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Retinal regions shape human and murine Müller cell proteome profile and functionality.
Lew Kaplan, Corinne Drexler, Anna M Pfaller, Santra Brenna, Kirsten A Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schlötzer-Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M Hauck, Antje Grosche
Nov 05, 2022
The human macula is a highly specialized retinal region with pit-like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We...
The Trope of Silence in the Work of Herta Müller
P Shopin
Aug 09, 2017
With reference to Herta Müller’s fiction and non-fiction, my essay explores how the trope of silence is engaged to make sense of more abstract concepts. Drawing on conceptual metaphor theory, I argue that Müller uses silence as...
Language as a force for good in the work of Herta Müller
P Shopin
Oct 02, 2017
Herta Müller creates sophisticated metaphors to convey her vision of language and its relationship to suffering and subjugation. With reference to both her fiction and non‐fiction, this essay explores how she uses the idea of...
A conceptual study of a high gradient trapped field magnet (HG-TFM) toward providing a quasi-zero gravity space on Earth
Abstract: In this work, we propose a new concept of a high gradient trapped field magnet (HG-TFM). The HG-TFM is made from (RE)BaCuO bulk superconductors, in which slit ring bulks (slit-TFMs) are tightly stacked with TFM...
A conceptual study of a high gradient trapped field magnet (HG-TFM) toward providing a quasi-zero gravity space on Earth
Abstract: In this work, we propose a new concept of a high gradient trapped field magnet (HG-TFM). The HG-TFM is made from (RE)BaCuO bulk superconductors, in which slit ring bulks (slit-TFMs) are tightly stacked with TFM...
Validation of a desktop-Type magnet providing a quasi-microgravity space in a room-Temperature bore of a high-gradient trapped field magnet (HG-TFM)
Abstract
The concept of a high-gradient trapped field magnet (HG-TFM), which incorporates a hybrid system of two (RE)BaCuO superconducting bulk components with different functions...
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment.
Josy Augustine, Sofia Pavlou, Imran Ali, Kevin Harkin, Ema Ozaki, Matthew Campbell, Alan W Stitt, Heping Xu, Mei Chen
Jan 20, 2020
BACKGROUND: Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health and...
Factors predicting the success of trabeculectomy bleb enhancement with needling.
BACKGROUND: Bleb needling is widely used to restore flow and lower intraocular pressure (IOP) in a failing trabeculectomy. We aimed to measure the safety and efficacy of needling in a large cohort and identify factors that were...
Glaucoma glaucoma drainage implants Intraocular Pressure medications needling SURGERY Trabeculectomy Aged Aged 80 and over Female Glaucoma Humans Intraocular Pressure Kaplan-Meier Estimate Male Medical Audit Middle Aged Needles Prognosis Proportional Hazards Models Retrospective Studies Risk Factors Surgical Stomas Tonometry Ocular Trabeculectomy Visual Acuity
Relationship Between Ascending Thoracic Aortic Diameter and Blood Pressure
John DePaolo, Michael G Levin, Catherine Tcheandjieu, James R Priest, Dipender Gill, Stephen Burgess, Scott M Damrauer, Julio A Chirinos
Feb 09, 2023
BACKGROUND: Observational studies identified elevated blood pressure (BP) as a strong risk factor for thoracic aortic dilation, and BP reduction is the primary medical intervention recommended to prevent progression of aortic...
Functionalization of cellulose carbon dots with different elements (N, B and S) for mercury ion detection and anti-counterfeit applications
Xiaoning Li, Quanyu Shi, Meng Li, Ningxin Song, Yumeng Xiao, Huining Xiao, Tony D. James, Lei Feng
Jul 01, 2024
Mercury ion (Hg2+), as one of the most toxic heavy metal ions, accumulates easily in the environment, which can generate potential hazards to the ecosystem and human health. To effectively detect and remove...
Atmospheric Mercury Outflow from China and Interprovincial Trade.
Long Chen, Sai Liang, Yanxu Zhang, Maodian Liu, Jing Meng, Haoran Zhang, Xi Tang, Yumeng Li, Yindong Tong, Wei Zhang, Xuejun Wang, Jiong Shu
Apr 12, 2019
Mercury (Hg) is characterized by its ability to migrate between continents and its adverse effects on human health, arousing great concern around the world. The transboundary transport of large anthropogenic Hg emissions from...
Estimating the Population Benefits of Blood Pressure Lowering
Hannah Higgins, Amy M Mason, Susanna C Larsson, Dipender Gill, Claudia Langenberg, Stephen Burgess
Sep 20, 2021
Background The causal relevance of elevated blood pressure for several cardiovascular diseases (CVDs) is uncertain, as is the population impact of blood pressure lowering. This study systematically assesses evidence of causality...
Mendelian randomization cardiovascular disease Genetic epidemiology high blood pressure Hypertension Adult Aged Biological Specimen Banks blood pressure Cardiovascular Diseases Causality Genome-Wide Association Study Humans Hypertension Mendelian Randomization Analysis Middle Aged Polymorphism Single Nucleotide Risk Factors United Kingdom
Self-assembling fluorescent hydrogel for highly efficient water purification and photothermal conversion
Meng Li, Mengqing Yang, Bowen Liu, Hongmin Guo, Haotian Wang, Xiaoning Li, Lidong Wang, Tony D. James
Mar 01, 2022
Employing fluorescent hydrogels for hazardous Hg(II) detection and removal is an efficient method for water purification. However, it remains challenging to establish a fluorescent system with low detection limit and high...
