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Results: 107
Serum Metabolites Associated with Computed Tomography Findings after Traumatic Brain Injury.
Alex M Dickens, Jussi P Posti, Riikka SK Takala, Henna Ala-Seppälä, Ismo Mattila, Jonathan P Coles, Janek Frantzén, Peter J Hutchinson, Ari J Katila, Anna Kyllönen, Henna-Riikka Maanpää, Virginia Newcombe, Joanne Outtrim, Jussi Tallus, Keri LH Carpenter, David K Menon, Tuulia Hyötyläinen, Olli Tenovuo, Matej Orešic
Sep 27, 2018
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury.
Correlation of Blood Biomarkers and Biomarker Panels with Traumatic Findings on Computed Tomography after Traumatic Brain Injury.
Jussi P Posti, Riikka SK Takala, Linnéa Lagerstedt, Alex M Dickens, Iftakher Hossain, Mehrbod Mohammadian, Henna Ala-Seppälä, Janek Frantzén, Mark van Gils, Peter J Hutchinson, Ari J Katila, Henna-Riikka Maanpää, David K Menon, Virginia F Newcombe, Jussi Tallus, Kevin Hrusovsky, David H Wilson, Jessica Gill, Jean-Charles Sanchez, Olli Tenovuo, Henrik Zetterberg, Kaj Blennow
Feb 15, 2019
The aim of the study was to examine the ability of eight protein biomarkers and their combinations in discriminating computed tomography (CT)-negative and CT-positive patients with traumatic brain injury (TBI), utilizing highly...
Early Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein in Predicting the Outcome of Mild Traumatic Brain Injury.
Iftakher Hossain, Mehrbod Mohammadian, Riikka SK Takala, Olli Tenovuo, Linnéa Lagerstedt, Henna Ala-Seppälä, Janek Frantzén, Mark van Gils, Peter Hutchinson, Ari J Katila, Henna-Riikka Maanpää, David K Menon, Virginia F Newcombe, Jussi Tallus, Kevin Hrusovsky, David H Wilson, Kaj Blennow, Jean-Charles Sanchez, Henrik Zetterberg, Jussi P Posti
Jan 09, 2019
The purpose of this study was to correlate the early levels of glial fibrillary acidic protein (GFAP) and neurofilament light protein (NF-L) with outcome in patients with mild traumatic brain injury (mTBI). A total of 107...
The Levels of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 During the First Week After a Traumatic Brain Injury
Jussi P Posti, Riikka SK Takala, Hilkka Runtti, Virginia F Newcombe, Joanne Outtrim, Ari J Katila, Janek Frantzén, Henna Ala-Seppälä, Jonathan P Coles, Md Iftakher Hossain, Anna Kyllönen, Henna-Riikka Maanpää, Jussi Tallus, Peter J Hutchinson, Mark van Gils, David K Menon, Olli Tenovuo
May 24, 2019
BACKGROUND: Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) are promising biomarkers of traumatic brain injury (TBI). OBJECTIVE: We investigated the relation of the GFAP and UCH-L1 levels to...
Antimicrobial surface grafted thermally responsive PNIPAM-co-ALA nano-gels
Thermally responsive Poly(N-isopropylacrylamide) co-allylamine (PNIPAM-co-ALA) nano-gels were synthesised and grafted onto non-woven polypropylene. Silver nitrate was incorporated into the nano-gels in their expanded state and...
Local alkylating chemotherapy applied immediately after 5-ALA guided resection of glioblastoma does not provide additional benefit.
William Sage, Mathew Guilfoyle, Catriona Luney, Adam Young, Rohitashwa Sinha, Donatella Sgubin, Joseph H McAbee, Ruichong Ma, Sarah Jefferies, Rajesh Jena, Fiona Harris, Kieren Allinson, Tomasz Matys, Wendi Qian, Thomas Santarius, Stephen Price, Colin Watts
May 25, 2018
Grade IV glioma is the most common and aggressive primary brain tumour. Gross total resection with 5-aminolevulinic acid (5-ALA) guided surgery combined with local chemotherapy (carmustine wafers) is an attractive treatment...
