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Results: 222
Electronic Origin of α″ to β Phase Transformation in Ti-Nb-Based Thin Films upon Hf Microalloying.
José Julio Gutiérrez Moreno, Nikolaos T Panagiotopoulos, Georgios A Evangelakis, Christina E Lekka
Mar 15, 2020
We present results on thin Ti-Nb-based films containing Hf at various concentrations grown by magnetron sputtering. The films exhibit α" patterns at Hf concentrations up to 11 at.%, while at 16 at.% Hf, the β-phase emerges as a...
Modulated self-assembly of hcp topology MOFs of Zr/Hf and the extended 4,4′-(ethyne-1,2-diyl)dibenzoate linker
Careful control of synthetic conditions allows isolation of highly porous hcp topology Zr and Hf MOFs containing a linker with a potentially reactive alkyne spacer.
SS Boyadjieva, FCN Firth, MR Alizadeh Kiapi, D Fairen-Jimenez, S Ling, MJ Cliffe, RS Forgan
Mar 20, 2023
Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury
MC Cnossen, JA Huijben, M van der Jagt, V Volovici, T van Essen, S Polinder, D Nelson, A Ercole, N Stocchetti, G Citerio, WC Peul, AIR Maas, D Menon, EW Steyerberg, HF Ligsma
Dec 07, 2017
Background: No definitive evidence exists on how intracranial hypertension should be treated in patients with traumatic brain injury (TBI). It is therefore likely that centers and practitioners individually balance potential...
High-Sensitivity Cardiac Troponin and New-Onset Heart Failure
Jonathan DW Evans, Stephen JH Dobbin, Stephen J Pettit, Emanuele Di Angelantonio, Peter Willeit
Feb 05, 2018
OBJECTIVES: The aim of this study was to systematically collate and appraise the available evidence regarding the association between high-sensitivity cardiac troponin (hs-cTn) and incident heart failure (HF) and the added value...
Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.
Emanuel Rognoni, Celine Gomez, Angela Oliveira Pisco, Emma L Rawlins, Ben D Simons, Fiona M Watt, Ryan R Driskell
Aug 17, 2018
New hair follicles (HFs) do not form in adult mammalian skin unless epidermal Wnt signalling is activated genetically or within large wounds. To understand the postnatal loss of hair forming ability we monitored HF formation at...
Fibroblast lineages Wounding β-catenin aging Animals Animals Newborn Apoptosis Biomarkers Cell Count Cell Differentiation Cell Proliferation Clone Cells Dermis FIBROBLASTS Gene Expression Profiling Gene Expression Regulation Developmental Green Fluorescent Proteins Hair Follicle Homeostasis Integrases Mice Inbred C57BL Organogenesis Receptor Platelet-Derived Growth Factor alpha Regeneration Signal Transduction Tail Time Factors Wnt Signaling Pathway Wound Healing beta Catenin
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K. Hedman, Jemma B. Wilk, Michael P. Morley, Mark D. Chaffin, Anna Helgadottir, Niek Verweij, Abbas Dehghan, Peter Almgren, Charlotte Andersson, Krishna G. Aragam, Johan Ärnlöv, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Jeffrey Brandimarto, Michael R. Brown, Leonard Buckbinder, David J. Carey, Daniel I. Chasman, Xing Chen, Xu Chen, Jonathan Chung, William Chutkow, James P. Cook, Graciela E. Delgado, Spiros Denaxas, Alexander S. Doney, Marcus Dörr, Samuel C. Dudley, Michael E. Dunn, Gunnar Engström, Tõnu Esko, Stephan B. Felix, Chris Finan, Ian Ford, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S. Gottdiener, Stefan Gross, Daníel F. Guðbjartsson, Rebecca Gutmann, Christopher M. Haggerty, Pim van der Harst, Craig L. Hyde, Erik Ingelsson, J. Wouter Jukema, Maryam Kavousi, Kay-Tee Khaw, Marcus E. Kleber, Lars Køber, Andrea Koekemoer, Claudia Langenberg, Lars Lind, Cecilia M. Lindgren, Barry London, Luca A. Lotta, Ruth