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Results: 362
Ice-Age Climate Adaptations Trap the Alpine Marmot in a State of Low Genetic Diversity.
Toni I Gossmann, Achchuthan Shanmugasundram, Stefan Börno, Ludovic Duvaux, Christophe Lemaire, Heiner Kuhl, Sven Klages, Lee D Roberts, Sophia Schade, Johanna M Gostner, Falk Hildebrand, Jakob Vowinckel, Coraline Bichet, Michael Mülleder, Enrica Calvani, Aleksej Zelezniak, Julian L Griffin, Peer Bork, Dominique Allaine, Aurélie Cohas, John J Welch, Bernd Timmermann, Markus Ralser
Apr 16, 2019
Coreceptor and cytokine concentrations may not explain differences in disease progression observed in HIV-1 clade A and D infected Ugandans.
Edward Wright, Susan Mugaba, Paul Grant, Rosalind Parkes-Ratanshi, Lieve Van der Paal, Heiner Grosskurth, Pontiano Kaleebu
Apr 09, 2019
BACKGROUND: The use of cellular coreceptors and modulation of cytokine concentrations by HIV to establish a productive infection is well documented. However, it is unknown whether the expression of these proteins affects the...
Genetic versus Non-Genetic Regulation of miR-103, miR-143 and miR-483-3p Expression in Adipose Tissue and Their Metabolic Implications-A Twin Study.
Jette Bork-Jensen, Anne Cathrine Baun Thuesen, Claus Heiner Bang-Bertelsen, Louise Groth Grunnet, Flemming Pociot, Henning Beck-Nielsen, Susan E Ozanne, Pernille Poulsen, Allan Vaag
Aug 12, 2020
Murine models suggest that the microRNAs miR-103 and miR-143 may play central roles in the regulation of subcutaneous adipose tissue (SAT) and development of type 2 diabetes (T2D). The microRNA miR-483-3p may reduce adipose...
Spontaneous organization of supracolloids into three-dimensional structured materials.
Mohammad-Amin Moradi, E Deniz Eren, Massimiliano Chiappini, Sebastian Rzadkiewicz, Maurits Goudzwaard, Mark MJ van Rijt, Arthur DA Keizer, Alexander F Routh, Marjolein Dijkstra, Gijsbertus de With, Nico Sommerdijk, Heiner Friedrich, Joseph P Patterson
Feb 15, 2021
Periodic nano- or microscale structures are used to control light, energy and mass transportation. Colloidal organization is the most versatile method used to control nano- and microscale order, and employs either the...
The value of sorafenib trough levels in patients with advanced hepatocellular carcinoma - a substudy of the SORAMIC trial.
Tim A Labeur, Quincy Hofsink, R Bart Takkenberg, Otto M van Delden, Ron AA Mathôt, Regina Schinner, Peter Malfertheiner, Holger Amthauer, Kerstin Schütte, Bristi Basu, Christiane Kuhl, Julia Mayerle, Jens Ricke, Heinz-Josef Klümpen
May 11, 2020
Background: Sorafenib for advanced hepatocellular carcinoma (HCC) is dose adjusted by toxicity. Preliminary studies have suggested an association between plasma concentrations of sorafenib and its main metabolite (M2) and...
hepatocellular carcinoma Pharmacokinetics Sorafenib survival toxicity Aged Antineoplastic Agents Carcinoma Hepatocellular Dose-Response Relationship Drug Drug-Related Side Effects and Adverse Reactions Female Humans Incidence Kaplan-Meier Estimate Liver Neoplasms Male Middle Aged Neoplasm Staging Prospective Studies Reference Values Severity of Illness Index Sorafenib
Using machine learning on tree-ring data to determine the geographical provenance of historical construction timbers
Eileen Kuhl, Christian Zang, Jan Esper, Dana FC Riechelmann, Ulf Buentgen, Martin Briesch, Frederick Reinig, Philipp Roemer, Oliver Konter, Martin Schmidhalter, Claudia Hartl
Mar 08, 2023
Comparison of mesospheric winds from a high-altitude meteorological analysis system and meteor radar observations during the boreal winters of 2009–2010 and 2012–2013
J. McCormack, K. Hoppel, D. Kuhl, R. de Wit, G. Stober, P. Espy, N. Baker, P. Brown, D. Fritts, C. Jacobi, D. Janches, N. Mitchell, B. Ruston, S. Swadley, K. Viner, T. Whitcomb, R. Hibbins
Feb 01, 2017
We present a study of horizontal winds in the mesosphere and lower thermosphere (MLT) during the boreal winters of 2009–2010 and 2012–2013 produced with a new high-altitude numerical weather prediction (NWP) system. This...
