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Annotation of mammalian primary microRNAs.
BACKGROUND: MicroRNAs (miRNAs) are important regulators of gene expression and have been implicated in development, differentiation and pathogenesis. Hundreds of miRNAs have been discovered in mammalian genomes. Approximately...
miRBase
miRBase is the central online repository for microRNA (miRNA) nomenclature, sequence data, annotation and target prediction. The current release (10.0) contains 5071 miRNA loci from 58 species, expressing 5922 distinct mature...
iMotifs
MOTIVATION: Short sequence motifs are an important class of models in molecular biology, used most commonly for describing transcription factor binding site specificity patterns. High-throughput methods have been recently...
MiR-221 influences effector functions and actin cytoskeleton in mast cells.
Ramon J Mayoral, Lorenzo Deho, Nicole Rusca, Nenad Bartonicek, Harpreet Kaur Saini, Anton J Enright, Silvia Monticelli
Jan 23, 2018
Mast cells have essential effector and immunoregulatory functions in IgE-associated allergic disorders and certain innate and adaptive immune responses, but the role of miRNAs in regulating mast cell functions is almost...
3T3 Cells Actin Cytoskeleton Actins Animals Base Sequence Bone Marrow Cells Cell Adhesion Cell Degranulation Cell Differentiation Cell Movement Cell Proliferation Cyclin-Dependent Kinase Inhibitor p27 Down-Regulation FIBROBLASTS Gene Knockdown Techniques Lentivirus Mast Cells Mice Mice Inbred C57BL MicroRNAs Molecular Sequence Data Oligonucleotide Array Sequence Analysis Up-Regulation
Transposon-driven transcription is a conserved feature of vertebrate spermatogenesis and transcript evolution.
Matthew P Davis, Claudia Carrieri, Harpreet K Saini, Stijn van Dongen, Tommaso Leonardi, Giovanni Bussotti, Jack M Monahan, Tania Auchynnikava, Angelo Bitetti, Juri Rappsilber, Robin C Allshire, Alena Shkumatava, Dónal O'Carroll, Anton J Enright
Nov 23, 2017
Spermatogenesis is associated with major and unique changes to chromosomes and chromatin. Here, we sought to understand the impact of these changes on spermatogenic transcriptomes. We show that long terminal repeats (LTRs) of...
endogenous retroviruses genome evolution lncRNA Spermatogenesis Transcriptome Animals DNA Transposable Elements Endogenous Retroviruses evolution Molecular Genomics Male Mice Open Reading Frames Promoter Regions Genetic RNA Long Noncoding Spermatocytes Spermatogenesis Terminal Repeat Sequences Transcription Genetic Transcriptome
Small non-coding RNA sequencing reveals global dysregulation of piwi-interacting RNA (piRNA) expression in gonadal malignant germ cell tumours.
Sean Laidlaw, Luz Alonso-Crisostomo, Shivani Bailey, Harpreet K Saini, Attila Molnár, James C Nicholson, Anton J Enright, Cinzia G Scarpini, Raheleh Rahbari, Nicholas Coleman, Matthew J Murray, on behalf the Children's Cancer and Leukaemia Group
Oct 26, 2022
The two most common histological subtypes of malignant germ cell tumour are distinguished by global microRNA profiles, associated with differential transcription factor expression.
Matthew J Murray, Harpreet K Saini, Stijn van Dongen, Roger D Palmer, Balaji Muralidhar, Mark R Pett, Matias Piipari, Claire M Thornton, James C Nicholson, Anton J Enright, Nicholas Coleman
Jun 14, 2011
Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia.
Carme Camps, Harpreet K Saini, David R Mole, Hani Choudhry, Martin Reczko, José Afonso Guerra-Assunção, Ya-Min Tian, Francesca M Buffa, Adrian L Harris, Artemis G Hatzigeorgiou, Anton J Enright, Jiannis Ragoussis
Jan 23, 2018
BACKGROUND: In mammalians, HIF is a master regulator of hypoxia gene expression through direct binding to DNA, while its role in microRNA expression regulation, critical in the hypoxia response, is not elucidated genome wide....
Visualization and analysis of RNA-Seq assembly graphs.
Fahmi W Nazarie, Barbara Shih, Tim Angus, Mark W Barnett, Sz-Hau Chen, Kim M Summers, Karsten Klein, Geoffrey J Faulkner, Harpreet K Saini, Mick Watson, Stijn van Dongen, Anton J Enright, Tom C Freeman
Jan 21, 2020
RNA-Seq is a powerful transcriptome profiling technology enabling transcript discovery and quantification. Whilst most commonly used for gene-level quantification, the data can be used for the analysis of transcript isoforms....
Extracellular vesicles are independent metabolic units with asparaginase activity.