Detection and adsorption Fluorescent hydrogel Solar steam generation Sulfydryl-based carbon dots /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
Functionalization of cellulose carbon dots with different elements (N, B and S) for mercury ion detection and anti-counterfeit applications
Xiaoning Li, Quanyu Shi, Meng Li, Ningxin Song, Yumeng Xiao, Huining Xiao, Tony D. James, Lei Feng
Jul 01, 2024
Mercury ion (Hg2+), as one of the most toxic heavy metal ions, accumulates easily in the environment, which can generate potential hazards to the ecosystem and human health. To effectively detect and remove...
HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.
Freya M Mowat, Ulrich FO Luhmann, Alexander J Smith, Clemens Lange, Yanai Duran, Sarah Harten, Deepa Shukla, Patrick H Maxwell, Robin R Ali, James WB Bainbridge
Mar 18, 2019
BACKGROUND: Hypoxia plays a key role in ischaemic and neovascular disorders of the retina. Cellular responses to oxygen are mediated by hypoxia-inducible transcription factors (HIFs) that are stabilised in hypoxia and induce the...
A practical graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>)based fluorescence sensor for the competitive detection of trithiocyanuric acid and mercury ions
Meng Li, Bo Wang, Xufei An, Zhiyong Li, Hongtao Zhu, Boyang Mao, David G. Calatayud, Tony D. James
Nov 01, 2019
A fluorescent sensor for the detection of trithiocyanuric acid (TCA)and Hg2+ was developed based on competitive interactions: non-covalent stacking between g-C3N4 and TCA vs coordinative...
A practical graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>)based fluorescence sensor for the competitive detection of trithiocyanuric acid and mercury ions
Meng Li, Bo Wang, Xufei An, Zhiyong Li, Hongtao Zhu, Boyang Mao, David G. Calatayud, Tony D. James
Nov 01, 2019
A fluorescent sensor for the detection of trithiocyanuric acid (TCA)and Hg2+ was developed based on competitive interactions: non-covalent stacking between g-C3N4 and TCA vs coordinative...
DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation
M Farlik, F Halbritter, F Müller, FA Choudry, P Ebert, J Klughammer, S Farrow, A Santoro, V Ciaurro, A Mathur, R Uppal, HG Stunnenberg, WH Ouwehand, E Laurenti, T Lengauer, M Frontini, C Bock
Jan 24, 2017
Efficacy and Safety of the Ab-interno Xen Gel Stent After Failed Trabeculectomy.
AIMS: To assess the efficacy and safety of the Xen gel stent in reducing intraocular pressure (IOP) in eyes with prior failed trabeculectomy and to determine the frequency of complications and further intervention. METHODS...
Glaucoma and intraocular pressure in EPIC-Norfolk Eye Study
Michelle PY Chan, David C Broadway, Anthony P Khawaja, Jennifer LY Yip, David F Garway-Heath, Jennifer M Burr, Robert Luben, Shabina Hayat, Nichola Dalzell, Kay-Tee Khaw, Paul J Foster
Jul 31, 2018
Objectives To report the distribution of intraocular pressure (IOP) by age and sex and the prevalence of glaucoma.Design Community based cross sectional observational study.Setting EPIC-Norfolk cohort in Norwich and the...
Self-assembling fluorescent hydrogel for highly efficient water purification and photothermal conversion
Meng Li, Mengqing Yang, Bowen Liu, Hongmin Guo, Haotian Wang, Xiaoning Li, Lidong Wang, Tony D. James
Mar 01, 2022
Employing fluorescent hydrogels for hazardous Hg(II) detection and removal is an efficient method for water purification. However, it remains challenging to establish a fluorescent system with low detection limit and high...
Detection and adsorption Fluorescent hydrogel Solar steam generation Sulfydryl-based carbon dots /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
Clinical impact of tissue sodium storage.
In recent times, the traditional nephrocentric, two-compartment model of body sodium has been challenged by long-term sodium balance studies and experimental work on the dermal interstitium and endothelial surface layer. In the...
Observations on the Cerebral Effects of Refractory Intracranial Hypertension After Severe Traumatic Brain Injury.
Joseph Donnelly, Peter Smielewski, Hadie Adams, Frederick A Zeiler, Danilo Cardim, Xiuyun Liu, Marta Fedriga, Peter Hutchinson, David K Menon, Marek Czosnyka
Jul 02, 2019
BACKGROUND: Raised intracranial pressure (ICP) is a prominent cause of morbidity and mortality after severe traumatic brain injury (TBI). However, in the clinical setting, little is known about the cerebral physiological...
autoregulation Cerebral hemodynamics Cerebral oxygenation cerebral perfusion pressure Intracranial Hypertension Intracranial Pressure Traumatic brain injury Adolescent Adult Arterial Pressure Brain Brain Injuries Traumatic Cerebrovascular Circulation Decompressive Craniectomy Female Glasgow Coma Scale Homeostasis Humans Intracranial Hypertension Male Mortality Oxygen Retrospective Studies Severity of Illness Index Time Factors Young Adult
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