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Regulation of the Heterochromatin Protein 1 by Phosphorylation of Histone H3 and the HP1 Hinge Domain
Holger Dormann
Jan 01, 0001
Chromatin, a polymer formed from DNA, histones, and associated proteins, is the physiological form of genetic information in all eukaryotic cells. Posttranslational modification of histones, such as acetylation, methylation, and...
Chromatin HISTONE H3 effector proteins heterochromatin protein 1 (HP1) Phosphorylation methyl-phos switching Life Sciences
Published by: Rockefeller University
Large-scale urban underground hydro-thermal modelling - A case study of the Royal Borough of Kensington and Chelsea, London.
Asal Bidarmaghz, Ruchi Choudhary, Kenichi Soga, Ricky L Terrington, Holger Kessler, Stephen Thorpe
Dec 20, 2019
Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil.
Nicole Pogodalla, Holger Kranenburg, Simone Rey, Silke Rodrigues, Albert Cardona, Christian Klämbt
Nov 04, 2021
In the central nervous system (CNS), functional tasks are often allocated to distinct compartments. This is also evident in the Drosophila CNS where synapses and dendrites are clustered in distinct neuropil regions. The neuropil...
Drosophila ß Heavy -Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil
Nicole Pogodalla, Holger Kranenburg, Simone Rey, Silke Rodrigues, Albert Cardona, Christian Klämbt
Jan 31, 2022
Abstract: In the central nervous system (CNS), functional tasks are often allocated to distinct compartments. This is also evident in the Drosophila CNS where synapses and dendrites are clustered in distinct neuropil regions....
Entrepreneurship and psychological disorders
Amidst predominant focus on positive traits for entrepreneurship, this paper explores how disorders such as ADHD influence the decision to engage in entrepreneurial action and the success of entrepreneurial action. Based on a...
Entrepreneurship and psychological disorders
Amidst predominant focus on positive traits for entrepreneurship, this paper explores how disorders such as ADHD influence the decision to engage in entrepreneurial action and the success of entrepreneurial action. Based on a...
DNA preserved in jetsam whale ambergris.
Ruairidh Macleod, Mikkel-Holger S Sinding, Morten Tange Olsen, Matthew J Collins, Steven J Rowland
Feb 10, 2020
Jetsam ambergris, found on beaches worldwide, has always been assumed to originate as a natural product of sperm whales (Physeteroidea). However, only indirect evidence has ever been produced for this, such as the presence of...
Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil.
Nicole Pogodalla, Holger Kranenburg, Simone Rey, Silke Rodrigues, Albert Cardona, Christian Klämbt
Feb 01, 2022
In the central nervous system (CNS), functional tasks are often allocated to distinct compartments. This is also evident in the Drosophila CNS where synapses and dendrites are clustered in distinct neuropil regions. The neuropil...
Nozzle geometry effects on supersonic wind tunnel studies of shock–boundary-layer interactions
Abstract Many supersonic wind tunnel experiments investigate shock–boundary-layer interactions by measuring the response of tunnel wall boundary layers to an incident shock wave. To generate the...
Drosophila ß<sub>Heavy</sub>-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil.
Nicole Pogodalla, Holger Kranenburg, Simone Rey, Silke Rodrigues, Albert Cardona, Christian Klämbt
Jan 06, 2022
In the central nervous system (CNS), functional tasks are often allocated to distinct compartments. This is also evident in the Drosophila CNS where synapses and dendrites are clustered in distinct neuropil regions. The neuropil...
Brain Neuroglia Neuropil Neurons Animals Drosophila Glycoproteins Phosphatidylinositol Phosphates Spectrin Drosophila Proteins Nerve Tissue Proteins Cell Lineage Larva
Published by: Nature Communications
Weapon injuries in the crusader mass graves from a 13th century attack on the port city of Sidon (Lebanon)
Richard N. R. Mikulski, Holger Schutkowski, Martin J. Smith, Claude Doumet-Serhal, Piers D. Mitchell
Aug 26, 2021
Archaeological excavations close to St Louis’ castle in Sidon, Lebanon have revealed two mass grave deposits containing partially articulated and disarticulated human skeletal remains. A minimum of 25 male individuals have been...
Glass-Transition Temperature of the β-Relaxation as the Major Predictive Parameter for Recrystallization of Neat Amorphous Drugs.