Comparison of mesospheric winds from a high-altitude meteorological analysis system and meteor radar observations during the boreal winters of 2009–2010 and 2012–2013
J. McCormack, K. Hoppel, D. Kuhl, R. de Wit, G. Stober, P. Espy, N. Baker, P. Brown, D. Fritts, C. Jacobi, D. Janches, N. Mitchell, B. Ruston, S. Swadley, K. Viner, T. Whitcomb, R. Hibbins
Feb 01, 2017
We present a study of horizontal winds in the mesosphere and lower thermosphere (MLT) during the boreal winters of 2009–2010 and 2012–2013 produced with a new high-altitude numerical weather prediction (NWP) system. This...
Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis—A Multicenter European Prospective Cohort Study (EPIC)
Yunxia Lu, Raul Zamora-Ros, Simon Chan, Amanda J Cross, Heather Ward, Paula Jakszyn, Robert Luben, Jorrit L Opstelten, Bas Oldenburg, Göran Hallmans, Pontus Karling, Olof Grip, Timothy Key, Manuela M Bergmann, Heiner Boeing, Kim Overvad, Domenico Palli, Giovanna Masala, Kay-Tee Khaw, Antoine Racine, Franck Carbonnel, Marie-Christine Boutron-Ruault, Vibeke Andersen, Anja Olsen, Anne Tjonneland, Rudolf Kaaks, Rosario Tumino, Antonia Trichopoulou, Augustin Scalbert, Elio Riboli, Andrew R Hart
Mar 26, 2018
Intake of Total and Subgroups of Fat Minimally Affect the Associations between Selected Single Nucleotide Polymorphisms in the PPARγ Pathway and Changes in Anthropometry among European Adults from Cohorts of the DiOGenes Study.
Sofus C Larsen, Lars Ängquist, Jane N Østergaard, Tarunveer S Ahluwalia, Karani S Vimaleswaran, Nina Roswall, Lotte M Mortensen, Birgit M Nielsen, Anne Tjønneland, Nicholas J Wareham, Domenico Palli, Giovanna Masala, Wim HM Saris, Daphne L van der A, Jolanda MA Boer, Edith JM Feskens, Heiner Boeing, Marianne U Jakobsen, Ruth JF Loos, Thorkild IA Sørensen, Kim Overvad
Aug 09, 2017
BACKGROUND: Although the peroxisome proliferator-activated receptor γ (PPARγ) pathway is central in adipogenesis, it remains unknown whether it influences change in body weight (BW) and whether dietary fat has a modifying effect...
Fatty Acids gene-diet interaction Genetics obesity weight change Adult Alleles Body Mass Index CCAAT-Enhancer-Binding Protein-beta Case-Control Studies Cohort Studies Diet Dietary Fats Fatty Acids Fatty Acids Monounsaturated Fatty Acids Unsaturated Female Follow-Up Studies Genotyping Techniques Humans Linkage Disequilibrium Male Middle Aged Nutrition Assessment PPAR gamma Phosphoenolpyruvate Carboxykinase (ATP) Polymorphism Single Nucleotide Sterol Regulatory Element Binding Protein 1 Waist Circumference Weight Gain White People
Axillary lymphadenopathy at the time of COVID-19 vaccination
Simone Schiaffino, Katja Pinker, Veronica Magni, Andrea Cozzi, Alexandra Athanasiou, Pascal AT Baltzer, Julia Camps Herrero, Paola Clauser, Eva M Fallenberg, Gábor Forrai, Michael H Fuchsjäger, Thomas H Helbich, Fleur Kilburn-Toppin, Christiane K Kuhl, Mihai Lesaru, Ritse M Mann, Pietro Panizza, Federica Pediconi, Ruud M Pijnappel, Tamar Sella, Isabelle Thomassin-Naggara, Sophia Zackrisson, Fiona J Gilbert, Francesco Sardanelli
Sep 09, 2021
Unilateral axillary lymphadenopathy is a frequent mild side effect of COVID-19 vaccination. European Society of Breast Imaging (EUSOBI) proposes ten recommendations to standardise its management and reduce unnecessary additional...
