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Recent Advances in the Development of Stem-Cell-Derived Dopaminergic Neuronal Transplant Therapies for Parkinson's Disease.
Peter A Barbuti, Roger A Barker, Patrik Brundin, Serge Przedborski, Stella M Papa, Lorraine V Kalia, Hideki Mochizuki, MDS Scientific Issues Committee
Mar 17, 2021
The last decade has seen exciting advances in the development of potential stem cell-based therapies for Parkinson's disease (PD), which have used different types of stem cells as starting material. These cells have been...
Experimental Test and Analysis of AC Losses in Multifilamentary MgB <sub>2</sub> Wire
AC losses in superconductors are essential for the design of cooling system for large scale power applications. Magnesium diboride (MgB 2 ) superconducting wires have been investigated and manufactured over the...
Comparing equilibration schemes of high-molecular-weight polymer melts with topological indicators.
Luca Tubiana, Hideki Kobayashi, Raffaello Potestio, Burkhard Dünweg, Kurt Kremer, Peter Virnau, Kostas Daoulas
Apr 28, 2021
Recent theoretical studies have demonstrated that the behaviour of molecular knots is a sensitive indicator of polymer structure. Here, we use knots to verify the ability of two state-of-the-art algorithms-configuration assembly...
Autocrine VEGF Isoforms Differentially Regulate Endothelial Cell Behavior.
Vascular endothelial growth factor A (VEGF) is involved in all the essential biology of endothelial cells, from proliferation to vessel function, by mediating intercellular interactions and monolayer integrity. It is expressed...
Comparing equilibration schemes of high-molecular-weight polymer melts with topological indicators.
Luca Tubiana, Hideki Kobayashi, Raffaello Potestio, Burkhard Dünweg, Kurt Kremer, Peter Virnau, Kostas Daoulas
Feb 10, 2022
Recent theoretical studies have demonstrated that the behaviour of molecular knots is a sensitive indicator of polymer structure. Here, we use knots to verify the ability of two state-of-the-art algorithms-configuration assembly...
Comparing equilibration schemes of high-molecular-weight polymer melts with topological indicators
Luca Tubiana, Hideki Kobayashi, Raffaello Potestio, Burkhard Dünweg, Kurt Kremer, Peter Virnau, Kostas Daoulas
Apr 28, 2021
Abstract: Recent theoretical studies have demonstrated that the behaviour of molecular knots is a sensitive indicator of polymer structure. Here, we use knots to verify the ability of two state-of-the-art...
Experimental Test and Analysis of AC Losses in Multifilamentary MgB <sub>2</sub> Wire
AC losses in superconductors are essential for the design of cooling system for large scale power applications. Magnesium diboride (MgB 2 ) superconducting wires have been investigated and manufactured over the...
Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.
Sanae Hamanaka, Ayumi Umino, Hideyuki Sato, Tomonari Hayama, Ayaka Yanagida, Naoaki Mizuno, Toshihiro Kobayashi, Mariko Kasai, Fabian Patrik Suchy, Satoshi Yamazaki, Hideki Masaki, Tomoyuki Yamaguchi, Hiromitsu Nakauchi
Dec 13, 2018
In the case of organ transplantation accompanied by vascular anastomosis, major histocompatibility complex mismatched vascular endothelial cells become a target for graft rejection. Production of a rejection-free, transplantable...
blastocyst complementation hematopoietic cells Pluripotent Stem Cells tissue regeneration vascular endothelial cells aging Animals Blastocyst Chimera Endothelial Cells Hematopoietic Stem Cells Induced Pluripotent Stem Cells Mice Inbred C57BL Mice Knockout Neovascularization Physiologic Pericytes Phenotype Platelet Endothelial Cell Adhesion Molecule-1 Vascular Endothelial Growth Factor Receptor-2
Towards prognostic functional brain biomarkers for cervical myelopathy
Shota Takenaka, Shigeyuki Kan, Ben Seymour, Takahiro Makino, Yusuke Sakai, Junichi Kushioka, Hisashi Tanaka, Yoshiyuki Watanabe, Masahiko Shibata, Hideki Yoshikawa, Takashi Kaito
Aug 02, 2019
Recently, there has been increasing interest in strategies to predict neurological recovery in cervical myelopathy (CM) based on clinical images of the cervical spine. In this study, we aimed to explore potential preoperative...
MADGAN
Changhee Han, Leonardo Rundo, Kohei Murao, Tomoyuki Noguchi, Yuki Shimahara, Zoltán Ádám Milacski, Saori Koshino, Evis Sala, Hideki Nakayama, Shin’ichi Satoh
Apr 26, 2021
Abstract: Background: Unsupervised learning can discover various unseen abnormalities, relying on large-scale unannotated medical images of healthy subjects. Towards this, unsupervised methods reconstruct a 2D/3D single medical...
Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.
Liang Weng, Atsushi Enomoto, Hiroshi Miyoshi, Kiyofumi Takahashi, Naoya Asai, Nobuhiro Morone, Ping Jiang, Jian An, Takuya Kato, Keisuke Kuroda, Takashi Watanabe, Masato Asai, Maki Ishida-Takagishi, Yoshiki Murakumo, Hideki Nakashima, Kozo Kaibuchi, Masahide Takahashi
May 28, 2019
In clathrin-mediated endocytosis (CME), specificity and selectivity for cargoes are thought to be tightly regulated by cargo-specific adaptors for distinct cellular functions. Here, we show that the actin-binding protein girdin...
MADGAN
Changhee Han, Leonardo Rundo, Kohei Murao, Tomoyuki Noguchi, Yuki Shimahara, Zoltán Ádám Milacski, Saori Koshino, Evis Sala, Hideki Nakayama, Shin'ichi Satoh
Jul 12, 2021
BACKGROUND: Unsupervised learning can discover various unseen abnormalities, relying on large-scale unannotated medical images of healthy subjects. Towards this, unsupervised methods reconstruct a 2D/3D single medical image to...
Towards prognostic functional brain biomarkers for cervical myelopathy
Shota Takenaka, Shigeyuki Kan, Ben Seymour, Takahiro Makino, Yusuke Sakai, Junichi Kushioka, Hisashi Tanaka, Yoshiyuki Watanabe, Masahiko Shibata, Hideki Yoshikawa, Takashi Kaito
Jul 17, 2020
Abstract: Recently, there has been increasing interest in strategies to predict neurological recovery in cervical myelopathy (CM) based on clinical images of the cervical spine. In this study, we aimed to explore potential...
Seedlings Lacking the PTM Protein Do Not Show a genomes uncoupled (gun) Mutant Phenotype.
Mike T Page, Sylwia M Kacprzak, Nobuyoshi Mochizuki, Haruko Okamoto, Alison G Smith, Matthew J Terry
May 04, 2018
The ptm mutant of Arabidopsis does not show a genomes uncoupled mutant phenotype and PTM is therefore unlikely to function in chloroplast-to-nucleus signaling as previously reported.
Efficient Bayesian inference of fully stochastic epidemiological models with applications to COVID-19.
Clarification of mural cell coverage of vascular endothelial cells by live imaging of zebrafish
Mural cells (MCs) consisting of vascular smooth muscle cells and pericytes cover the endothelial cells (ECs) to regulate vascular stability and homeostasis. Here, we clarified the mechanism how MCs develop and cover ECs by...
Efficient Bayesian inference of fully stochastic epidemiological models with applications to COVID-19.
Yuting I Li, Günther Turk, Paul B Rohrbach, Patrick Pietzonka, Julian Kappler, Rajesh Singh, Jakub Dolezal, Timothy Ekeh, Lukas Kikuchi, Joseph D Peterson, Austen Bolitho, Hideki Kobayashi, Michael E Cates, R Adhikari, Robert L Jack
Sep 25, 2021
Epidemiological forecasts are beset by uncertainties about the underlying epidemiological processes, and the surveillance process through which data are acquired. We present a Bayesian inference methodology that quantifies these...
Published by: Royal Society open science
Clarification of mural cell coverage of vascular endothelial cells by live imaging of zebrafish
Mural cells (MCs) consisting of vascular smooth muscle cells and pericytes cover the endothelial cells (ECs) to regulate vascular stability and homeostasis. Here, we clarified the mechanism how MCs develop and cover ECs by...
Enhanced trapped field performance of bulk high-temperature superconductors using split coil, pulsed field magnetization with an iron yoke
MD Ainslie, H Fujishiro, H Mochizuki, K Takahashi, YH Shi, DK Namburi, J Zou, D Zhou, AR Dennis, DA Cardwell
May 16, 2016
Measurement of caveolin-1 densities in the cell membrane for quantification of caveolar deformation after exposure to hypotonic membrane tension.
Masashi Tachikawa, Nobuhiro Morone, Yosuke Senju, Tadao Sugiura, Kyoko Hanawa-Suetsugu, Atsushi Mochizuki, Shiro Suetsugu
May 24, 2019
Caveolae are abundant flask-shaped invaginations of plasma membranes that buffer membrane tension through their deformation. Few quantitative studies on the deformation of caveolae have been reported. Each caveola contains...
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