C. Lovering, Jian’an Luan, Patrik Magnusson, Anubha Mahajan, Kenneth B. Margulies, Winfried März, Olle Melander, Ify R. Mordi, Thomas Morgan, Andrew D. Morris, Andrew P. Morris, Alanna C. Morrison, Michael W. Nagle, Christopher P. Nelson, Alexander Niessner, Teemu Niiranen, Michelle L. O’Donoghue, Anjali T. Owens, Colin N. A. Palmer, Helen M. Parry, Markus Perola, Eliana Portilla-Fernandez, Bruce M. Psaty, Kenneth M. Rice, Paul M. Ridker, Simon P. R. Romaine, Jerome I. Rotter, Perttu Salo, Veikko Salomaa, Jessica van Setten, Alaa A. Shalaby, Diane T. Smelser, Nicholas L. Smith, Steen Stender, David J. Stott, Per Svensson, Mari-Liis Tammesoo, Kent D. Taylor, Maris Teder-Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp-Pedersen, Stella Trompet, Benoit Tyl, Andre G. Uitterlinden, Abirami Veluchamy, Uwe Völker, Adriaan A. Voors, Xiaosong Wang, Nicholas J. Wareham, Dawn Waterworth, Peter E. Weeke, Raul Weiss, Kerri L. Wiggins, Heming Xing, Laura M. Yerges-Armstrong, Bing Yu, Faiez Zannad, Jing Hua Zhao, Harry Hemingway, Nilesh J. Samani, John J. V. McMurray, Jian Yang, Peter M. Visscher, Christopher Newton-Cheh, Anders Malarstig, Hilma Holm, Steven A. Lubitz, Naveed Sattar, Michael V. Holmes, Thomas P. Cappola, Folkert W. Asselbergs, Aroon D. Hingorani, Karoline Kuchenbaecker, Patrick T. Ellinor, Chim C. Lang, Kari Stefansson, J. Gustav Smith, Ramachandran S. Vasan, Daniel I. Swerdlow, R. Thomas Lumbers, Goncalo Abecasis, Joshua Backman, Xiaodong Bai, Suganthi Balasubramanian, Nilanjana Banerjee, Aris Baras, Leland Barnard, Christina Beechert, Andrew Blumenfeld, Michael Cantor, Yating Chai, Giovanni Coppola, Amy Damask, Frederick Dewey, Aris Economides, Gisu Eom, Caitlin Forsythe, Erin D. Fuller, Zhenhua Gu, Lauren Gurski, Paloma M. Guzzardo, Lukas Habegger, Young Hahn, Alicia Hawes, Cristopher van Hout, Marcus B. Jones, Shareef Khalid, Michael Lattari, Alexander Li, Nan Lin, Daren Liu, Alexander Lopez, Kia Manoochehri, Jonathan Marchini, Anthony Marcketta, Evan K. Maxwell, Shane McCarthy, Lyndon J. Mitnaul, Colm O’Dushlaine, John D. Overton, Maria Sotiropoulos Padilla, Charles Paulding, John Penn, Manasi Pradhan, Jeffrey G. Reid, Thomas D. Schleicher, Claudia Schurmann, Alan Shuldiner, Jeffrey C. Staples, Dylan Sun, Karina Toledo, Ricardo H. Ulloa, Louis Widom, Sarah E. Wolf, Ashish Yadav, Bin Ye
Jan 08, 2021
Abstract: Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded...
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K Hedman, Jemma B Wilk, Michael P Morley, Mark D Chaffin, Anna Helgadottir, Niek Verweij, Abbas Dehghan, Peter Almgren, Charlotte Andersson, Krishna G Aragam, Johan Ärnlöv, Joshua D Backman, Mary L Biggs, Heather L Bloom, Jeffrey Brandimarto, Michael R Brown, Leonard Buckbinder, David J Carey, Daniel I Chasman, Xing Chen, Xu Chen, Jonathan Chung, William Chutkow, James P Cook, Graciela E Delgado, Spiros Denaxas, Alexander S Doney, Marcus Dörr, Samuel C Dudley, Michael E Dunn, Gunnar Engström, Tõnu Esko, Stephan B Felix, Chris Finan, Ian Ford, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S Gottdiener, Stefan Gross, Daníel F Guðbjartsson, Rebecca Gutmann, Christopher M Haggerty, Pim van der Harst, Craig L Hyde, Erik Ingelsson, J Wouter Jukema, Maryam Kavousi, Kay-Tee Khaw, Marcus E Kleber, Lars Køber, Andrea Koekemoer, Claudia Langenberg, Lars Lind, Cecilia M Lindgren, Barry London, Luca A Lotta, Ruth C Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Kenneth B Margulies, Winfried März, Olle Melander, Ify R Mordi, Thomas Morgan, Andrew D Morris, Andrew P Morris, Alanna C Morrison, Michael W Nagle, Christopher P Nelson, Alexander Niessner, Teemu Niiranen, Michelle L