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A subset of dendritic cells induces CD4+ T cells to produce IFN-? by an IL-12-independent but CD70-dependent mechanism in vivo
Interferon (IFN)-?, a cytokine critical for resistance to infection and tumors, is produced by CD4+ helper T lymphocytes after stimulation by cultured dendritic cells (DCs) that secrete a cofactor, interleukin (IL)-12. We have...
Published by: Rockefeller University