A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns.
Wei Jiao,
Gurnit Atwal,
Paz Polak,
Rosa Karlic,
Edwin Cuppen,
PCAWG Tumor Subtypes and Clinical Translation Working Group,
Alexandra Danyi,
Jeroen de Ridder,
Carla van Herpen,
Martijn P Lolkema,
Neeltje Steeghs,
Gad Getz,
Quaid D Morris,
Lincoln D Stein,
PCAWG Consortium
May 14, 2020
In cancer, the primary tumour's organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of...