Search
Results: 69
Focus U-Net
BACKGROUND: Colonoscopy remains the gold-standard screening for colorectal cancer. However, significant miss rates for polyps have been reported, particularly when there are multiple small adenomas. This presents an opportunity...
Genetic Risk, Muscle Strength, and Incident Stroke
Youngwon Kim, Semi Hwang, Stephen J Sharp, Shan Luo, Shiu Lun Au Yeung, Craig C Teerlink
Jul 12, 2021
OBJECTIVE: To examine the associations of muscle strength and genetic risk for stroke with stroke incidence. PARTICIPANTS AND METHODS: We included 284,767 white British participants of UK Biobank without genetic relatedness and...
Framework-isomerism
Nianyong Zhu, Debobroto Sensharma, Paul Wix, Matthew Lennox, Tina Düren, Wai-Yeung Wong, Wolfgang Schmitt
May 01, 2016
The synthesis and structure of a new, highly augmented {Cu2} ‘paddlewheel’-based metal-organic framework (MOF) that is stabilized by tritopic benzoate ligands is reported. The structure adopts an uncommon, less-symmetrical...
Framework-isomerism
Nianyong Zhu, Debobroto Sensharma, Paul Wix, Matthew Lennox, Tina Düren, Wai-Yeung Wong, Wolfgang Schmitt
May 01, 2016
The synthesis and structure of a new, highly augmented {Cu2} ‘paddlewheel’-based metal-organic framework (MOF) that is stabilized by tritopic benzoate ligands is reported. The structure adopts an uncommon, less-symmetrical...
Efficient Red Organic Light Emitting Diodes of Nona Coordinate Europium Tris(β-diketonato) Complexes Bearing 4'-Phenyl-2,2'
Rashid Ilmi, Jingyu Wang, José D.L. Dutra, Liang Zhou, Wei-Yeung Wong, Paul R. Raithby, Muhammad Khan
Jul 03, 2023
Two novel nona-coordinated Eu(III) complexes [Eu(btfa) 3(Ph-TerPyr)] (Eu-1) and [Eu(NTA) 3(Ph-TerPyr)] (Eu-2) have been synthesized and characterized. The structure of the complexes was elucidated by...
Data-driven network models for genetic circuits from time-series data with incomplete measurements.
Synthetic gene networks are frequently conceptualized and visualized as static graphs. This view of biological programming stands in stark contrast to the transient nature of biomolecular interaction, which is frequently enacted...
Efficient Red Organic Light Emitting Diodes of Nona Coordinate Europium Tris(β-diketonato) Complexes Bearing 4'-Phenyl-2,2'
Rashid Ilmi, Jingyu Wang, José D.L. Dutra, Liang Zhou, Wei-Yeung Wong, Paul R. Raithby, Muhammad Khan
Jul 03, 2023
Two novel nona-coordinated Eu(III) complexes [Eu(btfa) 3(Ph-TerPyr)] (Eu-1) and [Eu(NTA) 3(Ph-TerPyr)] (Eu-2) have been synthesized and characterized. The structure of the complexes was elucidated by...
PERK Activation Promotes Medulloblastoma Tumorigenesis by Attenuating Premalignant Granule Cell Precursor Apoptosis.
Yeung Ho, Xiting Li, Stephanie Jamison, Heather P Harding, Peter J McKinnon, David Ron, Wensheng Lin
Mar 09, 2016
Adult Animals Apoptosis Blotting Western Carcinogenesis Cell Transformation Neoplastic Cerebellar Neoplasms Child Child Preschool Disease Models Animal Enzyme Activation Female Humans Immunohistochemistry In Situ Nick-End Labeling Infant Male Medulloblastoma Mice Mice 129 Strain Mice Inbred C57BL Mice Mutant Strains Neural Stem Cells Neurons Real-Time Polymerase Chain Reaction eIF-2 Kinase
Dual role of the integrated stress response in medulloblastoma tumorigenesis.
Sarrabeth Stone, Yeung Ho, Xiting Li, Stephanie Jamison, Heather P Harding, David Ron, Wensheng Lin
Aug 16, 2017
In response to endoplasmic reticulum (ER) stress, activation of pancreatic ER kinase (PERK) coordinates an adaptive program known as the integrated stress response (ISR) by phosphorylating translation initiation factor 2α...
ER stress GADD34 integrated stress response Medulloblastoma Tumorigenesis Animals Apoptosis Cell Line Tumor Cell Proliferation Cell Transformation Neoplastic Cerebellar Neoplasms Endoplasmic reticulum stress Enzyme Activation Eukaryotic Initiation Factor-2 Gene Expression Regulation Neoplastic Genetic Predisposition to Disease Homozygote Humans Medulloblastoma Mice Inbred C57BL Mice Knockout Mutation Neoplastic Stem Cells Neovascularization Pathologic Patched-1 Receptor Phenotype Phosphorylation Protein Phosphatase 1 Signal Transduction Time Factors eIF-2 Kinase
Using Machine Learning to Make Computationally Inexpensive Projections of 21st Century Stratospheric Column Ozone Changes in the Tropics
James Keeble, Yu Yeung Scott Yiu, Alexander T. Archibald, Fiona O’Connor, Alistair Sellar, Jeremy Walton, John A. Pyle
Jan 28, 2021
Stratospheric ozone projections in the tropics, modeled using the UKESM1 Earth system model, are explored under different Shared Socioeconomic Pathways (SSPs). Consistent with other studies, it is found that tropical...
