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Structural and Functional Analysis of Substrate Recognition and Inhibition of the Multidrug Transporters MRP1 and MRP2
Harlan Linver Pietz
Jan 01, 0001
Neuroblastoma is the most common extracranial tumor of young children, and the five-year overall survival of children with high-risk disease is less than 50%. Overexpression of multidrug resistance protein 1 (MRP1), a plasma...
Published by: Rockefeller University
The Ursinus Weekly, October 28, 1946
Jane Rathgeb
Jan 01, 0001
Students receive charter to F.T.A. from R.C. Webster Five students invited to join membership of English Club Men's council meets; elects Sheridan Much secretary-treasurer Seniors to have Alex Bartha play for annual dance ...
Ursinus College Collegeville Pennsylvania newspaper Future Teachers of America English Club student government Halloween Debate Club Anne Murkovich Maurice Armstrong Messiah Sigma Rho Lambda YMCA YWCA field hockey Football Soccer Eddie Miller cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease.
Connor A Emdin, Amit V Khera, Mark Chaffin, Derek Klarin, Pradeep Natarajan, Krishna Aragam, Mary Haas, Alexander Bick, Seyedeh M Zekavat, Akihiro Nomura, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Daniel Chasman, Paul Ridker, Joshua Denny, Lisa Bastarache, Judith H Lichtman, Gail D'Onofrio, Jennifer Mattera, John A Spertus, Wayne H-H Sheu, Kent D Taylor, Bruce M Psaty, Stephen S Rich, Wendy Post, Jerome I Rotter, Yii-Der Ida Chen, Harlan Krumholz, Danish Saleheen, Stacey Gabriel, Sekar Kathiresan
Jun 13, 2018
Less than 3% of protein-coding genetic variants are predicted to result in loss of protein function through the introduction of a stop codon, frameshift, or the disruption of an essential splice site; however, such predicted...
Equalization of four cardiovascular risk algorithms after systematic recalibration
Lisa Pennells, Stephen Kaptoge, Angela Wood, Mike Sweeting, Xiaohui Zhao, Ian White, Stephen Burgess, Peter Willeit, Thomas Bolton, Karel GM Moons, Yvonne T van der Schouw, Randi Selmer, Kay-Tee Khaw, Vilmundur Gudnason, Gerd Assmann, Philippe Amouyel, Veikko Salomaa, Mika Kivimaki, Børge G Nordestgaard, Michael J Blaha, Lewis H Kuller, Hermann Brenner, Richard F Gillum, Christa Meisinger, Ian Ford, Matthew W Knuiman, Annika Rosengren, Debbie A Lawlor, Henry Völzke, Cyrus Cooper, Alejandro Marín Ibañez, Edoardo Casiglia, Jussi Kauhanen, Jackie A Cooper, Beatriz Rodriguez, Johan Sundström, Elizabeth Barrett-Connor, Rachel Dankner, Paul J Nietert, Karina W Davidson, Robert B Wallace, Dan G Blazer, Cecilia Björkelund, Chiara Donfrancesco, Harlan M Krumholz, Aulikki Nissinen, Barry R Davis, Sean Coady, Peter H Whincup, Torben Jørgensen, Pierre Ducimetiere, Maurizio Trevisan, Gunnar Engström, Carlos J Crespo, Tom W Meade, Marjolein Visser, Daan Kromhout, Stefan Kiechl, Makoto Daimon, Jackie F Price, Agustin Gómez de la Cámara, J Wouter Jukema, Benoît Lamarche, Altan Onat, Leon A Simons, Maryam Kavousi, Yoav Ben-Shlomo, John Gallacher, Jacqueline M Dekker, Hisatomi Arima, Nawar Shara, Robert W Tipping, Ronan Roussel, Eric J Brunner, Wolfgang Koenig, Masaru Sakurai, Jelena Pavlovic, Ron T Gansevoort, Dorothea Nagel, Uri Goldbourt, Elizabeth LM Barr, Luigi Palmieri, Inger Njølstad, Shinichi Sato, WM Monique Verschuren, Cherian V Varghese, Ian Graham, Oyere Onuma, Philip Greenland, Mark Woodward, Majid Ezzati, Bruce M Psaty, Naveed Sattar, Rod Jackson, Paul M Ridker, Nancy R Cook, Ralph B D'Agostino, Simon G Thompson, John Danesh, Emanuele Di Angelantonio, Emerging Risk Factors Collaboration
Dec 11, 2018
AIMS: There is debate about the optimum algorithm for cardiovascular disease (CVD) risk estimation. We conducted head-to-head comparisons of four algorithms recommended by primary prevention guidelines, before and after...