Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma
Stefan Antonowicz,
Zsolt Bodai,
Tom Wiggins,
Sheraz R. Markar,
Piers R. Boshier,
Yan Mei Goh,
Mina E. Adam,
Haonan Lu,
Hiromi Kudo,
Francesca Rosini,
Robert Goldin,
Daniela Moralli,
Catherine M. Green,
Chris J. Peters,
Nagy Habib,
Hani Gabra,
Rebecca C. Fitzgerald,
Zoltan Takats,
George B. Hanna
Mar 05, 2021
Abstract: Volatile aldehydes are enriched in esophageal adenocarcinoma (EAC) patients’ breath and could improve early diagnosis, however the mechanisms of their production are unknown. Here, we show that weak aldehyde...