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beachmat
Biological experiments involving genomics or other high-throughput assays typically yield a data matrix that can be explored and analyzed using the R programming language with packages from the Bioconductor project. Improvements...
Hervé- and Krebs-Type Magnetic Polyoxometalate Dimers
Lacunary polyoxometalates (POMs) are negatively charged metal–oxo clusters, formally obtained from plenary topologies via fragment removal. Owing to the fragment removal, the lacunary POMs archetypes are rich in...
Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized 13C-methylglyoxal.
Dmitry Shishmarev, Philip W Kuchel, Guilhem Pagès, Alan J Wright, Richard L Hesketh, Felix Kreis, Kevin M Brindle
Feb 25, 2019
Methylglyoxal is a faulty metabolite. It is a ubiquitous by-product of glucose and amino acid metabolism that spontaneously reacts with proximal amino groups in proteins and nucleic acids, leading to impairment of their...
Mitochondrial and nuclear disease panel (Mito-aND-Panel)
Angela Abicht, Florentine Scharf, Stephanie Kleinle, Ulrike Schön, Elke Holinski-Feder, Rita Horvath, Anna Benet-Pagès, Isabel Diebold
Mar 07, 2019
BACKGROUND: The diagnosis of mitochondrial disorders is challenging because of the clinical variability and genetic heterogeneity of these conditions. Next-Generation Sequencing (NGS) technology offers a robust high-throughput...
NUMTs heteroplasmy detection high-throughput sequencing mitochondrial and nuclear disease panel mitochondrial disorders mtDNA-server Costs and Cost Analysis DNA Mitochondrial Genetic Testing High-Throughput Nucleotide Sequencing Humans Mitochondrial Diseases Sensitivity and Specificity Sequence Analysis DNA
Developmental Restriction of Retrotransposition Activated in Arabidopsis by Environmental Stress.
Retrotransposons (RTs) can rapidly increase in copy number due to periodic bursts of transposition. Such bursts are mutagenic and thus potentially deleterious. However, certain transposition-induced gain-of-function or...
Asymmetric division of contractile domains couples cell positioning and fate specification.
Jean-Léon Maître, Hervé Turlier, Rukshala Illukkumbura, Björn Eismann, Ritsuya Niwayama, François Nédélec, Takashi Hiiragi
Aug 06, 2020
During pre-implantation development, the mammalian embryo self-organizes into the blastocyst, which consists of an epithelial layer encapsulating the inner-cell mass (ICM) giving rise to all embryonic tissues. In mice, oriented...
Adaptor Proteins Signal Transducing Animals Blastocyst Blastocyst Inner Cell Mass Blastomeres Cell Cycle Proteins Cell Differentiation Cell Division Cell Lineage Cell Movement Cell Polarity Embryo Mammalian Embryonic Development Female Male Mice Phosphoproteins Protein Transport Reproducibility of Results YAP-Signaling Proteins
Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells.
Camille Martin-Gallausiaux, Pierre Larraufie, Anne Jarry, Fabienne Béguet-Crespel, Ludovica Marinelli, Florence Ledue, Frank Reimann, Hervé M Blottière, Nicolas Lapaque
Dec 20, 2018
Commensal bacteria are crucial for the development and maintenance of a healthy immune system therefore contributing to the global well-being of their host. A wide variety of metabolites produced by commensal bacteria are...
IDO-1 butyrate Gut microbiota immune gene regulation intestinal epithelial cells Bacteria Butyric Acid Caco-2 Cells Down-Regulation Epithelial Cells Female Gastrointestinal Microbiome Gene Expression Regulation Developmental Humans Indoleamine-Pyrrole 2 3 -Dioxygenase Interferon-gamma Intestinal Mucosa Male Middle Aged Receptors G-Protein-Coupled Transcription Factors
High-frequency recombination between members of an LTR retrotransposon family during transposition bursts.
Retrotransposons containing long terminal repeats (LTRs) form a substantial fraction of eukaryotic genomes. The timing of past transposition can be estimated by quantifying the accumulation of mutations in initially identical...
Alginates along the filament of the brown alga Ectocarpus help cells cope with stress.
Hervé Rabillé, Thomas A Torode, Benoit Tesson, Aude Le Bail, Bernard Billoud, Elodie Rolland, Sophie Le Panse, Murielle Jam, Bénédicte Charrier
Sep 09, 2020
Ectocarpus is a filamentous brown alga, which cell wall is composed mainly of alginates and fucans (80%), two non-crystalline polysaccharide classes. Alginates are linear chains of epimers of 1,4-linked uronic acids...
A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis.
