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Results: 7363
Variation in Structure and Process of Care in Traumatic Brain Injury
Maryse C Cnossen, Suzanne Polinder, Hester F Lingsma, Andrew IR Maas, David Menon, Ewout W Steyerberg, CENTER-TBI Investigators and Participants
Jun 19, 2018
INTRODUCTION: The strength of evidence underpinning care and treatment recommendations in traumatic brain injury (TBI) is low. Comparative effectiveness research (CER) has been proposed as a framework to provide evidence for...
Rehabilitation after traumatic brain injury
Maryse C Cnossen, Hester F Lingsma, Olli Tenovuo, Andrew IR Maas, David Menon, Ewout W Steyerberg, Gerard M Ribbers, Suzanne Polinder
Jun 25, 2018
OBJECTIVE: To describe variation in structural and process characteristics of acute in-hospital rehabilitation and referral to post-acute care for patients with traumatic brain injury across Europe. DESIGN: Survey study, of...
f-scLVM
Florian Buettner, Naruemon Pratanwanich, Davis J McCarthy, John C Marioni, Oliver Stegle
Mar 26, 2018
Single-cell RNA-sequencing (scRNA-seq) allows studying heterogeneity in gene expression in large cell populations. Such heterogeneity can arise due to technical or biological factors, making decomposing sources of variation...
Gene set annotations Single-cell RNA-seq Sparse factor analysis Animals Computer Simulation Databases as Topic Factor Analysis Statistical Gene Expression Regulation Mice Models Theoretical Mouse embryonic stem cells Neurons Reproducibility of Results Sequence Analysis RNA Single-Cell Analysis Software
Use and impact of high intensity treatments in patients with traumatic brain injury across Europe
Jilske A Huijben, Abhishek Dixit, Nino Stocchetti, Andrew IR Maas, Hester F Lingsma, Mathieu van der Jagt, David Nelson, Giuseppe Citerio, Lindsay Wilson, David K Menon, Ari Ercole, CENTER-TBI Investigators and Participants
Nov 03, 2020
PURPOSE: To study variation in, and clinical impact of high Therapy Intensity Level (TIL) treatments for elevated intracranial pressure (ICP) in patients with traumatic brain injury (TBI) across European Intensive Care Units...
Variation in neurosurgical management of traumatic brain injury
Thomas A van Essen, Hugo F den Boogert, Maryse C Cnossen, Godard CW de Ruiter, Iain Haitsma, Suzanne Polinder, Ewout W Steyerberg, David Menon, Andrew IR Maas, Hester F Lingsma, Wilco C Peul, CENTER-TBI Investigators and Participants
Apr 09, 2020
BACKGROUND: Neurosurgical management of traumatic brain injury (TBI) is challenging, with only low-quality evidence. We aimed to explore differences in neurosurgical strategies for TBI across Europe. METHODS: A survey was sent...
Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury.
Benjamin Y Gravesteijn, Daan Nieboer, Ari Ercole, Hester F Lingsma, David Nelson, Ben van Calster, Ewout W Steyerberg, CENTER-TBI collaborators
Feb 10, 2020
OBJECTIVE: We aimed to explore the added value of common machine learning (ML) algorithms for prediction of outcome for moderate and severe traumatic brain injury. STUDY DESIGN AND SETTING: We performed logistic regression (LR)...
The burden of traumatic brain injury from low-energy falls among patients from 18 countries in the CENTER-TBI Registry
Fiona E Lecky, Olubukola Otesile, Carl Marincowitz, Marek Majdan, Daan Nieboer, Hester F Lingsma, Marc Maegele, Giuseppe Citerio, Nino Stocchetti, Ewout W Steyerberg, David K Menon, Andrew I R Maas
Oct 18, 2021
Published by: PLoS Medicine
Management of Mild Traumatic Brain Injury at the Emergency Department and Hospital Admission in Europe
Kelly A Foks, Maryse C Cnossen, Diederik WJ Dippel, Andrew IR Maas, David Menon, Joukje van der Naalt, Ewout W Steyerberg, Hester F Lingsma, Suzanne Polinder
Nov 19, 2018
Previous studies have indicated that there is no consensus about management of mild traumatic brain injury (mTBI) at the emergency department (ED) and during hospital admission. We aim to study variability between management...
Synthesis and characterization of fluorinated β-ketoiminate zinc precursors and their utility in the AP-MOCVD growth of ZnO
Andrew L. Johnson, Samuel D. Cosham, Gabriele Kociok-Kohn, Jeff A. Hamilton, Michael S. Hill, Kieran C. Molloy, Remi Castaing
Sep 01, 2015
A novel family of zinc bis beta-ketoiminate complexes 2b-2h have been synthesized by reaction of the isolated free ligands (1a-h) with dimethylzinc. The isolated zinc complexes were characterized by elemental analysis, NMR...