Eric Ofosu Kissi, Holger Grohganz, Korbinian Löbmann, Michael T Ruggiero, J Axel Zeitler, Thomas Rades
May 08, 2018
Recrystallization of amorphous drugs is currently limiting the simple approach to improve solubility and bioavailability of poorly water-soluble drugs by amorphization of a crystalline form of the drug. In view of this...
Fast Ionic Conductivity in the Most Lithium-Rich Phosphidosilicate Li14SiP6.
Stefan Strangmüller, Henrik Eickhoff, David Müller, Wilhelm Klein, Gabriele Raudaschl-Sieber, Holger Kirchhain, Christian Sedlmeier, Volodymyr Baran, Anatoliy Senyshyn, Volker L Deringer, Leo van Wüllen, Hubert A Gasteiger, Thomas F Fässler
Sep 04, 2019
Solid electrolytes with superionic conductivity are required as a main component for all-solid-state batteries. Here we present a novel solid electrolyte with three-dimensional conducting pathways based on "lithium-rich"...
Weapon injuries in the crusader mass graves from a 13th century attack on the port city of Sidon (Lebanon).
Richard NR Mikulski, Holger Schutkowski, Martin J Smith, Claude Doumet-Serhal, Piers D Mitchell
Sep 25, 2021
Archaeological excavations close to St Louis' castle in Sidon, Lebanon have revealed two mass grave deposits containing partially articulated and disarticulated human skeletal remains. A minimum of 25 male individuals have been...
Enisamium Reduces Influenza Virus Shedding and Improves Patient Recovery by Inhibiting Viral RNA Polymerase Activity.
Aartjan JW Te Velthuis, Tatiana G Zubkova, Megan Shaw, Andrew Mehle, David Boltz, Norbert Gmeinwieser, Holger Stammer, Jens Milde, Lutz Müller, Victor Margitich
Jan 27, 2021
FAV00A RNA polymerase RNA synthesis Adenovirus Adenoviruses enisamium iodide influenza A and B influenza A and B viruses respiratory syncytial virus respiratory viruses Treatment Adolescent Adult Humans Influenza Human Middle Aged Orthomyxoviridae Pyridinium Compounds RNA Viral Respiratory Tract Infections Viral Replicase Complex Proteins Virus Shedding Young Adult
When and how to update systematic reviews
Paul Garner, Sally Hopewell, Jackie Chandler, Harriet MacLehose, Holger J Schünemann, Elie A Akl, Joseph Beyene, Stephanie Chang, Rachel Churchill, Karin Dearness, Gordon Guyatt, Carol Lefebvre, Beth Liles, Rachel Marshall, Laura Martínez García, Chris Mavergames, Mona Nasser, Amir Qaseem, Margaret Sampson, Karla Soares-Weiser, Yemisi Takwoingi, Lehana Thabane, Marialena Trivella, Peter Tugwell, Emma Welsh, Ed C Wilson, Holger J Schünemann, Panel for updating guidance for systematic reviews (PUGs)
Aug 16, 2016
Functional Relationships of Wood Anatomical Traits in Norway Spruce.
Alma Piermattei, Georg von Arx, Camilla Avanzi, Patrick Fonti, Holger Gärtner, Andrea Piotti, Carlo Urbinati, Giovanni Giuseppe Vendramin, Ulf Büntgen, Alan Crivellaro
Jun 04, 2020
The quantitative assessment of wood anatomical traits offers important insights into those factors that shape tree growth. While it is known that conduit diameter, cell wall thickness, and wood density vary substantially between...
A cross-cohort replicable and heritable latent dimension linking behaviour to multi-featured brain structure.
Eliana Nicolaisen-Sobesky, Agoston Mihalik, Shahrzad Kharabian-Masouleh, Fabio S Ferreira, Felix Hoffstaedter, Holger Schwender, Somayeh Maleki Balajoo, Sofie L Valk, Simon B Eickhoff, BT Thomas Yeo, Janaina Mourao-Miranda, Sarah Genon
Nov 27, 2022
Identifying associations between interindividual variability in brain structure and behaviour requires large cohorts, multivariate methods, out-of-sample validation and, ideally, out-of-cohort replication. Moreover, the...
Antibiotic resistance and clonal diversity of invasive Staphylococcus aureus in the rural Ashanti Region, Ghana.
