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Results: 51
Effectiveness of a Hospital-Based Computerized Decision Support System on Clinician Recommendations and Patient Outcomes
Lorenzo Moja, Hernan Polo Friz, Matteo Capobussi, Koren Kwag, Rita Banzi, Francesca Ruggiero, Marien González-Lorenzo, Elisa G Liberati, Massimo Mangia, Peter Nyberg, Ilkka Kunnamo, Claudio Cimminiello, Giuseppe Vighi, Jeremy M Grimshaw, Giovanni Delgrossi, Stefanos Bonovas
Sep 11, 2020
IMPORTANCE: Sophisticated evidence-based information resources can filter medical evidence from the literature, integrate it into electronic health records, and generate recommendations tailored to individual patients....
Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1.
David J Huggins, Bryn S Hardwick, Pooja Sharma, Amy Emery, Luca Laraia, Fengzhi Zhang, Ana J Narvaez, Meredith Roberts-Thomson, Alex T Crooks, Robert G Boyle, Richard Boyce, David W Walker, Natalia Mateu, Grahame J McKenzie, David R Spring, Ashok R Venkitaraman
Dec 16, 2019
Polo-like kinase 1 (PLK1) is a key regulator of mitosis and a recognized drug target for cancer therapy. Inhibiting the polo-box domain of PLK1 offers potential advantages of increased selectivity and subsequently reduced...
Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1.
David J Huggins, Bryn S Hardwick, Pooja Sharma, Amy Emery, Luca Laraia, Fengzhi Zhang, Ana J Narvaez, Meredith Roberts-Thomson, Alex T Crooks, Robert G Boyle, Richard Boyce, David W Walker, Natalia Mateu, Grahame J McKenzie, David R Spring, Ashok R Venkitaraman
Feb 19, 2020
Polo-like kinase 1 (PLK1) is a key regulator of mitosis and a recognized drug target for cancer therapy. Inhibiting the polo-box domain of PLK1 offers potential advantages of increased selectivity and subsequently reduced...
Published by: ACS omega
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
Pooja Sharma, Robert Mahen, Maxim Rossmann, Jamie E Stokes, Bryn Hardwick, David J Huggins, Amy Emery, Dominique L Kunciw, Marko Hyvönen, David R Spring, Grahame J McKenzie, Ashok R Venkitaraman
Dec 06, 2019
The human polo-like kinase PLK1 coordinates mitotic chromosome segregation by phosphorylating multiple chromatin- and kinetochore-binding proteins. How PLK1 activity is directed to specific substrates via phosphopeptide...
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
Pooja Sharma, Robert Mahen, Maxim Rossmann, Jamie E. Stokes, Bryn Hardwick, David J. Huggins, Amy Emery, Dominique L. Kunciw, Marko Hyvönen, David R. Spring, Grahame J. McKenzie, Ashok R. Venkitaraman
Nov 03, 2020
Abstract: The human polo-like kinase PLK1 coordinates mitotic chromosome segregation by phosphorylating multiple chromatin- and kinetochore-binding proteins. How PLK1 activity is directed to specific substrates via...
The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes during Drosophila oogenesis.
Alexis Leah Braun, Francesco Meghini, Gema Villa-Fombuena, Morgane Guermont, Elisa Fernandez-Martinez, Zhang Qian, Maria Dolores Martín-Bermudo, Acaimo González-Reyes, David Moore Glover, Yuu Kimata
Jun 29, 2021
A feature of metazoan reproduction is the elimination of maternal centrosomes from the oocyte. In animals that form syncytial cysts during oogenesis, including Drosophila and human, all centrosomes within the cyst migrate to the...
Putative link between Polo-like kinases (PLKs) and Toll-like receptor (TLR) signaling in transformed and primary human immune cells.
Souhayla El Maadidi, Alexander NR Weber, Precious Motshwene, Jan Moritz Schüssler, Daniel Backes, Sabine Dickhöfer, Hui Wang, Xiao Liu, Magno Delmiro Garcia, Christoph Taumer, Boumediene Soufi, Olaf-Oliver Wolz, Sascha N Klimosch, Mirita Franz-Wachtel, Boris Macek, Nicholas J Gay
Sep 10, 2020
Toll-like receptors (TLRs) are important sentinels of bacterial and viral infection and thus fulfil a critical sensory role in innate immunity. Polo-like kinases (PLKs), a five membered family of Ser/Thr protein kinases, have...
Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing.
Hongqing Liang, Alessandro Esposito, Siddharth De, Suzan Ber, Philippe Collin, Uttam Surana, Ashok R Venkitaraman
Jan 25, 2021
The G2 checkpoint monitors DNA damage, preventing mitotic entry until the damage can be resolved. The mechanisms controlling checkpoint recovery are unclear. Here, we identify non-genetic heterogeneity in the fidelity and timing...
Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells.