Handling of Missing Outcome Data in Traumatic Brain Injury Research
Sophie Richter, Susan Stevenson, Tom Newman, Lindsay Wilson, David K Menon, Andrew IR Maas, Daan Nieboer, Hester Lingsma, Ewout W Steyerberg, Virginia FJ Newcombe
Apr 17, 2019
Synthesis and characterization of fluorinated β-ketoiminate zinc precursors and their utility in the AP-MOCVD growth of ZnO
Andrew L. Johnson, Samuel D. Cosham, Gabriele Kociok-Kohn, Jeff A. Hamilton, Michael S. Hill, Kieran C. Molloy, Remi Castaing
Sep 01, 2015
A novel family of zinc bis beta-ketoiminate complexes 2b-2h have been synthesized by reaction of the isolated free ligands (1a-h) with dimethylzinc. The isolated zinc complexes were characterized by elemental analysis, NMR...
The burden of traumatic brain injury from low-energy falls among patients from 18 countries in the CENTER-TBI Registry
Fiona E. Lecky, Olubukola Otesile, Carl Marincowitz, Marek Majdan, Daan Nieboer, Hester F. Lingsma, Marc Maegele, Giuseppe Citerio, Nino Stocchetti, Ewout W. Steyerberg, David K. Menon, Andrew I. R. Maas, CENTER-TBI Participants and Investigators
Oct 13, 2021
Quality indicators for patients with traumatic brain injury in European intensive care units
Jilske A Huijben, Eveline J A Wiegers, Ari Ercole, Nicolette F de Keizer, Andrew I R Maas, Ewout W Steyerberg, Giuseppe Citerio, Lindsay Wilson, Suzanne Polinder, Daan Nieboer, David Menon, Hester F Lingsma, Mathieu van der Jagt
Apr 05, 2020
BACKGROUND:The aim of this study is to validate a previously published consensus-based quality indicator set for the management of patients with traumatic brain injury (TBI) at intensive care units (ICUs) in Europe and to study...
Quality indicators for patients with traumatic brain injury in European intensive care units
Jilske A Huijben, Eveline JA Wiegers, Ari Ercole, Nicolette F de Keizer, Andrew IR Maas, Ewout W Steyerberg, Giuseppe Citerio, Lindsay Wilson, Suzanne Polinder, Daan Nieboer, David Menon, Hester F Lingsma, Mathieu van der Jagt, CENTER-TBI investigators and participants for the ICU stratum
Feb 17, 2020
BACKGROUND: The aim of this study is to validate a previously published consensus-based quality indicator set for the management of patients with traumatic brain injury (TBI) at intensive care units (ICUs) in Europe and to study...
Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients
Ernest van Veen, Mathieu van der Jagt, Giuseppe Citerio, Nino Stocchetti, Diederik Gommers, Alex Burdorf, David K Menon, Andrew IR Maas, Erwin JO Kompanje, Hester F Lingsma, CENTER-TBI Investigators and Participants
Nov 05, 2021
BACKGROUND: In patients with severe brain injury, withdrawal of life-sustaining measures (WLSM) is common in intensive care units (ICU). WLSM constitutes a dilemma: instituting WLSM too early could result in death despite the...
Imputation strategies for missing baseline neurological assessment covariates after traumatic brain injury
Ari Ercole, Abhishek Dixit, David W Nelson, Shubhayu Bhattacharyay, Frederick A Zeiler, Daan Nieboer, Omar Bouamra, David K Menon, Andrew I R Maas, Simone A Dijkland, Hester F Lingsma, Lindsay Wilson, Fiona Lecky, Ewout W Steyerberg
Sep 08, 2021
Statistical models for outcome prediction are central to traumatic brain injury research and critical to baseline risk adjustment. Glasgow coma score (GCS) and pupil reactivity are crucial covariates in all such models but may...
Published by: PLOS ONE
Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury
Maryse C Cnossen, Jilske A Huijben, Mathieu van der Jagt, Victor Volovici, Thomas van Essen, Suzanne Polinder, David Nelson, Ari Ercole, Nino Stocchetti, Giuseppe Citerio, Wilco C Peul, Andrew I R Maas, David Menon, Ewout W Steyerberg, Hester F Lingsma
Sep 06, 2017
Abstract
Background
No definitive evidence exists on how intracranial hypertension should be treated in patients with traumatic brain injury (TBI). It is therefore likely that...
