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Dendrimer Technology in Glioma
Novel therapeutic and diagnostic methods are sorely needed for gliomas, which contribute yearly to hundreds of thousands of cancer deaths worldwide. Despite the outpouring of research efforts and funding aimed at improving...
Published by: Cancers
Molecular Pathways and Genomic Landscape of Glioblastoma Stem Cells
Glioblastoma (GBM) is an aggressive tumor of the central nervous system categorized by the World Health Organization as a Grade 4 astrocytoma. Despite treatment with surgical resection, adjuvant chemotherapy, and radiation...
Polymeric Nanoparticles in Brain Cancer Therapy
Chad A Caraway, Hallie Gaitsch, Elizabeth E Wicks, Anita Kalluri, Navya Kunadi, Betty M Tyler
Jul 22, 2022
Translation of novel therapies for brain cancer into clinical practice is of the utmost importance as primary brain tumors are responsible for more than 200,000 deaths worldwide each year. While many research efforts have been...
Molecular Pathways and Genomic Landscape of Glioblastoma Stem Cells
Glioblastoma (GBM) is an aggressive tumor of the central nervous system categorized by the World Health Organization as a Grade 4 astrocytoma. Despite treatment with surgical resection, adjuvant chemotherapy, and radiation...
Metformin and Cancer, an Ambiguanidous Relationship.
Sarah J Skuli, Safwan Alomari, Hallie Gaitsch, A'ishah Bakayoko, Nicolas Skuli, Betty M Tyler
May 21, 2022
The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus, drugs targeting cancer cell metabolism may have promising therapeutic potential. Previous reports demonstrate that the widely used...
Metformin and Cancer, an Ambiguanidous Relationship.
Sarah J Skuli, Safwan Alomari, Hallie Gaitsch, A'ishah Bakayoko, Nicolas Skuli, Betty M Tyler
Jun 29, 2022
The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus, drugs targeting cancer cell metabolism may have promising therapeutic potential. Previous reports demonstrate that the widely used...
Polymeric Nanoparticles in Brain Cancer Therapy
Chad A Caraway, Hallie Gaitsch, Elizabeth E Wicks, Anita Kalluri, Navya Kunadi, Betty M Tyler
Sep 02, 2022
Translation of novel therapies for brain cancer into clinical practice is of the utmost importance as primary brain tumors are responsible for more than 200,000 deaths worldwide each year. While many research efforts have been...
Paleoepidemiology of cribra orbitalia
Tianyi Wang, Clare McFadden, Hallie Buckley, Kate Domett, Anna Willis, Hiep H Trinh, Hirofumi Matsumura, Melandri Vlok, Marc F Oxenham
Apr 03, 2023
OBJECTIVES: We test the hypothesis that the condition(s) leading to the development of cribra orbitalia at Con Co Ngua, an early seventh millennium sedentary foraging community in Vietnam, effectively reduced the resilience of...
The Grizzly, October 26, 2006
Kerri Landis, Marlena M. McMahon-Purk, Sarah Keck, Erin Padovani, Amanda D'Amico, Hallie Andrew, Brandon Brown, Matt Terry, Alex Ernst, Chris Curley, Danielle Langdon, Matthew Pastor, Tyler Johnson
Jan 01, 0001
Editorial: Putting the Pieces Back Together Possible Scam Raises Concerns Town Hall Meeting Brings Forth Campus Issues Food Drive a Success Fall is in the Air Story Behind the Statue: "Praha" Get to Know the Nominees ...
Ursinus College Collegeville Pennsylvania newspaper Racism campus safety student government Sodexo Steve Tobin campus sculptures Homecoming Judiciary Board study abroad Volleyball Football Soccer cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Body mass index and risk of dying from a bloodstream infection
Tormod Rogne, Erik Solligård, Stephen Burgess, Ben M Brumpton, Julie Paulsen, Hallie C Prescott, Randi M Mohus, Lise T Gustad, Arne Mehl, Bjørn O Åsvold, Andrew T DeWan, Jan K Damås
Dec 16, 2020
BACKGROUND: In observational studies of the general population, higher body mass index (BMI) has been associated with increased incidence of and mortality from bloodstream infection (BSI) and sepsis. On the other hand, higher...
Forager and farmer evolutionary adaptations to malaria evidenced by 7000 years of thalassemia in Southeast Asia.
