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High proliferation and delamination during skin epidermal stratification.
Mareike Damen, Lisa Wirtz, Ekaterina Soroka, Houda Khatif, Christian Kukat, Benjamin D Simons, Hisham Bazzi
Jul 05, 2021
Adolescent Adult Aged Animals Asymmetric cell division Cell Differentiation Cell Proliferation Centrosome Child Child Preschool Embryo Mammalian epidermis Female Hair Follicle Humans Keratinocytes Male Mice Mice Knockout Middle Aged Models Biological Skin Physiological Phenomena Spindle Apparatus Time-Lapse Imaging Tumor Suppressor Protein p53 Tumor Suppressor p53-Binding Protein 1 Ubiquitin Thiolesterase Young Adult
High proliferation and delamination during skin epidermal stratification
Mareike Damen, Lisa Wirtz, Ekaterina Soroka, Houda Khatif, Christian Kukat, Benjamin D. Simons, Hisham Bazzi
May 28, 2021
Abstract: The development of complex stratified epithelial barriers in mammals is initiated from single-layered epithelia. How stratification is initiated and fueled are still open questions. Previous studies on skin epidermal...
High proliferation and delamination during skin epidermal stratification.
Mareike Damen, Lisa Wirtz, Ekaterina Soroka, Houda Khatif, Christian Kukat, Benjamin D Simons, Hisham Bazzi
Jun 29, 2021
The development of complex stratified epithelial barriers in mammals is initiated from single-layered epithelia. How stratification is initiated and fueled are still open questions. Previous studies on skin epidermal...
epidermis Hair Follicle Centrosome Keratinocytes Animals Mice Knockout Humans Mice Ubiquitin Thiolesterase Cell Differentiation Cell Proliferation Models Biological Adolescent Adult Aged Middle Aged Child Child Preschool Female Male Tumor Suppressor Protein p53 Embryo Mammalian Skin Physiological Phenomena Young Adult Time-Lapse Imaging Asymmetric cell division Spindle Apparatus Tumor Suppressor p53-Binding Protein 1
Published by: Nature Communications
The Carbon Savings and Health Co-Benefits from the Introduction of Mass Rapid Transit System in Greater Kuala Lumpur, Malaysia
SCK and JHH: Research was funded by the United Nations University- International Institute for Global Health and the National University of Malaysia under the project codes of UNU-IIGH 80814 and FF-2014-400, respectively.
MT...
Modelling the impact of lockdown-easing measures on cumulative COVID-19 cases and deaths in England.
OBJECTIVES: To assess the potential impacts of successive lockdown-easing measures in England, at a point in the COVID-19 pandemic when community transmission levels were relatively high. DESIGN: We developed a Bayesian model to...
A Hybrid Genetic Algorithm and Sperm Swarm Optimization (HGASSO) for Multimodal Functions
In this paper, we propose a hybrid algorithm combining two different metaheuristic methods, “Genetic Algorithms (GA)” and “Sperm Swarm Optimization (SSO)”, for the global optimization of multimodal benchmarks functions. The...
Published by: IGI Global Scientific Publishing
Modelling the impact of lockdown-easing measures on cumulative COVID-19 cases and deaths in England
Objectives: To assess the potential impacts of successive lockdown-easing measures in England, at a point in the COVID-19 pandemic when community transmission levels were relatively high. Design: We developed a Bayesian model to...
Combined effects of age and BMI are related to altered cortical thickness in adolescence and adulthood.
Margaret L Westwater, Raquel Vilar-López, Hisham Ziauddeen, Antonio Verdejo-García, Paul C Fletcher
Jan 03, 2020
Overweight and obesity are associated with functional and structural alterations in the brain, but how these associations change across critical developmental periods remains unknown. Here, we examined the relationship between...
Birth weight, family history of diabetes and diabetes onset in schizophrenia.
Emilio Fernandez-Egea, Ryan Walker, Hisham Ziauddeen, Rudolf N Cardinal, Edward T Bullmore
Mar 14, 2020
INTRODUCTION:The prevalence of diabetes in schizophrenia is twice that in the general population, but there are few reliable predictors of which individuals will develop glucose dysregulation. OBJECTIVE:To test if abnormal birth...
Published by: BMJ open diabetes research & care
Health co-benefits in mortality avoidance from implementation of the mass rapid transit (MRT) system in Kuala Lumpur, Malaysia.
INTRODUCTION: The mass rapid transit (MRT) is the largest transport infrastructure project under the national key economic area (NKEA) in Malaysia. As urban rail is anticipated to be the future spine of public transport network...
