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Results: 139
Use of preclinical models for malignant pleural mesothelioma.
Marie Shamseddin, Joanna Obacz, Mathew J Garnett, Robert Campbell Rintoul, Hayley Elizabeth Francies, Stefan John Marciniak
Mar 02, 2021
Itraconazole targets cell cycle heterogeneity in colorectal cancer.
Simon JA Buczacki, Semiramis Popova, Emma Biggs, Chrysa Koukorava, Jon Buzzelli, Louis Vermeulen, Lee Hazelwood, Hayley Francies, Mathew J Garnett, Douglas J Winton
Sep 05, 2018
Cellular dormancy and heterogeneity in cell cycle length provide important explanations for treatment failure after adjuvant therapy with S-phase cytotoxics in colorectal cancer (CRC), yet the molecular control of the dormant...
Animals Cell Cycle Cell Cycle Checkpoints Cell Differentiation Cell Line Tumor Cell Proliferation Cell Separation Cellular Senescence Colorectal Neoplasms Humans Itraconazole Mice Neoplastic Stem Cells Organoids Phenotype Receptors G-Protein-Coupled Spheroids Cellular Staining and Labeling Wnt Signaling Pathway
Metabolic Activation of Benzo[a]pyrene by Human Tissue Organoid Cultures.
Angela L Caipa Garcia, Jill E Kucab, Halh Al-Serori, Rebekah SS Beck, Franziska Fischer, Matthias Hufnagel, Andrea Hartwig, Andrew Floeder, Silvia Balbo, Hayley Francies, Mathew Garnett, Meritxell Huch, Jarno Drost, Matthias Zilbauer, Volker M Arlt, David H Phillips
Jan 24, 2023
Metabolic Activation of Benzo[a]pyrene by Human Tissue Organoid Cultures.
Angela L Caipa Garcia, Jill E Kucab, Halh Al-Serori, Rebekah SS Beck, Franziska Fischer, Matthias Hufnagel, Andrea Hartwig, Andrew Floeder, Silvia Balbo, Hayley Francies, Mathew Garnett, Meritxell Huch, Jarno Drost, Matthias Zilbauer, Volker M Arlt, David H Phillips
Feb 09, 2023
Organoids are 3D cultures that to some extent reproduce the structure, composition and function of the mammalian tissues from which they derive, thereby creating in vitro systems with more in vivo-like characteristics than 2D...
A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens.
Stacey Price, Shriram Bhosle, Emanuel Gonçalves, Xiaodun Li, Dylan P McClurg, Syd Barthorpe, Alex Beck, Caitlin Hall, Howard Lightfoot, Luke Farrow, Rizwan Ansari, David A Jackson, Laura Allen, Kirsty Roberts, Charlotte Beaver, Hayley E Francies, Mathew J Garnett
Apr 02, 2022
Organoid cell culture methodologies are enabling the generation of cell models from healthy and diseased tissue. Patient-derived cancer organoids that recapitulate the genetic and histopathological diversity of patient tumours...
A new trick for an old lipid.
Hayley Sharpe
Aug 16, 2017
Cholesterol can regulate the Hedgehog signalling pathway by directly binding to a receptor on the cell surface.
Cycloheximide and Hygromycin B-Induced Ribosome Stalling Leads to Decreased Prion Formation Rate for polyQ, but not Sup35, in Saccharomyces cerevisiae
Hayley Kane
Jan 01, 0001
Proteins are one of the four main macromolecules essential to life. They are responsible for a diverse array of processes, including cellular signaling, cell structure, and catalytic activity. These functions are directly...
Published by: Ursinus College
Book Review: Tying the Autocrat's Hands
Hayley Alexandra Russell
Aug 22, 2017
Published by: Memorial University of Newfoundland
Video Killed the Drag Star: Identity Presentation, Language, and Queer Habitus
Hayley Neiling
Jan 01, 0001
Pierre Bourdieu defines habitus as "the ability to produce classifiable practices and works, and the capacity to differentiate and appreciate these practices and products (taste), that the represented social world, i.e., the...
queer habitus Queer Theory Identity Presentation Drag Gender, Race, Sexuality, and Ethnicity in Communication Language Description and Documentation Social and Behavioral Sciences
Published by: Winthrop University
Will Enough ever be Enough?
Hayley Alexandra Russell
Sep 11, 2018
This paper examines the apparent discrepancy between public opinion and congressional action with regards to the implementation of further gun control policies within the United States. Through the examination of the history of...
Published by: Memorial University of Newfoundland
Unequal Under the Law
Hayley Russell
Sep 11, 2018
This paper examines the use of two contrasting doctrines of judicial interpretation utilized within Canadian constitutional jurisprudence. On one hand, the Supreme Court of Canada interprets cases involving non-indigenous...
Published by: Memorial University of Newfoundland
Unequal Under the Law
Hayley Russell
Sep 11, 2018
This paper examines the use of two contrasting doctrines of judicial interpretation utilized within Canadian constitutional jurisprudence. On one hand, the Supreme Court of Canada interprets cases involving non-indigenous...
