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Citalopram inhibits platelet function independently of SERT-mediated 5-HT transport.
Harvey G Roweth, Ruoling Yan, Nader H Bedwani, Alisha Chauhan, Nicole Fowler, Alice H Watson, Jean-Daniel Malcor, Stewart O Sage, Gavin E Jarvis
Apr 13, 2018
Citalopram prevents serotonin (5-HT) uptake into platelets by blocking the serotonin reuptake transporter (SERT). Although some clinical data suggest that selective serotonin reuptake inhibitors (SSRIs) may affect haemostasis...
Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity.
Edward T Wargent, Malgorzata S Martin-Gronert, Roselle L Cripps, Lora K Heisler, Giles SH Yeo, Susan E Ozanne, Jonathan RS Arch, Claire J Stocker
Aug 11, 2020
BACKGROUND: Though it is well established that neonatal nutrition plays a major role in lifelong offspring health, the mechanisms underpinning this have not been well defined. Early postnatal accelerated growth resulting from...
5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats.
Malgorzata S Martin-Gronert, Claire J Stocker, Edward T Wargent, Roselle L Cripps, Alastair S Garfield, Zorica Jovanovic, Giuseppe D'Agostino, Giles SH Yeo, Michael A Cawthorne, Jonathan RS Arch, Lora K Heisler, Susan E Ozanne
Apr 27, 2018
Although obesity is a global epidemic, the physiological mechanisms involved are not well understood. Recent advances reveal that susceptibility to obesity can be programmed by maternal and neonatal nutrition. Specifically, a...
Influence of Cholesterol and its Stereoisomers on Members of the Serotonin Receptor Family
Despite the ubiquity of cholesterol within the cell membrane, the mechanism by which it influences embedded proteins remains elusive. Numerous G-protein coupled receptors exhibit dramatic responses to membrane cholesterol...
Mismatch between midline shift and hematoma thickness as a prognostic factor of mortality in patients sustaining acute subdural hematoma.
Matheus Rodrigues de Souza, Caroline Ferreira Fagundes, Davi Jorge Fontoura Solla, Gustavo Carlos Lucena da Silva, Rafaela Borin Barreto, Manoel Jacobsen Teixeira, Robson Luis Oliveira de Amorim, Angelos G Kolias, Daniel Godoy, Wellingson Silva Paiva
Jul 09, 2021
BACKGROUND: Acute subdural hematoma (ASDH) is a traumatic lesion commonly found secondary to traumatic brain injury. Radiological findings on CT, such as hematoma thickness (HT) and structures midline shift (MLS), have an...
Mismatch between midline shift and hematoma thickness as a prognostic factor of mortality in patients sustaining acute subdural hematoma
Matheus Rodrigues de Souza, Caroline Ferreira Fagundes, Davi Jorge Fontoura Solla, Gustavo Carlos Lucena da Silva, Rafaela Borin Barreto, Manoel Jacobsen Teixeira, Robson Luis Oliveira de Amorim, Angelos G Kolias, Daniel Godoy, Wellingson Silva Paiva
May 26, 2021
Background: Acute subdural hematoma (ASDH) is a traumatic lesion commonly found secondary to traumatic brain injury. Radiological findings on CT, such as hematoma thickness (HT) and structures midline shift (MLS), have an...
Influence of Cholesterol and its Stereoisomers on Members of the Serotonin Receptor Family
Despite the ubiquity of cholesterol within the cell membrane, the mechanism by which it influences embedded proteins remains elusive. Numerous G-protein coupled receptors exhibit dramatic responses to membrane cholesterol...
Scene Walk
Abstract Scene Walk is a video viewing technique suited to first-person video recorded from wearable cameras. It integrates a 2D video player and visualisation of the camera trajectory into a...
Serotonin at the level of the amygdala and orbitofrontal cortex modulates distinct aspects of positive emotion in primates.
Impaired top-down regulation of the amygdala, and its modulation by serotonin (5-HT), is strongly implicated in the dysregulation of negative emotion that characterizes a number of affective disorders. However, the contribution...
Evidence for an effect of receptor density on ligand occupancy and agonist EC 50
Abstract: Drug-receptor interaction theory predicts that proportional receptor occupancy is a function of ligand concentration as defined by a ligand-receptor affinity constant, and is independent of receptor density. However...
