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Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2.
Jil Sander, Susanne V Schmidt, Branko Cirovic, Naomi McGovern, Olympia Papantonopoulou, Anna-Lena Hardt, Anna C Aschenbrenner, Christoph Kreer, Thomas Quast, Alexander M Xu, Lisa M Schmidleithner, Heidi Theis, Lan Do Thi Huong, Hermi Rizal Bin Sumatoh, Mario AR Lauterbach, Jonas Schulte-Schrepping, Patrick Günther, Jia Xue, Kevin Baßler, Thomas Ulas, Kathrin Klee, Natalie Katzmarski, Stefanie Herresthal, Wolfgang Krebs, Bianca Martin, Eicke Latz, Kristian Händler, Michael Kraut, Waldemar Kolanus, Marc Beyer, Christine S Falk, Bettina Wiegmann, Sven Burgdorf, Nicholas A Melosh, Evan W Newell, Florent Ginhoux, Andreas Schlitzer, Joachim L Schultze
Mar 07, 2018
Human in vitro generated monocyte-derived dendritic cells (moDCs) and macrophages are used clinically, e.g., to induce immunity against cancer. However, their physiological counterparts, ontogeny, transcriptional regulation, and...
IL-4 IL-4 activated macrophages M(IL-4) NCOR2 activation human inflammatory dendritic cells inflammatory macrophages MACROPHAGES monocyte-derived dendritic cells Monocytes Cell Differentiation Cell Lineage Dendritic Cells Gene Expression Profiling Gene Expression Regulation Granulocyte-Macrophage Colony-Stimulating Factor Humans Immunophenotyping Interleukin-4 Macrophage Activation Macrophage Colony-Stimulating Factor MACROPHAGES Monocytes Nuclear Receptor Co-Repressor 2 Primary Cell Culture Signal Transduction Time Factors Transcription Genetic
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species.
Martin Guilliams, Charles-Antoine Dutertre, Charlotte L Scott, Naomi McGovern, Dorine Sichien, Svetoslav Chakarov, Sofie Van Gassen, Jinmiao Chen, Michael Poidinger, Sofie De Prijck, Simon J Tavernier, Ivy Low, Sergio Erdal Irac, Citra Nurfarah Mattar, Hermi Rizal Sumatoh, Gillian Hui Ling Low, Tam John Kit Chung, Dedrick Kok Hong Chan, Ker Kan Tan, Tony Lim Kiat Hon, Even Fossum, Bjarne Bogen, Mahesh Choolani, Jerry Kok Yen Chan, Anis Larbi, Hervé Luche, Sandrine Henri, Yvan Saeys, Evan William Newell, Bart N Lambrecht, Bernard Malissen, Florent Ginhoux
Jun 28, 2018
Dendritic cells (DCs) are professional antigen-presenting cells that hold great therapeutic potential. Multiple DC subsets have been described, and it remains challenging to align them across tissues and species to analyze their...
Innovation In Banyuwangi Papring Batik In Efforts To Boost The Community’s Economy
Ratna Wijayanti Daniar PARAMITA, Noviansyah RIZAL, Riza Bahtiar SULISTYAN, Danang Wikan CARITO, Ikhwanul HAKIM, Fadhel Akhmad HIZHAM
Nov 30, 2022
Batik is one of the characteristics of Indonesia as a form of cultural heritage. Batik has developed and has given birth to various types and patterns of batik that are unique to each region. Batik has become the main focus of...
Published by: Indonesia Strategic Sustainability
The Abbreviated Maslach Burnout Inventory Can Overestimate Burnout
Wan Yen Lim, John Ong, Sharon Ong, Ying Hao, Hairil Rizal Abdullah, Darren Lk Koh, Un Sam May Mok
Dec 27, 2019
The Maslach Burnout Inventory for healthcare professionals (MBI-HSS) and its abbreviated version (aMBI), are the most common tools to detect burnout in clinicians. A wide range in burnout prevalence is reported in...
A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis.
Laura Whitworth, Jacob Coxon, Arjan van Laarhoven, Nguyen Thuy Thuong Thuong, Sofiati Dian, Bachti Alisjahbana, Ahmad Rizal Ganiem, Reinout van Crevel, Guy E Thwaites, Mark Troll, Paul H Edelstein, Roger Sewell, Lalita Ramakrishnan
Feb 04, 2021
Tuberculous meningitis has high mortality, linked to excessive inflammation. However, adjunctive anti-inflammatory corticosteroids reduce mortality by only 30%, suggesting that inflammatory pathophysiology causes only a subset...
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.
Naomi McGovern, Amanda Shin, Gillian Low, Donovan Low, Kaibo Duan, Leong Jing Yao, Rasha Msallam, Ivy Low, Nurhidaya Binte Shadan, Hermi R Sumatoh, Erin Soon, Josephine Lum, Esther Mok, Sandra Hubert, Peter See, Edwin Huang Kunxiang, Yie Hou Lee, Baptiste Janela, Mahesh Choolani, Citra Nurfarah Zaini Mattar, Yiping Fan, Tony Kiat Hon Lim, Dedrick Kok Hong Chan, Ker-Kan Tan, John Kit Chung Tam, Christopher Schuster, Adelheid Elbe-Bürger, Xiao-Nong Wang, Venetia Bigley, Matthew Collin, Muzlifah Haniffa, Andreas Schlitzer, Michael Poidinger, Salvatore Albani, Anis Larbi, Evan W Newell, Jerry Kok Yen Chan, Florent Ginhoux
Jun 18, 2018
During gestation the developing human fetus is exposed to a diverse range of potentially immune-stimulatory molecules including semi-allogeneic antigens from maternal cells, substances from ingested amniotic fluid, food...
A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis
Laura Whitworth, Jacob Coxon, Arjan van Laarhoven, Nguyen Thuy Thuong Thuong, Sofiati Dian, Bachti Alisjahbana, Ahmad Rizal Ganiem, Reinout van Crevel, Guy E Thwaites, Mark Troll, Paul H Edelstein, Roger Sewell, Lalita Ramakrishnan
Jan 08, 2021
Tuberculous meningitis has high mortality, linked to excessive inflammation. However, adjunctive anti-inflammatory corticosteroids reduce mortality by only 30%, suggesting that inflammatory pathophysiology causes only a subset...