Birth weight, family history of diabetes and diabetes onset in schizophrenia
Emilio Fernandez-Egea, Ryan Walker, Hisham Ziauddeen, Rudolf N Cardinal, Edward T Bullmore
Feb 10, 2020
Introduction: The prevalence of diabetes in schizophrenia is twice that in the general population, but there are few reliable predictors of which individuals will develop glucose dysregulation. Objective: To test if abnormal...
The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.
Zongling Ji, Hisham Mohammed, Aaron Webber, Jenna Ridsdale, Namshik Han, Jason S Carroll, Andrew D Sharrocks
Apr 23, 2019
There are numerous forkhead transcription factors in mammalian cells but we know little about the molecular functions of the majority of these. FOXK2 is a ubiquitously expressed family member suggesting an important function...
Association of birth weight and the development of antipsychotic induced adiposity in individuals with treatment resistant schizophrenia.
Hisham Ziauddeen, Clemente Garcia-Rizo, Miquel Bernardo, Brian Kirkpatrick, Susan E Ozanne, Peter B Jones, Emilio Fernandez-Egea
Mar 29, 2016
Covid-19 in the UK
Deepti Gurdasani, Christina Pagel, Martin McKee, Susan Michie, Trisha Greenhalgh, Kit Yates, Gabriel Scally, Hisham Ziauddeen
Aug 31, 2022
Key messages
Pandemic policy on children and schools reflected UK based scientific narratives that did not align with global scientific consensus
Government relied on evidence that downplayed the seriousness of covid-19...
Pandemic policy on children and schools reflected UK based scientific narratives that did not align with global scientific consensus
Government relied on evidence that downplayed the seriousness of covid-19...
RIME proteomics of estrogen and progesterone receptors in breast cancer.
Nuclear receptors play an important role in transcriptional regulation of diverse cellular processes and is also relevant in diseases such as cancer. In breast cancer, the nuclear receptors - estrogen receptor (ER) and...
Combined effects of age and BMI are related to altered cortical thickness in adolescence and adulthood.
Margaret L Westwater, Raquel Vilar-López, Hisham Ziauddeen, Antonio Verdejo-García, Paul C Fletcher
Nov 20, 2019
Birth weight, family history of diabetes and diabetes onset in schizophrenia.
Emilio Fernandez-Egea, Ryan Walker, Hisham Ziauddeen, Rudolf N Cardinal, Edward T Bullmore
Jan 08, 2020
Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution.
Tobias Messmer, Ferdinand von Meyenn, Aurora Savino, Fátima Santos, Hisham Mohammed, Aaron Tin Long Lun, John C Marioni, Wolf Reik
Mar 19, 2019
Conventional human embryonic stem cells are considered to be primed pluripotent but can be induced to enter a naive state. However, the transcriptional features associated with naive and primed pluripotency are still not fully...
Dissociable hormonal profiles for psychopathology and stress in anorexia and bulimia nervosa.
Margaret L Westwater, Flavia Mancini, Jane Shapleske, Jaco Serfontein, Monique Ernst, Hisham Ziauddeen, Paul C Fletcher
May 07, 2020
Covid-19 in the UK
Deepti Gurdasani, Christina Pagel, Martin McKee, Susan Michie, Trisha Greenhalgh, Kit Yates, Gabriel Scally, Hisham Ziauddeen
Aug 31, 2022
Key messages
Pandemic policy on children and schools reflected UK based scientific narratives that did not align with global scientific consensus
Government relied on evidence that downplayed the seriousness of covid-19...
Pandemic policy on children and schools reflected UK based scientific narratives that did not align with global scientific consensus
Government relied on evidence that downplayed the seriousness of covid-19...
Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development.
Thorsten Boroviak, Giuliano G Stirparo, Sabine Dietmann, Irene Hernando-Herraez, Hisham Mohammed, Wolf Reik, Austin Smith, Erika Sasaki, Jennifer Nichols, Paul Bertone
Dec 06, 2018
Blastocyst Embryo human Inner cell mass Pluripotency primate Animals Callithrix Conserved Sequence Embryo Mammalian Embryonic Development Endoderm Epigenesis Genetic Gene Expression Profiling Gene Expression Regulation Developmental Gene Regulatory Networks Germ Layers Humans Mice Otx Transcription Factors RNA Messenger Ribosomes Single-Cell Analysis Transcription Genetic Transcriptome
Dopamine modulates the neural representation of subjective value of food in hungry subjects.
Nenad Medic, Hisham Ziauddeen, Martin D Vestergaard, Elana Henning, Wolfram Schultz, I Sadaf Farooqi, Paul C Fletcher
Aug 14, 2014
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