Melandri Vlok, Hallie R Buckley, Justyna J Miszkiewicz, Meg M Walker, Kate Domett, Anna Willis, Hiep H Trinh, Tran T Minh, Mai Huong T Nguyen, Lan Cuong Nguyen, Hirofumi Matsumura, Tianyi Wang, Huu T Nghia, Marc F Oxenham
Mar 11, 2021
Global prevalence and disease burden of vitamin D deficiency
Daniel E Roth, Steven A Abrams, John Aloia, Gilles Bergeron, Megan W Bourassa, Kenneth H Brown, Mona S Calvo, Kevin D Cashman, Gerald Combs, Luz María De-Regil, Maria Elena Jefferds, Kerry S Jones, Hallie Kapner, Adrian R Martineau, Lynnette M Neufeld, Rosemary L Schleicher, Tom D Thacher, Susan J Whiting
Jul 24, 2019
Vitamin D is an essential nutrient for bone health and may influence the risks of respiratory illness, adverse pregnancy outcomes, and chronic diseases of adulthood. Because many countries have a relatively low supply of foods...
The Sequential Organ Failure Assessment (SOFA) Score
Rui Moreno, Andrew Rhodes, Lise Piquilloud, Glenn Hernandez, Jukka Takala, Hayley B Gershengorn, Miguel Tavares, Craig M Coopersmith, Sheila N Myatra, Mervyn Singer, Ederlon Rezende, Hallie C Prescott, Márcio Soares, Jean-François Timsit, Dylan W de Lange, Christian Jung, Jan J De Waele, Greg S Martin, Charlotte Summers, Elie Azoulay, Tomoko Fujii, Anthony S McLean, Jean-Louis Vincent
Jan 13, 2023
The Sequential Organ Failure Assessment (SOFA) score was developed more than 25 years ago to provide a simple method of assessing and monitoring organ dysfunction in critically ill patients. Changes in clinical practice over the...
The prehistoric peopling of Southeast Asia.
Hugh McColl, Fernando Racimo, Lasse Vinner, Fabrice Demeter, Takashi Gakuhari, J Víctor Moreno-Mayar, George van Driem, Uffe Gram Wilken, Andaine Seguin-Orlando, Constanza de la Fuente Castro, Sally Wasef, Rasmi Shoocongdej, Viengkeo Souksavatdy, Thongsa Sayavongkhamdy, Mohd Mokhtar Saidin, Morten E Allentoft, Takehiro Sato, Anna-Sapfo Malaspinas, Farhang A Aghakhanian, Thorfinn Korneliussen, Ana Prohaska, Ashot Margaryan, Peter de Barros Damgaard, Supannee Kaewsutthi, Patcharee Lertrit, Thi Mai Huong Nguyen, Hsiao-Chun Hung, Thi Minh Tran, Huu Nghia Truong, Giang Hai Nguyen, Shaiful Shahidan, Ketut Wiradnyana, Hiromi Matsumae, Nobuo Shigehara, Minoru Yoneda, Hajime Ishida, Tadayuki Masuyama, Yasuhiro Yamada, Atsushi Tajima, Hiroki Shibata, Atsushi Toyoda, Tsunehiko Hanihara, Shigeki Nakagome, Thibaut Deviese, Anne-Marie Bacon, Philippe Duringer, Jean-Luc Ponche, Laura Shackelford, Elise Patole-Edoumba, Anh Tuan Nguyen, Bérénice Bellina-Pryce, Jean-Christophe Galipaud, Rebecca Kinaston, Hallie Buckley, Christophe Pottier, Simon Rasmussen, Tom Higham, Robert A Foley, Marta Mirazón Lahr, Ludovic Orlando, Martin Sikora, Maude E Phipps, Hiroki Oota, Charles Higham, David M Lambert, Eske Willerslev
Oct 31, 2018
Sex specific associations in genome wide association analysis of renal cell carcinoma.