Rapid Alterations in Rat Brain Tryptophan Hydroxylase Activity; Effects of Adrenal Steroids, Drugs and Stressors
Efrain Charles Azmitia, Jr.
Jan 01, 0001
Tryptophan (TP) hydroxylase activity was measured using a modification of the method developed by Ichiyama et al. (l968). The distribution of the enzyme in the rat brain was determined and found to correlate with serotonin...
Published by: Rockefeller University
Chronic administration of 13-<em>cis</em>-retinoic acid does not alter the number of serotoninergic neurons in the mouse raphe nuclei
The synthetic retinoid previous term13-cis-retinoicnext term acid (previous term13-cisnext term-RA), prescribed for the treatment of severe nodular acne, has been linked to an increased incidence of depression. previous...
Collision-Induced Subduction Polarity Reversal Explains the Crustal Structure of Northern Borneo
Abstract: Subduction polarity reversal (SPR) is a key subduction initiation mechanism often associated with arc‐continent collision zones. Northern Borneo has long been recognized as a location where sequential but opposing...
Evidence for an effect of receptor density on ligand occupancy and agonist EC50.
Drug-receptor interaction theory predicts that proportional receptor occupancy is a function of ligand concentration as defined by a ligand-receptor affinity constant, and is independent of receptor density. However, we...
The enone motif of (+)-grandifloracin is not essential for 'anti-austerity' antiproliferative activity
Monika Ali Khan, Pauline J. Wood, Natasha M. Lamb-Guhren, Lorenzo Caggiano, Gabriele Kociok-Köhn, David Tosh, Simon E. Lewis
Jul 01, 2014
We report the synthesis and biological evaluation of three analogues of the natural product (+)-grandifloracin (+)-1. All three analogues exhibit enhanced antiproliferative activity against PANC-1 and HT-29 cells compared to the...
A SHORT NOTE ON CHANGES IN PRE-ASPIRATION IN WOODS CREE
Woods Cree has five pre-aspirated consonants which occur in coda position. While the coronal segments, ht and Jus, show little evidence of change, there is substantial evidence of weakening amongst the other three pre-aspirated...
Published by: Atlantic Provinces Linguistic Association
Diamond power devices
Abstract: With its remarkable electro-thermal properties such as the highest known thermal conductivity (~22 W cm−1∙K−1 at RT of any material, high hole mobility (>2000 cm2 V−1 s−1), high critical electric field (>10 MV cm−1)...
Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice.
Benjamin U Phillips, Sigma Dewan, Simon RO Nilsson, Trevor W Robbins, Christopher J Heath, Lisa M Saksida, Timothy J Bussey, Johan Alsiö
Jul 13, 2018
RATIONALE: Dysregulation of the serotonin (5-HT) system is a pathophysiological component in major depressive disorder (MDD), a condition closely associated with abnormal emotional responsivity to positive and negative feedback....
5-HT2C receptor SB 242084 WAY 163909 Aminopyridines Animals Azepines Depressive Disorder Major Discrimination Learning Indoles Male Mice Probability Learning Receptor Serotonin 5-HT2C Reinforcement psychology Reversal Learning Serotonin 5-HT2 Receptor Agonists Serotonin 5-HT2 Receptor Antagonists Task Performance and Analysis Visual Perception
The enone motif of (+)-grandifloracin is not essential for 'anti-austerity' antiproliferative activity
Monika Ali Khan, Pauline J. Wood, Natasha M. Lamb-Guhren, Lorenzo Caggiano, Gabriele Kociok-Köhn, David Tosh, Simon E. Lewis
Jul 01, 2014
We report the synthesis and biological evaluation of three analogues of the natural product (+)-grandifloracin (+)-1. All three analogues exhibit enhanced antiproliferative activity against PANC-1 and HT-29 cells compared to the...
Chronic administration of 13-<em>cis</em>-retinoic acid does not alter the number of serotoninergic neurons in the mouse raphe nuclei
The synthetic retinoid previous term13-cis-retinoicnext term acid (previous term13-cisnext term-RA), prescribed for the treatment of severe nodular acne, has been linked to an increased incidence of depression. previous...
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