Study Design Features Associated with Patient Attrition in Studies of Traumatic Brain Injury
Sophie Richter, Susan Stevenson, Tom Newman, Lindsay Wilson, Andrew IR Maas, Daan Nieboer, Hester Lingsma, Ewout W Steyerberg, Virginia FJ Newcombe
Apr 09, 2020
Primary versus early secondary referral to a specialized neurotrauma center in patients with moderate/severe traumatic brain injury
Charlie Aletta Sewalt, Benjamin Yaël Gravesteijn, David Menon, Hester Floor Lingsma, Andrew IR Maas, Nino Stocchetti, Esmee Venema, Fiona E Lecky, CENTER TBI Participants and Investigators
Aug 26, 2021
BACKGROUND: Prehospital care for patients with traumatic brain injury (TBI) varies with some emergency medical systems recommending direct transport of patients with moderate to severe TBI to hospitals with specialist...
Adjusting for confounding by indication in observational studies
Maryse C Cnossen, Thomas A van Essen, Iris E Ceyisakar, Suzanne Polinder, Teuntje M Andriessen, Joukje van der Naalt, Iain Haitsma, Janneke Horn, Gaby Franschman, Pieter E Vos, Wilco C Peul, David K Menon, Andrew IR Maas, Ewout W Steyerberg, Hester F Lingsma
Sep 20, 2018
INTRODUCTION: Observational studies of interventions are at risk for confounding by indication. The objective of the current study was to define the circumstances for the validity of methods to adjust for confounding by...
Intensive care admission criteria for traumatic brain injury patients across Europe.
Victor Volovici, Ari Ercole, Giuseppe Citerio, Nino Stocchetti, Iain K Haitsma, Jilske A Huijben, Clemens MF Dirven, Mathieu van der Jagt, Ewout W Steyerberg, David Nelson, Maryse C Cnossen, Andrew IR Maas, Suzanne Polinder, David K Menon, Hester F Lingsma
Dec 12, 2018
CENTER-TBI cost-effectiveness European policy Intensive care admission Intensive care occupancy Moderate and Severe TBI Brain Injuries Traumatic Cohort Studies Cost-Benefit Analysis Critical Care Europe Hospitalization Humans Intensive Care Units Israel Patient Admission Prospective Studies Surveys and Questionnaires Trauma Centers
Imputation of Ordinal Outcomes
Kevin Kunzmann, Lorenz Wernisch, Sylvia Richardson, Ewout W Steyerberg, Hester Lingsma, Ari Ercole, Andrew IR Maas, David Menon, Lindsay Wilson
Oct 15, 2020
Loss to follow-up and missing outcomes data are important issues for longitudinal observational studies and clinical trials in traumatic brain injury. One popular solution to missing 6-month outcomes has been to use the last...
GOSe imputation missing data Traumatic brain injury Adolescent Adult Aged Aged 80 and over Brain Injuries Traumatic Child Child Preschool Data Interpretation Statistical Female Glasgow Outcome Scale Humans Infant Infant Newborn Male Middle Aged Models Neurological Prognosis Recovery of Function Research Design Young Adult
Toward a New Multi-Dimensional Classification of Traumatic Brain Injury
Benjamin Y Gravesteijn, Charlie A Sewalt, Ari Ercole, Cecilia Akerlund, David Nelson, Andrew IR Maas, David Menon, Hester F Lingsma, Ewout W Steyerberg, Collaborative European NeuroTrauma Effectiveness Research for Traumatic Brain Injury Collaborators
Oct 28, 2019
Traumatic brain injury (TBI) is currently classified as mild, moderate, or severe TBI by trichotomizing the Glasgow Coma Scale (GCS). We aimed to explore directions for a more refined multidimensional classification system. For...
Development of a quality indicator set to measure and improve quality of ICU care for patients with traumatic brain injury.
Jilske A Huijben, Eveline JA Wiegers, Nicolette F de Keizer, Andrew IR Maas, David Menon, Ari Ercole, Giuseppe Citerio, Fiona Lecky, Lindsay Wilson, Maryse C Cnossen, Suzanne Polinder, Ewout W Steyerberg, Mathieu van der Jagt, Hester F Lingsma, Delphi panel
Feb 18, 2019
BACKGROUND: We aimed to develop a set of quality indicators for patients with traumatic brain injury (TBI) in intensive care units (ICUs) across Europe and to explore barriers and facilitators for implementation of these quality...
Benchmarking intensive care unit Quality Indicators quality of care Trauma registry Traumatic brain injury Benchmarking Brain Injuries Traumatic Delphi Technique Europe Expert Testimony Humans Intensive Care Units Quality Improvement Quality Indicators Health Care Quality of Health Care Registries Surveys and Questionnaires
Tracheal intubation in traumatic brain injury
Benjamin Yael Gravesteijn, Charlie Aletta Sewalt, Daan Nieboer, David Krishna Menon, Andrew Maas, Fiona Lecky, Markus Klimek, Hester Floor Lingsma, CENTER-TBI collaborators
Oct 07, 2021
BACKGROUND: We aimed to study the associations between pre- and in-hospital tracheal intubation and outcomes in traumatic brain injury (TBI), and whether the association varied according to injury severity. METHODS: Data from...
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