Impact of Genetically Predicted Red Blood Cell Traits on Venous Thromboembolism
Background Red blood cell (RBC) transfusion and erythropoiesis-stimulating agent administration are cornerstones of clinical practice, yet concerns exist as to potential increased risk of thrombotic events. This study aims to...
A Tris β-Diketonate Europium(III) Complex Based OLED Fabricated by Thermal Evaporation Method Displaying Efficient Bright Red Emission
Rashid Ilmi, Dayang Zhang, José D.L. Dutra, Necmi Dege, Liang Zhou, Wai-Yeung Wong, Paul Raithby, Muhammad Khan
Sep 30, 2021
A new tris β-diketonate europium(III) complex [Eu(btfa)3Py-Im] (Eu-1) (4,4,4-trifluoro-1-phenyl-1,3-butanedione (btfa) and 2-(2-pyridyl)benzimidazole (Py-Im)] has been synthesized and structurally characterized. A single crystal...
A Tris β-Diketonate Europium(III) Complex Based OLED Fabricated by Thermal Evaporation Method Displaying Efficient Bright Red Emission
Rashid Ilmi, Dayang Zhang, José D.L. Dutra, Necmi Dege, Liang Zhou, Wai-Yeung Wong, Paul Raithby, Muhammad Khan
Sep 30, 2021
A new tris β-diketonate europium(III) complex [Eu(btfa)3Py-Im] (Eu-1) (4,4,4-trifluoro-1-phenyl-1,3-butanedione (btfa) and 2-(2-pyridyl)benzimidazole (Py-Im)] has been synthesized and structurally characterized. A single crystal...
Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction
OBJECTIVE: To determine whether endogenous testosterone has a causal role in thromboembolism, heart failure, and myocardial infarction. DESIGN: Two sample mendelian randomisation study using genetic variants as instrumental...
Adult Aged Biological Specimen Banks Female Genetic Pleiotropy genetic variation Genome-Wide Association Study Heart Failure Humans Male Mendelian Randomization Analysis Middle Aged Myocardial Infarction Odds Ratio Randomized Controlled Trials as Topic Risk Factors Testosterone Thromboembolism United Kingdom White People
Calibrating the Dice Loss to Handle Neural Network Overconfidence for Biomedical Image Segmentation.
Michael Yeung, Leonardo Rundo, Yang Nan, Evis Sala, Carola-Bibiane Schönlieb, Guang Yang
Mar 25, 2023
The Dice similarity coefficient (DSC) is both a widely used metric and loss function for biomedical image segmentation due to its robustness to class imbalance. However, it is well known that the DSC loss is poorly calibrated...
Alpha-Synuclein Expression in the Oligodendrocyte Lineage
Mehdi Djelloul, Staffan Holmqvist, Antonio Boza-Serrano, Carla Azevedo, Maggie S Yeung, Stefano Goldwurm, Jonas Frisén, Tomas Deierborg, Laurent Roybon
Jun 01, 2020
In this study, we sought evidence for alpha-synuclein (ASYN) expression in oligodendrocytes, as a possible endogenous source of ASYN to explain its presence in glial inclusions found in multiple system atrophy (MSA) and...
Salts of Lanthanide(III) Hexafluoroacetylacetonates [Ln = Sm(III), Eu(III) and Tb(III)] with Dipyridylammonium Cations
Rashid Ilmi, Danyang Zhang, Leonardo Tensi, Houda Al-Sharji, Nawal K. Al-Rasbi, Alceo Macchioni, Liang Zhou, Wai-Yeung Wong, Paul Raithby, Muhammad S Khan
Jul 31, 2022
A series of tetrakis lanthanide complexes with the general formula [Ln(hfaa) 4] -(DpaH) + [Ln = (Sm-1), (Eu-1) and (Tb-1)], hfaa = hexafluroacetylacetonate and Dpa −2,2′-dipyridylamine] has...
Pharmacogenomics and the Yin/Yang actions of ginseng
Patrick Ying Kit Yue, Nai Ki Mak, Yuen Kit Cheng, Kar Wah Leung, Tzi Bun Ng, David Tai Ping Fan, Hin Wing Yeung, Ricky Ngok Shun Wong
Jun 16, 2011
In Chinese medicine, ginseng (Panax ginseng C.A. Meyer) has long been used as a general tonic or an adaptogen to promote longevity and enhance bodily functions. It has also been claimed to be effective in combating stress...
Salts of Lanthanide(III) Hexafluoroacetylacetonates [Ln = Sm(III), Eu(III) and Tb(III)] with Dipyridylammonium Cations
Rashid Ilmi, Danyang Zhang, Leonardo Tensi, Houda Al-Sharji, Nawal K. Al-Rasbi, Alceo Macchioni, Liang Zhou, Wai-Yeung Wong, Paul Raithby, Muhammad S Khan
Jul 31, 2022
A series of tetrakis lanthanide complexes with the general formula [Ln(hfaa) 4] -(DpaH) + [Ln = (Sm-1), (Eu-1) and (Tb-1)], hfaa = hexafluroacetylacetonate and Dpa −2,2′-dipyridylamine] has...
|
|< |
< |
1 |