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Acute ischaemic stroke in Listeria monocytogenes meningoencephalitis.
Surrin S Deen, Jennifer Boyes, Bankole Oyewole, Anna Bahk, George Thomas, Gunaratnam Gunathilagan
Oct 10, 2019
Listeria monocytogenes is the third most frequent cause of bacterial meningitis and has a predilection for elderly patients and the immunosuppressed. A small number of patients with Listeria monocytogenes meningoencephalitis...
Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule.
Chiara Marchetti, Katherine G Zyner, Stephan A Ohnmacht, Mathew Robson, Shozeb M Haider, Jennifer P Morton, Giovanni Marsico, Tam Vo, Sarah Laughlin-Toth, Ahmed A Ahmed, Gloria Di Vita, Ingrida Pazitna, Mekala Gunaratnam, Rachael J Besser, Ana CG Andrade, Seckou Diocou, Jeremy A Pike, David Tannahill, R Barbara Pedley, TR Jeffry Evans, W David Wilson, Shankar Balasubramanian, Stephen Neidle
Mar 26, 2018
Human pancreatic ductal adenocarcinoma (PDAC) involves the dysregulation of multiple signaling pathways. A novel approach to the treatment of PDAC is described, involving the targeting of cancer genes in PDAC pathways having...
Animals Antimetabolites Antineoplastic Antineoplastic Agents Carcinoma Pancreatic Ductal Cell Line Tumor Computational Biology Computer Simulation DNA Damage Deoxycytidine Down-Regulation Drug Design Drug Resistance Neoplasm G-Quadruplexes Gene Expression Regulation Neoplastic Humans Mice Mice Nude Pancreatic Neoplasms Xenograft Model Antitumor Assays Gemcitabine