O'Donoghue, Anjali T Owens, Colin N A Palmer, Helen M Parry, Markus Perola, Eliana Portilla-Fernandez, Bruce M Psaty, Kenneth M Rice, Paul M Ridker, Simon P R Romaine, Jerome I Rotter, Perttu Salo, Veikko Salomaa, Jessica van Setten, Alaa A Shalaby, Diane T Smelser, Nicholas L Smith, Steen Stender, David J Stott, Per Svensson, Mari-Liis Tammesoo, Kent D Taylor, Maris Teder-Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp-Pedersen, Stella Trompet, Benoit Tyl, Andre G Uitterlinden, Abirami Veluchamy, Uwe Völker, Adriaan A Voors, Xiaosong Wang, Nicholas J Wareham, Dawn Waterworth, Peter E Weeke, Raul Weiss, Kerri L Wiggins, Heming Xing, Laura M Yerges-Armstrong, Bing Yu, Faiez Zannad, Jing Hua Zhao, Harry Hemingway, Nilesh J Samani, John J V McMurray, Jian Yang, Peter M Visscher, Christopher Newton-Cheh, Anders Malarstig, Hilma Holm, Steven A Lubitz, Naveed Sattar, Michael V Holmes, Thomas P Cappola, Folkert W Asselbergs, Aroon D Hingorani, Karoline Kuchenbaecker, Patrick T Ellinor, Chim C Lang, Kari Stefansson, J Gustav Smith, Ramachandran S Vasan, Daniel I Swerdlow, R Thomas Lumbers
Feb 10, 2020
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only...
Published by: Nature Communications
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K Hedman, Jemma B Wilk, Michael P Morley, Mark D Chaffin, Anna Helgadottir, Niek Verweij, Abbas Dehghan, Peter Almgren, Charlotte Andersson, Krishna G Aragam, Johan Ärnlöv, Joshua D Backman, Mary L Biggs, Heather L Bloom, Jeffrey Brandimarto, Michael R Brown, Leonard Buckbinder, David J Carey, Daniel I Chasman, Xing Chen, Xu Chen, Jonathan Chung, William Chutkow, James P Cook, Graciela E Delgado, Spiros Denaxas, Alexander S Doney, Marcus Dörr, Samuel C Dudley, Michael E Dunn, Gunnar Engström, Tõnu Esko, Stephan B Felix, Chris Finan, Ian Ford, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S Gottdiener, Stefan Gross, Daníel F Guðbjartsson, Rebecca Gutmann, Christopher M Haggerty, Pim van der Harst, Craig L Hyde, Erik Ingelsson, J Wouter Jukema, Maryam Kavousi, Kay-Tee Khaw, Marcus E Kleber, Lars Køber, Andrea Koekemoer, Claudia Langenberg, Lars Lind, Cecilia M Lindgren, Barry London, Luca A Lotta, Ruth C Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Kenneth B Margulies, Winfried März, Olle Melander, Ify R Mordi, Thomas Morgan, Andrew D Morris, Andrew P Morris, Alanna C Morrison, Michael W Nagle, Christopher P Nelson, Alexander Niessner, Teemu Niiranen, Michelle L O'Donoghue, Anjali T Owens, Colin NA Palmer, Helen M Parry, Markus Perola, Eliana Portilla-Fernandez, Bruce M Psaty, Regeneron Genetics Center, Kenneth M Rice, Paul M Ridker, Simon PR Romaine, Jerome I Rotter, Perttu Salo, Veikko Salomaa, Jessica van Setten, Alaa A Shalaby, Diane T Smelser, Nicholas L Smith, Steen Stender, David J Stott, Per Svensson, Mari-Liis Tammesoo, Kent D Taylor, Maris Teder-Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp-Pedersen, Stella Trompet, Benoit Tyl, Andre G Uitterlinden, Abirami Veluchamy, Uwe Völker, Adriaan A Voors, Xiaosong Wang, Nicholas J Wareham, Dawn Waterworth, Peter E Weeke, Raul Weiss, Kerri L Wiggins, Heming Xing, Laura M Yerges-Armstrong, Bing Yu, Faiez Zannad, Jing Hua Zhao, Harry Hemingway, Nilesh J Samani, John JV McMurray, Jian Yang, Peter M Visscher, Christopher Newton-Cheh, Anders Malarstig, Hilma Holm, Steven A Lubitz, Naveed Sattar, Michael V Holmes, Thomas P Cappola, Folkert W Asselbergs, Aroon D Hingorani, Karoline Kuchenbaecker, Patrick T Ellinor, Chim C Lang, Kari Stefansson, J Gustav Smith, Ramachandran S Vasan, Daniel I Swerdlow, R Thomas Lumbers
Jan 29, 2020
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only...
