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The value of sorafenib trough levels in patients with advanced hepatocellular carcinoma - a substudy of the SORAMIC trial.
Tim A Labeur, Quincy Hofsink, R Bart Takkenberg, Otto M van Delden, Ron AA Mathôt, Regina Schinner, Peter Malfertheiner, Holger Amthauer, Kerstin Schütte, Bristi Basu, Christiane Kuhl, Julia Mayerle, Jens Ricke, Heinz-Josef Klümpen
May 11, 2020
Background: Sorafenib for advanced hepatocellular carcinoma (HCC) is dose adjusted by toxicity. Preliminary studies have suggested an association between plasma concentrations of sorafenib and its main metabolite (M2) and...
hepatocellular carcinoma Pharmacokinetics Sorafenib survival toxicity Aged Antineoplastic Agents Carcinoma Hepatocellular Dose-Response Relationship Drug Drug-Related Side Effects and Adverse Reactions Female Humans Incidence Kaplan-Meier Estimate Liver Neoplasms Male Middle Aged Neoplasm Staging Prospective Studies Reference Values Severity of Illness Index Sorafenib
Entity recognition in the biomedical domain using a hybrid approach.
BACKGROUND: This article describes a high-recall, high-precision approach for the extraction of biomedical entities from scientific articles. METHOD: The approach uses a two-stage pipeline, combining a dictionary-based entity...
Lawsuit by Former Women's Soccer Team Settled
Winthrop University
Jan 01, 0001
After Winthrop University did not renew her contract, Heinz filed suit alleging that she was terminated because she had complained about gender inequities and harassment. Heinz settled her claims against Winthrop University for...
Published by: Winthrop University
Open Source Software Adoption in the Financial Services Industry
Although OSS has gained traction across industries worldwide, few studies have been reported on OSS adoption in the financial industry and even less in the context of developing countries. This paper presents an exploratory...
Published by: IGI Global Scientific Publishing
Proliferating dendritic cell progenitors in human blood
Romani, N., Gruner, S., Brang, D., Kampgen, E., Lenz, A., Trockenbacher, B., Konwalinka, G., Fritsch, P.O., Steinman, R.M., and Schuler, G. Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180:83-93, 1994
blood cell Cell Division granulocyte macrophage colony stimulating factor dendritic cell umbilical cord blood stem cell
Published by: The Rockefeller University Press
Estimating White-Tailed Deer Abundance in Urban Freshwater Tidal Marsh Habitat
Ian Johnson
Jan 01, 0001
In the past century deer populations have responded extremely well to human development. Today deer populations are the highest that they have been for centuries. These animals thrive in anthropogenic landscapes and in many...
White-tailed deer John Heinz National Wildlife Refuge Tinicum population biology urban ecology Biology Life Sciences
Published by: Ursinus College
An Exploration of COVID-19 and Its Consideration as a Black Swan for the Construction Industry in Switzerland
COVID-19 and its devastating yet unforeseeable effects affect the entire global economy value chain. Effects will be long-lasting and interfere with the way construction worked so far. Losses in the industry are expected to run...
Published by: IGI Global Scientific Publishing
Prediction of individualized lifetime benefit from cholesterol lowering, blood pressure lowering, antithrombotic therapy, and smoking cessation in apparently healthy people.
Nicole EM Jaspers, Michael J Blaha, Kunihiro Matsushita, Yvonne T van der Schouw, Nicholas J Wareham, Kay-Tee Khaw, Marie H Geisel, Nils Lehmann, Raimund Erbel, Karl-Heinz Jöckel, Yolanda van der Graaf, WM Monique Verschuren, Jolanda MA Boer, Vijay Nambi, Frank LJ Visseren, Jannick AN Dorresteijn
Aug 07, 2019
AIMS: The benefit an individual can expect from preventive therapy varies based on risk-factor burden, competing risks, and treatment duration. We developed and validated the LIFEtime-perspective CardioVascular Disease...
Allograft rejection is associated with development of functional IgE specific for donor MHC antigens.
Andreas M Farkas, Ulrike Baranyi, Georg A Böhmig, Lukas Unger, Stefan Hopf, Markus Wahrmann, Heinz Regele, Benedikt Mahr, Christoph Schwarz, Karin Hock, Nina Pilat, Ivan Kristo, Jasmin Mraz, Christian Lupinek, Josef Thalhamer, Gregor Bond, Lorenz Kuessel, Elizabeth Wlodek, Jack Martin, Menna Clatworthy, Gavin Pettigrew, Rudolf Valenta, Thomas Wekerle
Dec 17, 2018
BACKGROUND: Donor-specific antibodies of the IgG isotype are measured routinely for diagnostic purposes in renal transplant recipients and are associated with antibody-mediated rejection and long-term graft loss. OBJECTIVE: This...
