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Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms.
Predrag Kukic, Hoi Tik Alvin Leung, Francesco Bemporad, Francesco A Aprile, Janet R Kumita, Alfonso De Simone, Carlo Camilloni, Michele Vendruscolo
May 20, 2015
A mutational signature in gastric cancer suggests therapeutic strategies.
Ludmil B Alexandrov, Serena Nik-Zainal, Hoi Cheong Siu, Suet Yi Leung, Michael R Stratton
Nov 01, 2018
Targeting defects in the DNA repair machinery of neoplastic cells, for example, those due to inactivating BRCA1 and/or BRCA2 mutations, has been used for developing new therapies in certain types of breast, ovarian and...
Association between home food preparation skills and behaviour, and consumption of ultra-processed foods
BACKGROUND: 'Ultra-processed foods' (UPF) have been industrially processed and tend to be higher in saturated fat, sodium and sugar than other foods. There is some evidence that consumption of UPF is associated with overweight...
Executive Control, Neural Correlate, and Visual Processing Changes During the Acquisition of Arabic Language
Alvin Varghese
Jan 01, 0001
Neurolinguistics is a branch of neuroscience that studies the language processing mechanisms in the brain. These processes can be better understood by analyzing the relationship between the visual processing, executive control...
Arabic language letters Neurolinguistics Language processing word naming Memory Life Sciences Modern Languages Neuroscience and Neurobiology
Published by: Ursinus College
Mutational landscape of normal epithelial cells in Lynch Syndrome patients.
Bernard CH Lee, Philip S Robinson, Tim HH Coorens, Helen HN Yan, Sigurgeir Olafsson, Henry Lee-Six, Mathijs A Sanders, Hoi Cheong Siu, James Hewinson, Sarah SK Yue, Wai Yin Tsui, Annie SY Chan, Anthony KW Chan, Siu Lun Ho, Peter J Campbell, Inigo Martincorena, Simon JA Buczacki, Siu Tsan Yuen, Suet Yi Leung, Michael R Stratton
Jun 29, 2022
Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal cancer due to germline heterozygous mutations in a DNA mismatch repair (MMR) gene. Although cancers in LS patients show elevated somatic...
Development and validation of a driving simulator for traffic control using field data
This paper presents the development and validation of a driving simulator for ramp traffic control on expressways using a traffic simulator and control (TSC). The TSC consists of two main components: car-following model (CFM)...
Travel demand management policies
This research study investigates the travel demand management (TDM) strategies and solutions and associated policies through a case study of Singapore to gain knowledge and experiences, and to evaluate the potentials for policy...
Comprehensive framework Policy transfer Transferability Transport policy Travel demand management /dk/atira/pure/subjectarea/asjc/3300/3305 name=Geography, Planning and Development /dk/atira/pure/subjectarea/asjc/3300/3313 name=Transportation /dk/atira/pure/subjectarea/asjc/3300/3322 name=Urban Studies /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities
Travel demand management policies
This research study investigates the travel demand management (TDM) strategies and solutions and associated policies through a case study of Singapore to gain knowledge and experiences, and to evaluate the potentials for policy...
Comprehensive framework Policy transfer Transferability Transport policy Travel demand management /dk/atira/pure/subjectarea/asjc/3300/3305 name=Geography, Planning and Development /dk/atira/pure/subjectarea/asjc/3300/3313 name=Transportation /dk/atira/pure/subjectarea/asjc/3300/3322 name=Urban Studies /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities
The Ursinus Weekly, December 15, 1947
Robert Juppe, John Burton, Richard Wentzel, Alvin Knepper, George Gazonas, Doris Gill, Roy Todd, George Saurman, Fay Horner, John Martin
Jan 01, 0001
Dance, banquet to highlight eventful pre-Christmas week Large audience lauds "Messiah" presentation Barrett-Browning story lives again at Ursinus in Curtain Club drama Thirteen Ursinus seniors will appear in '47-'48 "Who's...
Ursinus College Collegeville Pennsylvania newspaper Richard Wentzel student government Military veterans chapel attendance debate team Leon Erdang Tom McKenzie Jerry Seeders wrestling Basketball Swimming field hockey Norman Rowley Soccer Archie Simons cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Conceptual fuzzy-based decision support tool for soil improvement under highway embankment - a case study of HaNoi–HaiPhong expressway
In this research, a fuzzy rule–based decision support (FRBDS) tool is developed to assist selection of ground treatment techniques for road embankments. Using input variables such as embankment height, geological condition...