While the immune cell adaptor protein SKAP1 mediates LFA-1 activation induced by antigen-receptor (TCR/CD3) ligation on T-cells, it is unclear whether the adaptor interacts with other mediators of T-cell function. In this...
Evidence that a positive feedback loop drives centrosome maturation in fly embryos.
Ines Alvarez-Rodrigo, Thomas L Steinacker, Saroj Saurya, Paul T Conduit, Janina Baumbach, Zsofia A Novak, Mustafa G Aydogan, Alan Wainman, Jordan W Raff
Oct 31, 2019
Centrosomes are formed when mother centrioles recruit pericentriolar material (PCM) around themselves. The PCM expands dramatically as cells prepare to enter mitosis (a process termed centrosome maturation), but it is unclear...
D. melanogaster Spd-2 Cell Biology centriole Centrosome feedback loop pericentriolar material polo kinase Animals Centrosome Drosophila Proteins Drosophila melanogaster Embryo Nonmammalian Feedback Physiological Homeodomain Proteins Mitosis Phosphorylation Protein Processing Post-Translational Protein Serine-Threonine Kinases
Metal-organic frameworks post-synthetically modified with ferrocenyl groups
Metal-organic framework (MOF) materials based on zinc(II) and aluminium(III) dicarboxylate frameworks with covalently attached ferrocene functional redox groups were synthesised by post-synthetic modification and investigated by...
Metal-organic frameworks post-synthetically modified with ferrocenyl groups
Metal-organic framework (MOF) materials based on zinc(II) and aluminium(III) dicarboxylate frameworks with covalently attached ferrocene functional redox groups were synthesised by post-synthetic modification and investigated by...
Small Molecules as Probes for Cell Division and Intracellular Transport
Ulf Peters
Jan 01, 0001
Cell-permeable small molecules that can act on their targets on fast time scales are powerful probes of cell division mechanisms and intracellular transport processes. Phenotype-based screens with chemical libraries have been...
Published by: Rockefeller University
Enhancer Priming Enables Fast and Sustained Transcriptional Responses to Notch Signaling.
Drosophila notch signaling burst duration ENHANCER enhancer priming Live imaging transcriptional bursting Animals Animals Genetically Modified Binding Sites Drosophila Proteins Drosophila melanogaster Embryo Nonmammalian Embryonic Development Enhancer Elements Genetic Gene Expression Regulation Developmental Nuclear Proteins Phosphoproteins Receptors Notch Regulatory Sequences Nucleic Acid Signal Transduction Transcription Factors Transcription Genetic Transcriptional Activation Twist-Related Protein 1
Regulation of Anaphase Promoting Complex Coactivators
Jonathan Robbins
Jan 01, 0001
Ubiquitin-mediated proteolytic degradation is fundamental to eukaryotic cell cycle progression. From late mitosis through early G1, the Anaphase Promoting Complex (APC) is essential for cell-cycle relevant proteolytic...
Published by: Rockefeller University
The Ursinus Weekly, December 14, 1972
Charles Chambers, Joseph Van Wyk, Leanne Schelberg, Nesan Kadirgamar, Richard Whaley, Meredith Brown, John T. Fidler, Robert A. Searles, Ruthann Connell, Marilyn Harsch
Jan 01, 0001
Chemotherapist speaks to Pre-med group Messiah performance successful Union Board of Governors holds organizing meeting Special convocation grants degree Board of Control meets to select Weekly editors Ursinus Judo Club...
Ursinus College Collegeville Pennsylvania newspaper Brownback-Anders Pre-Med Society Leo C. Eddinger College Union student government Paul R. Michener Judo Club Fantasticks ProTheatre Frank Zappa fire company Basketball wrestling Women's Athletic Association swim team aquatics club cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Grizzly, February 23, 1998
Melinda Albert, Kristin Geist, Justin Harrison, Katrina Milton, Maria DeGracia, Brian Berg, Ryan Hemphill, Jay Wilkes, Ted Schaffer, Kim Inglot, Lou Nemphos, Carolyn Harfman, Jude Blessington, Stephanie Restine, Tricia Murname, Jennifer Heil, Meghan Gualtieri, Jesse Federman, Jacqueline Colvin, Jamie Hurvitz, Michael Bauer
Jan 01, 0001
State Representative Speaks to the Ursinus Community Bringing a Campus Together Bass Voices His Views on Anti-Semitism Opinion: Greeks Respond to Rudloff's Article; Alumna Remembers Separate Dorms; A Faculty Member's Concern...
Ursinus College Collegeville Pennsylvania newspaper Basketball gymnastics water polo Donny Asper Bucky Johnson Alcoholics Anonymous student housing French department ProTheatre pledging Charles Rice sororities fraternities Anthony Hardy Williams Leon Bass alcohol awareness cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Repurposed immunomodulatory drugs for Covid-19 in pre-ICu patients - mulTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19 - Repurposed Drugs (TACTIC-R)
Spoorthy Kulkarni, Marie Fisk, Michalis Kostapanos, Edward Banham-Hall, Simon Bond, Elena Hernan-Sancho, Sam Norton, Joseph Cheriyan, Andrew Cope, James Galloway, Frances Hall, David Jayne, Ian B Wilkinson
Jul 20, 2020
OBJECTIVES: To determine if a specific immunomodulatory intervention reduces progression of COVID-19-related disease to organ failure or death, compared to standard of care (SoC). TRIAL DESIGN: Randomised, parallel 3-arm (1:1:1...