Jonathan Bond, Aleksandra Krzywon, Ludovic Lhermitte, Christophe Roumier, Anne Roggy, Mohamed Belhocine, Alexander Abdulkader Kheirallah, Patrick Villarese, Guillaume Hypolite, Francine Garnache-Ottou, Sylvie Castaigne, Nicolas Boissel, Vahid Asnafi, Claude Preudhomme, Hervé Dombret, Elisa Laurenti, Elizabeth Macintyre
Jun 11, 2020
In vivo recordings of brain activity using organic transistors.
Dion Khodagholy, Thomas Doublet, Pascale Quilichini, Moshe Gurfinkel, Pierre Leleux, Antoine Ghestem, Esma Ismailova, Thierry Hervé, Sébastien Sanaur, Christophe Bernard, George G Malliaras
Mar 27, 2018
In vivo electrophysiological recordings of neuronal circuits are necessary for diagnostic purposes and for brain-machine interfaces. Organic electronic devices constitute a promising candidate because of their mechanical...
Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.
Arun Mouli Kolinjivadi, Vincenzo Sannino, Anna De Antoni, Karina Zadorozhny, Mairi Kilkenny, Hervé Técher, Giorgio Baldi, Rong Shen, Alberto Ciccia, Luca Pellegrini, Lumir Krejci, Vincenzo Costanzo
Sep 03, 2019
BRCA2 DNA Replication Mre11 RAD51 Xenopus laevis fork protection Animals BRCA2 Protein Binding Sites DNA DNA Helicases DNA Polymerase I DNA Polymerase III DNA Replication DNA-Binding Proteins Endodeoxyribonucleases Exodeoxyribonucleases Female Genomic Instability Humans MRE11 Homologue Protein Male Mutation Protein Binding Rad51 Recombinase Replication Origin Saccharomyces cerevisiae Proteins Time Factors Xenopus Proteins Xenopus laevis
Key contribution of eIF4H-mediated translational control in tumor promotion.
Charlotte Vaysse, Céline Philippe, Yvan Martineau, Cathy Quelen, Corinne Hieblot, Claire Renaud, Yvan Nicaise, Aurore Desquesnes, Maria Pannese, Thomas Filleron, Ghislaine Escourrou, Malcolm Lawson, Robert C Rintoul, Marie Bernadette Delisle, Stéphane Pyronnet, Pierre Brousset, Hervé Prats, Christian Touriol
Sep 05, 2018
Dysregulated expression of translation initiation factors has been associated with carcinogenesis, but underlying mechanisms remains to be fully understood. Here we show that eIF4H (eukaryotic translation initiation factor 4H)...
IRES chemoresistance eIF4H helicase lung carcinoma Translation Initiation Factor Animals Antineoplastic Agents Apoptosis Blotting Western Cell Cycle Cell Line Tumor Cell Proliferation cisplatin Etoposide Eukaryotic Initiation Factors Female Gene Expression Regulation Neoplastic HeLa Cells Humans Lung Neoplasms Male Mice Mice Nude NIH 3T3 Cells Protein Biosynthesis RNA Interference RNAi Therapeutics Reverse Transcriptase Polymerase Chain Reaction Tumor Burden Xenograft Model Antitumor Assays
Skin hepcidin initiates psoriasiform skin inflammation via Fe-driven hyperproliferation and neutrophil recruitment
Elise Abboud, Doha Chrayteh, Nadia Boussetta, Héloise Dalle, Mariangela Malerba, Ting Di Wu, Morgane Le Gall, Olivier Reelfs, Charareh Pourzand, Mark Mellett, Florence Assan, Hervé Bachelez, Joël Poupon, Selim Aractingi, Sophie Vaulont, Pierre Sohier, Bénédicte Oules, Zoubida Karim, Carole Peyssonnaux
Aug 07, 2024
Psoriasis is a multifactorial, chronic inflammatory skin disease with unresolved questions on its primary events. Iron overload has been described in the epidermis of psoriasis patients, but its relevance remains unknown. We...
Antibody Persistence at the Population Level 5 Years After Mass Vaccination With Meningococcal Serogroup A Conjugate Vaccine (PsA-TT) in Burkina Faso
Skin hepcidin initiates psoriasiform skin inflammation via Fe-driven hyperproliferation and neutrophil recruitment
Elise Abboud, Doha Chrayteh, Nadia Boussetta, Héloise Dalle, Mariangela Malerba, Ting Di Wu, Morgane Le Gall, Olivier Reelfs, Charareh Pourzand, Mark Mellett, Florence Assan, Hervé Bachelez, Joël Poupon, Selim Aractingi, Sophie Vaulont, Pierre Sohier, Bénédicte Oules, Zoubida Karim, Carole Peyssonnaux
Aug 07, 2024
Psoriasis is a multifactorial, chronic inflammatory skin disease with unresolved questions on its primary events. Iron overload has been described in the epidermis of psoriasis patients, but its relevance remains unknown. We...