IgE Transplantation alloreactivity donor-specific antibodies humoral rejection immunology Allografts Animals Female Graft Rejection Heart Transplantation Histocompatibility Antigens Class I Histocompatibility Antigens Class II Humans Immunoglobulin E Immunoglobulin G Kidney Transplantation Male Mice Mice Inbred BALB C Skin Transplantation
Baseline Interleukin-6 and -8 predict response and survival in patients with advanced hepatocellular carcinoma treated with sorafenib monotherapy
Osman Öcal, Kerstin Schütte, Juozas Kupčinskas, Egidijus Morkunas, Gabija Jurkeviciute, Enrico N de Toni, Najib Ben Khaled, Thomas Berg, Peter Malfertheiner, Heinz Josef Klümpen, Christian Sengel, Bristi Basu, Juan W Valle, Julia Benckert, Antonio Gasbarrini, Daniel Palmer, Ricarda Seidensticker, Moritz Wildgruber, Bruno Sangro, Maciej Pech, Jens Ricke, Max Seidensticker
Jan 30, 2022
hepatocellular carcinoma interleukin response Sorafenib Adolescent Adult Aged Aged 80 and over Carcinoma Hepatocellular Disease Progression Europe Female Follow-Up Studies Humans Interleukin-6 Interleukin-8 Liver Neoplasms Male Middle Aged Predictive Value of Tests Prognosis Sorafenib Survival Analysis Turkey Young Adult
The Grizzly, November 9, 2017
Valerie Osborne, Kevin Leon, Courtney A DuChene, Johnny Myers, Emily Jolly, Sophia DiBattista, Thomas Bantley, Julian Spain, David Mendelsohn
Jan 01, 0001
Department of Education Rolls Back Piece of Title IX Joe DeSimone '86 Receives Heinz Award New Education Major Created Nadler Awarded Tow Fellowship Dr. Kerr Appears on "Full Frontal with Samantha Bee" History of a...
Ursinus College Collegeville Pennsylvania newspaper Jessica Oros Joseph DeSimone Education Department Stephanie Mackler Tony Nadler Margee Kerr Ross Doughty Football cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Experimental Investigation of Ion Formation for Auto-Ignition Combustion in a High-Temperature and High-Pressure Combustion Vessel
One of the main challenges in internal combustion engine design is the simultaneous reduction of all engine pollutants like carbon monoxide (CO), total unburned hydrocarbons (THC), nitrogen oxides (NOx), and soot....
Experimental-Based Laminar Flame Speed Approximation Formulas of Efficiency-Optimized Biofuels for SI-Engine Modeling
Raik Hesse, Christian Schwenzer, Roman Glaznev, Stefania Esposito, Yann Fenard, Heinz Pitsch, Joachim Beeckmann
Sep 16, 2022
The transition towards sustainable mobility encourages research into biofuels for use in internal combustion engines. For these alternative energy carriers, high-fidelity experimental data of flame speeds influenced by...
3D-CFD RANS Methodology to Predict Engine-Out Emissions with Gasoline-Like Fuel and Methanol for a DISI Engine
Stefania Esposito, Ali Chaychizadeh, Dominik Golc, Raik Hesse, Joachim Beeckmann, Heinz Pitsch
Sep 16, 2022
Renewable fuels, such as bio- and e-fuels, are of great interest for the defossilization of the transport sector. Among these fuels, methanol represents a promising candidate for emission reduction and efficiency increase due...
Experimental comparison of combustion and emission characteristics between a market gasoline and its surrogate
Mixtures of few representative hydrocarbon species are often used in computational studies as surrogates of market petroleum fuels, which contain hundreds of components. While this simplification is imperative for...
Simple reaction time for broadband sounds compared to pure tones.
Although many studies have explored the relation between reaction time (RT) and loudness, including effects of intensity, frequency, and binaural summation, comparable work on spectral summation is rare. However, most real-world...
Development of Phenomenological Models for Engine-Out Hydrocarbon Emissions from an SI di Engine within a 0D Two-Zone Combustion Chamber Description
The increasingly stringent limits on pollutant emissions from internal combustion engine-powered vehicles require the optimization of advanced combustion systems by means of virtual development and simulation tools. Among the...
Experimental Investigation of Ion Formation for Auto-Ignition Combustion in a High-Temperature and High-Pressure Combustion Vessel
One of the main challenges in internal combustion engine design is the simultaneous reduction of all engine pollutants like carbon monoxide (CO), total unburned hydrocarbons (THC), nitrogen oxides (NOx), and soot....
The Grizzly, November 4, 2004
Lindsey Fund, Lauren A. Perotti, Kerri Landis, Tia Larese, Megan Helzner, Christina Rosci, Sarah Yemane, Katy Diana, Heather Turnbach, Ali Wagner, Amanda Bryman, Cecily Macconchie, Darron Harley, Eden Swick, Joseph Davido, Caitlin McHugh
Jan 01, 0001
Leadership Students Experience the Sounds of Halloween Bourbon Street & Beads: Homecoming Dance Preview Chris Heinz Visits Ursinus Four Ursinus Students Finalists for Watson Fellowship New Office Provides Extended...
Ursinus College Collegeville Pennsylvania newspaper Swimming field hockey wrestling Basketball Watson Foundation community service career services Chris Heinz Halloween Homecoming Sara Kessler cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Application of Bayesian Active Learning to the Estimation of Auditory Filter Shapes Using the Notched-Noise Method.
Time-efficient hearing tests are important in both clinical practice and research studies. This particularly applies to notched-noise tests, which are rarely done in clinical practice because of the time required....
Increasing incidence of immune-mediated necrotizing myopathy
Martin Klein, Heřman Mann, Lenka Pleštilová, Josef Zámečník, Zoe Betteridge, Neil McHugh, Jiří Vencovský
Aug 06, 2015
OBJECTIVES: Immune-mediated necrotizing myopathy (IMNM) is characterized by the predominant presence of necrotic muscle fibres in muscle biopsy and variable response to immunosuppressive treatment. The aims of this study were...
Constraints on lateral gene transfer in promoting fimbrial usher protein diversity and function.
Fimbriae are long, adhesive structures widespread throughout members of the family Enterobacteriaceae. They are multimeric extrusions, which are moved out of the bacterial cell through an integral outer membrane protein called...
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