Decision support decision-making Fuzzy rule base soft ground treatment technique /dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/1900/1909 name=Geotechnical Engineering and Engineering Geology /dk/atira/pure/subjectarea/asjc/1100/1111 name=Soil Science
Short-Term Travel Time Prediction using Support Vector Machine and Nearest Neighbor Method
This paper presents an investigation into the performance of support vector machine (SVM) in short-term travel-time prediction in comparison with baseline methods, including the historical mean, current time based, and time...
Controversial Issues in Arthroscopic Surgery for Femoroacetabular Impingement.
Femoroacetabular impingement (FAI) is a common cause of painful hip in the young and middle-aged population. This condition frequently leads to a labral tear, damage of acetabular cartilage, and secondary arthritis of the hip....
Multi-Stage Fuzzy Logic Controller for Expressway Traffic Control During Incidents
In this research study, a multistage fuzzy logic controller (MS-FLC) was developed for traffic control in incident management on expressways. The MS-FLC serves as the traffic operator’s decision-making support tool at the...
Conceptual fuzzy-based decision support tool for soil improvement under highway embankment - a case study of HaNoi–HaiPhong expressway
In this research, a fuzzy rule–based decision support (FRBDS) tool is developed to assist selection of ground treatment techniques for road embankments. Using input variables such as embankment height, geological condition...
Decision support decision-making Fuzzy rule base soft ground treatment technique /dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/1900/1909 name=Geotechnical Engineering and Engineering Geology /dk/atira/pure/subjectarea/asjc/1100/1111 name=Soil Science
Developing a fuzzy-based decision-making procedure for traffic control in expressway congestion management
This paper presents part of a multi-stage fuzzy logic controller (MS-FLC) that is developed for traffic control in congestion management on expressways. The decision-making process of traffic control for expressway congestion...
Congestion management Decision Making Fuzzy Logic Fuzzy rule base Ramp metering Traffic control /dk/atira/pure/subjectarea/asjc/3100/3109 name=Statistical and Nonlinear Physics /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/sustainabledevelopmentgoals/industry_innovation_and_infrastructure name=SDG 9 - Industry, Innovation, and Infrastructure
Adverse Childhood Experiences and Alcohol Consumption in Midlife and Early Old-Age.
AIMS: To examine the individual and cumulative effects of adverse childhood experiences (ACEs) on alcohol consumption in midlife and early old-age, and the role of ACEs in 10-year drinking trajectories across midlife. METHODS...
Mutational landscape of normal epithelial cells in Lynch Syndrome patients.
Bernard CH Lee, Philip S Robinson, Tim HH Coorens, Helen HN Yan, Sigurgeir Olafsson, Henry Lee-Six, Mathijs A Sanders, Hoi Cheong Siu, James Hewinson, Sarah SK Yue, Wai Yin Tsui, Annie SY Chan, Anthony KW Chan, Siu Lun Ho, Peter J Campbell, Inigo Martincorena, Simon JA Buczacki, Siu Tsan Yuen, Suet Yi Leung, Michael R Stratton
May 17, 2022
Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal cancer due to germline heterozygous mutations in a DNA mismatch repair (MMR) gene. Although cancers in LS patients show elevated somatic...
The F1000Research Antibody Validation Article Collection
Well validated antibodies are crucial to progress in a wide range of life science disciplines, but validating an antibody is a complex and ongoing process. Antibody validation is often carried out as preliminary work to a...
Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases.
Alvin Djajadikerta, Swati Keshri, Mariana Pavel, Ryan Prestil, Laura Ryan, David C Rubinsztein
Dec 11, 2019
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic contents to lysosomes for degradation. Genetic studies have revealed extensive links between autophagy and neurodegenerative disease, and...
BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-κB and Activating PKA/CREB.
Chuwen Li, Tongkai Chen, Hefeng Zhou, Yu Feng, Maggie PM Hoi, Dan Ma, Chao Zhao, Ying Zheng, Simon MY Lee
Oct 03, 2018
Microglia-mediated neuroinflammatory responses are inevitable and important pathological processes in several kinds of disorder of the central nervous system (CNS). Therefore, alleviating activated microglia-induced inflammatory...
Intrinsic flexibility of porous materials
Framework materials have structures containing strongly bonded polyhedral
groups of atoms connected through their vertices. Typically the energy cost for
variations of the inter-polyhedral geometry is much less than the...
groups of atoms connected through their vertices. Typically the energy cost for
variations of the inter-polyhedral geometry is much less than the...
Are in-hospital COVID-19-related mortality and morbidity in pregnancy associated with gestational age?
OBJECTIVE: Pregnancy involves dynamic changes in the maternal immune system, thus potentially affecting women's response to infection. The aim of this study was to investigate whether gestational age at the time of severe acute...
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