Axillary lymphadenopathy at the time of COVID-19 vaccination
Simone Schiaffino, Katja Pinker, Veronica Magni, Andrea Cozzi, Alexandra Athanasiou, Pascal A T Baltzer, Julia Camps Herrero, Paola Clauser, Eva M Fallenberg, Gábor Forrai, Michael H Fuchsjäger, Thomas H Helbich, Fleur Kilburn-Toppin, Christiane K Kuhl, Mihai Lesaru, Ritse M Mann, Pietro Panizza, Federica Pediconi, Ruud M Pijnappel, Tamar Sella, Isabelle Thomassin-Naggara, Sophia Zackrisson, Fiona J Gilbert, Francesco Sardanelli
Sep 21, 2021
Unilateral axillary lymphadenopathy is a frequent mild side effect of COVID-19 vaccination. European Society of Breast Imaging (EUSOBI) proposes ten recommendations to standardise its management and reduce unnecessary additional...
Published by: Insights into imaging
Axillary lymphadenopathy at the time of COVID-19 vaccination
Simone Schiaffino, Katja Pinker, Veronica Magni, Andrea Cozzi, Alexandra Athanasiou, Pascal A. T. Baltzer, Julia Camps Herrero, Paola Clauser, Eva M. Fallenberg, Gábor Forrai, Michael H. Fuchsjäger, Thomas H. Helbich, Fleur Kilburn-Toppin, Christiane K. Kuhl, Mihai Lesaru, Ritse M. Mann, Pietro Panizza, Federica Pediconi, Ruud M. Pijnappel, Tamar Sella, Isabelle Thomassin-Naggara, Sophia Zackrisson, Fiona J. Gilbert, Francesco Sardanelli
Aug 26, 2021
Abstract: Unilateral axillary lymphadenopathy is a frequent mild side effect of COVID-19 vaccination. European Society of Breast Imaging (EUSOBI) proposes ten recommendations to standardise its management and reduce unnecessary...
Circulating Fetuin-A and Risk of Type 2 Diabetes
Janine Kröger, Karina Meidtner, Norbert Stefan, Marcela Guevara, Nicola D Kerrison, Eva Ardanaz, Dagfinn Aune, Heiner Boeing, Miren Dorronsoro, Courtney Dow, Guy Fagherazzi, Paul W Franks, Heinz Freisling, Marc J Gunter, José María Huerta, Rudolf Kaaks, Timothy J Key, Kay Tee Khaw, Vittorio Krogh, Tilman Kühn, Francesca Romana Mancini, Amalia Mattiello, Peter M Nilsson, Anja Olsen, Kim Overvad, Domenico Palli, J Ramón Quirós, Olov Rolandsson, Carlotta Sacerdote, Núria Sala, Elena Salamanca-Fernández, Ivonne Sluijs, Annemieke MW Spijkerman, Anne Tjonneland, Konstantinos K Tsilidis, Rosario Tumino, Yvonne T van der Schouw, Nita G Forouhi, Stephen J Sharp, Claudia Langenberg, Elio Riboli, Matthias B Schulze, Nicholas J Wareham
Aug 23, 2018
Fetuin-A, a hepatic-origin protein, is strongly positively associated with risk of type 2 diabetes in human observational studies, but it is unknown whether this association is causal. We aimed to study the potential causal...
