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Being red, blue and green
Abstract: Background: Animal coloration is usually an adaptive attribute, under strong local selection pressures and often diversified among species or populations. The strawberry poison frog (Oophaga pumilio) shows an...
Being red, blue and green
Abstract: Background: Animal coloration is usually an adaptive attribute, under strong local selection pressures and often diversified among species or populations. The strawberry poison frog (Oophaga pumilio) shows an...
Being red, blue and green
BACKGROUND: Animal coloration is usually an adaptive attribute, under strong local selection pressures and often diversified among species or populations. The strawberry poison frog (Oophaga pumilio) shows an impressive array of...
Coloration genetics Gene Expression Pigments Poison frog SNPs Animals Anura Carotenoids Chromatophores Color Dioxygenases Gene Expression Regulation Genome Genomics Genotype Guanine Melanins Panama Phenotype Pigmentation Polymorphism Genetic Polymorphism Single Nucleotide Pteridines Scavenger Receptors Class B Transaminases Transcriptome
Being red, blue and green
BACKGROUND:Animal coloration is usually an adaptive attribute, under strong local selection pressures and often diversified among species or populations. The strawberry poison frog (Oophaga pumilio) shows an impressive array of...
Published by: BMC genomics
Structure and Function of Fbxo7/PARK15 in Parkinson's Disease.
Analysis of the FBXO7 promoter reveals overlapping Pax5 and c-Myb binding sites functioning in B cells.
Fbxo7 is a key player in the differentiation and function of numerous blood cell types, and in neurons, oligodendrocytes and spermatocytes. In an effort to gain insight into the physiological and pathological settings where...
B cells ELF4 Fbxo7 Pax5 promoter Transcription factor c-Myb B-Lymphocytes Base Sequence Binding Sites Cell Differentiation Cells Cultured Conserved Sequence DNA-Binding Proteins F-Box Proteins Humans PAX5 Transcription Factor Promoter Regions Genetic Proto-Oncogene Proteins c-myb Transcription Factors
Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish.
Zebrafish are becoming increasingly popular as an organism in which to model human disease and to study the effects of small molecules on complex physiological and pathological processes. Since larvae are no more than a few...
ATP Binding Cassette Transporter Subfamily B Member 1 ATP-Binding Cassette Transporters Amino Acid Sequence Animals Biological Transport Blood-Brain Barrier Fluorescent Dyes Gene Expression Regulation Larva Molecular Sequence Data Phylogeny Sequence Alignment Tight Junction Proteins Tight Junctions Zebrafish
Defective erythropoiesis in a mouse model of reduced Fbxo7 expression due to decreased p27 expression.
Fbxo7 anaemia Cell Cycle DIFFERENTIATION mitophagy rs11107 ubiquitin ligase Anemia Animals Cell Cycle Checkpoints Cell Line Tumor Cyclin-Dependent Kinase Inhibitor p27 Down-Regulation Erythrocytes Erythropoiesis F-Box Proteins Genotype Hemoglobins Mice Knockout Mitochondria Mitophagy Phenotype Protein Stability RNA Interference Signal Transduction Time Factors Transfection
Identification of Candidate Protein Markers in Skeletal Muscle of Laminin-211-Deficient CMD Type 1A-Patients.
Heike Kölbel, Denisa Hathazi, Matthew Jennings, Rita Horvath, Andreas Roos, Ulrike Schara
May 28, 2019
Laminin-211 deficiency leads to the most common form of congenital muscular dystrophy in childhood, MDC1A. The clinical picture is characterized by severe muscle weakness, brain abnormalities and delayed motor milestones...
F-box protein interactions with the hallmark pathways in cancer.
Cancer hallmarks E3 ubiquitin ligases F-Box Proteins Signalling Ubiquitination Animals Apoptosis Cell Cycle Cell Differentiation Cell Movement Cell Proliferation DNA Damage Epigenesis Genetic F-Box Proteins Gene Expression Regulation Neoplastic Genomic Instability Humans Mitochondria Neoplasm Invasiveness Neoplasms Neovascularization Pathologic Oxidative Stress Protein Binding Receptors Cell Surface Signal Transduction
Opposing effects on the cell cycle of T lymphocytes by Fbxo7 via Cdk6 and p27.