Fingerprint Presentation Attack Detection Using Transfer Learning Approach
In this busy world, biometric authentication methods are serving as fast authentication means. But with growing dependencies on these systems, attackers have tried to exploit these systems through various attacks; thus, there is...
Published by: IGI Global Scientific Publishing
Managing Consumer Loyalty
A growing body of academic and practitioner literature has highlighted the role of consumer experience management in maintaining long-term relationships with consumers. However, related studies are still divergent and there is...
Published by: IGI Global Scientific Publishing
Predicting Marathi News Class Using Semantic Entity-Driven Clustering Approach
Document management is a need for an era and managing documents in the regional languages is a significant and untouched area. Marathi corpus consisting of news is processed to form Group Entity document matrix Marathi (GEDMM)...
Published by: IGI Global Scientific Publishing
Thoracic metastasis in advanced ovarian cancer
OBJECTIVE: To determine which computed tomography (CT) imaging features predict pleural malignancy in patients with advanced epithelial ovarian carcinoma (EOC) using video-assisted thoracic surgery (VATS), pathology, and...
A Study on the Impact of the COVID-19 Pandemic on Primary, Secondary, and Tertiary Sectors of the Indian Economy
COVID-19 emerged in China in December. The World Health Organization declares this virus as Global Disaster in March. The coronavirus has affected the social, economic, political dimensions of the nations globally. In this...
Published by: IGI Global Scientific Publishing
Key ingredients and recycling strategy of personal protective equipment (PPE)
Samarjeet Singh Siwal, Gauri Chaudhary, Adesh Kumar Saini, Harjot Kaur, Vipin Saini, Sudesh Kumar Mokhta, Ramesh Chand, UK Chandel, Graham Christie, Vijay Kumar Thakur
Sep 16, 2021
The COVID-19 pandemic has intensified the complications of plastic trash management and disposal. The current situation of living in fear of transmission of the COVID-19 virus has further transformed our behavioural models, such...
In-Depth Analysis and Prediction of Coupling Metrics of Open Source Software Projects
This research was conducted to perform an in-depth analysis of the coupling metrics of 10 Open Source Software (OSS) projects obtained from the Comets dataset. More precisely, we analyze the dataset of object-oriented OSS...
Published by: IGI Global Scientific Publishing
Futuristic Prediction of Missing Value Imputation Methods Using Extended ANN
Missing data is universal complexity for most part of the research fields which introduces the part of uncertainty into data analysis. We can take place due to many types of motives such as samples mishandling, unable to collect...
Published by: IGI Global Scientific Publishing
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
Quality of life in the FOXFIRE, SIRFLOX and FOXFIRE-global randomised trials of selective internal radiotherapy for metastatic colorectal cancer.
Jane Wolstenholme, Francesco Fusco, Alastair M Gray, Joanna Moschandreas, Pradeep S Virdee, Sharon Love, Guy Van Hazel, Peter Gibbs, Harpreet S Wasan, Ricky A Sharma
Feb 21, 2020
Selective internal radiotherapy (SIRT) is a liver-directed treatment involving the injection of yttrium-90 microspheres into the blood supply of liver tumours. There are very few studies assessing health-related quality of life...
colorectal adenocarcinoma Liver metastasis Quality of life Radiotherapy Adult Aged Antineoplastic Combined Chemotherapy Protocols Chemoradiotherapy Colorectal Neoplasms fatigue Female Humans Liver Neoplasms Male Middle Aged Nausea Quality of life Surveys and Questionnaires Vomiting Yttrium Radioisotopes
Plasmodium falciparum PhIL1-associated complex plays an essential role in merozoite reorientation and invasion of host erythrocytes.
Ekta Saini, Pradeep Kumar Sheokand, Vaibhav Sharma, Prakhar Agrawal, Inderjeet Kaur, Shailja Singh, Asif Mohmmed, Pawan Malhotra
Sep 20, 2021
The human malaria parasite, Plasmodium falciparum possesses unique gliding machinery referred to as the glideosome that powers its entry into the insect and vertebrate hosts. Several parasite proteins including Photosensitized...
Improving Performance During Camera Surveillance by Integration of Edge Detection in IoT System
This paper is proposing an IoT-based camera surveillance system. The objective of research is to detect suspicious activities by camera automatically and take decision by comparing current frame to previous frame. Major...
Published by: IGI Global Scientific Publishing
Modified Transformer Architecture to Explain Black Box Models in Narrative Form
The current XAI techniques present explanations mainly as visuals and structured data. However, these explanations are difficult to interpret for a non-expert user. Here, the use of natural language generation (NLG)-based...
Published by: IGI Global Scientific Publishing
A Secure Data E-Governance for Healthcare Application in Cyber Physical Systems
The bio-medical devices gather patient information and communicate it to data consumers via wireless networks to take the appropriate action and decision by informing the doctors. However, IoMT is adopted by healthcare...
Published by: IGI Global Scientific Publishing
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