Adaptor Proteins Signal Transducing Apoptosis Regulatory Proteins Atrial fibrillation Cardiomyopathies Carrier Proteins Case-Control Studies Coronary Artery Disease Cyclin-Dependent Kinase Inhibitor p21 Genome-Wide Association Study Heart Failure Humans Mendelian Randomization Analysis Microfilament Proteins Muscle Proteins Risk Factors Ventricular Function Left
Energy Metabolites as Biomarkers in Ischemic and Dilated Cardiomyopathy.
Jan Haas, Karen S Frese, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Rewati Tappu, Rouven Nietsch, Oguz Firat Tugrul, Michael Wisdom, Carsten Dietrich, Ali Amr, Tanja Weis, Torsten Niederdränk, Michael P Murphy, Thomas Krieg, Marcus Dörr, Uwe Völker, Jens Fielitz, Norbert Frey, Stephan B Felix, Andreas Keller, Hugo A Katus, Benjamin Meder
Feb 25, 2021
With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and...
Time for correct diagnosis and categorisation of heart failure in primary care
Heart failure (HF) affects approximately 900 000 people in the UK and is a leading cause of hospitalisation, accounting for 5% of emergency admissions. Correct identification of patients with HF holds promise for ensuring that...
MICE or NICE? An economic evaluation of clinical decision rules in the diagnosis of heart failure in primary care.
Mark Monahan, Pelham Barton, Clare J Taylor, Andrea K Roalfe, FD Richard Hobbs, REFER investigators, Martin Cowie, Russell Davis, Jon Deeks, Jonathan Mant, Deborah McCahon, Theresa McDonagh, George Sutton, Lynda Tait
May 02, 2018
BACKGROUND: Detection and treatment of heart failure (HF) can improve quality of life and reduce premature mortality. However, symptoms such as breathlessness are common in primary care, have a variety of causes and not all...
Cost benefit analysis Economic model General Practice Medical economics Natriuretic Peptide Aged Clinical Decision-Making Cost-Benefit Analysis Edema England Female Follow-Up Studies Heart Failure Humans Male Myocardial Infarction Practice Guidelines as Topic Primary Health Care Prospective Studies State Medicine
General Approach for Multireference Ground and Excited States Using Nonorthogonal Configuration Interaction.
A balanced description of ground and excited states is essential for the description of many chemical processes. However, few methods can handle cases where static correlation is present, and often these scale very unfavorably...
Effects of carbohydrate dose and frequency on metabolism, gastrointestinal discomfort and cross-country skiing performance
This study investigated carbohydrate ingestion of varied doses and frequencies during a simulated cross-country skiing time-trial. Ten men and three women (age: 30±7 y; V ̇O2max: 59.6±5.7 mL·kg-1·min-1) completed four, 30-km...
Diurnal distribution of carbohydrates and fat affects substrate oxidation and adipokine secretion in humans.
Katharina Kessler, Silke Hornemann, Klaus J Petzke, Margrit Kemper, Mariya Markova, Natalia Rudovich, Tilman Grune, Achim Kramer, Andreas FH Pfeiffer, Olga Pivovarova-Ramich
Apr 16, 2019
BACKGROUND: A diet in which fat is mainly eaten in the morning and carbohydrates mainly in the evening (compared with the reverse order) was recently shown to worsen glycemic control in people with prediabetes. OBJECTIVE: We...
adipokines Adult Biomarkers Body Mass Index Circadian Rhythm Cross-Over Studies Cytokines Dietary Carbohydrates Dietary Fats Energy Metabolism Fasting Glucose Intolerance Humans Inflammation Leptin Lipids Male Middle Aged Nicotinamide Phosphoribosyltransferase Oxidation-Reduction Postprandial Period
Energy Metabolites as Biomarkers in Ischemic and Dilated Cardiomyopathy
Jan Haas, Karen S. Frese, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Rewati Tappu, Rouven Nietsch, Oguz Firat Tugrul, Michael Wisdom, Carsten Dietrich, Ali Amr, Tanja Weis, Torsten Niederdränk, Michael P. Murphy, Thomas Krieg, Marcus Dörr, Uwe Völker, Jens Fielitz, Norbert Frey, Stephan B. Felix, Andreas Keller, Hugo A. Katus, Benjamin Meder
Feb 20, 2021
With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and...