Adult Aged Biomarkers Case-Control Studies Cohort Studies Diabetes mellitus Type 2 Enzyme-Linked Immunosorbent Assay Europe Female Genetic Association Studies Germany Humans Immunoturbidimetry Incidence Male Mendelian Randomization Analysis Middle Aged Polymorphism Single Nucleotide Prospective Studies Reproducibility of Results risk alpha-2-HS-Glycoprotein
Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition.
Abhijit Sen, Nikos Papadimitriou, Pagona Lagiou, Aurora Perez-Cornago, Ruth C Travis, Timothy J Key, Neil Murphy, Marc Gunter, Heinz Freisling, Ioanna Tzoulaki, David C Muller, Amanda J Cross, David S Lopez, Manuela Bergmann, Heiner Boeing, Christina Bamia, Anastasia Kotanidou, Anna Karakatsani, Anne Tjønneland, Cecilie Kyrø, Malene Outzen, María-Luisa Redondo, Valerie Cayssials, Maria-Dolores Chirlaque, Aurelio Barricarte, Maria-Jose Sánchez, Nerea Larrañaga, Rosario Tumino, Sara Grioni, Domenico Palli, Saverio Caini, Carlotta Sacerdote, Bas Bueno-de-Mesquita, Tilman Kühn, Rudolf Kaaks, Lena Maria Nilsson, Rikard Landberg, Peter Wallström, Isabel Drake, Bodil Hammer Bech, Kim Overvad, Dagfinn Aune, Kay-Tee Khaw, Elio Riboli, Dimitrios Trichopoulos, Antonia Trichopoulou, Konstantinos K Tsilidis
Sep 05, 2018
The epidemiological evidence regarding the association of coffee and tea consumption with prostate cancer risk is inconclusive, and few cohort studies have assessed these associations by disease stage and grade. We examined the...
Nonsteroidal anti-inflammatory drug use and breast cancer risk in a European prospective cohort study.
Manon Cairat, Agnès Fournier, Neil Murphy, Carine Biessy, Augustin Scalbert, Sabina Rinaldi, Anne Tjønneland, Anja Olsen, Kim Overvad, Patrick Arveux, Marie-Christine Boutron-Ruault, Claire Cadeau, Renée Turzanski Fortner, Rudolf Kaaks, Heiner Boeing, Krasimira Aleksandrova, Petra Hm Peeters, Carla H van Gils, Nicholas J Wareham, Kay-Tee Khaw, Dagfinn Aune, Elio Riboli, Marc J Gunter, Laure Dossus
Sep 26, 2018
Experimental studies have shown a protective effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer development. However, results from epidemiological cohort studies are less consistent. Our objective was to...
General Framework for Meta-Analysis of Haplotype Association Tests.
Shuai Wang, Jing Hua Zhao, Ping An, Xiuqing Guo, Richard A Jensen, Jonathan Marten, Jennifer E Huffman, Karina Meidtner, Heiner Boeing, Archie Campbell, Kenneth M Rice, Robert A Scott, Jie Yao, Matthias B Schulze, Nicholas J Wareham, Ingrid B Borecki, Michael A Province, Jerome I Rotter, Caroline Hayward, Mark O Goodarzi, James B Meigs, Josée Dupuis
Apr 06, 2016
family samples haplotype association tests linear mixed effects model Meta-Analysis aging Co-Repressor Proteins Cohort Studies DNA-Binding Proteins Fasting Female Genetic Association Studies genetic variation Glucose Glucose-6-Phosphatase Haplotypes Heart Humans Least-Squares Analysis Male Meta-Analysis as Topic Models Genetic molecular epidemiology Multivariate Analysis Neoplasm Proteins Phenotype Reproducibility of Results Research Design
Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries
Paolo Vineis, Gerard Hoek, Michal Krzyzanowski, Federica Vigna-Taglianti, Fabrizio Veglia, Luisa Airoldi, Kim Overvad, Ole Raaschou-Nielsen, Francoise Clavel-Chapelon, Jacob Linseisen, Heiner Boeing, Antonia Trichopoulou, Domenico Palli, Vittorio Krogh, Rosario Tumino, Salvatore Panico, H Bas Bueno-De-Mesquita, Petra H Peeters, Eiliv Lund E, Antonio Agudo, Carmen Martinez, Miren Dorronsoro, Aurelio Barricarte, Lluis Cirera, J Ramon Quiros, Goran Berglund, Jonas Manjer, Bertil Forsberg, Nicholas E Day, Tim J Key, Rudolf Kaaks, Rodolfo Saracci, Elio Riboli