Multi-Center Evaluation of the Fully Automated PCR-Based Idylla™ KRAS Mutation Assay for Rapid KRAS Mutation Status Determination on Formalin-Fixed Paraffin-Embedded Tissue of Human Colorectal Cancer.
Jérôme Solassol, Julie Vendrell, Bruno Märkl, Christian Haas, Beatriz Bellosillo, Clara Montagut, Matthew Smith, Brendan O'Sullivan, Nicky D'Haene, Marie Le Mercier, Morten Grauslund, Linea Cecilie Melchior, Emma Burt, Finbarr Cotter, Daniel Stieber, Fernando de Lander Schmitt, Valentina Motta, Calogero Lauricella, Richard Colling, Elizabeth Soilleux, Matteo Fassan, Claudia Mescoli, Christine Collin, Jean-Christophe Pagès, Peter Sillekens
Dec 20, 2019
Since the advent of monoclonal antibodies against epidermal growth factor receptor (EGFR) in colorectal cancer therapy, the determination of RAS mutational status is needed for therapeutic decision-making. Most prevalent in...
A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis
Jonathan Bond, Aleksandra Krzywon, Ludovic Lhermitte, Christophe Roumier, Anne Roggy, Mohamed Belhocine, Alexander Abdulkader Kheirallah, Patrick Villarese, Guillaume Hypolite, Francine Garnache-Ottou, Sylvie Castaigne, Nicolas Boissel, Vahid Asnafi, Claude Preudhomme, Hervé Dombret, Elisa Laurenti, Elizabeth Macintyre
Jul 28, 2021
Abstract: Classification of acute lymphoblastic and myeloid leukemias (ALL and AML) remains heavily based on phenotypic resemblance to normal hematopoietic precursors. This framework can provide diagnostic challenges for...
A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis
Jonathan Bond, Aleksandra Krzywon, Ludovic Lhermitte, Christophe Roumier, Anne Roggy, Mohamed Belhocine, Alexander Abdulkader Kheirallah, Patrick Villarese, Guillaume Hypolite, Francine Garnache-Ottou, Sylvie Castaigne, Nicolas Boissel, Vahid Asnafi, Claude Preudhomme, Hervé Dombret, Elisa Laurenti, Elizabeth Macintyre
Mar 04, 2021
Abstract: Classification of acute lymphoblastic and myeloid leukemias (ALL and AML) remains heavily based on phenotypic resemblance to normal hematopoietic precursors. This framework can provide diagnostic challenges for...
Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people
Francis M Finucane, Jessica Horton, Lisa R Purslow, David B Savage, Soren Brage, Hervé Besson, Kenneth Horton, Ema De Lucia Rolfe, Alison Sleigh, Stephen J Sharp, Helen J Martin, Avan Aihie Sayer, Cyrus Cooper, Ulf Ekelund, Simon J Griffin, Nicholas J Wareham
Jun 16, 2011
1103 Clinical Sciences 1117 Public Health and Health Services Clinical Clinical Medicine and Science aging Cardiovascular Clinical Research obesity Nutrition Prevention Clinical Trials and Supportive Activities Metabolic and endocrine 6.7 Physical 3.1 Primary prevention interventions to modify behaviours or promote well-being
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.
Stephan C Collins, Anna Mikhaleva, Katarina Vrcelj, Valerie E Vancollie, Christel Wagner, Nestor Demeure, Helen Whitley, Meghna Kannan, Rebecca Balz, Lauren FE Anthony, Andrew Edwards, Hervé Moine, Jacqueline K White, David J Adams, Alexandre Reymond, Christopher J Lelliott, Caleb Webber, Binnaz Yalcin
Feb 04, 2021
Brain morphogenesis is an important process contributing to higher-order cognition, however our knowledge about its biological basis is largely incomplete. Here we analyze 118 neuroanatomical parameters in 1,566 mutant mouse...
The emergence of classical BSE from atypical/Nor98 scrapie.
Alvina Huor, Juan Carlos Espinosa, Enric Vidal, Hervé Cassard, Jean-Yves Douet, Séverine Lugan, Naima Aron, Alba Marín-Moreno, Patricia Lorenzo, Patricia Aguilar-Calvo, Juan Badiola, Rosa Bolea, Martí Pumarola, Sylvie L Benestad, Leonore Orge, Alana M Thackray, Raymond Bujdoso, Juan-Maria Torres, Olivier Andreoletti
Nov 25, 2019
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