A Comparative Study of Systolic and Diastolic Mechanical Synchrony in Canine, Primate, and Healthy and Failing Human Hearts.
Tiangang Zhu, Ming Lei, Zhilong Wang, Rongli Zhang, Yan Zhang, Wenying Jin, Chao Yu, Christopher L-H Huang, Dongyue Liu, Wen Zheng, Yuli Liu, Xin Quan, Lingyun Kong, Siying Liang, Xiuqin Zhang
Nov 12, 2021
Aim: Mechanical dyssynchrony (MD) is associated with heart failure (HF) and may be prognostically important in cardiac resynchronization therapy (CRT). Yet, little is known about its patterns in healthy or diseased hearts. We...
Time Domain Multiplexing for Efficiency Enhanced Piezoelectric Energy Harvesting in MEMS
The conversion efficiency of piezoelectric energy harvesters (EH) have been improved by several approaches including frequency up-conversion (FUC) techniques that trigger the high-frequency (HF) piezoelectric resonators using...
Effects of carbohydrate dose and frequency on metabolism, gastrointestinal discomfort and cross-country skiing performance
This study investigated carbohydrate ingestion of varied doses and frequencies during a simulated cross-country skiing time-trial. Ten men and three women (age: 30±7 y; V ̇O2max: 59.6±5.7 mL·kg-1·min-1) completed four, 30-km...
The effect of diurnal distribution of carbohydrates and fat on glycaemic control in humans
Katharina Kessler, Silke Hornemann, Klaus J Petzke, Margrit Kemper, Achim Kramer, Andreas FH Pfeiffer, Olga Pivovarova, Natalia Rudovich
Apr 03, 2019
Diurnal carbohydrate and fat distribution modulates glycaemic control in rodents. In humans, the optimal timing of both macronutrients and its effects on glycaemic control after prolonged consumption are not studied in detail....
Time Domain Multiplexing for Efficiency Enhanced Piezoelectric Energy Harvesting in MEMS
The conversion efficiency of piezoelectric energy harvesters (EH) have been improved by several approaches including frequency up-conversion (FUC) techniques that trigger the high-frequency (HF) piezoelectric resonators using...
The Role of SGLT2 Inhibitors in Heart Failure
Vasiliki Tsampasian, Ranu Baral, Rahul Chattopadhyay, Maciej Debski, Shruti S Joshi, Johannes Reinhold, Marc R Dweck, Pankaj Garg, Vassilios S Vassiliou
Oct 01, 2021
AIMS: Recent randomised controlled trials (RCTs) have shown a significant prognostic benefit of sodium-glucose cotransporter 2 (SGLT2) inhibitors in the cardiovascular (CV) profile of patients with diabetes. This systematic...
Genetic Evidence for Repurposing of GLP1R (Glucagon-Like Peptide-1 Receptor) Agonists to Prevent Heart Failure.
Iyas Daghlas, Ville Karhunen, Devleena Ray, Verena Zuber, Stephen Burgess, Philip S Tsao, Julie A Lynch, Kyung Min Lee, Benjamin F Voight, Kyong-Mi Chang, Emma H Baker, Scott M Damrauer, Joanna MM Howson, Marijana Vujkovic, Dipender Gill
May 27, 2021
Background This study was designed to investigate the genetic evidence for repurposing of GLP1R (glucagon-like peptide-1 receptor) agonists to prevent heart failure (HF) and whether the potential benefit exceeds the benefit...
GLP1R Mendelian randomization Diabetes mellitus ejection fraction Heart Failure Biomarkers Blood Glucose Diabetes mellitus Type 2 Drug Repositioning genetic variation Genome-Wide Association Study Glucagon-Like Peptide-1 Receptor Glycated Hemoglobin Heart Failure Humans Hypoglycemic Agents Incretins Mendelian Randomization Analysis Risk Assessment Risk Factors Stroke Volume Treatment Outcome Ventricular Function Left
The Role of SGLT2 Inhibitors in Heart Failure
Vasiliki Tsampasian, Ranu Baral, Rahul Chattopadhyay, Maciej Debski, Shruti S Joshi, Johannes Reinhold, Marc R Dweck, Pankaj Garg, Vassilios S Vassiliou
Aug 27, 2021
Aims. Recent randomised controlled trials (RCTs) have shown a significant prognostic benefit of sodium-glucose cotransporter 2 (SGLT2) inhibitors in the cardiovascular (CV) profile of patients with diabetes. This systematic...
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