Adaptive trial Baricitinib covid-19 Open-label Protocol randomised controlled trial Ravulizumab Repurposed drugs Antibodies Monoclonal Humanized azetidines Betacoronavirus covid-19 Coronavirus Infections Drug Repositioning Humans Immunologic Factors Intensive Care Units Pandemics Pneumonia Viral Purines Pyrazoles Randomized Controlled Trials as Topic SARS-CoV-2 Sulfonamides COVID-19 Drug Treatment
Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells.
Laura M Nolan, Amy K Cain, Thomas Clamens, R Christopher D Furniss, Eleni Manoli, Maria A Sainz-Polo, Gordon Dougan, David Albesa-Jové, Julian Parkhill, Despoina A I Mavridou, Alain Filloux
Sep 20, 2021
The Type VI secretion system (T6SS) is a bacterial nanomachine that delivers toxic effectors to kill competitors or subvert some of their key functions. Here, we use transposon directed insertion-site sequencing to identify T6SS...
Pseudomonas aeruginosa Multiprotein Complexes Bacterial Proteins Bacterial Toxins Protein Biosynthesis Protein Binding Type VI Secretion Systems
Published by: Nature microbiology
The Grizzly, October 13, 2011
Liz Kilmer, Nick Pane, Hilary Gibbs, Satchel Summers, Lisa Jobe, James Noebels, Connor Gregory, Ron Stranix, Jordan Demcher, Sabrina McGettigan, Kyu Chul Shin, Sophie Zander, Dave Muoio, Victoria Cameron
Jan 01, 0001
UCARE Draws More Blood, Donors "Ursinus is Talking About" Author Speaks on Novel Annual Security and Fire Safety Report Released Alcohol-Related Hospitalizations Rise, Confuse Administration Berman Exhibit Honors Muhlenberg...
Ursinus College Collegeville Pennsylvania newspaper UCARE Red Cross Edmund White campus safety Alcohol Berman Art Museum Lisa Minardi Henry Muhlenberg Gay Straight Alliance Marcia Clouser Renaissance Band water polo Soccer Rugby cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
Pooja Sharma, Robert Mahen, Maxim Rossmann, Jamie E Stokes, Bryn Hardwick, David J Huggins, Amy Emery, Dominique L Kunciw, Marko Hyvönen, David R Spring, Grahame J McKenzie, Ashok R Venkitaraman
Aug 21, 2019
3' Untranslated Regions Cell Cycle Proteins Cell Survival Chromosome Segregation HeLa Cells Histones Humans Kinetochores Mitosis Mutagenesis Protein Binding Protein Domains Protein Kinase Inhibitors Protein Serine-Threonine Kinases Protein Structure Tertiary Proto-Oncogene Proteins RNA Interference RNA Small Interfering Substrate Specificity
Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells.
Laura M Nolan, Amy K Cain, Thomas Clamens, R Christopher D Furniss, Eleni Manoli, Maria A Sainz-Polo, Gordon Dougan, David Albesa-Jové, Julian Parkhill, Despoina AI Mavridou, Alain Filloux
Oct 18, 2021
The Type VI secretion system (T6SS) is a bacterial nanomachine that delivers toxic effectors to kill competitors or subvert some of their key functions. Here, we use transposon directed insertion-site sequencing to identify T6SS...
Perspectives on Applications of Geospatial Technology and Landscape Ecology for Conservation Planning in the Global South
Henry Bulley, Oludunsin Arodudu, Esther Obonyo, Aniko Polo-Akpisso, Esther Ibrahim, Yazidhi Bamutaze
Jan 01, 2023
Rapidly changing landscapes and disturbance regimes in the Global South impact the viability of conservation planning. Although conservation planning processes benefit from reliable multi-scale and multi-temporal data on...
Published by: IGI Global Scientific Publishing
Relationships between species richness and ecosystem services in Amazonian forests strongly influenced by biogeographical strata and forest types.
Gijs Steur, Hans ter Steege, René W Verburg, Daniel Sabatier, Jean-François Molino, Olaf S Bánki, Hernan Castellanos, Juliana Stropp, Émile Fonty, Sofie Ruysschaert, David Galbraith, Michelle Kalamandeen, Tinde R van Andel, Roel Brienen, Oliver L Phillips, Kenneth J Feeley, John Terborgh, Pita A Verweij
Apr 08, 2022
Despite increasing attention for relationships between species richness and ecosystem services, for tropical forests such relationships are still under discussion. Contradicting relationships have been reported concerning carbon...
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