Ruhina S Laskar, David C Muller, Peng Li, Mitchell J Machiela, Yuanqing Ye, Valerie Gaborieau, Matthieu Foll, Jonathan N Hofmann, Leandro Colli, Joshua N Sampson, Zhaoming Wang, Delphine Bacq-Daian, Anne Boland, Behnoush Abedi-Ardekani, Geoffroy Durand, Florence Le Calvez-Kelm, Nivonirina Robinot, Helene Blanche, Egor Prokhortchouk, Konstantin G Skryabin, Laurie Burdett, Meredith Yeager, Sanja Radojevic-Skodric, Slavisa Savic, Lenka Foretova, Ivana Holcatova, Vladimir Janout, Dana Mates, Stefan Rascu, Anush Mukeria, David Zaridze, Vladimir Bencko, Cezary Cybulski, Eleonora Fabianova, Viorel Jinga, Jolanta Lissowska, Jan Lubinski, Marie Navratilova, Peter Rudnai, Beata Świątkowska, Simone Benhamou, Geraldine Cancel-Tassin, Olivier Cussenot, Antonia Trichopoulou, Elio Riboli, Kim Overvad, Salvatore Panico, Borje Ljungberg, Raviprakash T Sitaram, Graham G Giles, Roger L Milne, Gianluca Severi, Fiona Bruinsma, Tony Fletcher, Kvetoslava Koppova, Susanna C Larsson, Alicja Wolk, Rosamonde E Banks, Peter J Selby, Douglas F Easton, Paul Pharoah, Gabriella Andreotti, Laura E Beane Freeman, Stella Koutros, Demetrius Albanes, Satu Männistö, Stephanie Weinstein, Peter E Clark, Todd L Edwards, Loren Lipworth, Hallie Carol, Matthew L Freedman, Mark M Pomerantz, Eunyoung Cho, Peter Kraft, Mark A Preston, Kathryn M Wilson, J Michael Gaziano, Howard D Sesso, Amanda Black, Neal D Freedman, Wen-Yi Huang, John G Anema, Richard J Kahnoski, Brian R Lane, Sabrina L Noyes, David Petillo, Bin Tean Teh, Ulrike Peters, Emily White, Garnet L Anderson, Lisa Johnson, Juhua Luo, Wong-Ho Chow, Lee E Moore, Toni K Choueiri, Christopher Wood, Mattias Johansson, James D Mckay, Kevin M Brown, Nathaniel Rothman, Mark G Lathrop, Jean-Francois Deleuze, Xifeng Wu, Paul Brennan, Stephen J Chanock, Mark P Purdue, Ghislaine Scelo
Jun 25, 2019
Renal cell carcinoma (RCC) has an undisputed genetic component and a stable 2:1 male to female sex ratio in its incidence across populations, suggesting possible sexual dimorphism in its genetic susceptibility. We conducted the...
Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.
Mitchell J Machiela, Jonathan N Hofmann, Robert Carreras-Torres, Kevin M Brown, Mattias Johansson, Zhaoming Wang, Matthieu Foll, Peng Li, Nathaniel Rothman, Sharon A Savage, Valerie Gaborieau, James D Mckay, Yuanqing Ye, Marc Henrion, Fiona Bruinsma, Susan Jordan, Gianluca Severi, Kristian Hveem, Lars J Vatten, Tony Fletcher, Kvetoslava Koppova, Susanna C Larsson, Alicja Wolk, Rosamonde E Banks, Peter J Selby, Douglas F Easton, Paul Pharoah, Gabriella Andreotti, Laura E Beane Freeman, Stella Koutros, Demetrius Albanes, Satu Mannisto, Stephanie Weinstein, Peter E Clark, Todd E Edwards, Loren Lipworth, Susan M Gapstur, Victoria L Stevens, Hallie Carol, Matthew L Freedman, Mark M Pomerantz, Eunyoung Cho, Peter Kraft, Mark A Preston, Kathryn M Wilson, J Michael Gaziano, Howard S Sesso, Amanda Black, Neal D Freedman, Wen-Yi Huang, John G Anema, Richard J Kahnoski, Brian R Lane, Sabrina L Noyes, David Petillo, Leandro M Colli, Joshua N Sampson, Celine Besse, Helene Blanche, Anne Boland, Laurie Burdette, Egor Prokhortchouk, Konstantin G Skryabin, Meredith Yeager, Mirjana Mijuskovic, Miodrag Ognjanovic, Lenka Foretova, Ivana Holcatova, Vladimir Janout, Dana Mates, Anush Mukeriya, Stefan Rascu, David Zaridze, Vladimir Bencko, Cezary Cybulski, Eleonora Fabianova, Viorel Jinga, Jolanta Lissowska, Jan Lubinski, Marie Navratilova, Peter Rudnai, Neonila Szeszenia-Dabrowska, Simone Benhamou, Geraldine Cancel-Tassin, Olivier Cussenot, H Bas Bueno-De-Mesquita, Federico Canzian, Eric J Duell, Börje Ljungberg, Raviprakash T Sitaram, Ulrike Peters, Emily White, Garnet L Anderson, Lisa Johnson, Juhua Luo, Julie Buring, I-Min Lee, Wong-Ho Chow, Lee E Moore, Christopher Wood, Timothy Eisen, James Larkin, Toni K Choueiri, G Mark Lathrop, Bin Tean Teh, Jean-Francois Deleuze, Xifeng Wu, Richard S Houlston, Paul Brennan, Stephen J Chanock, Ghislaine Scelo, Mark P Purdue
Jun 15, 2018
BACKGROUND: Relative telomere length in peripheral blood leukocytes has been evaluated as a potential biomarker for renal cell carcinoma (RCC) risk in several studies, with conflicting findings. OBJECTIVE: We performed an...
