain
Guillermo A Cecchi
Jan 01, 0001
This thesis consists of three sections. In the first one, we overview the basic concepts and results of computation theory, the relationship with formal language theory, and present an introduction to the possible applications...
Published by: Rockefeller University
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