S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine
Glutamine (Gln) is often a difficult amino acid to incorporate during solution-phase peptide synthesis, owing to poor solubility and unwanted dehydrations as side-reactions. Current approaches to solving these problems are...
S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine
Glutamine (Gln) is often a difficult amino acid to incorporate during solution-phase peptide synthesis, owing to poor solubility and unwanted dehydrations as side-reactions. Current approaches to solving these problems are...
An Evaluation of the Tolerability and Feasibility of Combining 5-Amino-Levulinic Acid (5-ALA) with BCNU Wafers in the Surgical Management of Primary Glioblastoma.
Colin Watts, Keyoumars Ashkan, Michael D Jenkinson, Stephen J Price, Thomas Santarius, Tomasz Matys, Ting Ting Zhang, Alina Finch, Peter Collins, Kieren Allinson, Sarah J Jefferies, Daniel J Scoffings, Athanasios Zisakis, Mark Phillips, Katharina Wanek, Paul Smith, Laura Clifton-Hadley, Nicholas Counsell
Sep 05, 2021
Background Glioblastoma (GBM) is the commonest primary malignant brain tumour in adults and effective treatment options are limited. Combining local chemotherapy with enhanced surgical resection using 5-aminolevulinic acid...
Antimicrobial surface grafted thermally responsive PNIPAM-co-ALA nano-gels
Thermally responsive Poly(N-isopropylacrylamide) co-allylamine (PNIPAM-co-ALA) nano-gels were synthesised and grafted onto non-woven polypropylene. Silver nitrate was incorporated into the nano-gels in their expanded state and...
Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas
Georgios Solomou, Aref-Ali Gharooni, Waqqas Patel, Conor S Gillespie, Melissa Gough, Ashwin Venkatesh, Michael TC Poon, Victoria Wykes, Stephen John Price, Michael D Jenkinson, Colin Watts, Puneet Plaha
Jul 27, 2022
INTRODUCTION: 5-aminolevulinic acid (5-ALA) is a proagent developed for fluorescent-guided surgery for high-grade glioma patients associated with a significant increase in resection conferring survival. 5-ALA was shown to...
An Evaluation of the Tolerability and Feasibility of Combining 5-Amino-Levulinic Acid (5-ALA) with BCNU Wafers in the Surgical Management of Primary Glioblastoma
Colin Watts, Keyoumars Ashkan, Michael D. Jenkinson, Stephen J. Price, Thomas Santarius, Tomasz Matys, Ting Ting Zhang, Alina Finch, Peter Collins, Kieren Allinson, Sarah J. Jefferies, Daniel J. Scoffings, Athanasios Zisakis, Mark Phillips, Katharina Wanek, Paul Smith, Laura Clifton-Hadley, Nicholas Counsell
Jul 02, 2021
Background Glioblastoma (GBM) is the commonest primary malignant brain tumour in adults and effective treatment options are limited. Combining local chemotherapy with enhanced surgical resection using 5-aminolevulinic acid...
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury
Jussi P Posti, Iftakher Hossain, Riikka SK Takala, Hilkka Liedes, Virginia Newcombe, Joanne Outtrim, Ari J Katila, Janek Frantzen, Henna Ala-Seppala, Jonathan P Coles, Anna Kyllonen, Henna-Riikka Maanpaa, Jussi Tallus, Peter J Hutchinson, Mark van Gils, David K Menon, Olli Tenovuo, TBIcare Investigators
Aug 16, 2017
Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) have been studied as potential
biomarkers of mild traumatic brain injury (mTBI). We report the levels of GFAP and UCH-L1 in patients with...
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 as Outcome Predictors in Traumatic Brain Injury.