Genetic variants Mendelian randomization renal cell carcinoma risk telomere Length Carcinoma Renal Cell Case-Control Studies Genetic Predisposition to Disease Genome-Wide Association Study Humans Kidney Neoplasms Leukocytes Mendelian Randomization Analysis Odds Ratio Phenotype Polymorphism Single Nucleotide Risk Assessment Risk Factors Telomere Telomere Homeostasis
The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study.
Mattias Johansson, Robert Carreras-Torres, Ghislaine Scelo, Mark P Purdue, Daniela Mariosa, David C Muller, Nicolas J Timpson, Philip C Haycock, Kevin M Brown, Zhaoming Wang, Yuanqing Ye, Jonathan N Hofmann, Matthieu Foll, Valerie Gaborieau, Mitchell J Machiela, Leandro M Colli, Peng Li, Jean-Guillaume Garnier, Helene Blanche, Anne Boland, Laurie Burdette, Egor Prokhortchouk, Konstantin G Skryabin, Meredith Yeager, Sanja Radojevic-Skodric, Simona Ognjanovic, Lenka Foretova, Ivana Holcatova, Vladimir Janout, Dana Mates, Anush Mukeriya, Stefan Rascu, David Zaridze, Vladimir Bencko, Cezary Cybulski, Eleonora Fabianova, Viorel Jinga, Jolanta Lissowska, Jan Lubinski, Marie Navratilova, Peter Rudnai, Simone Benhamou, Geraldine Cancel-Tassin, Olivier Cussenot, Elisabete Weiderpass, Börje Ljungberg, Raviprakash Tumkur Sitaram, Christel Häggström, Fiona Bruinsma, Susan J Jordan, Gianluca Severi, Ingrid Winship, Kristian Hveem, Lars J Vatten, Tony Fletcher, Susanna C Larsson, Alicja Wolk, Rosamonde E Banks, Peter J Selby, Douglas F Easton, Gabriella Andreotti, Laura E Beane Freeman, Stella Koutros, Satu Männistö, Stephanie Weinstein, Peter E Clark, Todd L Edwards, Loren Lipworth, Susan M Gapstur, Victoria L Stevens, Hallie Carol, Matthew L Freedman, Mark M Pomerantz, Eunyoung Cho, Kathryn M Wilson, J Michael Gaziano, Howard D Sesso, Neal D Freedman, Alexander S Parker, Jeanette E Eckel-Passow, Wen-Yi Huang, Richard J Kahnoski, Brian R Lane, Sabrina L Noyes, David Petillo, Bin Tean Teh, Ulrike Peters, Emily White, Garnet L Anderson, Lisa Johnson, Juhua Luo, Julie Buring, I-Min Lee, Wong-Ho Chow, Lee E Moore, Timothy Eisen, Marc Henrion, James Larkin, Poulami Barman, Bradley C Leibovich, Toni K Choueiri, G Mark Lathrop, Jean-Francois Deleuze, Marc Gunter, James D Mckay, Xifeng Wu, Richard S Houlston, Stephen J Chanock, Caroline Relton, J Brent Richards, Richard M Martin, George Davey Smith, Paul Brennan
Feb 25, 2019
BACKGROUND: Several obesity-related factors have been associated with renal cell carcinoma (RCC), but it is unclear which individual factors directly influence risk. We addressed this question using genetic markers as proxies...