Published by: Memorial University of Newfoundland
Extended-spectrum β-lactamase-producing and carbapenemase-producing Enterobacteriaceae.
CPE ESBL Enterobacteriaceae Gram-negative Antimicrobial resistance Anti-Bacterial Agents Antimicrobial Stewardship Bacterial Proteins Carbapenem-Resistant Enterobacteriaceae Drug Resistance Multiple Bacterial Enterobacteriaceae Enterobacteriaceae Infections Genes Bacterial Humans molecular epidemiology prevalence whole genome sequencing beta-Lactamases
Will Enough ever be Enough?
Hayley Alexandra Russell
Sep 11, 2018
This paper examines the apparent discrepancy between public opinion and congressional action with regards to the implementation of further gun control policies within the United States. Through the examination of the history of...
Published by: Memorial University of Newfoundland
Cosmological distances with general-relativistic ray tracing
Abstract
In this work we present the first results from a new ray-tracing tool to calculate
cosmological distances in the context of fully nonlinear general relativity. We use...
Hayley J Macpherson
Mar 07, 2023
Book Review: Tying the Autocrat's Hands
Hayley Alexandra Russell
Aug 22, 2017
Published by: Memorial University of Newfoundland
Grking the Smoothened signal.
The kinase GRK2 has been linked to the clinically important Hedgehog (HH) signaling pathway, where it is paradoxically required for signal transduction yet also promotes internalization and degradation of the critical HH signal...
Assessing cognitive processes related to insomnia
Cognitive processes play an important role in the maintenance, and treatment of sleep difficulties, including insomnia. In 2002, a comprehensive model was proposed by Harvey. Since its inception the model has received >300...
Assessing cognitive processes related to insomnia
Cognitive processes play an important role in the maintenance, and treatment of sleep difficulties, including insomnia. In 2002, a comprehensive model was proposed by Harvey. Since its inception the model has received >300...
Skinny Dip: Carl Hiassen, Detective Fiction and the Murder of the Florida Everglades
Carl Hiaasen's 2004 novel, Skinny Dip, reworks the typical structures and tropes of detective fiction to argue that the most significant "murder" in this text is the large-scale destruction of the Florida Everglades. Using farce...
Published by: Winthrop University
Survival and disease characteristics of de novo versus recurrent metastatic breast cancer in a cohort of young patients.
Hayley S McKenzie, Tom Maishman, Peter Simmonds, Lorraine Durcan, POSH Steering Group, Diana Eccles, Ellen Copson
Nov 03, 2020
BACKGROUND: It is not clear how the pathology, presentation and outcome for patients who present with de novo metastatic breast cancer (dnMBC) compare with those who later develop distant metastases. DnMBC is uncommon in younger...
Recapture or precapture? Fallibility of standard capture-recapture methods in the presence of referrals between sources.
Hayley E Jones, Matthew Hickman, Nicky J Welton, Daniela De Angelis, Ross J Harris, AE Ades
Aug 16, 2018
Capture-recapture methods, largely developed in ecology, are now commonly used in epidemiology to adjust for incomplete registries and to estimate the size of difficult-to-reach populations such as problem drug users....
Bias log-linear models model selection parameter identifiability prevalence estimation problem drug use Bias Data Collection Data Interpretation Statistical England Epidemiologic Research Design Humans Linear Models Models Statistical Population Density Referral and Consultation Substance-Related Disorders
Power, participation and their problems
Ayako Ebata, Catherine Hodge, Dorien Braam, Linda Waldman, Joanne Sharp, Hayley MacGregor, Henrietta Moore
Apr 17, 2020
The use of Participatory Epidemiology in veterinary research intends to include livestock keepers and other local stakeholders in research processes and the development of solutions to animal health problems, including...
HES5 silencing is an early and recurrent change in prostate tumourigenesis.
Charles E Massie, Inmaculada Spiteri, Helen Ross-Adams, Hayley Luxton, Jonathan Kay, Hayley C Whitaker, Mark J Dunning, Alastair D Lamb, Antonio Ramos-Montoya, Daniel S Brewer, Colin S Cooper, Rosalind Eeles, UK Prostate ICGC Group, Anne Y Warren, Simon Tavaré, David E Neal, Andy G Lynch
Mar 12, 2015
AR ERG HES5 HES6 Notch epigenetics Methylation prostate cancer Basic Helix-Loop-Helix Transcription Factors Carcinogenesis Cell Line Tumor DNA Methylation Epigenesis Genetic Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Male Promoter Regions Genetic Prostatic Neoplasms Repressor Proteins Trans-Activators Transcriptional Regulator ERG
Disputing space-based biases in unilateral complex regional pain syndrome
Monika Halicka, Axel D Vittersø, Hayley McCullough, Andreas Goebel, Leila Heelas, Michael J Proulx, Janet H Bultitude
Jun 01, 2020
There is some evidence that people with Complex Regional Pain Syndrome (CRPS) show reduced attention to the affected relative to unaffected limb and its surrounding space, resembling hemispatial neglect after brain injury....
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