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Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells.
Glenn R Bantug, Marco Fischer, Jasmin Grählert, Maria L Balmer, Gunhild Unterstab, Leyla Develioglu, Rebekah Steiner, Lianjun Zhang, Ana SH Costa, Patrick M Gubser, Anne-Valérie Burgener, Ursula Sauder, Jordan Löliger, Réka Belle, Sarah Dimeloe, Jonas Lötscher, Annaïse Jauch, Mike Recher, Gideon Hönger, Michael N Hall, Pedro Romero, Christian Frezza, Christoph Hess
Jun 14, 2018
Glycolysis is linked to the rapid response of memory CD8+ T cells, but the molecular and subcellular structural elements enabling enhanced glucose metabolism in nascent activated memory CD8+ T cells are unknown. We found that...
Akt GSK3-beta IFN-gamma VDAC Endoplasmic Reticulum Glycolysis Hexokinase mTOR memory CD8(+) T cells Mitochondria CD8-Positive T-Lymphocytes Cell Respiration Endoplasmic Reticulum Energy Metabolism Glycogen Synthase Kinase 3 beta Glycolysis Immunologic Memory Intracellular Membranes Lymphocyte Activation Mechanistic Target of Rapamycin Complex 2 Mitochondria Models Biological Proto-Oncogene Proteins c-akt Rapamycin-Insensitive Companion of mTOR Protein Signal Transduction
Fracture Incidence and the Relevance of Dietary and Lifestyle Factors Differ in the United Kingdom and Hong Kong
Richard PG Hayhoe, Ruth Chan, Jane Skinner, Jason Leung, Amy Jennings, Kay-Tee Khaw, Jean Woo, Ailsa A Welch
Oct 01, 2021
Geographic variation in fracture risk may be due to divergent profiles of dietary, lifestyle, and other risk factors between populations. We investigated differences in fracture rates between two older-population cohorts: the...
Reconstitution and Mechanistic Studies on the Staphylococcal agr Quorum Sensing Circuit
Boyuan Wang
Jan 01, 0001
Quorum sensing (QS) plays a central role in virulence induction in the commensal pathogen, Staphylococcus aureus. This bacterium secretes an auto-inducer peptide (AIP), a small, cyclic peptide containing a thiolactone linkage as...
Published by: Rockefeller University
Vent d’est
HK Miller
Aug 01, 2017
An evocation of the milieu of the original (London) Film Society, and an account of its famous screening of Eisenstein’s Battleship Potemkin in November 1929 as the culmination of four years of attempts to persuade its Soviet...
Film studies before film studies
HK Miller
Oct 10, 2016
This is the author accepted manuscript. The final version is available from Oxford University Press via http://dx.doi.org/10.1093/screen/hjw032
Towards a finite-time singularity of the Navier-Stokes equations Part 1. Derivation and analysis of dynamical system
© 2018 Cambridge University Press. The evolution towards a finite-time singularity of the Navier-Stokes equations for flow of an incompressible fluid of kinematic viscosity is studied, starting from a finite-energy configuration...
A SHORT NOTE ON CHANGES IN PRE-ASPIRATION IN WOODS CREE
Woods Cree has five pre-aspirated consonants which occur in coda position. While the coronal segments, ht and Jus, show little evidence of change, there is substantial evidence of weakening amongst the other three pre-aspirated...
Published by: Atlantic Provinces Linguistic Association
Viscous Thread Falling on a Spinning Surface
A rotational version of the fluid-mechanical sewing machine (FMSM) is investigated experimentally. A thin thread of silicon oil was dispensed at a constant flow rate Q from a height H and fell on a table rotating at an...
CD154 Induces Interleukin-6 Secretion by Kidney Tubular Epithelial Cells under Hypoxic Conditions
Antoine Dewitte, Julien Villeneuve, Sébastien Lepreux, Marion Bouchecareilh, Xavier Gauthereau, Claire Rigothier, Christian Combe, Alexandre Ouattara, Jean Ripoche
Mar 26, 2020
Inflammation is a major contributor to tubular epithelium injury in kidney disorders, and the involvement of blood platelets in driving inflammation is increasingly stressed. CD154, the ligand of CD40, is one of the mediators...
Published by: Mediators of inflammation
The histidine kinase AHK5 integrates endogenous and environmental signals in <em>Arabidopsis</em> guard cells
R Desikan, J Horak, C Chaban, V Mira-Rodado, J Witthoft, K Elgass, C Grefen, M-K Cheung, A J Meixner, Richard Hooley, S J Neill, J Travers Hancock, K Harter
Jun 18, 2008
Background: Stomatal guard cells monitor and respond to environmental and endogenous signals such that the stomatal aperture is continually optimised for water use efficiency. A key signalling molecule produced in guard...
The histidine kinase AHK5 integrates endogenous and environmental signals in <em>Arabidopsis</em> guard cells
R Desikan, J Horak, C Chaban, V Mira-Rodado, J Witthoft, K Elgass, C Grefen, M-K Cheung, A J Meixner, Richard Hooley, S J Neill, J Travers Hancock, K Harter
Jun 18, 2008
Background: Stomatal guard cells monitor and respond to environmental and endogenous signals such that the stomatal aperture is continually optimised for water use efficiency. A key signalling molecule produced in guard...
Serum BDNF levels before and after the development of mood disorders
K Ihara, H Yoshida, PB Jones, M Hashizume, Y Suzuki, H Ishijima, HK Kim, T Suzuki, M Hachisu
Feb 17, 2016
A SHORT NOTE ON CHANGES IN PRE-ASPIRATION IN WOODS CREE
Woods Cree has five pre-aspirated consonants which occur in coda position. While the coronal segments, ht and Jus, show little evidence of change, there is substantial evidence of weakening amongst the other three pre-aspirated...
Published by: Atlantic Provinces Linguistic Association
Culture-Sex Interaction and the Self-Report Empathy in Australians and Mainland Chinese.
Qing Zhao, David L Neumann, Yuan Cao, Simon Baron-Cohen, Chao Yan, Raymond CK Chan, David HK Shum
May 09, 2019
Empathy is the ability to understand and share other people's emotions. Researchers have debated whether Westerners and Asians differ in their self-report empathy. This study aimed to replicate a previously reported culture-sex...
Perovskite quantum dot-induced monochromatization for broadband photodetection of wafer-scale molybdenum disulfide
Abstract Two-dimensional transition metal dichalcogenide (2D TMD) crystals are versatile platforms for realizing emergent optoelectronic devices. However, the ability to produce large-area 2D TMDs...
M Kim, G Bae, KN Kim, HK Jo, DS Song, S Ji, D Jeon, S Ko, SJ Lee, S Choi, S Yim, W Song, S Myung, DH Yoon, KS An, SS Lee
Nov 18, 2022
Volcanic air pollution and human health
Abstract Volcanic air pollution from both explosive and effusive activity can affect large populations as far as thousands of kilometers away from the source, for days to decades or even...
C Stewart, DE Damby, CJ Horwell, T Elias, E Ilyinskaya, I Tomašek, BM Longo, Anja Schmidt, HK Carlsen, Emily Mason, PJ Baxter, S Cronin, C Witham
Jan 05, 2022
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