Jun 16, 2011
CA19-9 and apolipoprotein-A2 isoforms as detection markers for pancreatic cancer
Kazufumi Honda, Verena A Katzke, Anika Hüsing, Shinobu Okaya, Hirokazu Shoji, Kaoru Onidani, Anja Olsen, Anne Tjønneland, Kim Overvad, Elisabete Weiderpass, Paolo Vineis, David Muller, Kostas Tsilidis, Domenico Palli, Valeria Pala, Rosario Tumino, Alessio Naccarati, Salvatore Panico, Krasimira Aleksandrova, Heiner Boeing, H Bas Bueno-De-Mesquita, Petra H Peeters, Antonia Trichopoulou, Pagona Lagiou, Kay-Tee Khaw, Nick Wareham, Ruth C Travis, Susana Merino, Eric J Duell, Miguel Rodríguez-Barranco, María Dolores Chirlaque, Aurelio Barricarte, Vinciane Rebours, Marie-Chiristine Boutron-Ruault, Francesca Romana Mancini, Paul Brennan, Ghislaine Scelo, Jonas Manjer, Malin Sund, Daniel Öhlund, Federico Canzian, Rudolf Kaaks
Nov 21, 2018
Recently, we identified unique processing patterns of apolipoprotein A2 (ApoA2) in patients with pancreatic cancer. Our study provides a first prospective evaluation of an ApoA2 isoform ("ApoA2-ATQ/AT"), alone and in combination...
CA19-9 apolipoprotein A2 Early detection isoforms pancreatic cancer prospective study Adult Aged Apolipoprotein A-II CA-19-9 Antigen Case-Control Studies Early Detection of Cancer Enzyme-Linked Immunosorbent Assay Female Humans Male Middle Aged Pancreas Pancreatic Neoplasms Predictive Value of Tests Prospective Studies Protein Isoforms ROC Curve Time Factors
Meat consumption and mortality--results from the European Prospective Investigation into Cancer and Nutrition.
Sabine Rohrmann, Kim Overvad, H Bas Bueno-De-Mesquita, Marianne U Jakobsen, Rikke Egeberg, Anne Tjønneland, Laura Nailler, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Vittorio Krogh, Domenico Palli, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Manuela M Bergmann, Heiner Boeing, Kuanrong Li, Rudolf Kaaks, Kay-Tee Khaw, Nicholas J Wareham, Francesca L Crowe, Timothy J Key, Androniki Naska, Antonia Trichopoulou, Dimitirios Trichopoulos, Max Leenders, Petra Hm Peeters, Dagrun Engeset, Christine L Parr, Guri Skeie, Paula Jakszyn, María-José Sánchez, José M Huerta, M Luisa Redondo, Aurelio Barricarte, Pilar Amiano, Isabel Drake, Emily Sonestedt, Göran Hallmans, Ingegerd Johansson, Veronika Fedirko, Isabelle Romieux, Pietro Ferrari, Teresa Norat, Anne C Vergnaud, Elio Riboli, Jakob Linseisen
Mar 08, 2013
Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition.
Julie A Schmidt, Georgina K Fensom, Sabina Rinaldi, Augustin Scalbert, Paul N Appleby, David Achaintre, Audrey Gicquiau, Marc J Gunter, Pietro Ferrari, Rudolf Kaaks, Tilman Kühn, Anna Floegel, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Eleutherios Anifantis, Claudia Agnoli, Domenico Palli, Morena Trevisan, Rosario Tumino, H Bas Bueno-De-Mesquita, Antonio Agudo, Nerea Larrañaga, Daniel Redondo-Sánchez, Aurelio Barricarte, José Maria Huerta, J Ramón Quirós, Nick Wareham, Kay-Tee Khaw, Aurora Perez-Cornago, Mattias Johansson, Amanda J Cross, Konstantinos K Tsilidis, Elio Riboli, Timothy J Key, Ruth C Travis
Jul 05, 2017
BACKGROUND: Little is known about how pre-diagnostic metabolites in blood relate to risk of prostate cancer. We aimed to investigate the prospective association between plasma metabolite concentrations and risk of prostate...