RSK Takala, JP Posti, H Runtti, VF Newcombe, JG Outtrim, AJ Katila, J Frantzén, H Ala-Seppälä, A Kyllönen, H-R Maanpää, J Tallus, MI Hossain, JP Coles, P Hutchinson, M van Gils, DK Menon, O Tenovuo
Dec 08, 2016
Biomarkers GFAP outcome Traumatic brain injury UCH-L1 Adolescent Adult Aged Area Under Curve Biomarkers Brain Injuries Female Glasgow Coma Scale Glial Fibrillary Acidic Protein Humans Injury Severity Score Logistic Models Male Middle Aged Predictive Value of Tests Prognosis Prospective Studies ROC Curve Ubiquitin Thiolesterase Young Adult
Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin.
BACKGROUND: Acquiring clinically annotated, spatially stratified tissue samples from human glioblastoma (GBM) is compromised by haemorrhage, brain shift and subjective identification of 'normal' brain. We tested the use of...
Peptide-targeted dendrimeric prodrugs of 5-aminolevulinic acid
Photodynamic therapy (PDT) is a promising approach for the targeted treatment of cancer and various other human disorders. An effective, clinically approved approach in PDT involves the administration of 5-aminolevulinic acid...
Peptide-targeted dendrimeric prodrugs of 5-aminolevulinic acid
Photodynamic therapy (PDT) is a promising approach for the targeted treatment of cancer and various other human disorders. An effective, clinically approved approach in PDT involves the administration of 5-aminolevulinic acid...
Glycolysis inhibition improves photodynamic therapy response rates for equine sarcoids.
Photodynamic therapy (PDT) holds great promise in treating veterinary and human dermatological neoplasms, including equine sarcoids, but is currently hindered by the amount of photosensitiser and light that can be delivered to...
Students, Staff to Spend Spring Break Helping Others
Winthrop University
Jan 01, 0001
Alternative Spring Break is coordinated by the Center for Career and Civic Engagement. This year's locations are Tuscaloosa, Ala., Washington, D.C. and Jacksonville, Fla.
Published by: Winthrop University
Dynamic Diastereomerism on Chiral Surfaces.
Adsorption of chiral molecules on chiral surfaces implies diastereomerism, evident in the adoption of distinct adsorption geometries. We show here that this diastereomerism produces a signature in the motion of chiral molecules...
Identification of the Effective E-Promotional Tools on Improving Destination Brand Image
The aim of this research is to evaluate the effect of promotional tools on creating a positive destination brand image and attracting international tourists to Iran. Mixed methods were employed based on semi-structured...
Published by: IGI Global Scientific Publishing
He Ala Kuikui Lima Kānaka
This article focuses on decolonizing, or specifically Indigenizing, a school of social work that has a stated focus on Native Hawaiians, other Pacific Islanders, and Asian populations in the Pacific region. Armed with Kanaka...
Native Hawaiians Kanaka ‘Ōiwi critical race theory Indigenization decolonization social work curriculum
Published by: Memorial University of Newfoundland
He Ala Kuikui Lima Kānaka
This article focuses on decolonizing, or specifically Indigenizing, a school of social work that has a stated focus on Native Hawaiians, other Pacific Islanders, and Asian populations in the Pacific region. Armed with Kanaka...
Published by: Memorial University of Newfoundland
The Grizzly, November 8, 2012
Jessica Orbon, Sara Sherr, Dave Muoio, Keith Miles, Alexa LaMontagne, Michael D'Amico, Christine Dobisch, Austin Fox, Amanda Frekot, Courtney Scott, Larissa Coyne, Michael Klazas, Chris Rountree, Marcus Foster
Jan 01, 0001
Hurricane Hits UC, Campus Evacuated Sandy: Climate Change? Alumni Give Back to Ursinus Hillel Fosters an Open Community Christmas Mall New Faculty Members in Residence 2012 Photography Club Returns to Campus Henna Event...
Ursinus College Collegeville Pennsylvania newspaper Hurricane Sandy fund raising Hillel Trinity United Church of Christ Jennifer Stevenson Garrett Hope Photography Club To Write Love on Her Arms Football Swimming Chris Rountree cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
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