Denise Dekker, Manuel Wolters, Eva Mertens, Kennedy Gyau Boahen, Ralf Krumkamp, Daniel Eibach, Norbert G Schwarz, Yaw Adu-Sarkodie, Holger Rohde, Martin Christner, Florian Marks, Nimako Sarpong, Jürgen May
Feb 19, 2019
BACKGROUND: Staphylococcus aureus is among the most common pathogens isolated from blood cultures in Ghana; yet the epidemiology of blood infections in rural settings is poorly described. This study aims to investigate...
antibiotic resistance Panton-Valentine leukocidin Rural ghana S. aureus Spa typing Adolescent Anti-Bacterial Agents Bacteremia Bacterial Proteins Bacterial Toxins Child Child Preschool Drug Resistance Multiple Bacterial Exotoxins Female genetic variation Ghana Hospitals Humans Infant Infant Newborn Leukocidins Male Methicillin-Resistant Staphylococcus aureus Microbial Sensitivity Tests Multiplex Polymerase Chain Reaction Penicillin-Binding Proteins Rural Population Staphylococcal Infections Staphylococcus aureus
Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5.
Andrzej Harris, Manuel Wagner, Dijun Du, Stefanie Raschka, Lea-Marie Nentwig, Holger Gohlke, Sander H J Smits, Ben F Luisi, Lutz Schmitt
Oct 08, 2021
Pdr5, a member of the extensive ABC transporter superfamily, is representative of a clinically relevant subgroup involved in pleiotropic drug resistance. Pdr5 and its homologues drive drug efflux through uncoupled hydrolysis of...
Vanadates Rhodamines ATP-Binding Cassette Transporters Saccharomyces cerevisiae Proteins Adenosine Triphosphate detergents Cryoelectron Microscopy Drug Resistance Fungal Catalytic Domain Protein Conformation Hydrolysis Mutation Genetic Pleiotropy Protein Domains
Published by: Nature Communications
A cross-cohort replicable and heritable latent dimension linking behaviour to multi-featured brain structure.
Eliana Nicolaisen-Sobesky, Agoston Mihalik, Shahrzad Kharabian-Masouleh, Fabio S Ferreira, Felix Hoffstaedter, Holger Schwender, Somayeh Maleki Balajoo, Sofie L Valk, Simon B Eickhoff, BT Thomas Yeo, Janaina Mourao-Miranda, Sarah Genon
Jan 04, 2023
Identifying associations between interindividual variability in brain structure and behaviour requires large cohorts, multivariate methods, out-of-sample validation and, ideally, out-of-cohort replication. Moreover, the...
The single-cell pathology landscape of breast cancer.
Hartland W Jackson, Jana R Fischer, Vito RT Zanotelli, H Raza Ali, Robert Mechera, Savas D Soysal, Holger Moch, Simone Muenst, Zsuzsanna Varga, Walter P Weber, Bernd Bodenmiller
Mar 11, 2020
Single-cell analyses have revealed extensive heterogeneity between and within human tumours1-4, but complex single-cell phenotypes and their spatial context are not at present reflected in the histological stratification that is...
Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5
Andrzej Harris, Manuel Wagner, Dijun Du, Stefanie Raschka, Lea-Marie Nentwig, Holger Gohlke, Sander H. J. Smits, Ben F. Luisi, Lutz Schmitt
Sep 08, 2021
Abstract: Pdr5, a member of the extensive ABC transporter superfamily, is representative of a clinically relevant subgroup involved in pleiotropic drug resistance. Pdr5 and its homologues drive drug efflux through uncoupled...
Enhanced Colorimetric Differentiation between Staphylococcus aureus and Pseudomonas aeruginosa Using a Shape-Encoded Sensor Hydrogel
Zhiyuan Jia, Lauren Gwynne, Adam C. Sedgwick, Mareike Müller, George T. Williams, Andrew Toby A. Jenkins, Tony D. James, Holger Schönherr
Jul 20, 2020
Herein, we demonstrate a combined fluorescent probe/shape-encoded hydrogel strategy for the fast, sensitive, and selective detection of bacterial species via their characteristic enzymes. A poly(vinyl alcohol) (PVA) hydrogel...
bacteria detection bacteria differentiation Biosensors Fluorescent probe Hydrogels /dk/atira/pure/subjectarea/asjc/2500/2502 name=Biomaterials /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2200/2204 name=Biomedical Engineering /dk/atira/pure/subjectarea/asjc/2700/2704 name=Biochemistry, medical
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