Cdk6 Cell Cycle Fbxo7 T-cell development p27 Animals Apoptosis CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Cell Cycle Cell Differentiation Cell Proliferation Cyclin-Dependent Kinase 6 Cyclin-Dependent Kinase Inhibitor p27 Down-Regulation F-Box Proteins Female Gene Deletion Lymphocyte Activation Male Mice Inbred C57BL Mutation T-Lymphocytes Thymus Gland
Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis.
Mikhail Lomonosov, El Kahina Meziane, Hongtao Ye, David E Nelson, Suzanne J Randle, Heike Laman
Jul 30, 2018
Fbxo7 is an unusual F box protein that augments D-type cyclin complex formation with Cdk6, but not Cdk4 or Cdk2, and its over-expression has been demonstrated to transform immortalised fibroblasts in a Cdk6-dependent manner....
Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling.
Hendrik J Kuiken, David A Egan, Heike Laman, Rene Bernards, Roderick L Beijersbergen, Annette M Dirac
Aug 03, 2018
The nuclear factor κB (NF-κB) signalling pathway controls important cellular events such as cell proliferation, differentiation, apoptosis and immune responses. Pathway activation occurs rapidly upon TNFα stimulation and is...
Adaptor Proteins Signal Transducing F-Box Proteins Gene Expression Regulation HEK293 Cells Humans Immunoblotting Immunoprecipitation Inhibitor of Apoptosis Proteins NF-kappa B Nuclear Pore Complex Proteins RNA Small Interfering RNA-Binding Proteins Signal Transduction Tumor Necrosis Factor-alpha Ubiquitination
Published by: J Cell Mol Med
Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells.
Rebecca Harris, Ming Yang, Christina Schmidt, Chloe Royet, Sarbjit Singh, Amarnath Natarajan, May Morris, Christian Frezza, Heike Laman
Jul 08, 2022
Assessing the Effects of Cytoprotectants on Selective Neuronal Loss, Sensorimotor Deficit and Microglial Activation after Temporary Middle Cerebral Occlusion.
Julius V Emmrich, Sohail Ejaz, David J Williamson, Young T Hong, Sergey Sitnikov, Tim D Fryer, Franklin I Aigbirhio, Heike Wulff, Jean-Claude Baron
Jan 09, 2020
Although early reperfusion after stroke salvages the still-viable ischemic tissue, peri-infarct selective neuronal loss (SNL) can cause sensorimotor deficits (SMD). We designed a longitudinal protocol to assess the effects of...
Exome reanalysis and proteomic profiling identified TRIP4 as a novel cause of cerebellar hypoplasia and spinal muscular atrophy (PCH1).
Ana Töpf, Angela Pyle, Helen Griffin, Leslie Matalonga, Katherine Schon, Solve-RD SNV-indel working group, Solve-RD DITF-euroNMD, Albert Sickmann, Ulrike Schara-Schmidt, Andreas Hentschel, Patrick F Chinnery, Heike Kölbel, Andreas Roos, Rita Horvath
Apr 08, 2021
TRIP4 is one of the subunits of the transcriptional coregulator ASC-1, a ribonucleoprotein complex that participates in transcriptional coactivation and RNA processing events. Recessive variants in the TRIP4 gene have been...
City-level climate change mitigation in China.
Yuli Shan, Dabo Guan, Klaus Hubacek, Bo Zheng, Steven J Davis, Lichao Jia, Jianghua Liu, Zhu Liu, Neil Fromer, Zhifu Mi, Jing Meng, Xiangzheng Deng, Yuan Li, Jintai Lin, Heike Schroeder, Helga Weisz, Hans Joachim Schellnhuber
Apr 12, 2019
As national efforts to reduce CO2 emissions intensify, policy-makers need increasingly specific, subnational information about the sources of CO2 and the potential reductions and economic implications of different possible...
Detection of titanium oxide in the atmosphere of a hot Jupiter.
Elyar Sedaghati, Henri MJ Boffin, Ryan J MacDonald, Siddharth Gandhi, Nikku Madhusudhan, Neale P Gibson, Mahmoudreza Oshagh, Antonio Claret, Heike Rauer
May 21, 2018
As an exoplanet transits its host star, some of the light from the star is absorbed by the atoms and molecules in the planet's atmosphere, causing the planet to seem bigger; plotting the planet's observed size as a function of...
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