Acylcarnitines Amino Acids Biogenic amines European Prospective Investigation into Cancer and Nutrition (EPIC) Glycerophospholipids Hexose Mass Spectrometry Metabolomics prospective study prostate cancer risk sphingolipids Aged Biomarkers Case-Control Studies Cohort Studies Follow-Up Studies Humans Logistic Models Male Mass Spectrometry Middle Aged Nutritional Status Odds Ratio Prospective Studies Prostatic Neoplasms
Osteoprotegerin and breast cancer risk by hormone receptor subtype
Renée T Fortner, Danja Sarink, Helena Schock, Theron Johnson, Anne Tjønneland, Anja Olsen, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Domenico Palli, Sabina Sieri, Amalia Mattiello, Rosario Tumino, Fulvio Ricceri, H Bas Bueno-De-Mesquita, Petra Hm Peeters, Carla H van Gils, Elisabete Weiderpass, Eiliv Lund, J Ramón Quirós, Antonio Agudo, Maria-José Sánchez, María-Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Tim Key, Kay-Tee Khaw, Sabina Rinaldi, Laure Dossus, Marc Gunter, Melissa A Merritt, Elio Riboli, Rudolf Kaaks
Feb 08, 2017
BACKGROUND: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and...
Autoimmunity plays a role in the onset of diabetes after 40 years of age.
Olov Rolandsson, Christiane S Hampe, Stephen J Sharp, Eva Ardanaz, Heiner Boeing, Guy Fagherazzi, Francesca Romana Mancini, Peter M Nilsson, Kim Overvad, Maria-Dolores Chirlaque, Miren Dorronsoro, Marc J Gunter, Rudolf Kaaks, Timothy J Key, Kay-Tee Khaw, Vittorio Krogh, Tilman Kühn, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, Maria-José Sánchez, Gianluca Severi, Annemieke MW Spijkerman, Rosario Tumino, Yvonne T van der Schouw, Elio Riboli, Nita G Forouhi, Claudia Langenberg, Nicholas J Wareham
Dec 03, 2019
AIMS/HYPOTHESIS: Type 1 and type 2 diabetes differ with respect to pathophysiological factors such as beta cell function, insulin resistance and phenotypic appearance, but there may be overlap between the two forms of diabetes....
Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma
Raul Zamora-Ros, Muath A Alghamdi, Valerie Cayssials, Silvia Franceschi, Martin Almquist, Joakim Hennings, Maria Sandström, Konstantinos K Tsilidis, Elisabete Weiderpass, Marie-Christine Boutron-Ruault, Bodil Hammer Bech, Kim Overvad, Anne Tjønneland, Kristina En Petersen, Francesca Romana Mancini, Yahya Mahamat-Saleh, Fabrice Bonnet, Tilman Kühn, Renée T Fortner, Heiner Boeing, Antonia Trichopoulou, Christina Bamia, Georgia Martimianaki, Giovanna Masala, Sara Grioni, Salvatore Panico, Rosario Tumino, Francesca Fasanelli, Guri Skeie, Tonje Braaten, Cristina Lasheras, Elena Salamanca-Fernández, Pilar Amiano, Maria-Dolores Chirlaque, Aurelio Barricarte, Jonas Manjer, Peter Wallström, H Bas Bueno-De-Mesquita, Petra H Peeters, Kay-Thee Khaw, Nicholas J Wareham, Julie A Schmidt, Dagfinn Aune, Graham Byrnes, Augustin Scalbert, Antonio Agudo, Sabina Rinaldi
Jan 02, 2019
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