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Probing the dynamic stalk region of the ribosome using solution NMR.
Xiaolin Wang, John P Kirkpatrick, Hélène MM Launay, Alfonso De Simone, Daniel Häussinger, Christopher M Dobson, Michele Vendruscolo, Lisa D Cabrita, Christopher A Waudby, John Christodoulou
Oct 28, 2019
We describe an NMR approach based on the measurement of residual dipolar couplings (RDCs) to probe the structural and motional properties of the dynamic regions of the ribosome. Alignment of intact 70S ribosomes in filamentous...
Probing the dynamic stalk region of the ribosome using solution NMR
Xiaolin Wang, John P. Kirkpatrick, Hélène M. M. Launay, Alfonso De Simone, Daniel Häussinger, Christopher M. Dobson, Michele Vendruscolo, Lisa D. Cabrita, Christopher A. Waudby, John Christodoulou
Sep 18, 2020
Abstract: We describe an NMR approach based on the measurement of residual dipolar couplings (RDCs) to probe the structural and motional properties of the dynamic regions of the ribosome. Alignment of intact 70S ribosomes in...
QM/MM simulations for methyl transfer in solution and catalysed by COMT
Sampling of structures from QM/MM molecular dynamics reveals distinct families of reactant-state conformers and yields kinetic isotope effects for reactions in enzyme active sites and in solution, averaged over thermal...
QM/MM simulations for methyl transfer in solution and catalysed by COMT
Sampling of structures from QM/MM molecular dynamics reveals distinct families of reactant-state conformers and yields kinetic isotope effects for reactions in enzyme active sites and in solution, averaged over thermal...
QM/MM kinetic isotope effects for chloromethane hydrolysis in water
Computational simulations for chloromethane hydrolysis have been performed using hybrid quantum-mechanical/molecular-mechanical methods with explicit solvation by large numbers of water molecules. In the first part of the...
Measuring the Dust Masses of Protoplanetary Disks in Lupus with ALMA
Abstract
Accurate disk mass measurements are necessary to constrain disk evolution and the timescale of planet formation, but such measurements are difficult to make and are very...
QM/MM kinetic isotope effects for chloromethane hydrolysis in water
Computational simulations for chloromethane hydrolysis have been performed using hybrid quantum-mechanical/molecular-mechanical methods with explicit solvation by large numbers of water molecules. In the first part of the...
Computational mutagenesis reveals the role of active-site tyrosine in stabilising a boat conformation for the substrate
Molecular dynamics simulations have been performed for non-covalent complexes of phenyl beta-xylobioside with the retaining endo-beta-1,4-xylanase from B. circulans (BCX) and its Tyr69Phe mutant using a hybrid QM/MM methodology....
Mauve/LYST limits fusion of lysosome-related organelles and promotes centrosomal recruitment of microtubule nucleating proteins.
Lysosome-related organelles (LROs) are endosomal compartments carrying tissue-specific proteins, which become enlarged in Chediak-Higashi syndrome (CHS) due to mutations in LYST. Here, we show that Drosophila Mauve, a...
Chediak-Higashi syndrome Drosophila LYST centrosomes endosomal vesicle trafficking lysosome-related organelles mauve microtubule nucleation minispindles/Ch-TOG Animals Cell Line Centrosome Chediak-Higashi Syndrome Cytoplasmic Granules Drosophila Drosophila Proteins Female Humans Lysosomes Microtubule-Associated Proteins Microtubules Mutation Oocytes Spindle Apparatus Vesicular Transport Proteins
Computational mutagenesis reveals the role of active-site tyrosine in stabilising a boat conformation for the substrate
Molecular dynamics simulations have been performed for non-covalent complexes of phenyl beta-xylobioside with the retaining endo-beta-1,4-xylanase from B. circulans (BCX) and its Tyr69Phe mutant using a hybrid QM/MM methodology....
Exploration of ICT Appropriation by Disabled People and Its Effect on Self-Perceived Normalcy
Information and communication technologies (ICTs) are omnipresent and define the interactions in society. Within society, there are vulnerable groups of people for whom ICT use is more challenging. Disabled people are the most...
Published by: IGI Global Scientific Publishing
The Algerian Works of Hélène Cixous
SS Everett
Apr 28, 2017
The Lifetime Earnings Premium in the Public Sector
In a context of widespread concern about budget deficits, it is important to assess whether public sector pay is in line with the private sector. Our paper proposes an estimation of differences in lifetime values of employment...
What Lessons Can Be Learned for the Agroecological Transition From the Use of Social Media in Preventive Medicine?
In agriculture, web-based social media are increasingly used to share knowledge concerning best practices. One goal of agroecology is to reduce the use of synthetic chemical inputs. Agroecology represents a contrast with...
Published by: IGI Global Scientific Publishing
Sin, slave status, and the “city,” Zanzibar, 1865-c.1930
MM Greenfield-Liebst
Apr 20, 2017
The Universities’ Mission to Central Africa (UMCA) missionaries equated urbanity with moral contagion, to which those with slave status were especially vulnerable. To the ex-slaves who came into contact with the mission, the...
The Lifetime Earnings Premium in the Public Sector
In a context of widespread concern about budget deficits, it is important to assess whether public sector pay is in line with the private sector. Our paper proposes an estimation of differences in lifetime values of employment...
Intracranial pressure in outer space
Mr Michael M. Tymko is funded by an NSERC CGS doctoral grant. Mr Lindsey M. Boulet is funded by an NSERC CGS master's grant. Dr Joseph Donnelly is funded by a Woolf Fisher Scholarship.
Motility and phototaxis of Gonium, the simplest differentiated colonial alga.
Green algae of the Volvocine lineage, spanning from unicellular Chlamydomonas to vastly larger Volvox, are models for the study of the evolution of multicellularity, flagellar dynamics, and developmental processes. Phototactic...
Spatially Resolved Operando Synchrotron-Based X-Ray Diffraction Measurements of Ni-Rich Cathodes for Li-Ion Batteries
Understanding the performance of commercially relevant cathode materials for lithium-ion (Li-ion) batteries is vital to realize the potential of high-capacity materials for automotive applications. Of particular interest...
Andrew Stephen Leach, Alice V Llewellyn, Chao Xu, Chun Tan, Thomas MM Heenan, Alex Dimitrijevic, Karin Kleiner, Clare P Grey, Dan JL Brett, Chiu C Tang, Paul R Shearing, Rhodri Jervis
Jan 28, 2022
Are there species smaller than 1 mm?
The rapid advance in genetic sequencing technologies has provided an unprecedented amount of data on the biodiversity of meiofauna. It was hoped that these data would allow the identification and counting of species...
Cortical microtubule nucleation can organise the cytoskeleton of Drosophila oocytes to define the anteroposterior axis.
Philipp Khuc Trong, Hélène Doerflinger, Jörn Dunkel, Daniel St Johnston, Raymond E Goldstein
Oct 01, 2015
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